{"id":"https://openalex.org/W2010624834","doi":"https://doi.org/10.1021/bi00261a009","title":"Conformational studies of secreted mouse pituitary prolactin","display_name":"Conformational studies of secreted mouse pituitary prolactin","publication_year":1982,"publication_date":"1982-08-01","ids":{"openalex":"https://openalex.org/W2010624834","doi":"https://doi.org/10.1021/bi00261a009","mag":"2010624834","pmid":"https://pubmed.ncbi.nlm.nih.gov/7126541"},"language":"en","primary_location":{"id":"doi:10.1021/bi00261a009","doi":"https://doi.org/10.1021/bi00261a009","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00261a009","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067642704","display_name":"Thomas A. Bewley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas A. Bewley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110021583","display_name":"Peter Colosi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Colosi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5033066814","display_name":"Frank J. Talamantes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frank Talamantes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.5303,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.81310162,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"18","first_page":"4238","last_page":"4243"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.015699999406933784,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prolactin","display_name":"prolactin","score":0.9850000143051147},{"id":"https://openalex.org/keywords/tryptophan","display_name":"tryptophan","score":0.7070000171661377},{"id":"https://openalex.org/keywords/protein-conformation","display_name":"protein conformation","score":0.8690000176429749},{"id":"https://openalex.org/keywords/circular-dichroism","display_name":"circular dichroism","score":0.8650000095367432},{"id":"https://openalex.org/keywords/helical-content","display_name":"alpha-helix content","score":0.9710000157356262},{"id":"https://openalex.org/keywords/protein-secretion","display_name":"protein secretion","score":0.5389999747276306}],"concepts":[{"id":"https://openalex.org/C2779064019","wikidata":"https://www.wikidata.org/wiki/Q66590068","display_name":"Prolactin","level":3,"score":0.9617123603820801},{"id":"https://openalex.org/C133571119","wikidata":"https://www.wikidata.org/wiki/Q899102","display_name":"Circular dichroism","level":2,"score":0.6675331592559814},{"id":"https://openalex.org/C2776706248","wikidata":"https://www.wikidata.org/wiki/Q181003","display_name":"Tryptophan","level":3,"score":0.6552873253822327},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.6370726823806763},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5119489431381226},{"id":"https://openalex.org/C54799321","wikidata":"https://www.wikidata.org/wiki/Q3016161","display_name":"Prolactin cell","level":4,"score":0.477211058139801},{"id":"https://openalex.org/C2781338088","wikidata":"https://www.wikidata.org/wiki/Q903495","display_name":"Residue (chemistry)","level":2,"score":0.4624856114387512},{"id":"https://openalex.org/C2777658017","wikidata":"https://www.wikidata.org/wiki/Q156871","display_name":"Pituitary gland","level":3,"score":0.42901700735092163},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.41561973094940186},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3304290175437927},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3276025652885437},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3243568241596222},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.22245970368385315},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.1691242754459381},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09577664732933044}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011388","descriptor_name":"Prolactin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013056","descriptor_name":"Spectrophotometry, Ultraviolet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013820","descriptor_name":"Thermolysin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi00261a009","doi":"https://doi.org/10.1021/bi00261a009","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00261a009","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:7126541","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7126541","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.4699999988079071,"id":"https://metadata.un.org/sdg/15","display_name":"Life on land"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W150126746","https://openalex.org/W576409360","https://openalex.org/W1142053625","https://openalex.org/W1424913112","https://openalex.org/W1502928110","https://openalex.org/W1557272981","https://openalex.org/W1584808612","https://openalex.org/W1975937504","https://openalex.org/W1983043515","https://openalex.org/W1986476287","https://openalex.org/W1986618242","https://openalex.org/W1986950349","https://openalex.org/W1996993933","https://openalex.org/W2004325771","https://openalex.org/W2011884134","https://openalex.org/W2028116079","https://openalex.org/W2036354214","https://openalex.org/W2045419992","https://openalex.org/W2046369641","https://openalex.org/W2048834051","https://openalex.org/W2062228103","https://openalex.org/W2068000459","https://openalex.org/W2072717510","https://openalex.org/W2079619319","https://openalex.org/W2081618410","https://openalex.org/W2090270124","https://openalex.org/W2093898396","https://openalex.org/W2129551151"],"related_works":["https://openalex.org/W2024104629","https://openalex.org/W2074309941","https://openalex.org/W2022547416","https://openalex.org/W1996993933","https://openalex.org/W2011884134","https://openalex.org/W1984792394","https://openalex.org/W1990428014","https://openalex.org/W1983043515","https://openalex.org/W2113346799","https://openalex.org/W2001212579"],"abstract_inverted_index":{"A":[0],"secreted":[1,29,53,56],"form":[2],"of":[3,38,71,86,93],"mouse":[4,30,57],"pituitary":[5],"prolactin":[6,31,39,58,72,87],"has":[7],"been":[8],"shown":[9],"to":[10,35,74],"contain":[11,21],"only":[12],"a":[13],"single":[14],"tryptophan":[15,61,78],"residue.":[16],"All":[17,68],"previously":[18,40],"reported":[19],"prolactins":[20],"two":[22],"tryptophans.":[23],"Circular":[24],"dichroism":[25,66],"spectra":[26],"indicate":[27],"that":[28,84],"is":[32],"conformationally":[33],"similar":[34],"stored":[36,69],"forms":[37,70],"isolated":[41],"from":[42],"several":[43],"other":[44],"species,":[45],"including":[46],"its":[47,64],"alpha-helix":[48],"content":[49],"(65%).":[50],"However,":[51],"like":[52],"rat":[54],"prolactin,":[55],"shows":[59],"no":[60],"signal":[62],"in":[63],"circular":[65],"spectrum.":[67],"studied":[73],"date":[75],"display":[76],"distinct":[77],"signals.":[79],"This":[80],"suggests":[81],"the":[82,94],"possibility":[83],"secretion":[85],"may":[88],"be":[89],"accompanied":[90],"by":[91],"modification":[92],"protein's":[95],"tertiary":[96],"structure.":[97]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}