{"id":"https://openalex.org/W2010670231","doi":"https://doi.org/10.1590/s0036-46651991000200016","title":"ANNUAL REVIEW OF IMMUNOLOGY","display_name":"ANNUAL REVIEW OF IMMUNOLOGY","publication_year":1991,"publication_date":"1991-04-01","ids":{"openalex":"https://openalex.org/W2010670231","doi":"https://doi.org/10.1590/s0036-46651991000200016","mag":"2010670231"},"language":"en","primary_location":{"id":"doi:10.1590/s0036-46651991000200016","doi":"https://doi.org/10.1590/s0036-46651991000200016","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s0036-46651991000200016","pdf_url":"https://www.scielo.br/j/rimtsp/a/gtKFYJ74g6qQNSntf9TGDXd/?lang=pt&format=pdf","source":{"id":"https://openalex.org/S182450478","display_name":"Revista do Instituto de Medicina Tropical de S\u00e3o Paulo","issn_l":"0036-4665","issn":["0036-4665","1678-9946"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","latindex","medline","poland-70","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310312331","host_organization_name":"University of S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/P4310312331"],"host_organization_lineage_names":["University of S\u00e3o Paulo"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista do Instituto de Medicina Tropical de S\u00e3o Paulo","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.scielo.br/j/rimtsp/a/gtKFYJ74g6qQNSntf9TGDXd/?lang=pt&format=pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110180932","display_name":"William E. Paul","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William E. PAUL","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063861097","display_name":"C. Garrison Fathman","orcid":"https://orcid.org/0000-0002-7534-1497","observed_orcids":["https://orcid.org/0000-0002-7534-1497"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. GARRISON FATHMAN","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109533241","display_name":"Henry Metzger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"HENRY METZGER","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"33","issue":"2","first_page":"168","last_page":"168"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.8759999871253967,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.8759999871253967,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.07970000058412552,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.0203000009059906,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-1-receptor-antagonist","display_name":"interleukin-1 receptor antagonist","score":0.8640000224113464},{"id":"https://openalex.org/keywords/nk-cell-receptors","display_name":"NK cell receptors","score":0.9900000095367432},{"id":"https://openalex.org/keywords/bcl-2-family-proteins","display_name":"Bcl-2 family proteins","score":0.9390000104904175},{"id":"https://openalex.org/keywords/receptor-dimerization","display_name":"receptor dimerization","score":0.7580000162124634},{"id":"https://openalex.org/keywords/jak-stat-signaling","display_name":"JAK/STAT signaling","score":0.8389999866485596},{"id":"https://openalex.org/keywords/b-cell-development","display_name":"B cell development","score":0.8560000061988831},{"id":"https://openalex.org/keywords/t-cell-memory","display_name":"T cell memory","score":0.9860000014305115},{"id":"https://openalex.org/keywords/fc-receptors","display_name":"Fc receptors","score":0.9909999966621399},{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.8539999723434448},{"id":"https://openalex.org/keywords/xenotransplantation","display_name":"xenotransplantation","score":0.9110000133514404},{"id":"https://openalex.org/keywords/reed-sternberg-cells","display_name":"Reed-Sternberg cells","score":0.9290000200271606},{"id":"https://openalex.org/keywords/hodgkin-lymphoma","display_name":"Hodgkin's disease","score":0.5509999990463257},{"id":"https://openalex.org/keywords/t-cell-receptor-gene-rearrangement","display_name":"T-cell receptor gene