{"id":"https://openalex.org/W2010645035","doi":"https://doi.org/10.1177/1947601910383011","title":"The Unfolded Protein Response, Degradation from the Endoplasmic Reticulum, and Cancer","display_name":"The Unfolded Protein Response, Degradation from the Endoplasmic Reticulum, and Cancer","publication_year":2010,"publication_date":"2010-07-01","ids":{"openalex":"https://openalex.org/W2010645035","doi":"https://doi.org/10.1177/1947601910383011","mag":"2010645035","pmid":"https://pubmed.ncbi.nlm.nih.gov/21331300","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3039444"},"language":"en","primary_location":{"id":"doi:10.1177/1947601910383011","doi":"https://doi.org/10.1177/1947601910383011","is_oa":true,"landing_page_url":"https://doi.org/10.1177/1947601910383011","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/1947601910383011","source":{"id":"https://openalex.org/S47803330","display_name":"Genes & Cancer","issn_l":"1947-6019","issn":["1947-6019","1947-6027"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes &amp; Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.sagepub.com/doi/pdf/10.1177/1947601910383011","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021545775","display_name":"Yien Che Tsai","orcid":"https://orcid.org/0000-0001-9624-1092","observed_orcids":["https://orcid.org/0000-0001-9624-1092"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Y. C. Tsai","raw_affiliation_strings":["Laboratory of Protein Dynamics and Signaling Center for Cancer Research National Cancer Institute - Frederick Frederick, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Protein Dynamics and Signaling Center for Cancer Research National Cancer Institute - Frederick Frederick, Maryland","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083498586","display_name":"Allan M. Weissman","orcid":"https://orcid.org/0000-0002-7865-7702","observed_orcids":["https://orcid.org/0000-0002-7865-7702"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"A. M. Weissman","raw_affiliation_strings":["Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute\u2013Frederick, Frederick, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute\u2013Frederick, Frederick, MD, USA","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5021545775","https://openalex.org/A5083498586"],"corresponding_institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884","https://openalex.org/I4210149717"],"apc_list":null,"apc_paid":null,"fwci":7.5564,"has_fulltext":false,"cited_by_count":268,"citation_normalized_percentile":{"value":0.98035817,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"1","issue":"7","first_page":"764","last_page":"778"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"unfolded protein response","score":1.0},{"id":"https://openalex.org/keywords/er-associated-degradation","display_name":"ER-associated degradation","score":0.9610000252723694},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9290000200271606},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.6230000257492065},{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.753000020980835},{"id":"https://openalex.org/keywords/protein-quality-control","display_name":"protein quality control","score":0.8700000047683716},{"id":"https://openalex.org/keywords/secretory-pathway","display_name":"secretory pathway","score":0.7960000038146973},{"id":"https://openalex.org/keywords/cholesterol-synthesis","display_name":"cholesterol biosynthesis","score":0.8479999899864197},{"id":"https://openalex.org/keywords/lipogenesis","display_name":"lipogenesis","score":0.7490000128746033},{"id":"https://openalex.org/keywords/calcium-homeostasis","display_name":"calcium homeostasis","score":0.753000020980835},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.722000002861023}],"concepts":[{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.8794010877609253},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.6673843860626221},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6095922589302063},{"id":"https://openalex.org/C158619295","wikidata":"https://www.wikidata.org/wiki/Q21101062","display_name":"Endoplasmic-reticulum-associated protein