{"id":"https://openalex.org/W2010800358","doi":"https://doi.org/10.1172/jci111359","title":"Defective glucose counterregulation after subcutaneous insulin in noninsulin-dependent diabetes mellitus. Paradoxical suppression of glucose utilization and lack of compensatory increase in glucose production, roles of insulin resistance, abnormal neuroendocrine responses, and islet paracrine interactions.","display_name":"Defective glucose counterregulation after subcutaneous insulin in noninsulin-dependent diabetes mellitus. Paradoxical suppression of glucose utilization and lack of compensatory increase in glucose production, roles of insulin resistance, abnormal neuroendocrine responses, and islet paracrine interactions.","publication_year":1984,"publication_date":"1984-06-01","ids":{"openalex":"https://openalex.org/W2010800358","doi":"https://doi.org/10.1172/jci111359","mag":"2010800358","pmid":"https://pubmed.ncbi.nlm.nih.gov/6373827","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/437063"},"language":"en","primary_location":{"id":"doi:10.1172/jci111359","doi":"https://doi.org/10.1172/jci111359","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci111359","pdf_url":"http://www.jci.org/articles/view/111359/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/111359/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057323309","display_name":"Geremia B. Bolli","orcid":"https://orcid.org/0000-0003-4966-4003","observed_orcids":["https://orcid.org/0000-0003-4966-4003"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G B Bolli","raw_affiliation_strings":["Endocrine Research Unit, Departments ofMedicine and Physiology, Mayo Medical School and Mayo Clinic, Rochester, Minnesota 55901; Metabolism Division, Department ofMedicine,","Washington University School ofMedicine, St. Louis, Missouri 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Research Unit, Departments ofMedicine and Physiology, Mayo Medical School and Mayo Clinic, Rochester, Minnesota 55901; Metabolism Division, Department ofMedicine,","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Washington University School ofMedicine, St. Louis, Missouri 63110","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024638744","display_name":"Eva Tsalikian","orcid":"https://orcid.org/0000-0003-3429-2796","observed_orcids":["https://orcid.org/0000-0003-3429-2796"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E Tsalikian","raw_affiliation_strings":["Endocrine Research Unit, Departments ofMedicine and Physiology, Mayo Medical School and Mayo Clinic, Rochester, Minnesota 55901; Metabolism Division, Department ofMedicine,","Washington University School ofMedicine, St. Louis, Missouri 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Research Unit, Departments ofMedicine and Physiology, Mayo Medical School and Mayo Clinic, Rochester, Minnesota 55901; Metabolism Division, Department ofMedicine,","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Washington University School ofMedicine, St. Louis, Missouri 63110","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027183958","display_name":"Morey W. Haymond","orcid":"https://orcid.org/0000-0003-0631-2913","observed_orcids":["https://orcid.org/0000-0003-0631-2913"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M W Haymond","raw_affiliation_strings":["Metabolism Division , Department ofMedicine , Washington University School ofMedicine , St. Louis , Missouri 63110","Endocrine Research Unit, Departments ofMedicine and Physiology, Mayo Medical School and Mayo Clinic, Rochester, Minnesota 55901; Metabolism Division, Department ofMedicine,","Washington University School ofMedicine, St. Louis, Missouri 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolism Division , Department ofMedicine , Washington University School ofMedicine , St. Louis , Missouri 63110","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Endocrine Research Unit, Departments ofMedicine and Physiology, Mayo Medical School and Mayo Clinic, Rochester, Minnesota 55901; Metabolism Division, Department ofMedicine,","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Washington University School ofMedicine, St. Louis, Missouri 