{"id":"https://openalex.org/W2010729236","doi":"https://doi.org/10.1042/bj20110502","title":"A drug targeting only p110\u03b1 can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types","display_name":"A drug targeting only p110\u03b1 can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types","publication_year":2011,"publication_date":"2011-07-04","ids":{"openalex":"https://openalex.org/W2010729236","doi":"https://doi.org/10.1042/bj20110502","mag":"2010729236","pmid":"https://pubmed.ncbi.nlm.nih.gov/21668414","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3174055"},"language":"en","primary_location":{"id":"doi:10.1042/bj20110502","doi":"https://doi.org/10.1042/bj20110502","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj20110502","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1042/bj20110502","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078146193","display_name":"Stephen M. F. Jamieson","orcid":"https://orcid.org/0000-0002-5485-9211","observed_orcids":["https://orcid.org/0000-0002-5485-9211"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]},{"id":"https://openalex.org/I4210129442","display_name":"Maurice Wilkins Centre","ror":"https://ror.org/0327mmx61","country_code":"NZ","type":"facility","lineage":["https://openalex.org/I154130895","https://openalex.org/I4210129442"]}],"countries":["NZ"],"is_corresponding":true,"raw_author_name":"Stephen Jamieson","raw_affiliation_strings":["Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1042, New Zealand","Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Private Bag 92019, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1042, New Zealand","institution_ids":["https://openalex.org/I154130895"]},{"raw_affiliation_string":"Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Private Bag 92019, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895","https://openalex.org/I4210129442"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004460571","display_name":"Jack U. Flanagan","orcid":"https://orcid.org/0000-0002-3246-2248","observed_orcids":["https://orcid.org/0000-0002-3246-2248"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]},{"id":"https://openalex.org/I4210129442","display_name":"Maurice Wilkins Centre","ror":"https://ror.org/0327mmx61","country_code":"NZ","type":"facility","lineage":["https://openalex.org/I154130895","https://openalex.org/I4210129442"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Jack\u00a0U. Flanagan","raw_affiliation_strings":["Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1042, New Zealand","Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Private Bag 92019, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1042, New Zealand","institution_ids":["https://openalex.org/I154130895"]},{"raw_affiliation_string":"Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Private Bag 92019, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895","https://openalex.org/I4210129442"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084470237","display_name":"Sharada Kolekar","orcid":"https://orcid.org/0000-0003-1765-7378","observed_orcids":["https://orcid.org/0000-0003-1765-7378"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Sharada Kolekar","raw_affiliation_strings":["Department of Molecular Medicine and Pathology, University of Auckland, Medical School, Private Bag 92019, Auckland 1042, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine and Pathology, University of Auckland, Medical School, Private Bag 92019, Auckland 1042, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038428720","display_name":"Christina Maree Buchanan","orcid":"https://orcid.org/0000-0002-6482-3474","observed_orcids":["https://orcid.org/0000-0002-6482-3474"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]},{"id":"https://openalex.org/I4210129442","display_name":"Maurice Wilkins Centre","ror":"https://ror.org/0327mmx61","country_code":"NZ","type":"facility","lineage":["https://openalex.org/I154130895","https://openalex.org/I4210129442"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Christina Buchanan","raw_affiliation_strings":["Department of Molecular Medicine and Pathology, University of Auckland, Medical School, Private Bag 92019, Auckland 1042, New Zealand","Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Private Bag 92019, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine and Pathology, University of Auckland, Medical School, Private Bag 92019, Auckland 1042, New Zealand","institution_ids":["https://openalex.org/I154130895"]},{"raw_affiliation_string":"Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Private Bag 92019, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895","https://openalex.org/I4210129442"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059160852","display_name":"Jackie D. Kendall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]},{"id":"https://openalex.org/I4210129442","display_name":"Maurice Wilkins Centre","ror":"https://ror.org/0327mmx61","country_code":"NZ","type":"facility","lineage":["https://openalex.org/I154130895","https://openalex.org/I4210129442"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Jackie\u00a0D. Kendall","raw_affiliation_strings":["Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1042, New