degradation","level":4,"score":0.5965692400932312},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4627411961555481},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.43155354261398315},{"id":"https://openalex.org/C2779679103","wikidata":"https://www.wikidata.org/wiki/Q5251805","display_name":"Degradation (telecommunications)","level":2,"score":0.41022157669067383},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.35103291273117065},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3207539916038513},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22711509466171265},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20896953344345093},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.17035958170890808},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1177/1947601910383011","doi":"https://doi.org/10.1177/1947601910383011","is_oa":true,"landing_page_url":"https://doi.org/10.1177/1947601910383011","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/1947601910383011","source":{"id":"https://openalex.org/S47803330","display_name":"Genes & Cancer","issn_l":"1947-6019","issn":["1947-6019","1947-6027"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes &amp; Cancer","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3039444","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3039444","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes Cancer","raw_type":"Text"},{"id":"pmid:21331300","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21331300","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes & cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1177/1947601910383011","doi":"https://doi.org/10.1177/1947601910383011","is_oa":true,"landing_page_url":"https://doi.org/10.1177/1947601910383011","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/1947601910383011","source":{"id":"https://openalex.org/S47803330","display_name":"Genes & Cancer","issn_l":"1947-6019","issn":["1947-6019","1947-6027"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes &amp; Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2472862502","display_name":"Enzymes and Substrates of the Ubiquitin Conjugating System","funder_award_id":"ZIABC010292","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2010645035.pdf"},"referenced_works_count":196,"referenced_works":["https://openalex.org/W169941181","https://openalex.org/W1495945591","https://openalex.org/W1510150165","https://openalex.org/W1533199958","https://openalex.org/W1543921112","https://openalex.org/W1546139069","https://openalex.org/W1743523754","https://openalex.org/W1823288226","https://openalex.org/W1874144828","https://openalex.org/W1877364173","https://openalex.org/W1905806846","https://openalex.org/W1964231591","https://openalex.org/W1964643678","https://openalex.org/W1965827991","https://openalex.org/W1968064976","https://openalex.org/W1968921444","https://openalex.org/W1970436894","https://openalex.org/W1971663775","https://openalex.org/W1974004166","https://openalex.org/W1975133676","https://openalex.org/W1975329694","https://openalex.org/W1976191374","https://openalex.org/W1978611748","https://openalex.org/W1979592430","https://openalex.org/W1979733074","https://openalex.org/W1980438612","https://openalex.org/W1980819818","https://openalex.org/W1981625315","https://openalex.org/W1984423498","https://openalex.org/W1986186343","https://openalex.org/W1986362606","https://openalex.org/W1986627314","https://openalex.org/W1986737010","https://openalex.org/W1987428238","https://openalex.org/W1988482079","https://openalex.org/W1988740579","https://openalex.org/W1990425294","https://openalex.org/W1990649805","https://openalex.org/W1991631628","https://openalex.org/W1992653519","https://openalex.org/W1992996578","https://openalex.org/W1993433559","https://openalex.org/W1993829398","https://openalex.org/W1993964409","https://openalex.org/W1996656575","https://openalex.org/W1996826558","https://openalex.org/W1997559284","https://openalex.org/W1998306653","https://openalex.org/W1999042302","https://openalex.org/W1999124126","https://openalex.org/W2000447975","https://openalex.org/W2001648286","https://openalex.org/W2002994930","https://openalex.org/W2004543547","https://openalex.org/W2005973571","https://openalex.org/W2008014896","https://openalex.org/W2008025085","https://openalex.org/W2008055344","https://openalex.org/W2008559063","https://openalex.org/W2009240587","https://openalex.org/W2009619033","https://openalex.org/W2012166934","https://openalex.org/W2014280102","https://openalex.org/W2015519581","https://openalex.org/W2015667782","https://openalex.org/W2017767253","https://openalex.org/W2018467767","https://openalex.org/W2018515506","https://openalex.org/W2019192392","https://openalex.org/W2019672253","https://openalex.org/W2020470519","https://openalex.org/W2023662773","https://openalex.org/W2025183726","https://openalex.org/W2026639615","https://openalex.org/W2027706325","https://openalex.org/W2030770436","https://openalex.org/W2031305815","https://openalex.org/W2031488588","https://openalex.org/W2031735388","https://openalex.org/W2031907729","https://openalex.org/W2032379590","https://openalex.org/W2033088972","https://openalex.org/W2034087770","https://openalex.org/W2035535713","https://openalex.org/W2038449857","https://openalex.org/W2041092523","https://openalex.org/W2043297474","https://openalex.org/W2045151558","https://openalex.org/W2045504804","https://openalex.org/W2047211900","https://openalex.org/W2049020904","https://openalex.org/W2049881558","https://openalex.org/W2051881845","https://openalex.org/W2054439243","https://openalex.org/W2054650920","https://openalex.org/W2055402356","https://openalex.org/W2056984964","https://openalex.org/W2057668553","https://openalex.org/W2057689901","https://openalex.org/W2058209707","https://openalex.org/W2059240823","https://openalex.org/W2061573300","https://openalex.org/W2062652157","https://openalex.org/W2063651758","https://openalex.org/W2064194904","https://openalex.org/W2064609154","https://openalex.org/W2066791176","https://openalex.org/W2068806054","https://openalex.org/W2069068290","https://openalex.org/W2069924169","https://openalex.org/W2071133957","https://openalex.org/W2072715438","https://openalex.org/W2072796784","https://openalex.org/W2074802590","https://openalex.org/W2074885850","https://openalex.org/W2078197564","https://openalex.org/W2079420530","https://openalex.org/W2080389159","https://openalex.org/W2080503525","https://openalex.org/W2080729278","https://openalex.org/W2081104776","https://openalex.org/W2083516848","https://openalex.org/W2083690210","https://openalex.org/W2085201901","https://openalex.org/W2085586604","https://openalex.org/W2086302029","https://openalex.org/W2086868506","https://openalex.org/W2087839913","https://openalex.org/W2088506747","https://openalex.org/W2088510522","https://openalex.org/W2088666424","https://openalex.org/W2089198803","https://openalex.org/W2089910117","https://openalex.org/W2091557924","https://openalex.org/W2093650005","https://openalex.org/W2093930948","https://openalex.org/W2094689890","https://openalex.org/W2097868610","https://openalex.org/W2098076627","https://openalex.org/W2098365491","https://openalex.org/W2101684796","https://openalex.org/W2102416115","https://openalex.org/W2103334789","https://openalex.org/W2103355923","https://openalex.org/W2106263242","https://openalex.org/W2106444069","https://openalex.org/W2106958893","https://openalex.org/W2107442883","https://openalex.org/W2108326484","https://openalex.org/W2109773179","https://openalex.org/W2110682723","https://openalex.org/W2110780830","https://openalex.org/W2111858828","https://openalex.org/W2115205812","https://openalex.org/W2116059104","https://openalex.org/W2116064456","https://openalex.org/W2120736516","https://openalex.org/W2125262828","https://openalex.org/W2127639686","https://openalex.org/W2127848114","https://openalex.org/W2128327076","https://openalex.org/W2131210945","https://openalex.org/W2131575598","https://openalex.org/W2131632095","https://openalex.org/W2132702191","https://openalex.org/W2134272121","https://openalex.org/W2137560688","https://openalex.org/W2137755719","https://openalex.org/W2139577310","https://openalex.org/W2142780460","https://openalex.org/W2143659623","https://openalex.org/W2144135883","https://openalex.org/W2145345