{"id":"https://openalex.org/W2010748775","doi":"https://doi.org/10.1007/s00262-006-0194-y","title":"CD4 regulatory T cells in human cancer pathogenesis","display_name":"CD4 regulatory T cells in human cancer pathogenesis","publication_year":2006,"publication_date":"2006-07-04","ids":{"openalex":"https://openalex.org/W2010748775","doi":"https://doi.org/10.1007/s00262-006-0194-y","mag":"2010748775","pmid":"https://pubmed.ncbi.nlm.nih.gov/16819631","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11030088"},"language":"en","primary_location":{"id":"doi:10.1007/s00262-006-0194-y","doi":"https://doi.org/10.1007/s00262-006-0194-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00262-006-0194-y","pdf_url":null,"source":{"id":"https://openalex.org/S203303425","display_name":"Cancer Immunology Immunotherapy","issn_l":"0340-7004","issn":["0340-7004","1432-0851"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunology, Immunotherapy","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11030088","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031005364","display_name":"Keith L. Knutson","orcid":"https://orcid.org/0000-0001-9932-4467","observed_orcids":["https://orcid.org/0000-0001-9932-4467"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Keith L. Knutson","raw_affiliation_strings":["Department of Immunology, Mayo Clinic College of Medicine, Mayo Clinic, 342C Guggenheim, 200 First Street SW, Rochester, MN 55905, USA. knutson.keith@mayo.edu","Department of Immunology, Mayo Clinic College of Medicine, Rochester, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Mayo Clinic College of Medicine, Mayo Clinic, 342C Guggenheim, 200 First Street SW, Rochester, MN 55905, USA. knutson.keith@mayo.edu","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Immunology, Mayo Clinic College of Medicine, Rochester, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039848435","display_name":"Mary Lenora Disis","orcid":"https://orcid.org/0000-0001-7653-4648","observed_orcids":["https://orcid.org/0000-0001-7653-4648"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mary L. Disis","raw_affiliation_strings":["Tumor Vaccine Group, Center for Translational Medicine in Women\u2019s Health, Seattle, WA, 98195, USA","Center for Translational Medicine in Women\u2019s Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumor Vaccine Group, Center for Translational Medicine in Women\u2019s Health, Seattle, WA, 98195, USA","institution_ids":[]},{"raw_affiliation_string":"Center for Translational Medicine in Women\u2019s Health","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085036384","display_name":"Lupe G. Salazar","orcid":"https://orcid.org/0009-0003-8916-3024","observed_orcids":["https://orcid.org/0009-0003-8916-3024"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lupe G. Salazar","raw_affiliation_strings":["Tumor Vaccine Group, Center for Translational Medicine in Women\u2019s Health, Seattle, WA, 98195, USA","Center for Translational Medicine in Women\u2019s Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumor Vaccine Group, Center for Translational Medicine in Women\u2019s Health, Seattle, WA, 98195, USA","institution_ids":[]},{"raw_affiliation_string":"Center for Translational Medicine in Women\u2019s Health","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5031005364"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":null,"fwci":0.9073,"has_fulltext":false,"cited_by_count":119,"citation_normalized_percentile":{"value":0.7030303,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"56","issue":"3","first_page":"271","last_page":"285"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.014700000174343586,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd4-regulatory-t-cells","display_name":"CD4+ regulatory T cells","score":0.9559999704360962},{"id":"https://openalex.org/keywords/tumor-associated-regulatory-t-cells","display_name":"tumor-associated regulatory T cells","score":0.8190000057220459},{"id":"https://openalex.org/keywords/tumor-immunosuppression","display_name":"tumor immunosuppression","score":0.7229999899864197},{"id":"https://openalex.org/keywords/immune-regulation","display_name":"immune regulation","score":0.6190000176429749},{"id":"https://openalex.org/keywords/natural-regulatory-t-cells","display_name":"natural regulatory T cells","score":0.7760000228881836},{"id":"https://openalex.org/keywords/induced-regulatory-t-cells","display_name":"induced regulatory T cells","score":0.8700000047683716},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.7799999713897705},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.6169999837875366},{"id":"https://openalex.org/keywords/immune-homeostasis","display_name":"immune homeostasis","score":0.6460000276565552},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.5120000243186951}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.8325270414352417},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.6429123282432556},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6259531378746033},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6162648797035217},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.48674464225769043},{"id":"https://openalex.org/C2777702733","wikidata":"https://www.wikidata.org/wiki/Q1356761","display_name":"Immune tolerance","level":3,"score":0.47861212491989136},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4517669677734375},{"id":"https://openalex.org/C81444415","wikidata":"https://www.wikidata.org/wiki/Q7243535","display_name":"Priming (agriculture)","level":3,"score":0.4514242708683014},{"id":"https://openalex.org/C2778296632","wikidata":"https://www.wikidata.org/wiki/Q1550619","display_name":"Regulatory T cell","level":5,"score":0.4280024766921997},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42761263251304626},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3359367251396179},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32394275069236755},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.13100942969322205},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09192454814910889},{"id":"https://openalex.org/C100701293","wikidata":"https://www.wikidata.org/wiki/Q193838","display_name":"Germination","level":2,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1007/s00262-006-0194-y","doi":"https://doi.org/10.1007/s00262-006-0194-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00262-006-0194-y","pdf_url":null,"source":{"id":"https://openalex.org/S203303425","display_name":"Cancer Immunology Immunotherapy","issn_l":"0340-7004","issn":["0340-7004","1432-0851"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunology, Immunotherapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11030088","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11030088","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunol Immunother","raw_type":"Text"},{"id":"pmid:16819631","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16819631","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer immunology, immunotherapy : CII","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.328.7066","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.328.7066","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://depts.washington.edu/tumorvac/MultiMedia/Publications/ReviewArticles/2007_CanImmunoImmunother_271-85.