Zealand","Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Private Bag 92019, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1042, New Zealand","institution_ids":["https://openalex.org/I154130895"]},{"raw_affiliation_string":"Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Private Bag 92019, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895","https://openalex.org/I4210129442"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100712829","display_name":"Woo Jung Lee","orcid":"https://orcid.org/0000-0001-9273-261X","observed_orcids":["https://orcid.org/0000-0001-9273-261X"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Woo-Jeong Lee","raw_affiliation_strings":["Department of Molecular Medicine and Pathology, University of Auckland, Medical School, Private Bag 92019, Auckland 1042, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine and Pathology, University of Auckland, Medical School, Private Bag 92019, Auckland 1042, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065865758","display_name":"Gordon W. Rewcastle","orcid":"https://orcid.org/0000-0001-9083-3214","observed_orcids":["https://orcid.org/0000-0001-9083-3214"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]},{"id":"https://openalex.org/I4210129442","display_name":"Maurice Wilkins Centre","ror":"https://ror.org/0327mmx61","country_code":"NZ","type":"facility","lineage":["https://openalex.org/I154130895","https://openalex.org/I4210129442"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Gordon\u00a0W. Rewcastle","raw_affiliation_strings":["Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1042, New Zealand","Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Private Bag 92019, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1042, New Zealand","institution_ids":["https://openalex.org/I154130895"]},{"raw_affiliation_string":"Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Private Bag 92019, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895","https://openalex.org/I4210129442"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023901201","display_name":"William Alexander Denny","orcid":"https://orcid.org/0000-0001-7997-1843","observed_orcids":["https://orcid.org/0000-0001-7997-1843"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]},{"id":"https://openalex.org/I4210129442","display_name":"Maurice Wilkins Centre","ror":"https://ror.org/0327mmx61","country_code":"NZ","type":"facility","lineage":["https://openalex.org/I154130895","https://openalex.org/I4210129442"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"William\u00a0A. Denny","raw_affiliation_strings":["Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1042, New Zealand","Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Private Bag 92019, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1042, New Zealand","institution_ids":["https://openalex.org/I154130895"]},{"raw_affiliation_string":"Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Private Bag 92019, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895","https://openalex.org/I4210129442"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058844911","display_name":"Ripudaman Singh","orcid":"https://orcid.org/0000-0003-2657-0661","observed_orcids":["https://orcid.org/0000-0003-2657-0661"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":true,"raw_author_name":"Ripudaman Singh","raw_affiliation_strings":["Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1042, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1042, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109151809","display_name":"James M. J. J. Dickson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"James Dickson","raw_affiliation_strings":["School of Biological Science, University of Auckland, Private Bag 92019, Auckland 1042, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Science, University of Auckland, Private Bag 92019, Auckland 1042, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061684371","display_name":"Bruce C. Baguley","orcid":"https://orcid.org/0000-0001-9943-6987","observed_orcids":["https://orcid.org/0000-0001-9943-6987"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]},{"id":"https://openalex.org/I4210129442","display_name":"Maurice Wilkins Centre","ror":"https://ror.org/0327mmx61","country_code":"NZ","type":"facility","lineage":["https://openalex.org/I154130895","https://openalex.org/I4210129442"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Bruce\u00a0C. Baguley","raw_affiliation_strings":["Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1042, New Zealand","Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Private Bag 92019, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1042, New Zealand","institution_ids":["https://openalex.org/I154130895"]},{"raw_affiliation_string":"Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Private Bag 92019, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895","https://openalex.org/I4210129442"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005007188","display_name":"Peter Robin