{"id":"https://openalex.org/W2010768982","doi":"https://doi.org/10.5562/cca1779","title":"Clinical Relevance of CD-68 Positive Cells in Normal Buccal Mucosa in Patients with Inflammatory Bowel Disease","display_name":"Clinical Relevance of CD-68 Positive Cells in Normal Buccal Mucosa in Patients with Inflammatory Bowel Disease","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2010768982","doi":"https://doi.org/10.5562/cca1779","mag":"2010768982"},"language":"en","primary_location":{"id":"doi:10.5562/cca1779","doi":"https://doi.org/10.5562/cca1779","is_oa":true,"landing_page_url":"https://doi.org/10.5562/cca1779","pdf_url":null,"source":{"id":"https://openalex.org/S36275936","display_name":"Croatica Chemica Acta","issn_l":"0011-1643","issn":["0011-1643","1334-417X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["ddh","doaj","dongbi-c","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310314830","host_organization_name":"Croatian Chemical Society","host_organization_lineage":["https://openalex.org/P4310314830"],"host_organization_lineage_names":["Croatian Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Croatica Chemica Acta","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.5562/cca1779","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027371271","display_name":"Brankica Mijandru\u0161i\u0107 Sin\u010di\u0107","orcid":"https://orcid.org/0000-0002-4795-3445","observed_orcids":["https://orcid.org/0000-0002-4795-3445"]},"institutions":[{"id":"https://openalex.org/I154347574","display_name":"University of Rijeka","ror":"https://ror.org/05r8dqr10","country_code":"HR","type":"education","lineage":["https://openalex.org/I154347574"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Brankica Mijandru\u0161i\u0107 Sin\u010di\u0107","raw_affiliation_strings":["Department of Gastroenterology, University Hospital Centre Rijeka, Rijeka, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, University Hospital Centre Rijeka, Rijeka, Croatia","institution_ids":["https://openalex.org/I154347574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071441659","display_name":"Maja Ili\u0107 Toma\u0161","orcid":"https://orcid.org/0000-0001-5863-9251","observed_orcids":["https://orcid.org/0000-0001-5863-9251"]},"institutions":[{"id":"https://openalex.org/I154347574","display_name":"University of Rijeka","ror":"https://ror.org/05r8dqr10","country_code":"HR","type":"education","lineage":["https://openalex.org/I154347574"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Maja Ili\u0107 Toma\u0161","raw_affiliation_strings":["Department of Physiology and Immunology; Medical Faculty; University of Rijeka; Rijeka; Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Immunology; Medical Faculty; University of Rijeka; Rijeka; Croatia","institution_ids":["https://openalex.org/I154347574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009125094","display_name":"Margita Belu\u0161i\u0107-Gobi\u0107","orcid":"https://orcid.org/0000-0002-3647-2021","observed_orcids":["https://orcid.org/0000-0002-3647-2021"]},"institutions":[{"id":"https://openalex.org/I4210122486","display_name":"Klini\u010dki Bolni\u010dki Centar Rijeka","ror":"https://ror.org/027wyhf03","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I4210122486"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Margita Belu\u0161i\u0107 Gobi\u0107","raw_affiliation_strings":["Depertment of Maxillofacial and Oral Surgery, University Hospital Centre Rijeka, Rijeka, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depertment of Maxillofacial and Oral Surgery, University Hospital Centre Rijeka, Rijeka, Croatia","institution_ids":["https://openalex.org/I4210122486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111402748","display_name":"Mirna Jureti\u0107","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122486","display_name":"Klini\u010dki Bolni\u010dki Centar Rijeka","ror":"https://ror.org/027wyhf03","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I4210122486"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Mirna Jureti\u0107","raw_affiliation_strings":["Depertment of Maxillofacial and Oral Surgery, University Hospital Centre Rijeka, Rijeka, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depertment of Maxillofacial and Oral Surgery, University Hospital Centre Rijeka, Rijeka, Croatia","institution_ids":["https://openalex.org/I4210122486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103413181","display_name":"Dra\u017een Kova\u010d","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154347574","display_name":"University of Rijeka","ror":"https://ror.org/05r8dqr10","country_code":"HR","type":"education","lineage":["https://openalex.org/I154347574"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Dra\u017een Kova\u010d","raw_affiliation_strings":["Department of Pathology, Medical Faculty, University of