{"id":"https://openalex.org/W2010773093","doi":"https://doi.org/10.1186/1471-2164-15-s7-s2","title":"Computational identification of multi-omic correlates of anticancer therapeutic response","display_name":"Computational identification of multi-omic correlates of anticancer therapeutic response","publication_year":2014,"publication_date":"2014-10-01","ids":{"openalex":"https://openalex.org/W2010773093","doi":"https://doi.org/10.1186/1471-2164-15-s7-s2","mag":"2010773093","pmid":"https://pubmed.ncbi.nlm.nih.gov/25573145","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4243102"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2164-15-s7-s2","doi":"https://doi.org/10.1186/1471-2164-15-s7-s2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2164-15-s7-s2","pdf_url":"https://link.springer.com/content/pdf/10.1186/1471-2164-15-S7-S2.pdf","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/1471-2164-15-S7-S2.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030099017","display_name":"Lindsay C. Stetson","orcid":"https://orcid.org/0000-0002-4061-3261","observed_orcids":["https://orcid.org/0000-0002-4061-3261"]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lindsay C Stetson","raw_affiliation_strings":["Case Comprehensive Cancer Center, USA","Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, Ohio, 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Comprehensive Cancer Center, USA","institution_ids":["https://openalex.org/I4390039247"]},{"raw_affiliation_string":"Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, Ohio, 44106, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057716559","display_name":"Taylor M. Pearl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Taylor Pearl","raw_affiliation_strings":["Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100732042","display_name":"Yanwen Chen","orcid":"https://orcid.org/0000-0002-3467-2871","observed_orcids":["https://orcid.org/0000-0002-3467-2871","https://orcid.org/0000-0001-7959-5040"]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanwen Chen","raw_affiliation_strings":["Case Comprehensive Cancer Center, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Comprehensive Cancer Center, USA","institution_ids":["https://openalex.org/I4390039247"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051948022","display_name":"Jill S. Barnholtz\u2010Sloan","orcid":"https://orcid.org/0000-0001-6190-9304","observed_orcids":["https://orcid.org/0000-0001-6190-9304"]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jill S Barnholtz-Sloan","raw_affiliation_strings":["Case Comprehensive Cancer Center, USA","Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, Ohio, 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Comprehensive Cancer Center, USA","institution_ids":["https://openalex.org/I4390039247"]},{"raw_affiliation_string":"Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, Ohio, 44106, USA","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5051948022"],"corresponding_institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":1.8686,"has_fulltext":true,"cited_by_count":50,"citation_normalized_percentile":{"value":0.83321505,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"15","issue":"S7","first_page":"481","last_page":"481"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9023000001907349,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9023000001907349,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.021400000900030136,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.014700000174343586,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anticancer-drug-response-prediction","display_name":"anticancer drug response prediction","score":0.9290000200271606},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"cancer cell lines","score":0.7480000257492065},{"id":"https://openalex.org/keywords/pharmacogenomics","display_name":"pharmacogenomics","score":0.9409999847412109},{"id":"https://openalex.org/keywords/precision-oncology","display_name":"precision oncology","score":0.6959999799728394},{"id":"https://openalex.org/keywords/random-forest","display_name":"random forest","score":0.7540000081062317},{"id":"https://openalex.org/keywords/support-vector-machine","display_name":"support vector machine","score":0.9629999995231628},{"id":"https://openalex.org/keywords/elastic-net","display_name":"elastic net","score":0.8220000267028809},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.7639999985694885},{"id":"https://openalex.org/keywords/patient-stratification","display_name":"patient