Shepherd","orcid":"https://orcid.org/0000-0001-9742-5811","observed_orcids":["https://orcid.org/0000-0001-9742-5811","https://orcid.org/0000-0001-8591-7309"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]},{"id":"https://openalex.org/I4210129442","display_name":"Maurice Wilkins Centre","ror":"https://ror.org/0327mmx61","country_code":"NZ","type":"facility","lineage":["https://openalex.org/I154130895","https://openalex.org/I4210129442"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Peter\u00a0R. Shepherd","raw_affiliation_strings":["Department of Molecular Medicine and Pathology, University of Auckland, Medical School, Private Bag 92019, Auckland 1042, New Zealand","Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Private Bag 92019, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine and Pathology, University of Auckland, Medical School, Private Bag 92019, Auckland 1042, New Zealand","institution_ids":["https://openalex.org/I154130895"]},{"raw_affiliation_string":"Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Private Bag 92019, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895","https://openalex.org/I4210129442"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5058844911","https://openalex.org/A5078146193"],"corresponding_institution_ids":["https://openalex.org/I154130895","https://openalex.org/I4210129442"],"apc_list":null,"apc_paid":null,"fwci":8.2386,"has_fulltext":false,"cited_by_count":165,"citation_normalized_percentile":{"value":0.98723685,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"438","issue":"1","first_page":"53","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p110alpha","display_name":"p110\u03b1","score":0.828000009059906},{"id":"https://openalex.org/keywords/pi3k-inhibitors","display_name":"PI3K inhibitors","score":0.7929999828338623},{"id":"https://openalex.org/keywords/isoform-selective-inhibition","display_name":"isoform-selective inhibition","score":0.6679999828338623},{"id":"https://openalex.org/keywords/pik3ca-h1047r-mutation","display_name":"PIK3CA H1047R mutation","score":0.9789999723434448},{"id":"https://openalex.org/keywords/insulin-signaling","display_name":"insulin signaling","score":0.7940000295639038},{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.906000018119812},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.8149999976158142},{"id":"https://openalex.org/keywords/xenograft-models","display_name":"xenograft models","score":0.8050000071525574},{"id":"https://openalex.org/keywords/growth-factor-signaling","display_name":"growth factor signaling","score":0.6769999861717224},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.47099998593330383},{"id":"https://openalex.org/keywords/pik3ca-amplification","display_name":"PIK3CA amplification","score":0.765999972820282},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.5239999890327454}],"concepts":[{"id":"https://openalex.org/C2781465904","wikidata":"https://www.wikidata.org/wiki/Q14887700","display_name":"P110\u03b1","level":4,"score":0.839586079120636},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.8372217416763306},{"id":"https://openalex.org/C2781322055","wikidata":"https://www.wikidata.org/wiki/Q423725","display_name":"Phosphoinositide 3-kinase","level":4,"score":0.7863497734069824},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.7488528490066528},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.6407232284545898},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6230082511901855},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.51601243019104},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.48553013801574707},{"id":"https://openalex.org/C2779549131","wikidata":"https://www.wikidata.org/wiki/Q83167294","display_name":"Tensin","level":5,"score":0.4733070135116577},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.45724061131477356},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.385761022567749},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.29932576417922974},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23365768790245056}],"mesh":[{"descriptor_ui":"D000081082","descriptor_name":"Phosphoinositide-3 Kinase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058543","descriptor_name":"Class Ia Phosphatidylinositol 3-Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1042/bj20110502","doi":"https://doi.org/10.1042/bj20110502","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj20110502","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3174055","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3174055","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"},{"id":"pmid:21668414","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21668414","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"},{"id":"pmh:oai:researchspace.auckland.ac.nz:2292/9205","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2292/9205","pdf_url":null,"source":{"id":"https://openalex.org/S7407055463","display_name":"ResearchSpace (University of Auckland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I154130895","host_organization_name":"University of