{"id":"https://openalex.org/W2010667379","doi":"https://doi.org/10.1016/j.anl.2009.12.002","title":"Overexpression of glucocorticoid receptor-\u03b2 in severe allergic rhinitis","display_name":"Overexpression of glucocorticoid receptor-\u03b2 in severe allergic rhinitis","publication_year":2010,"publication_date":"2010-02-25","ids":{"openalex":"https://openalex.org/W2010667379","doi":"https://doi.org/10.1016/j.anl.2009.12.002","mag":"2010667379","pmid":"https://pubmed.ncbi.nlm.nih.gov/20185258"},"language":"en","primary_location":{"id":"doi:10.1016/j.anl.2009.12.002","doi":"https://doi.org/10.1016/j.anl.2009.12.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.anl.2009.12.002","pdf_url":null,"source":{"id":"https://openalex.org/S66787336","display_name":"Auris Nasus Larynx","issn_l":"0385-8146","issn":["0385-8146","1879-1476"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Auris Nasus Larynx","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111521999","display_name":"Akihiro Ishida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I112524849","display_name":"Yamagata University","ror":"https://ror.org/00xy44n04","country_code":"JP","type":"education","lineage":["https://openalex.org/I112524849"]},{"id":"https://openalex.org/I4210165438","display_name":"Yamagata University Hospital","ror":"https://ror.org/05gg4qm19","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210165438"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akihiro Ishida","raw_affiliation_strings":["Department of Otolaryngology, Yamagata University School of Medicine, 2-2-2, Iida-nishi, Yamagata, Yamagata 990-9585, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Yamagata University School of Medicine, 2-2-2, Iida-nishi, Yamagata, Yamagata 990-9585, Japan","institution_ids":["https://openalex.org/I112524849","https://openalex.org/I4210165438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102708743","display_name":"Nobuo Ohta","orcid":"https://orcid.org/0000-0002-9716-8920","observed_orcids":["https://orcid.org/0000-0002-9716-8920"]},"institutions":[{"id":"https://openalex.org/I112524849","display_name":"Yamagata University","ror":"https://ror.org/00xy44n04","country_code":"JP","type":"education","lineage":["https://openalex.org/I112524849"]},{"id":"https://openalex.org/I4210165438","display_name":"Yamagata University Hospital","ror":"https://ror.org/05gg4qm19","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210165438"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Nobuo Ohta","raw_affiliation_strings":["Department of Otolaryngology, Yamagata University School of Medicine, 2-2-2, Iida-nishi, Yamagata, Yamagata 990-9585, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Yamagata University School of Medicine, 2-2-2, Iida-nishi, Yamagata, Yamagata 990-9585, Japan","institution_ids":["https://openalex.org/I112524849","https://openalex.org/I4210165438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112090359","display_name":"Shuji Koike","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I112524849","display_name":"Yamagata University","ror":"https://ror.org/00xy44n04","country_code":"JP","type":"education","lineage":["https://openalex.org/I112524849"]},{"id":"https://openalex.org/I4210165438","display_name":"Yamagata University Hospital","ror":"https://ror.org/05gg4qm19","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210165438"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shuji Koike","raw_affiliation_strings":["Department of Otolaryngology, Yamagata University School of Medicine, 2-2-2, Iida-nishi, Yamagata, Yamagata 990-9585, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Yamagata University School of Medicine, 2-2-2, Iida-nishi, Yamagata, Yamagata 990-9585, Japan","institution_ids":["https://openalex.org/I112524849","https://openalex.org/I4210165438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102969900","display_name":"Masaru Aoyagi","orcid":"https://orcid.org/0000-0002-0154-3512","observed_orcids":["https://orcid.org/0000-0002-0154-3512"]},"institutions":[{"id":"https://openalex.org/I112524849","display_name":"Yamagata University","ror":"https://ror.org/00xy44n04","country_code":"JP","type":"education","lineage":["https://openalex.org/I112524849"]},{"id":"https://openalex.org/I4210165438","display_name":"Yamagata University Hospital","ror":"https://ror.org/05gg4qm19","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210165438"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaru Aoyagi","raw_affiliation_strings":["Department of Otolaryngology, Yamagata University School of Medicine, 2-2-2, Iida-nishi, Yamagata, Yamagata 990-9585, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Yamagata University School of Medicine, 2-2-2, Iida-nishi, Yamagata, Yamagata 990-9585, Japan","institution_ids":["https://openalex.org/I112524849","https://openalex.org/I4210165438"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033082016","display_name":"Mitsunori Yamakawa","orcid":"https://orcid.org/0000-0003-4393-2695","observed_orcids":["https://orcid.org/0000-0003-4393-2695"]},"institutions":[{"id":"https://openalex.org/I112524849","display_name":"Yamagata University","ror":"https://ror.org/00xy44n04","country_code":"JP","type":"education","lineage":["https://openalex.org/I112524849"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsunori Yamakawa","raw_affiliation_strings":["First Department of Pathology, Yamagata University School of Medicine, Yamagata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Pathology, Yamagata University School of Medicine, Yamagata, Japan","institution_ids":["https://openalex.org/I112524849"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5102708743"],"corresponding_institution_ids":["https://openalex.org/I112524849","https://openalex.org/I4210165438"],"apc_list":{"value":3520,"currency":"USD","value_usd":3520},"apc_paid":null,"fwci":1.4871,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.80298229,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"37","issue":"5","first_page":"584","last_page":"588"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10984","display_name":"Sinusitis