{"id":"https://openalex.org/W2010676385","doi":"https://doi.org/10.1093/intimm/4.8.935","title":"Structural analysis of human anti-mouse H-2E xenorecognition: T cell receptor bias and impaired CD4 interaction contribute to weak xenoresponses","display_name":"Structural analysis of human anti-mouse H-2E xenorecognition: T cell receptor bias and impaired CD4 interaction contribute to weak xenoresponses","publication_year":1992,"publication_date":"1992-01-01","ids":{"openalex":"https://openalex.org/W2010676385","doi":"https://doi.org/10.1093/intimm/4.8.935","mag":"2010676385","pmid":"https://pubmed.ncbi.nlm.nih.gov/1358190"},"language":"en","primary_location":{"id":"doi:10.1093/intimm/4.8.935","doi":"https://doi.org/10.1093/intimm/4.8.935","is_oa":false,"landing_page_url":"https://doi.org/10.1093/intimm/4.8.935","pdf_url":null,"source":{"id":"https://openalex.org/S5544371","display_name":"International Immunology","issn_l":"0953-8178","issn":["0953-8178","1460-2377"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"P. Ramesh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P. Ramesh","raw_affiliation_strings":["Department of Immunology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK","institution_ids":["https://openalex.org/I2801748203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112276884","display_name":"Linda D. Barber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"L. Barber","raw_affiliation_strings":["Department of Immunology, Royal Postgraduate Medical School, Hammersmith Hospitalondon W12 ONN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Royal Postgraduate Medical School, Hammersmith Hospitalondon W12 ONN, UK","institution_ids":["https://openalex.org/I2801748203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039528377","display_name":"J Richard Batchelor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. R. Batchelor","raw_affiliation_strings":["Department of Immunology, Royal Postgraduate Medical School, Hammersmith Hospitalondon W12 ONN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Royal Postgraduate Medical School, Hammersmith Hospitalondon W12 ONN, UK","institution_ids":["https://openalex.org/I2801748203"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108242111","display_name":"Robert Ian Lechler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"R. I. Lechler","raw_affiliation_strings":["Department of Immunology, Royal Postgraduate Medical School, Hammersmith Hospitalondon W12 ONN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Royal Postgraduate Medical School, Hammersmith Hospitalondon W12 ONN, UK","institution_ids":["https://openalex.org/I2801748203"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5108242111"],"corresponding_institution_ids":["https://openalex.org/I2801748203"],"apc_list":{"value":3530,"currency":"USD","value_usd":3530},"apc_paid":null,"fwci":0.1507,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.40744173,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"4","issue":"8","first_page":"935","last_page":"943"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.7368000149726868,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.7368000149726868,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.12479999661445618,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12654","display_name":"Xenotransplantation and immune response","score":0.09880000352859497,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mhc-class-ii","display_name":"MHC class II","score":0.8330000042915344},{"id":"https://openalex.org/keywords/t-cell-receptor","display_name":"T cell receptor","score":0.6930000185966492},{"id":"https://openalex.org/keywords/hla-dr1","display_name":"HLA-DR1","score":0.7960000038146973},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.6769999861717224}],"concepts":[{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.6538766622543335},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.5686139464378357},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.5383350253105164},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5032493472099304},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4743267893791199},{"id":"https://openalex.org/C170627219","wikidata":"https://www.wikidata.org/wiki/Q13218497","display_name":"MHC class