Auckland","host_organization_lineage":["https://openalex.org/I154130895"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1042/bj20110502","doi":"https://doi.org/10.1042/bj20110502","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj20110502","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W1524785967","https://openalex.org/W1588880778","https://openalex.org/W1594020010","https://openalex.org/W1841050729","https://openalex.org/W1969292035","https://openalex.org/W1971525986","https://openalex.org/W1971791161","https://openalex.org/W1978981032","https://openalex.org/W1981711832","https://openalex.org/W1981817858","https://openalex.org/W1989008399","https://openalex.org/W1991761103","https://openalex.org/W1995115263","https://openalex.org/W1998044465","https://openalex.org/W1998836974","https://openalex.org/W2000954296","https://openalex.org/W2001999652","https://openalex.org/W2006734560","https://openalex.org/W2007271805","https://openalex.org/W2010784970","https://openalex.org/W2011554530","https://openalex.org/W2024676945","https://openalex.org/W2037649861","https://openalex.org/W2043377688","https://openalex.org/W2045975323","https://openalex.org/W2054607545","https://openalex.org/W2054958296","https://openalex.org/W2057370954","https://openalex.org/W2062234434","https://openalex.org/W2085483616","https://openalex.org/W2087693130","https://openalex.org/W2090038231","https://openalex.org/W2092284194","https://openalex.org/W2099019742","https://openalex.org/W2108401385","https://openalex.org/W2109799459","https://openalex.org/W2121945278","https://openalex.org/W2124593509","https://openalex.org/W2127224873","https://openalex.org/W2129172946","https://openalex.org/W2135244179","https://openalex.org/W2140522666","https://openalex.org/W2144809933","https://openalex.org/W2147275512","https://openalex.org/W2151258296","https://openalex.org/W2154692501","https://openalex.org/W2154714625","https://openalex.org/W2158305336","https://openalex.org/W2162003888","https://openalex.org/W2167009545","https://openalex.org/W2167010784","https://openalex.org/W2344973376","https://openalex.org/W2345039063","https://openalex.org/W2399949777","https://openalex.org/W6659920766"],"related_works":["https://openalex.org/W2053661826","https://openalex.org/W2112233713","https://openalex.org/W1436721071","https://openalex.org/W2033999408","https://openalex.org/W2069897539","https://openalex.org/W2075995968","https://openalex.org/W1977556560","https://openalex.org/W2010570203","https://openalex.org/W2166188515","https://openalex.org/W1514378709"],"abstract_inverted_index":{"Genetic":[0],"alterations":[1],"in":[2,9,14,29,44,49,58,145,163,175,208,228,249],"PI3K":[3,55,185],"(phosphoinositide":[4],"3-kinase)":[5],"signalling":[6,62,130,160,245],"are":[7],"common":[8],"cancer":[10],"and":[11,17,27,42,63,103,110,177,183,205,211,246],"include":[12],"deletions":[13],"PTEN":[15],"(phosphatase":[16],"tensin":[18],"homologue":[19],"deleted":[20],"on":[21],"chromosome":[22],"10),":[23],"amplifications":[24],"of":[25,33,54,69,79,117,123,142,152,181,193,203,218,235,252],"PIK3CA":[26,35,176],"mutations":[28,174],"two":[30,217],"distinct":[31],"regions":[32],"the":[34,77,85,96,115,139,190,201,219,239],"gene.":[36],"This":[37,187],"suggests":[38],"drugs":[39],"targeting":[40],"PI3K,":[41],"p110\u03b1":[43,70,105,153,182,197,236],"particular,":[45],"might":[46],"be":[47,99],"useful":[48],"treating":[50],"cancers.":[51],"Broad-spectrum":[52],"inhibition":[53,151,234],"is":[56,136],"effective":[57],"preventing":[59],"growth":[60,207,243,248],"factor":[61,244],"tumour":[64,206],"growth,":[65],"but":[66],"suitable":[67],"inhibitors":[68],"have":[71,178],"not":[72],"been":[73],"available":[74],"to":[75,98,131,157,161,196,226,241],"study":[76,87],"effects":[78,141],"inhibiting":[80,143],"this":[81,118],"isoform":[82],"alone.":[83],"In":[84],"present":[86],"we":[88,113,126],"characterize":[89],"a":[90,100,121,250],"novel":[91],"small":[92],"molecule,":[93],"A66,":[94],"showing":[95],"S-enantiomer":[97],"highly":[101],"specific":[102],"selective":[104],"inhibitor.":[106],"Using":[107,120],"molecular":[108],"modelling":[109],"biochemical":[111],"studies,":[112],"explain":[114,189],"basis":[116],"selectivity.":[119],"panel":[122],"isoform-selective":[124],"inhibitors,":[125],"show":[127,232],"that":[128,213,233],"insulin":[129,159],"Akt/PKB":[132,162,204],"(protein":[133],"kinase":[134],"B)":[135],"attenuated":[137],"by":[138],"additive":[140],"p110\u03b1/p110\u03b2/p110\u03b4":[144],"all":[146,171],"cell":[147,165,169,221],"lines":[148,170,222],"tested.":[149],"However,":[150],"alone":[154,237],"was":[155],"sufficient":[156],"block":[158,242],"certain":[164],"lines.":[166],"The":[167],"responsive":[168,220,225],"harboured":[172],"H1047R":[173],"high":[179],"levels":[180],"class-Ia":[184],"activity.":[186],"may":[188],"increased":[191],"sensitivity":[192],"these":[194],"cells":[195],"inhibitors.":[198],"We":[199],"assessed":[200],"activation":[202],"xenograft":[209],"models":[210],"found":[212],"tumours":[214],"derived":[215],"from":[216],"were":[223],"also":[224],"A66":[227],"vivo.":[229],"These":[230],"results":[231],"has":[238],"potential":[240],"reduce":[247],"subset":[251],"tumours.":[253]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":20},{"year":2013,"cited_by_count":27},{"year":2012,"cited_by_count":13}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
