{"id":"https://openalex.org/W2010680815","doi":"https://doi.org/10.1371/journal.ppat.1001285","title":"Atypical/Nor98 Scrapie Infectivity in Sheep Peripheral Tissues","display_name":"Atypical/Nor98 Scrapie Infectivity in Sheep Peripheral Tissues","publication_year":2011,"publication_date":"2011-02-10","ids":{"openalex":"https://openalex.org/W2010680815","doi":"https://doi.org/10.1371/journal.ppat.1001285","mag":"2010680815","pmid":"https://pubmed.ncbi.nlm.nih.gov/21347349","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3037359"},"language":"en","primary_location":{"id":"doi:10.1371/journal.ppat.1001285","doi":"https://doi.org/10.1371/journal.ppat.1001285","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1001285","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1001285&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1001285&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042897654","display_name":"Olivier Andr\u00e9oletti","orcid":"https://orcid.org/0000-0002-7369-6016","observed_orcids":["https://orcid.org/0000-0002-7369-6016"]},"institutions":[{"id":"https://openalex.org/I176063091","display_name":"\u00c9cole Nationale V\u00e9t\u00e9rinaire de Toulouse","ror":"https://ror.org/03m3gzv89","country_code":"FR","type":"education","lineage":["https://openalex.org/I176063091","https://openalex.org/I205747304","https://openalex.org/I4210117091"]},{"id":"https://openalex.org/I4210088668","display_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","ror":"https://ror.org/003vg9w96","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668"]},{"id":"https://openalex.org/I4210146726","display_name":"Interactions h\u00f4tes-agents pathog\u00e8nes","ror":"https://ror.org/041yk0b68","country_code":"FR","type":"facility","lineage":["https://openalex.org/I176063091","https://openalex.org/I205747304","https://openalex.org/I4210088668","https://openalex.org/I4210117091","https://openalex.org/I4210146726"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Olivier Andr\u00e9oletti","raw_affiliation_strings":["UMR INRA ENVT 1225, Interactions H\u00f4tes Agents Pathog\u00e8nes, Ecole Nationale V\u00e9t\u00e9rinaire de Toulouse, Toulouse, France. o.andreoletti@envt.fr","UMR INRA ENVT 1225, Interactions H\u00f4tes Agents Pathog\u00e8nes, Ecole Nationale V\u00e9t\u00e9rinaire de Toulouse, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR INRA ENVT 1225, Interactions H\u00f4tes Agents Pathog\u00e8nes, Ecole Nationale V\u00e9t\u00e9rinaire de Toulouse, Toulouse, France. o.andreoletti@envt.fr","institution_ids":["https://openalex.org/I176063091","https://openalex.org/I4210088668","https://openalex.org/I4210146726"]},{"raw_affiliation_string":"UMR INRA ENVT 1225, Interactions H\u00f4tes Agents Pathog\u00e8nes, Ecole Nationale V\u00e9t\u00e9rinaire de Toulouse, Toulouse, France","institution_ids":["https://openalex.org/I176063091","https://openalex.org/I4210088668","https://openalex.org/I4210146726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068225920","display_name":"Leonor Orge","orcid":"https://orcid.org/0000-0002-2673-2758","observed_orcids":["https://orcid.org/0000-0002-2673-2758"]},"institutions":[{"id":"https://openalex.org/I4405253187","display_name":"Laborat\u00f3rio Nacional de Investiga\u00e7\u00e3o Veterin\u00e1ria","ror":"https://ror.org/00cxt9737","country_code":"PT","type":"other","lineage":["https://openalex.org/I4405253187"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Leonor Orge","raw_affiliation_strings":["Laborat\u00f3rio Nacional de Investiga\u00e7\u00e3o Veterin\u00e1ria, Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio Nacional de Investiga\u00e7\u00e3o Veterin\u00e1ria, Lisboa, Portugal","institution_ids":["https://openalex.org/I4405253187"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013839751","display_name":"Sylvie Lafond Benestad","orcid":"https://orcid.org/0000-0002-3011-0484","observed_orcids":["https://orcid.org/0000-0002-3011-0484"]},"institutions":[{"id":"https://openalex.org/I4210164950","display_name":"Norwegian Veterinary Institute","ror":"https://ror.org/05m6y3182","country_code":"NO","type":"facility","lineage":["https://openalex.org/I4210164950"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Sylvie L. Benestad","raw_affiliation_strings":["National Veterinary Institute, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Veterinary Institute, Oslo, Norway","institution_ids":["https://openalex.org/I4210164950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014484178","display_name":"Vincent B\u00e9ringue","orcid":"https://orcid.org/0000-0001-6706-5712","observed_orcids":["https://orcid.org/0000-0001-6706-5712"]},"institutions":[{"id":"https://openalex.org/I4210114484","display_name":"Virologie et Immunologie