{"id":"https://openalex.org/W2010705270","doi":"https://doi.org/10.1161/01.cir.101.1.86","title":"Electrophysiological Effects of Dofetilide in an In Vitro Model of \u201cBorder Zone\u201d Between Normal and Ischemic/Reperfused Myocardium","display_name":"Electrophysiological Effects of Dofetilide in an In Vitro Model of \u201cBorder Zone\u201d Between Normal and Ischemic/Reperfused Myocardium","publication_year":2000,"publication_date":"2000-01-04","ids":{"openalex":"https://openalex.org/W2010705270","doi":"https://doi.org/10.1161/01.cir.101.1.86","mag":"2010705270","pmid":"https://pubmed.ncbi.nlm.nih.gov/10618309"},"language":"en","primary_location":{"id":"doi:10.1161/01.cir.101.1.86","doi":"https://doi.org/10.1161/01.cir.101.1.86","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.cir.101.1.86","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109227401","display_name":"Ren\u00e9 Rouet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210090627","display_name":"Lille\u2019s Cardiology Hospital","ror":"https://ror.org/000z46s85","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406","https://openalex.org/I4210090627"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Rene\u0301 Rouet","raw_affiliation_strings":["From Anesthe\u0301siologie Expe\u0301rimentale et Physiologie Cellulaire, Universite\u0301, Caen (R.R., S.P., J.-L.G.); Pharmacologie, Centre d\u2019Investigations Cliniques, CH&amp;U-INSERM, Ho\u0302pital Cardiologique, Lille (C.L.), France; and Pfizer Ltd, Central Research, Sandwich, Kent CT13 9NJ, UK (M.G., C.A.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Anesthe\u0301siologie Expe\u0301rimentale et Physiologie Cellulaire, Universite\u0301, Caen (R.R., S.P., J.-L.G.); Pharmacologie, Centre d\u2019Investigations Cliniques, CH&amp;U-INSERM, Ho\u0302pital Cardiologique, Lille (C.L.), France; and Pfizer Ltd, Central Research, Sandwich, Kent CT13 9NJ, UK (M.G., C.A.)","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210090627"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082967517","display_name":"Sandra Picard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210090627","display_name":"Lille\u2019s Cardiology Hospital","ror":"https://ror.org/000z46s85","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406","https://openalex.org/I4210090627"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sandra Picard","raw_affiliation_strings":["From Anesthe\u0301siologie Expe\u0301rimentale et Physiologie Cellulaire, Universite\u0301, Caen (R.R., S.P., J.-L.G.); Pharmacologie, Centre d\u2019Investigations Cliniques, CH&amp;U-INSERM, Ho\u0302pital Cardiologique, Lille (C.L.), France; and Pfizer Ltd, Central Research, Sandwich, Kent CT13 9NJ, UK (M.G., C.A.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Anesthe\u0301siologie Expe\u0301rimentale et Physiologie Cellulaire, Universite\u0301, Caen (R.R., S.P., J.-L.G.); Pharmacologie, Centre d\u2019Investigations Cliniques, CH&amp;U-INSERM, Ho\u0302pital Cardiologique, Lille (C.L.), France; and Pfizer Ltd, Central Research, Sandwich, Kent CT13 9NJ, UK (M.G., C.A.)","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210090627"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057504753","display_name":"Christian Libersa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210090627","display_name":"Lille\u2019s Cardiology Hospital","ror":"https://ror.org/000z46s85","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406","https://openalex.org/I4210090627"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christian Libersa","raw_affiliation_strings":["From Anesthe\u0301siologie Expe\u0301rimentale et Physiologie Cellulaire, Universite\u0301, Caen (R.R., S.P., J.-L.G.); Pharmacologie, Centre d\u2019Investigations Cliniques, CH&amp;U-INSERM, Ho\u0302pital Cardiologique, Lille (C.L.), France; and Pfizer Ltd, Central Research, Sandwich, Kent CT13 9NJ, UK (M.G., C.A.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Anesthe\u0301siologie Expe\u0301rimentale et Physiologie Cellulaire, Universite\u0301, Caen (R.R., S.P., J.-L.G.); Pharmacologie, Centre d\u2019Investigations Cliniques, CH&amp;U-INSERM, Ho\u0302pital Cardiologique, Lille (C.L.), France; and Pfizer Ltd, Central Research, Sandwich, Kent CT13 9NJ, UK (M.G., C.A.)","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210090627"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005144960","display_name":"Mathieu M. Ghadanfar","orcid":"https://orcid.org/0000-0002-3608-7625","observed_orcids":["https://orcid.org/0000-0002-3608-7625"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210090627","display_name":"Lille\u2019s Cardiology Hospital","ror":"https://ror.org/000z46s85","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406","https://openalex.org/I4210090627"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mathieu Ghadanfar","raw_affiliation_strings":["From Anesthe\u0301siologie Expe\u0301rimentale et Physiologie Cellulaire, Universite\u0301, Caen (R.R., S.P., J.