{"id":"https://openalex.org/W2010667900","doi":"https://doi.org/10.4103/0019-509x.27934","title":"Study of the RET gene and his implication in thyroid cancer: Morocco case family","display_name":"Study of the RET gene and his implication in thyroid cancer: Morocco case family","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2010667900","doi":"https://doi.org/10.4103/0019-509x.27934","mag":"2010667900","pmid":"https://pubmed.ncbi.nlm.nih.gov/17065770"},"language":"en","primary_location":{"id":"doi:10.4103/0019-509x.27934","doi":"https://doi.org/10.4103/0019-509x.27934","is_oa":false,"landing_page_url":"https://doi.org/10.4103/0019-509x.27934","pdf_url":null,"source":{"id":"https://openalex.org/S165423279","display_name":"Indian Journal of Cancer","issn_l":"0019-509X","issn":["0019-509X","1998-4774"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://www.bioline.org.br/abstract?id=cn06019","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028808439","display_name":"Abdelhakim Ainahi","orcid":"https://orcid.org/0000-0001-5287-8059","observed_orcids":["https://orcid.org/0000-0001-5287-8059"]},"institutions":[{"id":"https://openalex.org/I4210164065","display_name":"Universit\u00e9 Hassan II Mohammedia","ror":"https://ror.org/058gnfy87","country_code":"MA","type":"education","lineage":["https://openalex.org/I4210164065"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"A Ainahi","raw_affiliation_strings":["Laboratoire de Physiologie et Pharmacologie \"UFR Environnement et Sant\u00e9\" FST, Mohammedia, Universit\u00e9 Hassan II, Maroc. abdelhakim.ainahi@pasteur.ma","Laboratoire de Physiologie et Pharmacologie"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Physiologie et Pharmacologie \"UFR Environnement et Sant\u00e9\" FST, Mohammedia, Universit\u00e9 Hassan II, Maroc. abdelhakim.ainahi@pasteur.ma","institution_ids":["https://openalex.org/I4210164065"]},{"raw_affiliation_string":"Laboratoire de Physiologie et Pharmacologie","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035466198","display_name":"M. Kebbou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138534","display_name":"Centre Hospitalier Universitaire Ibn Rochd","ror":"https://ror.org/03sbc8x80","country_code":"MA","type":"healthcare","lineage":["https://openalex.org/I4210138534"]},{"id":"https://openalex.org/I99297268","display_name":"University of Hassan II Casablanca","ror":"https://ror.org/001q4kn48","country_code":"MA","type":"education","lineage":["https://openalex.org/I99297268"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"M Kebbou","raw_affiliation_strings":["Service de M\u00e9decine Nucl\u00e9aire, CHU Ibn Rochd, Facult\u00e9 de M\u00e9decine et de Pharmacie, Universit\u00e9 HASSAN II, Maroc, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de M\u00e9decine Nucl\u00e9aire, CHU Ibn Rochd, Facult\u00e9 de M\u00e9decine et de Pharmacie, Universit\u00e9 HASSAN II, Maroc, Morocco","institution_ids":["https://openalex.org/I4210138534","https://openalex.org/I99297268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011962876","display_name":"Mohammed Timinouni","orcid":"https://orcid.org/0009-0007-9004-0151","observed_orcids":["https://orcid.org/0009-0007-9004-0151"]},"institutions":[{"id":"https://openalex.org/I4210151823","display_name":"Institut Pasteur du Maroc","ror":"https://ror.org/04yb4j419","country_code":"MA","type":"facility","lineage":["https://openalex.org/I4210151823"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"M Timinouni","raw_affiliation_strings":["Laboratoire de Microbiologie et Biologie Mol\u00e9culaire, Institut Pasteur du Maroc, Maroc, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Microbiologie et Biologie Mol\u00e9culaire, Institut Pasteur du Maroc, Maroc, Morocco","institution_ids":["https://openalex.org/I4210151823"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039769118","display_name":"N Benabdeljalil","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151823","display_name":"Institut Pasteur du Maroc","ror":"https://ror.org/04yb4j419","country_code":"MA","type":"facility","lineage":["https://openalex.org/I4210151823"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"N Benabdeljalil","raw_affiliation_strings":["Laboratoire d'Hormonologie et Marqueurs tumoraux, Institut Pasteur du Maroc, Maroc, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Hormonologie et Marqueurs tumoraux, Institut Pasteur du Maroc, Maroc, Morocco","institution_ids":["https://openalex.org/I4210151823"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112378818","display_name":"Taoufiq Fechtali","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Fechtali","raw_affiliation_strings":["Laboratoire