Mol\u00e9culaires","ror":"https://ror.org/01jvz7e61","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I195731000","https://openalex.org/I277688954","https://openalex.org/I4210088668","https://openalex.org/I4210114484"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Vincent Beringue","raw_affiliation_strings":["INRA UR892, Virologie et Immunologie Mol\u00e9culaires, INRA, F-78350 Jouy-en-Josas, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INRA UR892, Virologie et Immunologie Mol\u00e9culaires, INRA, F-78350 Jouy-en-Josas, France","institution_ids":["https://openalex.org/I4210114484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076927317","display_name":"Claire Litaise","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I176063091","display_name":"\u00c9cole Nationale V\u00e9t\u00e9rinaire de Toulouse","ror":"https://ror.org/03m3gzv89","country_code":"FR","type":"education","lineage":["https://openalex.org/I176063091","https://openalex.org/I205747304","https://openalex.org/I4210117091"]},{"id":"https://openalex.org/I4210088668","display_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","ror":"https://ror.org/003vg9w96","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668"]},{"id":"https://openalex.org/I4210146726","display_name":"Interactions h\u00f4tes-agents pathog\u00e8nes","ror":"https://ror.org/041yk0b68","country_code":"FR","type":"facility","lineage":["https://openalex.org/I176063091","https://openalex.org/I205747304","https://openalex.org/I4210088668","https://openalex.org/I4210117091","https://openalex.org/I4210146726"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Claire Litaise","raw_affiliation_strings":["UMR INRA ENVT 1225, Interactions H\u00f4tes Agents Pathog\u00e8nes, Ecole Nationale V\u00e9t\u00e9rinaire de Toulouse, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR INRA ENVT 1225, Interactions H\u00f4tes Agents Pathog\u00e8nes, Ecole Nationale V\u00e9t\u00e9rinaire de Toulouse, Toulouse, France","institution_ids":["https://openalex.org/I176063091","https://openalex.org/I4210088668","https://openalex.org/I4210146726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047839691","display_name":"St\u00e9phanie Simon","orcid":"https://orcid.org/0000-0002-6071-8255","observed_orcids":["https://orcid.org/0000-0002-6071-8255"]},"institutions":[{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I4210128565","display_name":"CEA Paris-Saclay","ror":"https://ror.org/03n15ch10","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210128565"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"St\u00e9phanie Simon","raw_affiliation_strings":["CEA, Service de Pharmacologie et d'Immunoanalyse, IBiTec-S, DSV, CEA/Saclay, Gif sur Yvette cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEA, Service de Pharmacologie et d'Immunoanalyse, IBiTec-S, DSV, CEA/Saclay, Gif sur Yvette cedex, France","institution_ids":["https://openalex.org/I2738703131","https://openalex.org/I4210128565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030414513","display_name":"Annick Ledur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114484","display_name":"Virologie et Immunologie Mol\u00e9culaires","ror":"https://ror.org/01jvz7e61","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I195731000","https://openalex.org/I277688954","https://openalex.org/I4210088668","https://openalex.org/I4210114484"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Annick Le Dur","raw_affiliation_strings":["INRA UR892, Virologie et Immunologie Mol\u00e9culaires, INRA, F-78350 Jouy-en-Josas, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INRA UR892, Virologie et Immunologie Mol\u00e9culaires, INRA, F-78350 Jouy-en-Josas, France","institution_ids":["https://openalex.org/I4210114484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110931959","display_name":"Hubert Laude","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114484","display_name":"Virologie et Immunologie Mol\u00e9culaires","ror":"https://ror.org/01jvz7e61","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I195731000","https://openalex.org/I277688954","https://openalex.org/I4210088668","https://openalex.org/I4210114484"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Hubert Laude","raw_affiliation_strings":["INRA UR892, Virologie et Immunologie Mol\u00e9culaires, INRA, F-78350 Jouy-en-Josas, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INRA UR892, Virologie et Immunologie Mol\u00e9culaires, INRA, F-78350 Jouy-en-Josas, France","institution_ids":["https://openalex.org/I4210114484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059330260","display_name":"Hugh Simmons","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hugh Simmons","raw_affiliation_strings":["VLA Weybridge, ASU, Addlestone, Surrey, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VLA