63110","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108624170","display_name":"Philip E. Cryer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P E Cryer","raw_affiliation_strings":["Endocrine Research Unit , Departments ofMedicine and Physiology , Mayo Medical School and Mayo Clinic , Rochester , Minnesota 55901 ;","Endocrine Research Unit, Departments ofMedicine and Physiology, Mayo Medical School and Mayo Clinic, Rochester, Minnesota 55901; Metabolism Division, Department ofMedicine,","Washington University School ofMedicine, St. Louis, Missouri 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Research Unit , Departments ofMedicine and Physiology , Mayo Medical School and Mayo Clinic , Rochester , Minnesota 55901 ;","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Endocrine Research Unit, Departments ofMedicine and Physiology, Mayo Medical School and Mayo Clinic, Rochester, Minnesota 55901; Metabolism Division, Department ofMedicine,","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Washington University School ofMedicine, St. Louis, Missouri 63110","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5114012252","display_name":"John E. Gerich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J E Gerich","raw_affiliation_strings":["Endocrine Research Unit , Departments ofMedicine and Physiology , Mayo Medical School and Mayo Clinic , Rochester , Minnesota 55901 ;","Endocrine Research Unit, Departments ofMedicine and Physiology, Mayo Medical School and Mayo Clinic, Rochester, Minnesota 55901; Metabolism Division, Department ofMedicine,","Washington University School ofMedicine, St. Louis, Missouri 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Research Unit , Departments ofMedicine and Physiology , Mayo Medical School and Mayo Clinic , Rochester , Minnesota 55901 ;","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Endocrine Research Unit, Departments ofMedicine and Physiology, Mayo Medical School and Mayo Clinic, Rochester, Minnesota 55901; Metabolism Division, Department ofMedicine,","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Washington University School ofMedicine, St. Louis, Missouri 63110","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":4.3479,"has_fulltext":true,"cited_by_count":108,"citation_normalized_percentile":{"value":0.94676885,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"73","issue":"6","first_page":"1532","last_page":"1541"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.6987000107765198,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.6987000107765198,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.28690001368522644,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8539999723434448},{"id":"https://openalex.org/keywords/glucose-counterregulation","display_name":"glucose counterregulation","score":0.9750000238418579},{"id":"https://openalex.org/keywords/hypoglycemia","display_name":"hypoglycemia","score":0.8679999709129333},{"id":"https://openalex.org/keywords/glucagon-secretion","display_name":"glucagon secretion","score":0.7350000143051147},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.550000011920929},{"id":"https://openalex.org/keywords/glucose-production","display_name":"glucose production","score":0.7319999933242798},{"id":"https://openalex.org/keywords/glucose-utilization","display_name":"glucose utilization","score":0.9929999709129333},{"id":"https://openalex.org/keywords/neuroendocrine-response","display_name":"neuroendocrine response","score":0.6819999814033508},{"id":"https://openalex.org/keywords/epinephrine","display_name":"epinephrine","score":0.8360000252723694},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.9269999861717224},{"id":"https://openalex.org/keywords/growth-hormone","display_name":"growth hormone","score":0.921999990940094},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.9919999837875366},{"id":"https://openalex.org/keywords/endogenous-insulin-secretion","display_name":"endogenous insulin secretion","score":0.7440000176429749},{"id":"https://openalex.org/keywords/subcutaneous-insulin","display_name":"subcutaneous