{"id":"https://openalex.org/W2010743690","doi":"https://doi.org/10.1002/1097-0142(197810)42:4<1826::aid-cncr2820420422>3.0.co;2-x","title":"Cryopathic gangrene with an IgM lambda cryoprecipitating cold agglutinin","display_name":"Cryopathic gangrene with an IgM lambda cryoprecipitating cold agglutinin","publication_year":1978,"publication_date":"1978-10-01","ids":{"openalex":"https://openalex.org/W2010743690","doi":"https://doi.org/10.1002/1097-0142(197810)42:4<1826::aid-cncr2820420422>3.0.co;2-x","mag":"2010743690","pmid":"https://pubmed.ncbi.nlm.nih.gov/101298"},"language":"en","primary_location":{"id":"doi:10.1002/1097-0142(197810)42:4<1826::aid-cncr2820420422>3.0.co;2-x","doi":"https://doi.org/10.1002/1097-0142(197810)42:4<1826::aid-cncr2820420422>3.0.co;2-x","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(197810)42:4<1826::aid-cncr2820420422>3.0.co;2-x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%28197810%2942%3A4%3C1826%3A%3AAID-CNCR2820420422%3E3.0.CO%3B2-X","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%28197810%2942%3A4%3C1826%3A%3AAID-CNCR2820420422%3E3.0.CO%3B2-X","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026488938","display_name":"Jerry W. Kuenn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerry W. Kuenn","raw_affiliation_strings":["Division of Hematology, Department of Internal Medicine and the Division of Clinical Immunology, Department of Pathology, and the Department of Medical Microbiology, University of Florida College of Medicine, Gainesville, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Internal Medicine and the Division of Clinical Immunology, Department of Pathology, and the Department of Medical Microbiology, University of Florida College of Medicine, Gainesville, Florida","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022484995","display_name":"Richard J. Weber","orcid":"https://orcid.org/0000-0002-2145-1279","observed_orcids":["https://orcid.org/0000-0002-2145-1279"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Weber","raw_affiliation_strings":["Division of Hematology, Department of Internal Medicine and the Division of Clinical Immunology, Department of Pathology, and the Department of Medical Microbiology, University of Florida College of Medicine, Gainesville, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Internal Medicine and the Division of Clinical Immunology, Department of Pathology, and the Department of Medical Microbiology, University of Florida College of Medicine, Gainesville, Florida","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086661752","display_name":"Perry O. Teague","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Perry O. Teague","raw_affiliation_strings":["Division of Hematology, Department of Internal Medicine and the Division of Clinical Immunology, Department of Pathology, and the Department of Medical Microbiology, University of Florida College of Medicine, Gainesville, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Internal Medicine and the Division of Clinical Immunology, Department of Pathology, and the Department of Medical Microbiology, University of Florida College of Medicine, Gainesville, Florida","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067589488","display_name":"Alan S. Keitt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alan S. Keitt","raw_affiliation_strings":["Division of Hematology, Department of Internal Medicine and the Division of Clinical Immunology, Department of Pathology, and the Department of Medical Microbiology, University of Florida College of Medicine, Gainesville, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Internal Medicine and the Division of Clinical Immunology, Department of Pathology, and the Department of Medical Microbiology, University of Florida College of Medicine, Gainesville, Florida","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5067589488"],"corresponding_institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":1.0744,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.75930135,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"42","issue":"4","first_page":"1826","last_page":"1833"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11660","display_name":"Blood groups and transfusion","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11660","display_name":"Blood groups and transfusion","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cold-agglutinin-disease","display_name":"cold agglutinin disease","score":0.843999981880188},{"id":"https://openalex.org/keywords/cryoproteins","display_name":"cryoproteins","score":0.7020000219345093},{"id":"https://openalex.org/keywords/i-antigen","display_name":"I antigen","score":0.718999981880188},{"id":"https://openalex.org/keywords/red-cell-antibodies","display_name":"blood group antibodies","score":0.4440000057220459},{"id":"https://openalex.org/keywords/graves-disease","display_name":"Graves' disease","score":0.6679999828338623},{"id":"https://openalex.org/keywords/waldenstrom-macroglobulinemia","display_name":"Waldenstr\u00f6m macroglobulinemia","score":0.8799999952316284},{"id":"https://openalex.org/keywords/lymphoproliferative-disorders","display_name":"lymphoproliferative disorders","score":0.7979999780654907},{"id":"https://openalex.org/keywords/cryoglobulinemia","display_name":"cryoglobulinemia","score":0.574999988079071}],"concepts":[{"id":"https://openalex.org/C2910849039","wikidata":"https://www.wikidata.org/wiki/Q3606543","display_name":"Cold Agglutinin","level":3,"score":0.9066214561462402},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6500245332717896},{"id":"https://openalex.org/C2776391228","wikidata":"https://www.wikidata.org/wiki/Q4118092","display_name":"Macroglobulinemia","level":3,"score":0.5825513601303101},{"id":"https://openalex.org/C2910612865","wikidata":"https://www.wikidata.org/wiki/Q3606543","display_name":"Cryoglobulins","level":3,"score":0.5782381296157837},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5770622491836548},{"id":"https://openalex.org/C45189115","wikidata":"https://www.wikidata.org/wiki/Q502159","display_name":"Serology","level":3,"score":0.5600816011428833},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.500596284866333},{"id":"https://openalex.org/C2776553844","wikidata":"https://www.wikidata.org/wiki/Q79451","display_name":"Immunoglobulin