stratification","score":0.6169999837875366},{"id":"https://openalex.org/keywords/17-aag","display_name":"17-AAG","score":0.7459999918937683},{"id":"https://openalex.org/keywords/erlotinib","display_name":"erlotinib","score":0.800000011920929},{"id":"https://openalex.org/keywords/lapatinib","display_name":"lapatinib","score":0.9240000247955322},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.7739999890327454},{"id":"https://openalex.org/keywords/plx4720","display_name":"PLX4720","score":0.8199999928474426},{"id":"https://openalex.org/keywords/pd0325901","display_name":"PD0325901","score":0.7710000276565552},{"id":"https://openalex.org/keywords/palbociclib","display_name":"palbociclib","score":0.8730000257492065},{"id":"https://openalex.org/keywords/selumetinib","display_name":"selumetinib","score":0.7699999809265137},{"id":"https://openalex.org/keywords/azd0530","display_name":"AZD0530","score":0.9179999828338623}],"concepts":[{"id":"https://openalex.org/C169258074","wikidata":"https://www.wikidata.org/wiki/Q245748","display_name":"Random forest","level":2,"score":0.69967120885849},{"id":"https://openalex.org/C170734499","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenomics","level":2,"score":0.6666014790534973},{"id":"https://openalex.org/C2994119904","wikidata":"https://www.wikidata.org/wiki/Q1251001","display_name":"Drug response","level":3,"score":0.6292198896408081},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.5720348954200745},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.5441227555274963},{"id":"https://openalex.org/C22019652","wikidata":"https://www.wikidata.org/wiki/Q331309","display_name":"Overfitting","level":3,"score":0.5150963664054871},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.49720051884651184},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.48117977380752563},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.47203341126441956},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4603962302207947},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.441516637802124},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4400232136249542},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.399985134601593},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.39260947704315186},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.39045587182044983},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32320505380630493},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3051545321941376},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.23295095562934875},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.11197847127914429},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066264","descriptor_name":"Datasets as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1186/1471-2164-15-s7-s2","doi":"https://doi.org/10.1186/1471-2164-15-s7-s2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2164-15-s7-s2","pdf_url":"https://link.springer.com/content/pdf/10.1186/1471-2164-15-S7-S2.pdf","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4243102","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4243102","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"Text"},{"id":"pmid:25573145","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25573145","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC genomics","raw_type":"Evaluation Study"},{"id":"pmid:26122008","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26122008","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC genomics","raw_type":"Published Erratum"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.774.561","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.774.561","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/92/db/1471-2164-15-S7-S2.PMC4243102.pdf","raw_type":"text"},{"id":"pmh:oai:dspace.mit.edu:1721.1/91264","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1721.1/91264","pdf_url":null,"source":{"id":"https://openalex.org/S4306400425","display_name":"DSpace@MIT (Massachusetts Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I63966007","host_organization_name":"Massachusetts Institute of Technology","host_organization_lineage":["https://openalex.org/I63966007"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BioMed Central Ltd","raw_type":"Article"},{"id":"mag:2249990376","doi":null,"is_oa":false,"landing_page_url":"http://dspace.mit.edu/handle/1721.1/91264","pdf_url":null,"source":{"id":"https://openalex.org/S4306504412","display_name":"BioMed Central Ltd","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"BioMed Central Ltd","raw_type":null}],"best_oa_location":{"id":"doi:10.1186/1471-2164-15-s7-s2","doi":"https://doi.org/10.1186/1471-2164-15-s7-s2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2164-15-s7-s2","pdf_url":"https://link.springer.com/content/pdf/10.1186/1471-2164-15-S7-S2.pdf","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1273157147","display_name":null,"funder_award_id":"P30 CA043703","funder_id":"https://openalex.org/F4320310595","funder_display_name":"Case Comprehensive Cancer Center, Case Western Reserve University"},{"id":"https://openalex.org/G1777644978","display_name":null,"funder_award_id":"DGEO 9517830","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5822270753","display_name":null,"funder_award_id":"CA043703","funder_id":"https://openalex.org/F4320310595","funder_display_name":"Case Comprehensive Cancer Center, Case Western Reserve University"},{"id":"https://openalex.org/G9000862237","display_name":"Case Comprehensive Cancer Center Support Grant","funder_award_id":"P30CA043703","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320310595","display_name":"Case Comprehensive Cancer Center, Case Western Reserve University","ror":"https://ror.org/051fd9666"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2010773093.pdf","grobid_xml":"https://content.openalex.org/works/W2010773093.