239","https://openalex.org/W2145922063","https://openalex.org/W2146969978","https://openalex.org/W2147305647","https://openalex.org/W2147336345","https://openalex.org/W2149368193","https://openalex.org/W2151878529","https://openalex.org/W2152354289","https://openalex.org/W2153229328","https://openalex.org/W2155015733","https://openalex.org/W2155163967","https://openalex.org/W2156705211","https://openalex.org/W2159466552","https://openalex.org/W2160731095","https://openalex.org/W2160967860","https://openalex.org/W2161007540","https://openalex.org/W2161874576","https://openalex.org/W2162470793","https://openalex.org/W2164468996","https://openalex.org/W2165019570","https://openalex.org/W2166472526","https://openalex.org/W2169221124","https://openalex.org/W2169869172","https://openalex.org/W4238261567"],"related_works":["https://openalex.org/W2894960207","https://openalex.org/W2778057735","https://openalex.org/W2326948772","https://openalex.org/W1992753274","https://openalex.org/W2989041835","https://openalex.org/W7118216981","https://openalex.org/W2093535002","https://openalex.org/W4366124143","https://openalex.org/W2765488733","https://openalex.org/W2554316608"],"abstract_inverted_index":{"The":[0,46,132,189],"endoplasmic":[1],"reticulum":[2],"(ER)":[3],"is":[4,117,134,217],"an":[5,118,177],"essential":[6],"organelle":[7,138],"involved":[8],"in":[9,34,52,96,101,161,211,224,247],"many":[10,225],"cellular":[11,53],"functions":[12],"including":[13],"protein":[14,54,97,185],"folding":[15,98],"and":[16,20,41,59,84,99,112,141,233,245,249],"secretion,":[17],"lipid":[18],"biosynthesis":[19,109],"calcium":[21],"homeostasis.":[22,201],"Proteins":[23],"destined":[24],"for":[25,30,139,252],"the":[26,35,102,105,108,126,162,183,196,240,243],"cell":[27,212],"surface":[28],"or":[29,67],"secretion":[31],"are":[32,39,63,87,129],"made":[33],"ER,":[36,163],"where":[37],"they":[38],"folded":[40,66,83],"assembled":[42,68,85],"into":[43,69],"multi-subunit":[44],"complexes.":[45,71],"ER":[47,106,133,153,168,173,200,203,215],"plays":[48],"a":[49,136,164,192,222],"vital":[50],"role":[51,95],"quality":[55],"control":[56],"by":[57,175,195],"extracting":[58],"degrading":[60],"proteins":[61,86,160],"that":[62,80,123,151,209],"not":[64],"correctly":[65],"native":[70],"This":[72],"process,":[73],"known":[74,166],"as":[75,144,167,221,229],"ER-associated":[76],"degradation":[77],"(ERAD),":[78],"ensures":[79],"only":[81],"properly":[82],"transported":[88],"to":[89,121,147,156,172,198],"their":[90,148],"final":[91],"destinations.":[92],"Besides":[93],"its":[94],"transport":[100],"secretory":[103],"pathway,":[104],"regulates":[107],"of":[110,125,158,242],"cholesterol":[111],"other":[113],"membrane":[114],"lipids.":[115],"ERAD":[116,246],"important":[119],"means":[120],"ensure":[122],"levels":[124],"responsible":[127],"enzymes":[128],"appropriately":[130],"maintained.":[131],"also":[135],"major":[137],"oxygen":[140],"nutrient":[142],"sensing":[143],"cells":[145,197,206],"adapt":[146,171],"microenvironment.":[149],"Stresses":[150],"disrupt":[152],"function":[154],"leads":[155],"accumulation":[157],"unfolded":[159,184],"condition":[165],"stress.":[169],"Cells":[170],"stress":[174,204,216],"activating":[176],"integrated":[178],"signal":[179],"transduction":[180],"pathway":[181],"called":[182],"response":[186,194],"(UPR)":[187],"(1).":[188],"UPR":[190,244],"represents":[191],"survival":[193],"restore":[199],"If":[202],"persists,":[205],"activate":[207],"mechanisms":[208],"result":[210],"death.":[213],"Chronic":[214],"increasingly":[218],"being":[219],"recognized":[220],"factor":[223],"human":[226],"diseases":[227],"such":[228],"diabetes,":[230],"neurodegenerative":[231],"disorders":[232],"cancer.":[234],"In":[235],"this":[236],"review":[237],"we":[238],"discuss":[239],"roles":[241],"cancer":[248],"suggest":[250],"directions":[251],"future":[253],"research.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":27},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":22},{"year":2016,"cited_by_count":22},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":17},{"year":2012,"cited_by_count":18}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