Rijeka, Rijeka, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Medical Faculty, University of Rijeka, Rijeka, Croatia","institution_ids":["https://openalex.org/I154347574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051007511","display_name":"Andrica Leki\u0107","orcid":"https://orcid.org/0000-0002-6175-635X","observed_orcids":["https://orcid.org/0000-0002-6175-635X"]},"institutions":[{"id":"https://openalex.org/I154347574","display_name":"University of Rijeka","ror":"https://ror.org/05r8dqr10","country_code":"HR","type":"education","lineage":["https://openalex.org/I154347574"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Andrica Leki\u0107","raw_affiliation_strings":["Department of Physics, Medical Faculty, University of Rijeka, Rijeka, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, Medical Faculty, University of Rijeka, Rijeka, Croatia","institution_ids":["https://openalex.org/I154347574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025526084","display_name":"Ester Pernjak Pugel","orcid":"https://orcid.org/0000-0002-6714-483X","observed_orcids":["https://orcid.org/0000-0002-6714-483X"]},"institutions":[{"id":"https://openalex.org/I154347574","display_name":"University of Rijeka","ror":"https://ror.org/05r8dqr10","country_code":"HR","type":"education","lineage":["https://openalex.org/I154347574"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Ester Pernjak Pugel","raw_affiliation_strings":["Department of Histology and Embryology, Medical Faculty, University of Rijeka, Rijeka, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology and Embryology, Medical Faculty, University of Rijeka, Rijeka, Croatia","institution_ids":["https://openalex.org/I154347574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103194550","display_name":"Robert Cerovi\u0107","orcid":"https://orcid.org/0000-0003-1831-4422","observed_orcids":["https://orcid.org/0000-0003-1831-4422"]},"institutions":[{"id":"https://openalex.org/I4210122486","display_name":"Klini\u010dki Bolni\u010dki Centar Rijeka","ror":"https://ror.org/027wyhf03","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I4210122486"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Robert Cerovi\u0107","raw_affiliation_strings":["Depertment of Maxillofacial and Oral Surgery, University Hospital Centre Rijeka, Rijeka, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depertment of Maxillofacial and Oral Surgery, University Hospital Centre Rijeka, Rijeka, Croatia","institution_ids":["https://openalex.org/I4210122486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065520120","display_name":"Davor \u0160timac","orcid":"https://orcid.org/0000-0001-8243-2453","observed_orcids":["https://orcid.org/0000-0001-8243-2453","https://orcid.org/0009-0006-0015-4183"]},"institutions":[{"id":"https://openalex.org/I154347574","display_name":"University of Rijeka","ror":"https://ror.org/05r8dqr10","country_code":"HR","type":"education","lineage":["https://openalex.org/I154347574"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Davor \u0160timac","raw_affiliation_strings":["Department of Gastroenterology, University Hospital Centre Rijeka, Rijeka, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, University Hospital Centre Rijeka, Rijeka, Croatia","institution_ids":["https://openalex.org/I154347574"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.11358318,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"85","issue":"2","first_page":"171","last_page":"176"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11452","display_name":"Oral Health Pathology and Treatment","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12328","display_name":"Autoimmune and Inflammatory Disorders","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/buccal-mucosa","display_name":"buccal mucosa","score":0.9800000190734863},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.9750000238418579},{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":1.0},{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":1.0},{"id":"https://openalex.org/keywords/mucosal-inflammation","display_name":"mucosal inflammation","score":0.5400000214576721},{"id":"https://openalex.org/keywords/differential-diagnosis","display_name":"differential diagnosis","score":0.5529999732971191},{"id":"https://openalex.org/keywords/oral-mucosa","display_name":"oral mucosa","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.7564308643341064},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6212177872657776},{"id":"https://openalex.org/C2991923528","wikidata":"https://www.wikidata.org/wiki/Q1776131","display_name":"Buccal mucosa","level":3,"score":0.5742520689964294},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5709421038627625},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.5336939096450806},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5042425394058228},{"id":"https://openalex.org/C3019368612","wikidata":"https://www.wikidata.org/wiki/Q17154506","display_name":"Intestinal