-L.G.); Pharmacologie, Centre d\u2019Investigations Cliniques, CH&amp;U-INSERM, Ho\u0302pital Cardiologique, Lille (C.L.), France; and Pfizer Ltd, Central Research, Sandwich, Kent CT13 9NJ, UK (M.G., C.A.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Anesthe\u0301siologie Expe\u0301rimentale et Physiologie Cellulaire, Universite\u0301, Caen (R.R., S.P., J.-L.G.); Pharmacologie, Centre d\u2019Investigations Cliniques, CH&amp;U-INSERM, Ho\u0302pital Cardiologique, Lille (C.L.), France; and Pfizer Ltd, Central Research, Sandwich, Kent CT13 9NJ, UK (M.G., C.A.)","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210090627"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110193271","display_name":"Colin T. Alabaster","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210090627","display_name":"Lille\u2019s Cardiology Hospital","ror":"https://ror.org/000z46s85","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406","https://openalex.org/I4210090627"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Colin Alabaster","raw_affiliation_strings":["From Anesthe\u0301siologie Expe\u0301rimentale et Physiologie Cellulaire, Universite\u0301, Caen (R.R., S.P., J.-L.G.); Pharmacologie, Centre d\u2019Investigations Cliniques, CH&amp;U-INSERM, Ho\u0302pital Cardiologique, Lille (C.L.), France; and Pfizer Ltd, Central Research, Sandwich, Kent CT13 9NJ, UK (M.G., C.A.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Anesthe\u0301siologie Expe\u0301rimentale et Physiologie Cellulaire, Universite\u0301, Caen (R.R., S.P., J.-L.G.); Pharmacologie, Centre d\u2019Investigations Cliniques, CH&amp;U-INSERM, Ho\u0302pital Cardiologique, Lille (C.L.), France; and Pfizer Ltd, Central Research, Sandwich, Kent CT13 9NJ, UK (M.G., C.A.)","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210090627"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109086641","display_name":"Jean\u2010Louis G\u00e9rard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210090627","display_name":"Lille\u2019s Cardiology Hospital","ror":"https://ror.org/000z46s85","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406","https://openalex.org/I4210090627"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Louis Ge\u0301rard","raw_affiliation_strings":["From Anesthe\u0301siologie Expe\u0301rimentale et Physiologie Cellulaire, Universite\u0301, Caen (R.R., S.P., J.-L.G.); Pharmacologie, Centre d\u2019Investigations Cliniques, CH&amp;U-INSERM, Ho\u0302pital Cardiologique, Lille (C.L.), France; and Pfizer Ltd, Central Research, Sandwich, Kent CT13 9NJ, UK (M.G., C.A.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Anesthe\u0301siologie Expe\u0301rimentale et Physiologie Cellulaire, Universite\u0301, Caen (R.R., S.P., J.-L.G.); Pharmacologie, Centre d\u2019Investigations Cliniques, CH&amp;U-INSERM, Ho\u0302pital Cardiologique, Lille (C.L.), France; and Pfizer Ltd, Central Research, Sandwich, Kent CT13 9NJ, UK (M.G., C.A.)","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210090627"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4936,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.70460324,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"101","issue":"1","first_page":"86","last_page":"93"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9229000210762024,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9229000210762024,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.06790000200271606,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dofetilide","display_name":"dofetilide","score":1.0},{"id":"https://openalex.org/keywords/class-iii-antiarrhythmic-drugs","display_name":"class III antiarrhythmic agents","score":0.9010000228881836},{"id":"https://openalex.org/keywords/myocardial-ischemia-reperfusion-injury","display_name":"myocardial ischemia-reperfusion injury","score":0.8420000076293945},{"id":"https://openalex.org/keywords/border-zone","display_name":"border zone","score":0.6990000009536743},{"id":"https://openalex.org/keywords/ventricular-action-potential-duration","display_name":"ventricular action potential duration","score":0.6190000176429749},{"id":"https://openalex.org/keywords/ventricular-arrhythmias","display_name":"ventricular arrhythmias","score":0.7720000147819519}],"concepts":[{"id":"https://openalex.org/C2777796741","wikidata":"https://www.wikidata.org/wiki/Q3712521","display_name":"Dofetilide","level":3,"score":0.9906638264656067},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8042703866958618},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.6220152378082275},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5944714546203613},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5633195638656616},{"id":"https://openalex.org/C2779096242","wikidata":"https://www.wikidata.org/wiki/Q218719","display_name":"Border zone","level":3,"score":0.5075763463973999},{"id":"https://openalex.org/C146403970","wikidata":"https://www.wikidata.org/wiki/Q205729","display_name":"Repolarization","level":3,"score":0.5042368173599243},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.4675155282020569},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.39524632692337036},{"id":"https://openalex.org/C118441451","wikidata":"https://www.wikidata.org/wiki/Q12074763","display_name":"QT