de Physiologie et Pharmacologie"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Physiologie et Pharmacologie","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080928778","display_name":"S Oufara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Oufara","raw_affiliation_strings":["Laboratoire de Physiologie et Pharmacologie"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Physiologie et Pharmacologie","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030439154","display_name":"Sa\u00efd El Antri","orcid":"https://orcid.org/0000-0003-3534-2476","observed_orcids":["https://orcid.org/0000-0003-3534-2476"]},"institutions":[{"id":"https://openalex.org/I4210111777","display_name":"Laboratoire de Biochimie","ror":"https://ror.org/01thw2g46","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I190752583","https://openalex.org/I2746051580","https://openalex.org/I4210111777","https://openalex.org/I4210139971","https://openalex.org/I4210161506","https://openalex.org/I98910050"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"S El Antri","raw_affiliation_strings":["Laboratoire de Biochimie, Environnement et Agroalimentaire"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Biochimie, Environnement et Agroalimentaire","institution_ids":["https://openalex.org/I4210111777"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1812,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.58503607,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"43","issue":"3","first_page":"122","last_page":"122"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ret-proto-oncogene","display_name":"RET proto-oncogene","score":0.9929999709129333},{"id":"https://openalex.org/keywords/multiple-endocrine-neoplasia-type-2a","display_name":"multiple endocrine neoplasia type 2A","score":0.9879999756813049},{"id":"https://openalex.org/keywords/medullary-thyroid-carcinoma","display_name":"medullary thyroid carcinoma","score":0.925000011920929},{"id":"https://openalex.org/keywords/germline-mutations","display_name":"germline mutations","score":0.6980000138282776},{"id":"https://openalex.org/keywords/de-novo-mutations","display_name":"de novo mutations","score":0.7540000081062317},{"id":"https://openalex.org/keywords/hereditary-cancer-syndromes","display_name":"hereditary cancer","score":0.5649999976158142},{"id":"https://openalex.org/keywords/moroccan-families","display_name":"Moroccan families","score":0.6069999933242798}],"concepts":[{"id":"https://openalex.org/C75563809","wikidata":"https://www.wikidata.org/wiki/Q2656896","display_name":"Missense mutation","level":4,"score":0.6516497135162354},{"id":"https://openalex.org/C188997412","wikidata":"https://www.wikidata.org/wiki/Q1640386","display_name":"Proband","level":4,"score":0.6289924383163452},{"id":"https://openalex.org/C2779644188","wikidata":"https://www.wikidata.org/wiki/Q415976","display_name":"RET proto-oncogene","level":5,"score":0.5632545351982117},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5565478801727295},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5539299249649048},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.552161455154419},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5257424116134644},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5059377551078796},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35296696424484253},{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.31825733184814453},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28673240542411804}],"mesh":[{"descriptor_ui":"D000090063","descriptor_name":"Proto-Oncogene Mas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000310","descriptor_name":"Adrenal Gland Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005190","descriptor_name":"Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009018","descriptor_name":"Morocco","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010375","descriptor_name":"Pedigree","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010673","descriptor_name":"Pheochromocytoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D013965","descriptor_name":"Thyroidectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018276","descriptor_name":"Carcinoma, Medullary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018276","descriptor_name":"Carcinoma, Medullary","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D018813","descriptor_name":"Multiple Endocrine Neoplasia Type 2a","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D018813","descriptor_name":"Multiple Endocrine Neoplasia Type 2a","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051096","descriptor_name":"Proto-Oncogene Proteins