insulin","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.9314178228378296},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.9101989269256592},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.7341783046722412},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.6781209111213684},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6488412618637085},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5941879749298096},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5222578644752502},{"id":"https://openalex.org/C2780668416","wikidata":"https://www.wikidata.org/wiki/Q202758","display_name":"Hypoglycemia","level":3,"score":0.49630123376846313}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002096","descriptor_name":"C-Peptide","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006442","descriptor_name":"Glycated Hemoglobin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007279","descriptor_name":"Injections, Subcutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci111359","doi":"https://doi.org/10.1172/jci111359","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci111359","pdf_url":"http://www.jci.org/articles/view/111359/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:437063","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/437063","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:6373827","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6373827","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1172/jci111359","doi":"https://doi.org/10.1172/jci111359","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci111359","pdf_url":"http://www.jci.org/articles/view/111359/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337356","display_name":"Fogarty International Center","ror":"https://ror.org/02xey9a22"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2010800358.pdf","grobid_xml":"https://content.openalex.org/works/W2010800358.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W191654938","https://openalex.org/W1510134797","https://openalex.org/W1541139654","https://openalex.org/W1600232156","https://openalex.org/W1963659823","https://openalex.org/W1965105130","https://openalex.org/W1969809022","https://openalex.org/W1972233039","https://openalex.org/W1973179480","https://openalex.org/W1974540301","https://openalex.org/W1991574615","https://openalex.org/W2013089541","https://openalex.org/W2025374971","https://openalex.org/W2027150124","https://openalex.org/W2029037252","https://openalex.org/W2029837852","https://openalex.org/W2039193863","https://openalex.org/W2039556928","https://openalex.org/W2050019582","https://openalex.org/W2059802140","https://openalex.org/W2070862761","https://openalex.org/W2072271848","https://openalex.org/W2079028200","https://openalex.org/W2079170821","https://openalex.org/W2079577855","https://openalex.org/W2090278466","https://openalex.org/W2090568763","https://openalex.org/W2096017546","https://openalex.org/W2103557599","https://openalex.org/W2104564587","https://openalex.org/W2114475154","https://openalex.org/W2116412594","https://openalex.org/W2119891717","https://openalex.org/W2124111875","https://openalex.org/W2125591445","https://openalex.org/W2129686285","https://openalex.org/W2133440135","https://openalex.org/W2134244652","https://openalex.org/W2136726170","https://openalex.org/W2145936925","https://openalex.org/W2150416141","https://openalex.org/W2151836253","https://openalex.org/W2156281997","https://openalex.org/W2160126122","https://openalex.org/W2168588540","https://openalex.org/W2169558934","https://openalex.org/W2171532347","https://openalex.org/W2171960002","https://openalex.org/W2318127375","https://openalex.org/W2324213779","https://openalex.org/W2329736408","https://openalex.org/W2336151281","https://openalex.org/W2343313464","https://openalex.org/W2410927355","https://openalex.org/W2465962015","https://openalex.org/W2470146375","https://openalex.org/W6776644756"],"related_works":["https://openalex.org/W2156281997","https://openalex.org/W7099276795","https://openalex.org/W2082546932","https://openalex.org/W123244810","https://openalex.org/W2187746723","https://openalex.org/W1972079319","https://openalex.org/W2092734860","https://openalex.org/W2019613