rearrangement","score":0.34299999475479126}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5277175307273865},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5001730918884277},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.49849939346313477},{"id":"https://openalex.org/C175773311","wikidata":"https://www.wikidata.org/wiki/Q5156412","display_name":"Complement receptor","level":4,"score":0.46977800130844116},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.46753618121147156},{"id":"https://openalex.org/C2779234475","wikidata":"https://www.wikidata.org/wiki/Q14897851","display_name":"CD154","level":5,"score":0.4352499842643738},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27540653944015503},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.21538490056991577},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.17306572198867798},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15474960207939148},{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.15254732966423035},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1590/s0036-46651991000200016","doi":"https://doi.org/10.1590/s0036-46651991000200016","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s0036-46651991000200016","pdf_url":"https://www.scielo.br/j/rimtsp/a/gtKFYJ74g6qQNSntf9TGDXd/?lang=pt&format=pdf","source":{"id":"https://openalex.org/S182450478","display_name":"Revista do Instituto de Medicina Tropical de S\u00e3o Paulo","issn_l":"0036-4665","issn":["0036-4665","1678-9946"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","latindex","medline","poland-70","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310312331","host_organization_name":"University of S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/P4310312331"],"host_organization_lineage_names":["University of S\u00e3o Paulo"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista do Instituto de Medicina Tropical de S\u00e3o Paulo","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:0d4d495cab054f70a10e930e608bd996","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/0d4d495cab054f70a10e930e608bd996","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Revista do Instituto de Medicina Tropical de S\u00e3o Paulo, Vol 33, Iss 2, Pp 168-168 (1991)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1590/s0036-46651991000200016","doi":"https://doi.org/10.1590/s0036-46651991000200016","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s0036-46651991000200016","pdf_url":"https://www.scielo.br/j/rimtsp/a/gtKFYJ74g6qQNSntf9TGDXd/?lang=pt&format=pdf","source":{"id":"https://openalex.org/S182450478","display_name":"Revista do Instituto de Medicina Tropical de S\u00e3o Paulo","issn_l":"0036-4665","issn":["0036-4665","1678-9946"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","latindex","medline","poland-70","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310312331","host_organization_name":"University of S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/P4310312331"],"host_organization_lineage_names":["University of S\u00e3o Paulo"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista do Instituto de Medicina Tropical de S\u00e3o Paulo","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2010670231.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2054011919","https://openalex.org/W1499428153","https://openalex.org/W2123281034","https://openalex.org/W587411712","https://openalex.org/W1924489622","https://openalex.org/W2041619295","https://openalex.org/W638166312","https://openalex.org/W2140646145","https://openalex.org/W2810174753","https://openalex.org/W2036085444"],"abstract_inverted_index":{"Eureka!":[0],"and":[1,20,60,73,78,86,99,111,128,133,141,146,161,175,186,196,205,224,237,245,250,262,269,281,292,299,306,314,318,332],"other":[2],"pleasures,":[3],"Henry":[4],"Metzger":[5],"interleukin-1":[6],"receptor":[7],"antagonist":[8],"-":[9,65,92,135,149,201],"role":[10,202,242],"in":[11,80