c-ret","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.4103/0019-509x.27934","doi":"https://doi.org/10.4103/0019-509x.27934","is_oa":false,"landing_page_url":"https://doi.org/10.4103/0019-509x.27934","pdf_url":null,"source":{"id":"https://openalex.org/S165423279","display_name":"Indian Journal of Cancer","issn_l":"0019-509X","issn":["0019-509X","1998-4774"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:17065770","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17065770","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian journal of cancer","raw_type":"Case Reports"},{"id":"pmh:cria:bioline:cn:cn06019","doi":null,"is_oa":true,"landing_page_url":"http://www.bioline.org.br/abstract?id=cn06019","pdf_url":"http://www.bioline.org.br/abstract?id=cn06019","source":{"id":"https://openalex.org/S4306402188","display_name":"Bioline International (Bioline International)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Indian Journal of Cancer (ISSN: 0019-509X) Vol 43 Num 3","raw_type":"AA"},{"id":"mag:3216046757","doi":null,"is_oa":false,"landing_page_url":"https://www.academia.edu/62603835/Study_of_the_RET_gene_and_his_implication_in_thyroid_cancer_Morocco_case_family","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:cria:bioline:cn:cn06019","doi":null,"is_oa":true,"landing_page_url":"http://www.bioline.org.br/abstract?id=cn06019","pdf_url":"http://www.bioline.org.br/abstract?id=cn06019","source":{"id":"https://openalex.org/S4306402188","display_name":"Bioline International (Bioline International)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Indian Journal of Cancer (ISSN: 0019-509X) Vol 43 Num 3","raw_type":"AA"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2010667900.pdf","grobid_xml":"https://content.openalex.org/works/W2010667900.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2109993042","https://openalex.org/W7215959920","https://openalex.org/W2105132682","https://openalex.org/W2067220002","https://openalex.org/W3046256193","https://openalex.org/W7097654522","https://openalex.org/W1964893667","https://openalex.org/W3031568495","https://openalex.org/W2092749410","https://openalex.org/W1907798903"],"abstract_inverted_index":{"BACKGROUND:":[0],"Multiple":[1],"endocrine":[2],"neoplasia":[3],"type":[4],"2A":[5,44,78,180],"(MEN":[6],"2A)":[7],"is":[8,27,88],"an":[9],"autosomal":[10],"dominant":[11],"inherited":[12],"cancer":[13],"syndrome":[14],"that":[15,146,212],"affects":[16],"multiple":[17],"tissues":[18],"derived":[19],"from":[20,189],"the":[21,30,36,48,51,55,62,66,72,143,156,159,167,170,193,205],"neural":[22],"crest.":[23],"Inheritance":[24],"of":[25,32,47,54,61,71,139,158,169,177,198,207],"MTC":[26,96],"related":[28],"to":[29,98,150,185,204,216],"presence":[31],"specific":[33],"mutations":[34,41],"in":[35,42,50,101,142,155,166],"RET":[37,56,144,199],"proto-oncogene.":[38],"Almost":[39],"all":[40],"MEN":[43,77,179],"involve":[45],"one":[46],"cysteines":[49],"extracellular":[52],"domain":[53],"receptor.":[57],"AIMS:":[58],"The":[59,175],"objective":[60],"present":[63],"study":[64,90],"was":[65,163],"biochemical":[67],"and":[68,80,113,124],"molecular":[69],"characterization":[70],"first":[73],"Moroccan":[74],"clinically":[75],"established":[76],"patient":[79],"at-risk":[81],"family":[82,93],"members.":[83],"SETTINGS":[84],"AND":[85,104],"DESIGN:":[86],"This":[87],"a":[89,92,130,148],"on":[91],"presented":[94],"with":[95],"referred":[97],"our":[99],"institute":[100],"2004.":[102],"MATERIALS":[103],"METHODS:":[105],"Peripheral":[106],"blood":[107],"leukocyte":[108],"DNA":[109,125,157,168],"samples":[110],"were":[111],"isolated":[112],"amplified":[114],"by":[115,120],"polymerase":[116],"chain":[117],"reaction":[118],"followed":[119],"restriction":[121],"enzyme":[122],"analysis":[123],"sequencing.":[126],"RESULTS:":[127],"We":[128],"identified":[129],"heterozygous":[131],"germ":[132],"line":[133],"missense":[134],"mutation":[135,162,211],"at":[136],"codon":[137],"634":[138],"exon":[140],"11":[141],"gene":[145,181],"causes":[147],"cysteine":[149],"arginine":[151],"amino":[152],"acid":[153],"substitution":[154],"proband;":[160],"this":[161],"not":[164],"found":[165],"parents":[171],"or":[172],"relatives.":[173],"CONCLUSIONS:":[174],"detection":[176,206],"mutated":[178],"carriers":[182],"enables":[183],"us":[184],"differentiate":[186],"high-risk":[187],"members":[188],"those":[190],"who":[191],"bear":[192],"wild-type":[194],"gene.":[195],"Occasionally,":[196],"application":[197],"proto-oncogene":[200],"testing":[201],"may":[202],"lead":[203],"unexpected":[208],"de":[209],"novo":[210],"could":[213],"be":[214],"transmitted":[215],"children.":[217]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}