I","level":4,"score":0.4714292883872986},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.45675286650657654},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4554152488708496},{"id":"https://openalex.org/C2778814158","wikidata":"https://www.wikidata.org/wiki/Q959350","display_name":"MHC class II","level":4,"score":0.4493836760520935},{"id":"https://openalex.org/C2778740727","wikidata":"https://www.wikidata.org/wiki/Q12055129","display_name":"Mixed lymphocyte reaction","level":4,"score":0.43449339270591736},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4032721519470215},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3892447352409363},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26430901885032654},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006183","descriptor_name":"H-2 Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006183","descriptor_name":"H-2 Antigens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015798","descriptor_name":"HLA-DR1 Antigen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015798","descriptor_name":"HLA-DR1 Antigen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/intimm/4.8.935","doi":"https://doi.org/10.1093/intimm/4.8.935","is_oa":false,"landing_page_url":"https://doi.org/10.1093/intimm/4.8.935","pdf_url":null,"source":{"id":"https://openalex.org/S5544371","display_name":"International Immunology","issn_l":"0953-8178","issn":["0953-8178","1460-2377"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Immunology","raw_type":"journal-article"},{"id":"pmid:1358190","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1358190","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1618480967","https://openalex.org/W1961999272","https://openalex.org/W1996017127","https://openalex.org/W2136981189","https://openalex.org/W2120766171","https://openalex.org/W328156659","https://openalex.org/W1577432969","https://openalex.org/W2112196937","https://openalex.org/W2067919160","https://openalex.org/W2055375887"],"abstract_inverted_index":{"T":[0,89,175],"lymphocyte":[1],"responses":[2,18,48,109],"to":[3,13,30,71,95,129,170,190,208],"the":[4,32,42,59,120,146,161,185,191,195,203,221,226],"MHC":[5,21,36,50,66],"of":[6,34,44,54,61,119,133,145,150,160,165,199,202,212,220,225],"an":[7],"evolutionarily":[8],"distant":[9],"species":[10],"are":[11,180],"known":[12],"be":[14],"weak":[15,106],"compared":[16],"with":[17,124,152],"against":[19,49,112],"allogeneic":[20,99],"products":[22,60],"within":[23],"a":[24,130,139,171,209],"species.":[25],"This":[26,214],"fact":[27],"was":[28,79,102,215],"used":[29],"examine":[31],"regions":[33],"human":[35,88],"class":[37,67],"II":[38,68],"molecules":[39,101],"required":[40],"for":[41,86,194],"stimulation":[43],"strong":[45,92],"primary":[46],"immune":[47],"alloantigens.":[51],"A":[52,91],"panel":[53],"mouse":[55],"DAP.3":[56,96,113],"transfectants":[57,97],"expressing":[58,98,115],"wild-type":[62],"and":[63,81],"recombinant":[64],"DR1/H-2Ek":[65],"genes":[69,78],"paired":[70],"either":[72,200],"DR":[73],"alpha":[74,77,135],"or":[75,107],"H-2E":[76,116,125,153],"generated,":[80],"tested":[82],"as":[83],"stimulator":[84],"cells":[85,114],"purified":[87],"cells.":[90],"proliferative":[93],"response":[94],"HLA-DR":[100],"seen.":[103],"In":[104],"contrast,":[105],"absent":[108],"were":[110],"recorded":[111],"molecules.":[117],"Substitution":[118,198],"DR1":[121,151,166],"beta":[122,126,147,162,186,204],"chain":[123,136],"k":[127],"led":[128,169,207],"dramatic":[131],"loss":[132,211],"recognition;":[134],"substitution":[137,219],"had":[138],"less":[140],"marked":[141,210],"effect.":[142],"Furthermore,":[143],"replacement":[144],"2":[148,163,187],"domain":[149,164,188,206],"sequence":[154],"caused":[155],"90%":[156],"inhibition,":[157],"whereas":[158],"introduction":[159],"into":[167],"H-2Ek":[168],"10-fold":[172],"increase":[173],"in":[174],"cell":[176],"response.":[177,213],"These":[178],"results":[179],"most":[181],"readily":[182],"explained":[183],"if":[184],"contributes":[189],"interaction":[192],"site":[193],"CD4":[196],"molecule.":[197],"half":[201],"1":[205],"more":[216],"impressive":[217],"following":[218],"TCR-contacting":[222],"alpha-helical":[223],"region":[224],"domain.(ABSTRACT":[227],"TRUNCATED":[228],"AT":[229],"250":[230],"WORDS)":[231]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}