101","https://openalex.org/W2055645626","https://openalex.org/W2054293703"],"abstract_inverted_index":{"To":[0],"characterize":[1],"glucose":[2,50,54,117,128,193,205,253,408],"counterregulatory":[3],"mechanisms":[4],"in":[5,20,63,83,87,106,116,119,127,142,157,172,185,192,204,223,251,285,304,325,332,355,392,400,413,429],"patients":[6,91],"with":[7,92,100,406],"noninsulin-dependent":[8],"diabetes":[9],"mellitus":[10],"(NIDDM)":[11],"and":[12,56,58,76,187,310,368,420],"to":[13,61,81,375],"test":[14],"the":[15,18,36,64,120,164,255,268,333,378],"hypothesis":[16],"that":[17,166],"increase":[19,115,126],"glucagon":[21,265,402],"secretion":[22,86,425],"during":[23],"hypoglycemia":[24],"occurs":[25],"primarily":[26,111],"via":[27],"a":[28,39,113,201,259],"paracrine":[29],"islet":[30],"A-B":[31],"cell":[32],"interaction,":[33],"we":[34],"examined":[35],"effects":[37],"of":[38,44,53,67,96,209,262,377,397,422],"subcutaneously":[40],"injected":[41],"therapeutic":[42],"dose":[43],"insulin":[45,85,168,210,424],"(0.15":[46],"U/kg)":[47],"on":[48],"plasma":[49,167,252,340,370,401,407],"kinetics,":[51],"rates":[52],"production":[55,129,194],"utilization,":[57],"their":[59,339,369],"relationships":[60],"changes":[62,82],"circulating":[65],"concentrations":[66,169,409],"neuroendocrine":[68],"glucoregulatory":[69],"factors":[70],"(glucagon,":[71],"epinephrine,":[72],"norepinephrine,":[73],"growth":[74,311],"hormone,":[75],"cortisol),":[77],"as":[78,80],"well":[79],"endogenous":[84,423],"13":[88],"nonobese":[89],"NIDDM":[90],"no":[93,124],"clinical":[94],"evidence":[95],"autonomic":[97],"neuropathy.":[98],"Compared":[99],"11":[101],"age-weight":[102],"matched":[103],"nondiabetic":[104],"volunteers":[105],"whom":[107],"euglycemia":[108],"was":[109,123,195,258],"restored":[110],"by":[112,200,249],"compensatory":[114,125],"production,":[118],"diabetics":[121,143,186,224,334],"there":[122],"(basal":[130,211],"2.08":[131,227],"+/-":[132,134,147,149,178,182,213,215,228,230,275,279,294,298,315,319,345,349,382,386],"0.04----1.79":[133],"0.07":[135],"mg/kg":[136,151,217,232],"per":[137,152,218,233],"min":[138,153,219,234],"at":[139,154,220,235],"21/2":[140,155,221,236],"h":[141,156,222,237,284,303,324,354,391],"vs.":[144,180,225,277,296,317,347,384],"basal":[145,226],"2.06":[146],"0.04----2.32":[148],"0.11":[150,231],"nondiabetics,":[158,188,238,286,305,326,356],"P":[159,239,287,306,327,357,416],"less":[160,240,288,307,328,358,365,417],"than":[161,241,289,308,329,359,366,418],"0.01)":[162,419],"despite":[163],"fact":[165],"were":[170,335,361,373,403],"similar":[171,374],"both":[173,395,414],"groups":[174,396],"(peak":[175],"values":[176],"22":[177],"2":[179,183],"23":[181,278],"microU/ml":[184],"respectively).":[189],"This":[190],"abnormality":[191],"nearly":[196],"completely":[197],"compensated":[198],"for":[199,248],"paradoxical":[202],"decrease":[203],"utilization":[206],"after":[207],"injection":[208],"2.11":[212],"0.03----1.86":[214],"0.06":[216],"0.04----2.39":[229],"0.01),":[242],"which":[243],"could":[244],"not":[245],"be":[246],"accounted":[247],"differences":[250],"concentrations;":[254],"net":[256],"result":[257],"modest":[260],"prolongation":[261],"hypoglycemia.":[263],"Plasma":[264],"(area":[266],"under":[267],"curve":[269],"[AUC]":[270],"above":[271],"base":[272],"line,":[273],"12":[274,283,302,323,346,353,390],"3":[276,280],"mg/ml":[281],"X":[282,301,322,352,389],"0.05),":[290,309],"cortisol":[291],"(AUC":[292,313,343,380],"2.2":[293],"0.5":[295],"4.0":[297],"0.7":[299],"mg/dl":[300],"hormone":[312],"1.6":[314],"0.4":[316,320],"2.9":[318],"micrograms/ml":[321],"0.05)":[330,360,367],"responses":[331,342,372],"decreased":[336],"50%":[337],"while":[338],"norepinephrine":[341],"49":[344],"21":[348],"5":[350],"ng/ml":[351,388],"increased":[362],"twofold":[363],"(P":[364],"epinephrine":[371],"those":[376],"nondiabetics":[379],"106":[381],"17":[383],"112":[385],"10":[387],"nondiabetics).":[393],"In":[394],"subjects,":[398],"increases":[399],"inversely":[404],"correlated":[405],"(r":[410,426],"=":[411,427],"-0.80":[412],"groups,":[415],"suppression":[421],"-0.57":[428],"nondiabe":[430]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