Weybridge, ASU, Addlestone, Surrey, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109230613","display_name":"S\u00e9verine Lugan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I176063091","display_name":"\u00c9cole Nationale V\u00e9t\u00e9rinaire de Toulouse","ror":"https://ror.org/03m3gzv89","country_code":"FR","type":"education","lineage":["https://openalex.org/I176063091","https://openalex.org/I205747304","https://openalex.org/I4210117091"]},{"id":"https://openalex.org/I4210088668","display_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","ror":"https://ror.org/003vg9w96","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668"]},{"id":"https://openalex.org/I4210146726","display_name":"Interactions h\u00f4tes-agents pathog\u00e8nes","ror":"https://ror.org/041yk0b68","country_code":"FR","type":"facility","lineage":["https://openalex.org/I176063091","https://openalex.org/I205747304","https://openalex.org/I4210088668","https://openalex.org/I4210117091","https://openalex.org/I4210146726"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"S\u00e9verine Lugan","raw_affiliation_strings":["UMR INRA ENVT 1225, Interactions H\u00f4tes Agents Pathog\u00e8nes, Ecole Nationale V\u00e9t\u00e9rinaire de Toulouse, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR INRA ENVT 1225, Interactions H\u00f4tes Agents Pathog\u00e8nes, Ecole Nationale V\u00e9t\u00e9rinaire de Toulouse, Toulouse, France","institution_ids":["https://openalex.org/I176063091","https://openalex.org/I4210088668","https://openalex.org/I4210146726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038465862","display_name":"Fabien Corbi\u00e8re","orcid":"https://orcid.org/0000-0003-3006-5561","observed_orcids":["https://orcid.org/0000-0003-3006-5561"]},"institutions":[{"id":"https://openalex.org/I176063091","display_name":"\u00c9cole Nationale V\u00e9t\u00e9rinaire de Toulouse","ror":"https://ror.org/03m3gzv89","country_code":"FR","type":"education","lineage":["https://openalex.org/I176063091","https://openalex.org/I205747304","https://openalex.org/I4210117091"]},{"id":"https://openalex.org/I4210088668","display_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","ror":"https://ror.org/003vg9w96","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668"]},{"id":"https://openalex.org/I4210146726","display_name":"Interactions h\u00f4tes-agents pathog\u00e8nes","ror":"https://ror.org/041yk0b68","country_code":"FR","type":"facility","lineage":["https://openalex.org/I176063091","https://openalex.org/I205747304","https://openalex.org/I4210088668","https://openalex.org/I4210117091","https://openalex.org/I4210146726"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fabien Corbi\u00e8re","raw_affiliation_strings":["UMR INRA ENVT 1225, Interactions H\u00f4tes Agents Pathog\u00e8nes, Ecole Nationale V\u00e9t\u00e9rinaire de Toulouse, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR INRA ENVT 1225, Interactions H\u00f4tes Agents Pathog\u00e8nes, Ecole Nationale V\u00e9t\u00e9rinaire de Toulouse, Toulouse, France","institution_ids":["https://openalex.org/I176063091","https://openalex.org/I4210088668","https://openalex.org/I4210146726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063993414","display_name":"Pierrette Costes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I176063091","display_name":"\u00c9cole Nationale V\u00e9t\u00e9rinaire de Toulouse","ror":"https://ror.org/03m3gzv89","country_code":"FR","type":"education","lineage":["https://openalex.org/I176063091","https://openalex.org/I205747304","https://openalex.org/I4210117091"]},{"id":"https://openalex.org/I4210088668","display_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","ror":"https://ror.org/003vg9w96","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668"]},{"id":"https://openalex.org/I4210146726","display_name":"Interactions h\u00f4tes-agents pathog\u00e8nes","ror":"https://ror.org/041yk0b68","country_code":"FR","type":"facility","lineage":["https://openalex.org/I176063091","https://openalex.org/I205747304","https://openalex.org/I4210088668","https://openalex.org/I4210117091","https://openalex.org/I4210146726"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierrette Costes","raw_affiliation_strings":["UMR INRA ENVT 1225, Interactions H\u00f4tes Agents Pathog\u00e8nes, Ecole Nationale V\u00e9t\u00e9rinaire de Toulouse, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR INRA ENVT 1225, Interactions H\u00f4tes Agents Pathog\u00e8nes, Ecole Nationale V\u00e9t\u00e9rinaire de Toulouse, Toulouse, France","institution_ids":["https://openalex.org/I176063091","https://openalex.org/I4210088668","https://openalex.org/I4210146726"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Nathalie Morel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I4210128565","display_name":"CEA