,96,102,120,203,248,264,309],"biology,":[12],"William":[13],"Avend,":[14],"Mark":[15,30],"Malyak,":[16],"Carla":[17],"J.":[18,33,71,139,159,239],"Guthridge":[19],"Cem":[21],"Gabay":[22],"ligand":[23],"recognition":[24],"by":[25,168,232],"alpha-beta":[26],"T":[27,189],"cell":[28,47,68,100,182,190],"receptors,":[29,48,171],"M.":[31,213],"Davis,":[32],"Jay":[34],"Boniface,":[35],"Ziv":[36],"Reich,":[37],"Daniel":[38],"Lyons,":[39],"Johannes":[40],"Hampl,":[41],"Bernhard":[42],"Arden,":[43],"Yueh-hsiu":[44],"Chien":[45],"NK":[46],"Lewis":[49],"Lanier":[50],"mechanisms":[51],"of":[52,67,153,229,243,252,304,338],"MHC":[53],"class":[54],"1-restricted":[55],"antigen":[56,170],"processing,":[57],"Eric":[58],"Pamer":[59],"Peter":[61],"Cresswell":[62],"BCL-2":[63],"family":[64],"regulators":[66],"death,":[69],"Stanley":[70],"Korsmeyer":[72],"Debra":[74],"T.":[75,113],"Chao":[76],"CD40":[77],"CD154":[79],"cell-mediated":[81],"immunity,":[82,253],"Iqbal":[83],"S.":[84,218],"Grewal":[85],"Richard":[87],"A.":[88,271],"Flavell":[89],"CD81":[90],"(TAPA-1)":[91],"a":[93,117,322],"molecule":[94],"invloved":[95],"signal":[97],"transduction":[98],"adhesion":[101],"the":[103,241,302,336],"immune":[104,154,207,230],"system,":[105],"Shoshona":[106],"Levy,":[107],"Scott":[108],"C.":[109,255,330],"Todd":[110],"Holden":[112],"Maecker":[114],"dimerization":[115],"as":[116],"regulatory":[118],"mechanism":[119],"signalling":[121,167],"transduction,":[122],"Juli":[123],"Klemm,":[124],"Stuart":[125],"L.":[126],"Schreiber":[127],"Gerald":[129],"R.":[130],"Crabtree":[131],"JAKS":[132],"STATS":[134],"biological":[136],"implications,":[137],"Warren":[138],"Leonard":[140],"John":[142,238],"O'Shea":[143],"NP-Kappa":[144],"B":[145,181],"rel":[147],"proteins":[148],"evolutionarily":[150],"conserved":[151],"mediators":[152],"responses,":[155,208],"Sankar":[156],"Ghosh,":[157],"Michael":[158,254,326],"May":[160],"Elizabeth":[162],"Kopp":[163],"positive":[164],"versus":[165],"negative":[166],"lymphocyte":[169],"James":[172],"I.":[173],"Healy":[174],"Christopher":[176],"Goodnow":[177],"transcriptional":[178],"regulation":[179,228,251],"during":[180],"development,":[183],"Andrew":[184],"Henderson":[185],"Kathryn":[187],"Calame":[188],"memory,":[191],"R.W.":[192],"Dutton,":[193],"L.M.":[194],"Bradley":[195],"S.L.":[197],"Swain":[198],"interleukin-12/interleukin-12-receptor":[199],"system":[200],"normal":[204],"pathologic":[206],"Maurice":[209],"K.":[210],"Gateley,":[211],"Louis":[212,333],"Renzetti,":[214],"Jeanne":[215],"Magram,":[216],"Alvin":[217],"Stern,":[219],"Luciano":[220],"Adorini,":[221],"Ueli":[222],"Gubler":[223],"David":[225,300,329],"H.":[226,334],"Presky":[227],"responses":[231],"TGF-beta,":[233],"Anita":[234],"B.":[235],"Roberts":[236],"Letterio":[240],"complement":[244,246,263],"receptors":[247,261],"induction":[249],"Carroll":[256],"divergent":[257],"roles":[258],"for":[259],"Fc":[260],"vivo,":[265],"Jeffrey":[266],"V.":[267],"Ravetch":[268],"Raphael":[270],"Clynes":[272],"genetic":[273],"susceptibility":[274],"to":[275,320],"systemic":[276],"lupus":[277],"erythematosus,":[278],"T.J.":[279],"Vyse":[280],"B.L.":[282],"Kotzin":[283],"how":[284],"do":[285],"monoclonal":[286],"antibodies":[287],"induce":[288],"tolerance?,":[289],"Herman":[290],"Waldmann":[291],"Stephen":[293],"Cobbold":[294],"xenogeneic":[295],"transplantation,":[296],"Hugh":[297],"Auchincloss":[298],"Sachs":[301],"origin":[303],"Hodgkin":[305],"Reed/Sternberg":[307],"cells":[308],"Hodgkin's":[310],"disease,":[311],"Ralf":[312],"Kuppers":[313],"Klaus":[315],"Rajewsky":[316],"pathways":[317],"strategies":[319],"developing":[321],"malaria":[323],"blood-stage":[324],"vaccine,":[325],"F.":[327],"Good,":[328],"Kaslow,":[331],"Miller":[335],"immunogenetics":[337],"infectious":[339],"diseases,":[340],"Adrian":[341],"V.S.":[342],"Hill.":[343]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-05T09:50:58.205359","created_date":"2016-06-24T00:00:00"}