interval","level":2,"score":0.2386440932750702},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.08639892935752869}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000889","descriptor_name":"Anti-Arrhythmia Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010627","descriptor_name":"Phenethylamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015425","descriptor_name":"Myocardial Reperfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017202","descriptor_name":"Myocardial Ischemia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1161/01.cir.101.1.86","doi":"https://doi.org/10.1161/01.cir.101.1.86","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.cir.101.1.86","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"pmid:10618309","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10618309","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1569484665","https://openalex.org/W1926137227","https://openalex.org/W1967151871","https://openalex.org/W1977921500","https://openalex.org/W1979884480","https://openalex.org/W1982582485","https://openalex.org/W1984484076","https://openalex.org/W1986248273","https://openalex.org/W1991123421","https://openalex.org/W1998813410","https://openalex.org/W1998932167","https://openalex.org/W2002711428","https://openalex.org/W2003313725","https://openalex.org/W2003632755","https://openalex.org/W2003712236","https://openalex.org/W2023454665","https://openalex.org/W2027665464","https://openalex.org/W2028128998","https://openalex.org/W2028184499","https://openalex.org/W2033505725","https://openalex.org/W2034298434","https://openalex.org/W2034573541","https://openalex.org/W2042987139","https://openalex.org/W2057397415","https://openalex.org/W2083714418","https://openalex.org/W2093545350","https://openalex.org/W2107130972","https://openalex.org/W2130680932","https://openalex.org/W2141121342","https://openalex.org/W2142612297","https://openalex.org/W2244658434","https://openalex.org/W2289211815","https://openalex.org/W2292323680","https://openalex.org/W2318034718","https://openalex.org/W2326108148","https://openalex.org/W2327032335","https://openalex.org/W2327195083","https://openalex.org/W2440592726","https://openalex.org/W4233306427"],"related_works":["https://openalex.org/W2075050918","https://openalex.org/W2039119796","https://openalex.org/W2033505725","https://openalex.org/W2095697270","https://openalex.org/W2067814190","https://openalex.org/W2074534342","https://openalex.org/W2440592726","https://openalex.org/W2318034718","https://openalex.org/W2141121342","https://openalex.org/W2061090096"],"abstract_inverted_index":{"BACKGROUND:":[0],"To":[1],"evaluate":[2],"both":[3],"class":[4,54,183],"III":[5,55,184],"activity":[6],"and":[7,36,61,77,129,138,141,156,163,178,192,210,212,225,228],"antiarrhythmic":[8],"action":[9,68],"of":[10,15,51,57,66,84,149,158,198],"dofetilide":[11,58,105,125,174,219],"at":[12,71,126,139,175,226],"the":[13,16,52,64,67,133,147,190,196,214,233],"level":[14],"\"border":[17],"zone,\"":[18],"we":[19],"investigated":[20],"its":[21],"electrophysiological":[22],"effects":[23,56],"on":[24],"guinea":[25],"pig":[26],"ventricular":[27],"strips":[28],"submitted":[29],"partly":[30,37],"to":[31,38],"normoxia":[32],"(normal":[33],"zone,":[34,45],"NZ)":[35],"simulated":[39],"severe":[40],"ischemia,":[41],"then":[42],"reperfusion":[43],"(altered":[44],"AZ).":[46],"METHODS":[47],"AND":[48],"RESULTS:":[49],"Because":[50],"differential":[53],"in":[59,99,121,169,189],"normal":[60],"ischemic":[62],"regions,":[63],"dispersion":[65,207],"potential":[69],"duration":[70],"90%":[72],"repolarization":[73],"(APD(90))":[74],"between":[75,208],"NZ":[76,209],"AZ":[78,94,116,211],"was":[79,95,117],"reduced":[80,213],"by":[81],"5":[82,203],"nmol/L":[83,104,131,180,204,221],"drug":[85],"during":[86,108],"early":[87,134,215],"ischemia":[88,110],"(at":[89,111],"10":[90,140,162,227],"minutes,":[91,113],"APD(90)":[92,114,206,223],"NZ/APD(90)":[93,115],"1.68+/-0.22":[96],"versus":[97,119,167],"2.82+/-0.17":[98],"control,":[100,122,170],"P<0.05),":[101],"whereas":[102],"50":[103,130,142,164,179,220,229],"worsened":[106],"it":[107,144,187,231],"late":[109,150,234],"30":[112],"4.62+/-0.76":[118],"2.57+/-0.21":[120],"P<0.05).":[123,171],"Concomitantly,":[124],"5,":[127,176],"10,":[128,177],"abolished":[132],"extrastimulus":[135],"(ES)-induced":[136],"arrhythmias,":[137],"nmol/L,":[143,165,230],"significantly":[145],"enhanced":[146],"incidence":[148,197],"spontaneous":[151,199,235],"repetitive":[152],"responses":[153],"(in":[154],"86%":[155],"75%":[157],"preparations":[159],"treated":[160],"with":[161],"respectively,":[166],"25%":[168],"During":[172],"reperfusion,":[173],"exhibited":[181],"concentration-dependent":[182],"effects,":[185],"as":[186],"did":[188,193],"NZ,":[191],"not":[194],"modify":[195],"arrhythmias.":[200,217,236],"CONCLUSIONS:":[201],"Dofetilide":[202],"decreased":[205],"ES-induced":[216],"However,":[218],"increased":[222,232],"dispersion,":[224]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