Paris-Saclay","ror":"https://ror.org/03n15ch10","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210128565"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nathalie Morel","raw_affiliation_strings":["CEA, Service de Pharmacologie et d'Immunoanalyse, IBiTec-S, DSV, CEA/Saclay, Gif sur Yvette cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEA, Service de Pharmacologie et d'Immunoanalyse, IBiTec-S, DSV, CEA/Saclay, Gif sur Yvette cedex, France","institution_ids":["https://openalex.org/I2738703131","https://openalex.org/I4210128565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054328796","display_name":"Fran\u00e7ois Schelcher","orcid":"https://orcid.org/0000-0001-8822-4292","observed_orcids":["https://orcid.org/0000-0001-8822-4292"]},"institutions":[{"id":"https://openalex.org/I176063091","display_name":"\u00c9cole Nationale V\u00e9t\u00e9rinaire de Toulouse","ror":"https://ror.org/03m3gzv89","country_code":"FR","type":"education","lineage":["https://openalex.org/I176063091","https://openalex.org/I205747304","https://openalex.org/I4210117091"]},{"id":"https://openalex.org/I4210088668","display_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","ror":"https://ror.org/003vg9w96","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668"]},{"id":"https://openalex.org/I4210146726","display_name":"Interactions h\u00f4tes-agents pathog\u00e8nes","ror":"https://ror.org/041yk0b68","country_code":"FR","type":"facility","lineage":["https://openalex.org/I176063091","https://openalex.org/I205747304","https://openalex.org/I4210088668","https://openalex.org/I4210117091","https://openalex.org/I4210146726"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fran\u00e7ois Schelcher","raw_affiliation_strings":["UMR INRA ENVT 1225, Interactions H\u00f4tes Agents Pathog\u00e8nes, Ecole Nationale V\u00e9t\u00e9rinaire de Toulouse, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR INRA ENVT 1225, Interactions H\u00f4tes Agents Pathog\u00e8nes, Ecole Nationale V\u00e9t\u00e9rinaire de Toulouse, Toulouse, France","institution_ids":["https://openalex.org/I176063091","https://openalex.org/I4210088668","https://openalex.org/I4210146726"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027788590","display_name":"Caroline Lacroux","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I176063091","display_name":"\u00c9cole Nationale V\u00e9t\u00e9rinaire de Toulouse","ror":"https://ror.org/03m3gzv89","country_code":"FR","type":"education","lineage":["https://openalex.org/I176063091","https://openalex.org/I205747304","https://openalex.org/I4210117091"]},{"id":"https://openalex.org/I4210088668","display_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","ror":"https://ror.org/003vg9w96","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668"]},{"id":"https://openalex.org/I4210146726","display_name":"Interactions h\u00f4tes-agents pathog\u00e8nes","ror":"https://ror.org/041yk0b68","country_code":"FR","type":"facility","lineage":["https://openalex.org/I176063091","https://openalex.org/I205747304","https://openalex.org/I4210088668","https://openalex.org/I4210117091","https://openalex.org/I4210146726"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Caroline Lacroux","raw_affiliation_strings":["UMR INRA ENVT 1225, Interactions H\u00f4tes Agents Pathog\u00e8nes, Ecole Nationale V\u00e9t\u00e9rinaire de Toulouse, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR INRA ENVT 1225, Interactions H\u00f4tes Agents Pathog\u00e8nes, Ecole Nationale V\u00e9t\u00e9rinaire de Toulouse, Toulouse, France","institution_ids":["https://openalex.org/I176063091","https://openalex.org/I4210088668","https://openalex.org/I4210146726"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5042897654"],"corresponding_institution_ids":["https://openalex.org/I176063091","https://openalex.org/I4210088668","https://openalex.org/I4210146726"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":4.3166,"has_fulltext":true,"cited_by_count":140,"citation_normalized_percentile":{"value":0.9599007,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"7","issue":"2","first_page":"e1001285","last_page":"e1001285"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atypical-scrapie","display_name":"atypical scrapie","score":0.9190000295639038},{"id":"https://openalex.org/keywords/prion-disease","display_name":"prion disease","score":0.9649999737739563},{"id":"https://openalex.org/keywords/sheep","display_name":"sheep","score":0.6039999723434448},{"id":"https://openalex.org/keywords/peripheral-tissues","display_name":"peripheral tissues","score":0.7670000195503235},{"id":"https://openalex.org/keywords/lymphoid-tissue","display_name":"lymphoid