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11030088","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11030088","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunol Immunother","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G10684862","display_name":"Ex vivo expansion of HER-2/neu specific T helper cells","funder_award_id":"K01CA100764","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1727281504","display_name":"HLA classl complex expression in breast cancer immunity","funder_award_id":"R01CA113861","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":136,"referenced_works":["https://openalex.org/W74777366","https://openalex.org/W1486722793","https://openalex.org/W1499151513","https://openalex.org/W1525143304","https://openalex.org/W1529036199","https://openalex.org/W1536480181","https://openalex.org/W1544915365","https://openalex.org/W1560277370","https://openalex.org/W1567420244","https://openalex.org/W1571861420","https://openalex.org/W1575585006","https://openalex.org/W1593325979","https://openalex.org/W1642873092","https://openalex.org/W1676967216","https://openalex.org/W1862410697","https://openalex.org/W1898102248","https://openalex.org/W1905845038","https://openalex.org/W1966289025","https://openalex.org/W1972308909","https://openalex.org/W1972746775","https://openalex.org/W1979049274","https://openalex.org/W1982395758","https://openalex.org/W1983306083","https://openalex.org/W1983664228","https://openalex.org/W1984484036","https://openalex.org/W1985137297","https://openalex.org/W1988474688","https://openalex.org/W1989170436","https://openalex.org/W1990227965","https://openalex.org/W1990662369","https://openalex.org/W1991344211","https://openalex.org/W1992249154","https://openalex.org/W1994850185","https://openalex.org/W1995097896","https://openalex.org/W1995570137","https://openalex.org/W1996087599","https://openalex.org/W1996123836","https://openalex.org/W1998722289","https://openalex.org/W1999068498","https://openalex.org/W2002648400","https://openalex.org/W2005293308","https://openalex.org/W2005721095","https://openalex.org/W2009759593","https://openalex.org/W2010854505","https://openalex.org/W2015780294","https://openalex.org/W2017193054","https://openalex.org/W2019060341","https://openalex.org/W2019253287","https://openalex.org/W2019858577","https://openalex.org/W2021249886","https://openalex.org/W2028000100","https://openalex.org/W2030431013","https://openalex.org/W2035847993","https://openalex.org/W2043142666","https://openalex.org/W2043176282","https://openalex.org/W2043946720","https://openalex.org/W2044135873","https://openalex.org/W2045522415","https://openalex.org/W2046972425","https://openalex.org/W2047203592","https://openalex.org/W2048152449","https://openalex.org/W2048607324","https://openalex.org/W2050514979","https://openalex.org/W2052329251","https://openalex.org/W2058877398","https://openalex.org/W2059377172","https://openalex.org/W2060872878","https://openalex.org/W2062142808","https://openalex.org/W2066172817","https://openalex.org/W2068639447","https://openalex.org/W2068859282","https://openalex.org/W2070154027","https://openalex.org/W2072447036","https://openalex.org/W2073266148","https://openalex.org/W2073310925","https://openalex.org/W2077940776","https://openalex.org/W2084579140","https://openalex.org/W2085257327","https://openalex.org/W2087061585","https://openalex.org/W2088985230","https://openalex.org/W2094430543","https://openalex.org/W2094798767","https://openalex.org/W2097074641","https://openalex.org/W2098394317","https://openalex.org/W2102250111","https://openalex.org/W2102537478","https://openalex.org/W2103180268","https://openalex.org/W2105630018","https://openalex.org/W2107758715","https://openalex.org/W2108782816","https://openalex.org/W2110351748","https://openalex.org/W2110714188","https://openalex.org/W2113657892","https://openalex.org/W2118373290","https://openalex.org/W2122445377","https://openalex.org/W2123987776","https://openalex.org/W2127402662","https://openalex.org/W2127654037","https://openalex.org/W2127892995","https://openalex.org/W2128097796","https://openalex.org/W2130486201","https://openalex.org/W2132207502","https://openalex.org/W2132561915","https://openalex.org/W2134638467","https://openalex.org/W2135398071","https://openalex.org/W2136757504","https://openalex.org/W2137049683","https://openalex.org/W2137074525","https://openalex.org/W2137467818","https://openalex.org/W2138002048","https://openalex.org/W2138163780","https://openalex.org/W2138418234","https://openalex.org/W2139276825","https://openalex.org/W2139557613","https://openalex.org/W2140419616","https://openalex.org/W2140460887","https://openalex.org/W2141077451","https://openalex.org/W2141785549","https://openalex.org/W2146781066","https://openalex.org/W2147350757","https://openalex.org/W2149864243","https://openalex.org/W2150627675","https://openalex.org/W2150678612","https://openalex.org/W2151937278","https://openalex.org/W2159101109","https://openalex.org/W2160117150","https://openalex.org/W2160683795","https://openalex.org/W2164701887","https://openalex.org/W2168972481","https://openalex.org/W2270737010","https://openalex.org/W2410313936","https://openalex.org/W2560367415","https://openalex.org/W2564152524","https://openalex.org/W2737785069","https://openalex.org/W4239710358","https://openalex.org/W4313324526"],"related_works":["https://openalex.org/W7095486748","https://openalex.org/W2021891700","https://openalex.org/W994034649","https://openalex.org/W1984677655","https://openalex.org/W87307560","https://openalex.org/W4312537991","https://openalex.org/W2298664903","https://openalex.org/W2020996229","https://openalex.org/W2093448096","https://openalex.org/W4393490874"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
