{"id":"https://openalex.org/W2010620459","doi":"https://doi.org/10.1159/000345386","title":"Sarcoidal Granulomas in Cytological Specimens from Intrathoracic Adenopathy: Morphologic Characteristics and Radiographic Correlations","display_name":"Sarcoidal Granulomas in Cytological Specimens from Intrathoracic Adenopathy: Morphologic Characteristics and Radiographic Correlations","publication_year":2012,"publication_date":"2012-12-29","ids":{"openalex":"https://openalex.org/W2010620459","doi":"https://doi.org/10.1159/000345386","mag":"2010620459","pmid":"https://pubmed.ncbi.nlm.nih.gov/23296305"},"language":"en","primary_location":{"id":"doi:10.1159/000345386","doi":"https://doi.org/10.1159/000345386","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000345386","pdf_url":null,"source":{"id":"https://openalex.org/S121535265","display_name":"Respiration","issn_l":"0025-7931","issn":["0025-7931","1423-0356"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiration","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061423439","display_name":"Alessandra Cancellieri","orcid":"https://orcid.org/0000-0002-5895-4419","observed_orcids":["https://orcid.org/0000-0002-5895-4419"]},"institutions":[{"id":"https://openalex.org/I4210098325","display_name":"Ospedale Maggiore Carlo Alberto Pizzardi","ror":"https://ror.org/010tmdc88","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210098325","https://openalex.org/I4210119117","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandra Cancellieri","raw_affiliation_strings":["Anatomic Pathology Unit, Maggiore Hospital, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anatomic Pathology Unit, Maggiore Hospital, Bologna, Italy","institution_ids":["https://openalex.org/I4210098325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113591381","display_name":"Kevin Orr Leslie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin O. Leslie","raw_affiliation_strings":["Mayo Clinic, Scottsdale, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Scottsdale, AZ","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018414791","display_name":"Carmine Tinelli","orcid":"https://orcid.org/0000-0002-8749-1978","observed_orcids":["https://orcid.org/0000-0002-8749-1978"]},"institutions":[{"id":"https://openalex.org/I4210151645","display_name":"Policlinico San Matteo Fondazione","ror":"https://ror.org/05w1q1c88","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210151645","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carmine Tinelli","raw_affiliation_strings":["IRCCS Fondazione Policlinico San Matteo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Fondazione Policlinico San Matteo","institution_ids":["https://openalex.org/I4210151645"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048684190","display_name":"Marco Patelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I189158943","https://openalex.org/I2803066834","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210087357","display_name":"Ospedale Maggiore","ror":"https://ror.org/0053ctp29","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210087357"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Patelli","raw_affiliation_strings":["Ospedale Maggiore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ospedale Maggiore","institution_ids":["https://openalex.org/I2803066834","https://openalex.org/I4210087357"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019176149","display_name":"Rocco Trisolini","orcid":"https://orcid.org/0000-0002-1067-4696","observed_orcids":["https://orcid.org/0000-0002-1067-4696"]},"institutions":[{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I189158943","https://openalex.org/I2803066834","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210087357","display_name":"Ospedale Maggiore","ror":"https://ror.org/0053ctp29","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210087357"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rocco Trisolini","raw_affiliation_strings":["Ospedale Maggiore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ospedale Maggiore","institution_ids":["https://openalex.org/I2803066834","https://openalex.org/I4210087357"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.225,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.81551,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"85","issue":"3","first_page":"244","last_page":"251"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11571","display_name":"Sarcoidosis and Beryllium Toxicity Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11571","display_name":"Sarcoidosis and Beryllium Toxicity Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11909","display_name":"Histiocytic Disorders and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sarcoidosis","display_name":"sarcoidosis","score":0.9380000233650208},{"id":"https://openalex.org/keywords/sarcoidal-granulomas","display_name":"sarcoidal granulomas","score":0.9779999852180481},{"id":"https://openalex.org/keywords/intrathoracic-lymphadenopathy","display_name":"intrathoracic lymphadenopathy","score":0.906000018119812},{"id":"https://openalex.org/keywords/transbronchial-needle-aspiration","display_name":"transbronchial needle aspiration","score":0.9520000219345093},{"id":"https://openalex.org/keywords/ebus-tbna","display_name":"EBUS-TBNA","score":0.9100000262260437},{"id":"https://openalex.org/keywords/cytological-diagnosis","display_name":"cytological diagnosis","score":0.6859999895095825},{"id":"https://openalex.org/keywords/tuberculosis","display_name":"tuberculosis","score":0.5580000281333923},{"id":"https://openalex.org/keywords/necrosis","display_name":"necrosis","score":0.6150000095367432},{"id":"https://openalex.org/keywords/differential-diagnosis","display_name":"differential diagnosis","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9296060800552368},{"id":"https://openalex.org/C2781301800","wikidata":"https://www.wikidata.org/wiki/Q193894","display_name":"Sarcoidosis","level":2,"score":0.8330409526824951},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.5577422380447388},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.48923468589782715},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.467923641204834},{"id":"https://openalex.org/C36454342","wikidata":"https://www.wikidata.org/wiki/Q245341","display_name":"Radiography","level":2,"score":0.43796974420547485},{"id":"https://openalex.org/C3020762335","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Endobronchial