tissue","score":0.796999990940094},{"id":"https://openalex.org/keywords/nerves","display_name":"nerves","score":0.6980000138282776},{"id":"https://openalex.org/keywords/muscle","display_name":"muscle","score":0.765999972820282},{"id":"https://openalex.org/keywords/transmissibility","display_name":"transmissibility","score":0.6970000267028809},{"id":"https://openalex.org/keywords/classical-scrapie","display_name":"classical scrapie","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C2776735649","wikidata":"https://www.wikidata.org/wiki/Q170102","display_name":"Scrapie","level":4,"score":0.9883762001991272},{"id":"https://openalex.org/C106358424","wikidata":"https://www.wikidata.org/wiki/Q1662346","display_name":"Infectivity","level":3,"score":0.8546976447105408},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.690472424030304},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6207947134971619},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4892005920410156},{"id":"https://openalex.org/C2781131914","wikidata":"https://www.wikidata.org/wiki/Q154666","display_name":"Bovine spongiform encephalopathy","level":4,"score":0.44462859630584717},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.42539194226264954},{"id":"https://openalex.org/C2992046845","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Infectious agent","level":3,"score":0.4246100187301636},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3429739475250244},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2674335837364197},{"id":"https://openalex.org/C3019804061","wikidata":"https://www.wikidata.org/wiki/Q14881255","display_name":"Prion protein","level":3,"score":0.24327093362808228},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.19459176063537598},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16817501187324524},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.059332042932510376}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012608","descriptor_name":"Scrapie","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012608","descriptor_name":"Scrapie","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012608","descriptor_name":"Scrapie","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012757","descriptor_name":"Sheep Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012757","descriptor_name":"Sheep Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018620","descriptor_name":"PrPSc Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018620","descriptor_name":"PrPSc Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018620","descriptor_name":"PrPSc Proteins","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.ppat.1001285","doi":"https://doi.org/10.1371/journal.ppat.1001285","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1001285","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1001285&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},{"id":"pmid:21347349","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21347349","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS pathogens","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3037359","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3037359/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathog","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-02650188v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.inrae.fr/hal-02650188","pdf_url":"https://hal.inrae.fr/hal-02650188v1/document","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, 2011, 7 (2), pp.e1001285. &#x27E8;10.1371/journal.ppat.1001285&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.654.6249","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.654.6249","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037359/pdf/ppat.1001285.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:30d9590d064043eba600ccc38db17639","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/30d9590d064043eba600ccc38db17639","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, Vol 7, Iss 2, p e1001285 (2011)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/138946","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/Atypical_Nor98_Scrapie_Infectivity_in_Sheep_Peripheral_Tissues/138946","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.ppat.1001285","doi":"https://doi.org/10.1371/journal.ppat.1001285","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1001285","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1001285&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7547553652","display_name":"New Ways to Value and Market Forest Externalities","funder_award_id":"243950","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320338366","display_name":"FP7 Food, Agriculture and Fisheries, Biotechnology","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2010680815.pdf","grobid_xml":"https://content.openalex.org/works/W2010680815.