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1966701961","https://openalex.org/W1971884763","https://openalex.org/W1980609156","https://openalex.org/W1988278380","https://openalex.org/W1989305420","https://openalex.org/W2009187320","https://openalex.org/W2019813306","https://openalex.org/W2025396651","https://openalex.org/W2043398720","https://openalex.org/W2052825782","https://openalex.org/W2083358720","https://openalex.org/W2087312216","https://openalex.org/W2102794349","https://openalex.org/W2104830962","https://openalex.org/W2107268345","https://openalex.org/W2108728387","https://openalex.org/W2110366569","https://openalex.org/W2113878188","https://openalex.org/W2125789330","https://openalex.org/W2128542677","https://openalex.org/W2129296674","https://openalex.org/W2137499573","https://openalex.org/W2139517025","https://openalex.org/W2142769937","https://openalex.org/W2145825942","https://openalex.org/W2160979370","https://openalex.org/W2162107265","https://openalex.org/W2162371443","https://openalex.org/W2164786997","https://openalex.org/W2171632978","https://openalex.org/W2326150029","https://openalex.org/W2544883878","https://openalex.org/W2911964244","https://openalex.org/W4236075469","https://openalex.org/W4285719527","https://openalex.org/W4294541781"],"related_works":["https://openalex.org/W7098140713","https://openalex.org/W6922300023","https://openalex.org/W2110366569","https://openalex.org/W3000373012","https://openalex.org/W7203814916","https://openalex.org/W4252009156","https://openalex.org/W3139877182","https://openalex.org/W2798788651","https://openalex.org/W2965152867","https://openalex.org/W2887685819"],"abstract_inverted_index":{"BACKGROUND:":[0],"A":[1],"challenge":[2],"in":[3,90],"precision":[4,137],"medicine":[5],"is":[6],"the":[7,33,49,75,158,198,216,248,257],"transformation":[8],"of":[9,68,78,109,140,167,186,250,261],"genomic":[10],"data":[11],"into":[12,21,234],"knowledge":[13],"that":[14,65],"can":[15,189,228],"be":[16,190,229],"used":[17,219,230],"to":[18,36,51,103,211,231,254],"stratify":[19,232],"patients":[20,233],"treatment":[22,235],"groups":[23,236],"based":[24,237],"on":[25,238],"predicted":[26],"clinical":[27,30],"response.":[28,111],"Although":[29],"trials":[31],"remain":[32],"only":[34],"way":[35],"truly":[37],"measure":[38],"drug":[39,70,110,114,142,187,225],"toxicities":[40],"and":[41,105,124,132,138,181,192,205,215,256,259],"effectiveness,":[42],"as":[43],"a":[44,119],"scientific":[45],"community":[46],"we":[47],"lack":[48],"resources":[50],"clinically":[52],"assess":[53],"all":[54],"drugs":[55,154,170,253],"presently":[56],"under":[57],"development.":[58],"Therefore,":[59],"an":[60],"effective":[61],"preclinical":[62,252],"model":[63,123],"system":[64],"enables":[66],"prediction":[67,162,207],"anticancer":[69,88,263],"response":[71,115,143,188,226],"could":[72],"significantly":[73],"speed":[74],"broader":[76],"adoption":[77],"personalized":[79],"medicine.":[80],"RESULTS:":[81],"Three":[82],"large-scale":[83],"pharmacogenomic":[84],"studies":[85],"have":[86],"screened":[87],"compounds":[89],"greater":[91],"than":[92],"1000":[93],"distinct":[94],"human":[95],"cancer":[96],"cell":[97],"lines.":[98],"We":[99,112,160],"combined":[100],"these":[101],"datasets":[102],"generate":[104],"validate":[106],"multi-omic":[107],"predictors":[108,185],"compared":[113,210],"signatures":[116,163,208,227],"built":[117],"using":[118,147],"penalized":[120],"linear":[121],"regression":[122],"two":[125,244],"non-linear":[126],"machine":[127],"learning":[128],"techniques,":[129],"random":[130,199],"forest":[131,200],"support":[133,212],"vector":[134,213],"machine.":[135],"The":[136,223],"robustness":[139],"each":[141],"signature":[144],"was":[145],"assessed":[146],"cross-validation":[148],"across":[149],"three":[150],"independent":[151],"datasets.":[152,159],"Fifteen":[153],"were":[155],"common":[156],"among":[157],"validated":[161,193],"for":[164,194],"eleven":[165],"out":[166],"fifteen":[168],"tested":[169],"(17-AAG,":[171],"AZD0530,":[172],"AZD6244,":[173],"Erlotinib,":[174],"Lapatinib,":[175],"Nultin-3,":[176],"Paclitaxel,":[177],"PD0325901,":[178],"PD0332991,":[179],"PF02341066,":[180],"PLX4720).":[182],"CONCLUSIONS:":[183],"Multi-omic":[184],"generated":[191,202],"many":[195],"drugs.":[196],"Specifically,":[197],"algorithm":[201],"more":[203,217],"precise":[204],"robust":[206],"when":[209],"machines":[214],"commonly":[218],"elastic":[220],"net":[221],"regression.":[222],"resulting":[224],"their":[239],"individual":[240],"tumor":[241],"biology,":[242],"with":[243],"major":[245],"benefits:":[246],"speeding":[247],"process":[249],"bringing":[251],"market,":[255],"repurposing":[258],"repositioning":[260],"existing":[262],"therapies.":[264]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