ultrasound","level":3,"score":0.4221528470516205},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3873630166053772},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.35025620460510254},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2974920868873596},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.13637849688529968},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001707","descriptor_name":"Biopsy, Needle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003937","descriptor_name":"Diagnosis, Differential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006099","descriptor_name":"Granuloma","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006099","descriptor_name":"Granuloma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008482","descriptor_name":"Mediastinum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011859","descriptor_name":"Radiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012507","descriptor_name":"Sarcoidosis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D012507","descriptor_name":"Sarcoidosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000345386","doi":"https://doi.org/10.1159/000345386","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000345386","pdf_url":null,"source":{"id":"https://openalex.org/S121535265","display_name":"Respiration","issn_l":"0025-7931","issn":["0025-7931","1423-0356"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiration","raw_type":"journal-article"},{"id":"pmid:23296305","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23296305","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiration; international review of thoracic diseases","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W154698520","https://openalex.org/W1986477480","https://openalex.org/W2009761164","https://openalex.org/W2029513568","https://openalex.org/W2031064919","https://openalex.org/W2039250695","https://openalex.org/W2042983417","https://openalex.org/W2043380495","https://openalex.org/W2050367582","https://openalex.org/W2059686064","https://openalex.org/W2068011267","https://openalex.org/W2070838999","https://openalex.org/W2074074600","https://openalex.org/W2074653105","https://openalex.org/W2077868816","https://openalex.org/W2079332238","https://openalex.org/W2085494265","https://openalex.org/W2085651982","https://openalex.org/W2090316440","https://openalex.org/W2095550754","https://openalex.org/W2095724576","https://openalex.org/W2100000394","https://openalex.org/W2102659852","https://openalex.org/W2107260492","https://openalex.org/W2112950818","https://openalex.org/W2115776773","https://openalex.org/W2117538052","https://openalex.org/W2127808946","https://openalex.org/W2138636650","https://openalex.org/W2151744088","https://openalex.org/W2162038647","https://openalex.org/W2178527090","https://openalex.org/W2423815702"],"related_works":["https://openalex.org/W2594021490","https://openalex.org/W2159299306","https://openalex.org/W2040830869","https://openalex.org/W2343171217","https://openalex.org/W3031861438","https://openalex.org/W3095534551","https://openalex.org/W4410851752","https://openalex.org/W2115776773","https://openalex.org/W1984085994","https://openalex.org/W2139050217"],"abstract_inverted_index":{"BACKGROUND:":[0],"Clinical":[1],"experience":[2],"and":[3,23,36,51,64,78,107,114,145,226],"literature":[4],"data":[5],"suggest":[6],"that":[7],"the":[8,27,42,54,59,65,92,177,218,232,242,249],"ability":[9],"of":[10,29,44,56,62,68,133,206,210,231,241],"pathologists":[11,89],"to":[12,52,91,160],"identify":[13],"granulomas":[14,46,63,97,134,207,243],"in":[15,112,163,167,176,208,228,248],"cytological":[16,60,72,195],"specimens":[17,50,73],"from":[18,74],"intrathoracic":[19],"lymphadenopathy":[20,209],"varies":[21],"considerably":[22],"may":[24],"negatively":[25],"influence":[26],"yield":[28],"transbronchial":[30],"needle":[31],"aspiration":[32],"(TBNA),":[33],"both":[34],"conventional":[35],"ultrasound-guided":[37],"(EBUS-TBNA).":[38],"OBJECTIVES:":[39],"To":[40],"describe":[41],"cytomorphology":[43,200],"sarcoidal":[45,246],"on":[47,193],"TBNA":[48,71,194,225],"cytology":[49],"analyze":[53],"presence":[55],"associations":[57],"between":[58],"characteristics":[61],"radiographic":[66],"stage":[67,164,168,211,230],"sarcoidosis.":[69,170],"METHODS:":[70],"123":[75],"sarcoidosis":[76,213],"patients":[77,81,214],"14":[79],"tuberculosis":[80,178],"(control":[82],"population)":[83],"were":[84,98],"reviewed":[85],"independently":[86],"by":[87,224],"two":[88],"blinded":[90],"clinical-radiological":[93],"details.":[94],"RESULTS:":[95],"Sarcoidal":[96],"small":[99],"[median":[100,130,147],"(IQR)":[101,131,148],"largest":[102,149],"diameter:":[103,150],"0.478":[104],"(0.318-0.701)":[105],"mm]":[106],"well-formed,":[108],"round":[109],"or":[110,126],"elliptical":[111],"shape,":[113],"almost":[115],"invariably":[116],"had":[117],"a":[118,238,245],"regular":[119],"contour.":[120],"Background":[121],"elements":[122],"lacked":[123],"necrotic":[124,172,235],"debris":[125],"exudate.":[127],"The":[128],"density":[129,205],"number":[132],"per":[135],"slide:":[136],"6.85":[137],"(3.66-11)":[138],"vs.":[139,153,182],"5.25":[140],"(2.5-8),":[141],"p":[142,156,184],"=":[143,157],"0.073]":[144],"size":[146],"0.51":[151],"(0.319-0.733)":[152],"0.398":[154],"(0.318-0.522),":[155],"0.071]":[158],"tended":[159],"be":[161,190],"larger":[162],"I":[165,212],"than":[166],"II":[169],"A":[171,203,234],"background":[173,236],"was":[174],"common":[175],"cohort":[179],"studied":[180],"(79":[181],"0%,":[183],"<":[185],"0.0001).":[186],"CONCLUSIONS:":[187],"Granulomas":[188],"can":[189],"reliably":[191],"identified":[192],"material":[196],"once":[197],"their":[198],"characteristic":[199],"is":[201],"delineated.":[202],"higher":[204,219],"could":[215],"partly":[216],"explain":[217],"success":[220],"rate":[221],"constantly":[222],"obtained":[223],"EBUS-TBNA":[227],"this":[229],"disease.":[233],"suggests":[237],"tubercular":[239],"etiology":[240],"over":[244],"one,":[247],"appropriate":[250],"clinical":[251],"setting.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}