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1557724928","https://openalex.org/W1965499278","https://openalex.org/W1971516663","https://openalex.org/W1973001315","https://openalex.org/W1977336505","https://openalex.org/W1979839204","https://openalex.org/W1983292653","https://openalex.org/W1985273834","https://openalex.org/W1990156631","https://openalex.org/W1991644458","https://openalex.org/W1994111832","https://openalex.org/W1996051740","https://openalex.org/W1997241801","https://openalex.org/W2001911362","https://openalex.org/W2008575392","https://openalex.org/W2013679718","https://openalex.org/W2014043573","https://openalex.org/W2014742609","https://openalex.org/W2025757264","https://openalex.org/W2037138700","https://openalex.org/W2045576278","https://openalex.org/W2047517054","https://openalex.org/W2047626450","https://openalex.org/W2047812422","https://openalex.org/W2050025870","https://openalex.org/W2053699160","https://openalex.org/W2057060905","https://openalex.org/W2059981931","https://openalex.org/W2064722614","https://openalex.org/W2069460222","https://openalex.org/W2070334780","https://openalex.org/W2071773948","https://openalex.org/W2076838105","https://openalex.org/W2076932736","https://openalex.org/W2089523284","https://openalex.org/W2090844619","https://openalex.org/W2093624865","https://openalex.org/W2095514734","https://openalex.org/W2099264128","https://openalex.org/W2111516213","https://openalex.org/W2120925356","https://openalex.org/W2127462856","https://openalex.org/W2129150732","https://openalex.org/W2136872412","https://openalex.org/W2138609868","https://openalex.org/W2138742774","https://openalex.org/W2146246590","https://openalex.org/W2150497169","https://openalex.org/W2151000339","https://openalex.org/W2155727218","https://openalex.org/W2156023394","https://openalex.org/W2157886654","https://openalex.org/W2160322119","https://openalex.org/W2165062718","https://openalex.org/W2413719144"],"related_works":["https://openalex.org/W2127462856","https://openalex.org/W2146246590","https://openalex.org/W4206537536","https://openalex.org/W2139353335","https://openalex.org/W3126491610","https://openalex.org/W7097488459","https://openalex.org/W7099219453","https://openalex.org/W4309717350","https://openalex.org/W2158744866","https://openalex.org/W2157349433"],"abstract_inverted_index":{"Atypical/Nor98":[0,36,62,128,143,156,192],"scrapie":[1,37,63,129,144,157,195],"was":[2],"first":[3],"identified":[4],"in":[5,7,34,41,65,82,118,135,159,187,190],"1998":[6],"Norway.":[8],"It":[9],"is":[10,69,116,132,180],"now":[11],"considered":[12,100],"as":[13],"a":[14,23],"worldwide":[15],"disease":[16,172],"of":[17,26,60,78,85,155,170,182],"small":[18,52,212],"ruminants":[19,53,213],"and":[20,50,58,89,122,162,174,193],"currently":[21,198],"represents":[22],"significant":[24],"part":[25],"the":[27,61,76,160,164,171,183,200],"detected":[28],"transmissible":[29],"spongiform":[30],"encephalopathies":[31],"(TSE)":[32],"cases":[33,38,158,196],"Europe.":[35],"were":[39],"reported":[40],"ARR/ARR":[42],"sheep,":[43],"which":[44],"are":[45],"highly":[46],"resistant":[47],"to":[48,93,137,166,211],"BSE":[49],"other":[51,138],"TSE":[54,96,139,214],"agents.":[55],"The":[56,203],"biology":[57],"pathogenesis":[59],"agent":[64,97],"its":[66],"natural":[67,125],"host":[68],"still":[70],"poorly":[71],"understood.":[72],"However,":[73],"based":[74],"on":[75],"absence":[77],"detectable":[79],"abnormal":[80,114],"PrP":[81,115],"peripheral":[83,188],"tissues":[84,189],"affected":[86],"individuals,":[87],"human":[88],"animal":[90],"exposure":[91,209],"risk":[92,210],"this":[94,103],"specific":[95],"has":[98],"been":[99],"low.":[101],"In":[102],"study":[104],"we":[105],"demonstrate":[106],"that":[107,197,207],"infectivity":[108,145,184],"can":[109],"accumulate,":[110],"even":[111],"if":[112],"no":[113],"detectable,":[117],"lymphoid":[119],"tissues,":[120],"nerves,":[121],"muscles":[123],"from":[124],"and/or":[126],"experimental":[127],"cases.":[130],"Evidence":[131],"provided":[133],"that,":[134],"comparison":[136],"agents,":[140],"samples":[141],"containing":[142],"could":[146],"remain":[147],"PrP(Sc)":[148],"negative.":[149],"This":[150],"feature":[151],"will":[152],"impact":[153],"detection":[154],"field,":[161],"highlights":[163],"need":[165],"review":[167],"current":[168],"evaluations":[169],"prevalence":[173],"potential":[175],"transmissibility.":[176],"Finally,":[177],"an":[178],"estimate":[179],"made":[181],"loads":[185],"accumulating":[186],"both":[191],"classical":[194],"enter":[199],"food":[201],"chain.":[202],"results":[204],"obtained":[205],"indicate":[206],"dietary":[208],"agents":[215],"may":[216],"be":[217],"higher":[218],"than":[219],"commonly":[220],"believed.":[221]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