and nasal conditions","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucocorticoid-receptor-beta","display_name":"glucocorticoid receptor beta","score":0.9269999861717224},{"id":"https://openalex.org/keywords/allergic-rhinitis","display_name":"allergic rhinitis","score":0.9129999876022339},{"id":"https://openalex.org/keywords/glucocorticoid-resistance","display_name":"glucocorticoid resistance","score":0.9319999814033508},{"id":"https://openalex.org/keywords/glucocorticoid-receptor-alpha","display_name":"glucocorticoid receptor alpha","score":0.9179999828338623},{"id":"https://openalex.org/keywords/nuclear-factor-kappab","display_name":"nuclear factor-kappaB","score":0.8989999890327454},{"id":"https://openalex.org/keywords/fluticasone","display_name":"fluticasone","score":0.8289999961853027},{"id":"https://openalex.org/keywords/nasal-mucosa","display_name":"nasal mucosa","score":0.8169999718666077},{"id":"https://openalex.org/keywords/inferior-turbinate","display_name":"inferior turbinate","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C59493245","wikidata":"https://www.wikidata.org/wiki/Q14877410","display_name":"Glucocorticoid receptor","level":3,"score":0.8589969873428345},{"id":"https://openalex.org/C2780084704","wikidata":"https://www.wikidata.org/wiki/Q552065","display_name":"Turbinectomy","level":2,"score":0.8307188749313354},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.8280736207962036},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8255568742752075},{"id":"https://openalex.org/C2781212218","wikidata":"https://www.wikidata.org/wiki/Q1002165","display_name":"Fluticasone","level":3,"score":0.6401115655899048},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.5579473972320557},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.550649106502533},{"id":"https://openalex.org/C85663871","wikidata":"https://www.wikidata.org/wiki/Q6966562","display_name":"Nasal administration","level":2,"score":0.5147674083709717},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.47059571743011475},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.467096745967865},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.41382667422294617},{"id":"https://openalex.org/C2776804153","wikidata":"https://www.wikidata.org/wiki/Q210420","display_name":"Corticosteroid","level":2,"score":0.37404194474220276},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37119096517562866},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15853631496429443},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.09400543570518494},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068298","descriptor_name":"Fluticasone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000281","descriptor_name":"Administration, Intranasal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000730","descriptor_name":"Androstadienes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009297","descriptor_name":"Nasal Mucosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009297","descriptor_name":"Nasal Mucosa","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009297","descriptor_name":"Nasal Mucosa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011965","descriptor_name":"Receptors, Glucocorticoid","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D011965","descriptor_name":"Receptors, Glucocorticoid","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012221","descriptor_name":"Rhinitis, Allergic, Perennial","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012221","descriptor_name":"Rhinitis, Allergic, Perennial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012221","descriptor_name":"Rhinitis, Allergic, Perennial","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.anl.2009.12.002","doi":"https://doi.org/10.1016/j.anl.2009.12.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.anl.2009.12.002","pdf_url":null,"source":{"id":"https://openalex.org/S66787336","display_name":"Auris Nasus Larynx","issn_l":"0385-8146","issn":["0385-8146","1879-1476"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Auris Nasus Larynx","raw_type":"journal-article"},{"id":"pmid:20185258","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20185258","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Auris, nasus, larynx","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6799476075","display_name":null,"funder_award_id":"C14571605","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"}],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W38545112","https://openalex.org/W1966146541","https://openalex.org/W1970042812","https://openalex.org/W1983518744","https://openalex.org/W2001759590","https://openalex.org/W2005934692","https://openalex.org/W2021146420","https://openalex.org/W2027374885","https://openalex.org/W2034843058","https://openalex.org/W2045151561","https://openalex.org/W2048396983","https://openalex.org/W2048445979","https://openalex.org/W2077638588","https://openalex.org/W2083303897","https://openalex.org/W2083837589","https://openalex.org/W2098078683","https://openalex.org/W2143845186","https://openalex.org/W2143911884","https://openalex.org/W2322375809","https://openalex.org/W2395942853","https://openalex.org/W2577841327"],"related_works":["https://openalex.org/W2014225154","https://openalex.org/W2895538734","https://openalex.org/W2360283558","https://openalex.org/W1979072908","https://openalex.org/W2023020078","https://openalex.org/W2048445979","https://openalex.org/W4293200841","https://openalex.org/W125991721","https://openalex.org/W2145161328","https://openalex.org/W4403189161"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}