M","level":4,"score":0.47152480483055115},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4535825848579407},{"id":"https://openalex.org/C2777884830","wikidata":"https://www.wikidata.org/wiki/Q3961632","display_name":"Cold agglutinin disease","level":4,"score":0.4467869997024536},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3620924949645996},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.17204353213310242},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.14598235487937927},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.08354964852333069}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000373","descriptor_name":"Agglutinins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D002699","descriptor_name":"Chlorambucil","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003450","descriptor_name":"Cryoglobulins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005734","descriptor_name":"Gangrene","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006111","descriptor_name":"Graves Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007146","descriptor_name":"Immunoglobulin lambda-Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008228","descriptor_name":"Lymphoma, Non-Hodgkin","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008232","descriptor_name":"Lymphoproliferative Disorders","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D008232","descriptor_name":"Lymphoproliferative Disorders","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008258","descriptor_name":"Waldenstrom Macroglobulinemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008258","descriptor_name":"Waldenstrom Macroglobulinemia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D010265","descriptor_name":"Paraproteinemias","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D010265","descriptor_name":"Paraproteinemias","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D010956","descriptor_name":"Plasmapheresis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/1097-0142(197810)42:4<1826::aid-cncr2820420422>3.0.co;2-x","doi":"https://doi.org/10.1002/1097-0142(197810)42:4<1826::aid-cncr2820420422>3.0.co;2-x","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(197810)42:4<1826::aid-cncr2820420422>3.0.co;2-x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%28197810%2942%3A4%3C1826%3A%3AAID-CNCR2820420422%3E3.0.CO%3B2-X","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:101298","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/101298","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.1002/1097-0142(197810)42:4<1826::aid-cncr2820420422>3.0.co;2-x","doi":"https://doi.org/10.1002/1097-0142(197810)42:4<1826::aid-cncr2820420422>3.0.co;2-x","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(197810)42:4<1826::aid-cncr2820420422>3.0.co;2-x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%28197810%2942%3A4%3C1826%3A%3AAID-CNCR2820420422%3E3.0.CO%3B2-X","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2010743690.pdf"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W187204255","https://openalex.org/W306065653","https://openalex.org/W1259249587","https://openalex.org/W1502953431","https://openalex.org/W1580122063","https://openalex.org/W1585297565","https://openalex.org/W1888962919","https://openalex.org/W1972904411","https://openalex.org/W1980104629","https://openalex.org/W1985089150","https://openalex.org/W1989758403","https://openalex.org/W1999864116","https://openalex.org/W2005791627","https://openalex.org/W2009771809","https://openalex.org/W2018377262","https://openalex.org/W2024641596","https://openalex.org/W2028754631","https://openalex.org/W2035456207","https://openalex.org/W2036028289","https://openalex.org/W2038666423","https://openalex.org/W2040206694","https://openalex.org/W2057940890","https://openalex.org/W2062761161","https://openalex.org/W2078329953","https://openalex.org/W2080527249","https://openalex.org/W2085820938","https://openalex.org/W2089087918","https://openalex.org/W2106933968","https://openalex.org/W2158977173","https://openalex.org/W2285458529","https://openalex.org/W2397622229","https://openalex.org/W2461770463","https://openalex.org/W4297907566"],"related_works":["https://openalex.org/W2318431021","https://openalex.org/W1980104629","https://openalex.org/W2078329953","https://openalex.org/W1550916709","https://openalex.org/W1780628194","https://openalex.org/W2070653221","https://openalex.org/W1974885851","https://openalex.org/W4385726760","https://openalex.org/W2410256550","https://openalex.org/W2034693670"],"abstract_inverted_index":{"Immunochemical":[0],"and":[1,53,76,83],"serologic":[2],"studies":[3],"of":[4,21,31,37,57,68,95,98,104],"cold":[5,11,84],"agglutinis":[6],"in":[7,42],"patients":[8,38],"with":[9,25,64,74],"chronic":[10],"agglutinin":[12],"disease":[13,73],"(CCAD)":[14],"have":[15],"shown":[16],"the":[17,28,44,81,90,102],"almost":[18],"exclusive":[19],"occurrence":[20,94],"IgM":[22,47],"kappa":[23],"antibodies":[24],"specificity":[26,52],"for":[27],"I":[29,51],"antigen":[30],"red":[32],"cells.":[33],"An":[34],"unusual":[35,66],"subgroup":[36],"has":[39],"been":[40],"delineated":[41],"which":[43],"cryoprotein":[45],"is":[46],"lambda,":[48],"frequently":[49],"lacks":[50],"often":[54],"cryoprecipitates.":[55],"Studies":[56],"such":[58],"a":[59,62,105],"protein":[60],"from":[61,89],"patient":[63],"an":[65],"array":[67],"immunoproliferative":[69],"disorders":[70],"including":[71],"Grave's":[72],"exophthalmos":[75],"Waldenstrom's":[77],"macroglobulinemia":[78],"indicate":[79],"that":[80],"cryoprecipitating":[82],"agglutinating":[85],"properties":[86],"probably":[87],"derive":[88],"sam":[91],"protein.":[92],"The":[93],"this":[96],"type":[97],"antibody":[99],"should":[100],"suggest":[101],"presence":[103],"more":[106],"aggressive":[107],"lymphoproliferative":[108],"disorder":[109],"than":[110],"simple":[111],"CCAD.":[112]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}