mucosa","level":2,"score":0.4692416489124298},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4534303545951843},{"id":"https://openalex.org/C2779280984","wikidata":"https://www.wikidata.org/wiki/Q1472","display_name":"Crohn's disease","level":3,"score":0.4342223107814789},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3627000153064728},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.13454142212867737},{"id":"https://openalex.org/C2986629439","wikidata":"https://www.wikidata.org/wiki/Q9635","display_name":"Oral cavity","level":2,"score":0.0521242618560791}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.5562/cca1779","doi":"https://doi.org/10.5562/cca1779","is_oa":true,"landing_page_url":"https://doi.org/10.5562/cca1779","pdf_url":null,"source":{"id":"https://openalex.org/S36275936","display_name":"Croatica Chemica Acta","issn_l":"0011-1643","issn":["0011-1643","1334-417X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["ddh","doaj","dongbi-c","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310314830","host_organization_name":"Croatian Chemical Society","host_organization_lineage":["https://openalex.org/P4310314830"],"host_organization_lineage_names":["Croatian Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Croatica Chemica Acta","raw_type":"journal-article"},{"id":"pmh:oai:hrcak.srce.hr:84529","doi":null,"is_oa":true,"landing_page_url":"http://hrcak.srce.hr/84529","pdf_url":null,"source":{"id":"https://openalex.org/S4306400071","display_name":"University of Zagreb University Computing Centre (SRCE)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I181343428","host_organization_name":"University of Zagreb","host_organization_lineage":["https://openalex.org/I181343428"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Croatica Chemica Acta","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2788717927","doi":null,"is_oa":false,"landing_page_url":"https://www.bib.irb.hr/356740","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.5562/cca1779","doi":"https://doi.org/10.5562/cca1779","is_oa":true,"landing_page_url":"https://doi.org/10.5562/cca1779","pdf_url":null,"source":{"id":"https://openalex.org/S36275936","display_name":"Croatica Chemica Acta","issn_l":"0011-1643","issn":["0011-1643","1334-417X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["ddh","doaj","dongbi-c","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310314830","host_organization_name":"Croatian Chemical Society","host_organization_lineage":["https://openalex.org/P4310314830"],"host_organization_lineage_names":["Croatian Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Croatica Chemica Acta","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7100865604","https://openalex.org/W2806236519","https://openalex.org/W2046667750","https://openalex.org/W2047114414","https://openalex.org/W1976374883","https://openalex.org/W2316676440","https://openalex.org/W1963646962","https://openalex.org/W1985308079","https://openalex.org/W2316810802","https://openalex.org/W2047791816"],"abstract_inverted_index":{"The":[0,59,104],"aim":[1],"of":[2,10,12,61,92,128],"this":[3],"study":[4],"was":[5,66,85],"to":[6],"investigate":[7],"the":[8,79],"presence":[9],"microaggregates":[11,65,95,108],"macrophages":[13],"(CD-\r\n68":[14],"positive":[15,63,94,98],"cells)":[16],"in":[17,22,90,114,119],"macroscopically":[18],"normal":[19,116],"buccal":[20,117],"mucosa":[21,118],"patients":[23,30,38,44,70,74,120,139],"with":[24,31,45,72,97,121,125,140],"inflammatory":[25],"bowel":[26],"disease\r\n(IBD).":[27],"Fifty":[28],"two":[29,43],"clinically":[32],"and":[33,49,55,78],"pathohistologically":[34],"diagnosed":[35],"IBD,":[36],"thirty":[37],"with\r\nCrohn\u2019s":[39],"disease":[40,142],"(CD),":[41],"twenty":[42,50],"ulcerative":[46],"colitis":[47],"(UC),":[48],"five":[51],"controls,":[52],"matched\r\nfor":[53],"sex":[54],"age,":[56],"were":[57],"involved.":[58],"occurrence":[60,91],"CD-68":[62,93],"cells":[64],"more":[67,111],"frequent\r\nin":[68],"CD":[69,122],"comparing":[71],"UC":[73,126,144],"(P":[75,81,101],"=":[76,82,102],"0.0093),":[77],"controls":[80],"0.0001)":[83],"respectively.\r\nThere":[84],"no":[86],"statistically":[87],"significant":[88],"difference":[89],"in\r\npatients":[96,124],"microbiological":[99,129],"findings":[100],"0.8258).":[103],"results":[105],"suggest":[106],"that":[107],"of\r\nmacrophages":[109],"are":[110],"frequently":[112],"present":[113],"apparently":[115],"than":[123],"independently":[127],"findings.":[130],"Therefore,":[131],"it":[132],"could":[133],"be":[134],"a":[135],"potential":[136],"marker":[137],"for\r\ndifferentiating":[138],"Crohn\u2019s":[141],"from":[143],"patients,":[145],"when":[146],"standard":[147],"tools":[148],"failed.":[149],"(doi:\r\n10.5562/cca1779)":[150]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}