{"id":"https://openalex.org/W2010599103","doi":"https://doi.org/10.1001/archophthalmol.2012.393","title":"A 2-Year Prospective Randomized Controlled Trial of Intravitreal Bevacizumab or Laser Therapy (BOLT) in the Management of Diabetic Macular Edema","display_name":"A 2-Year Prospective Randomized Controlled Trial of Intravitreal Bevacizumab or Laser Therapy (BOLT) in the Management of Diabetic Macular Edema","publication_year":2012,"publication_date":"2012-04-09","ids":{"openalex":"https://openalex.org/W2010599103","doi":"https://doi.org/10.1001/archophthalmol.2012.393","mag":"2010599103","pmid":"https://pubmed.ncbi.nlm.nih.gov/22491395"},"language":"en","primary_location":{"id":"doi:10.1001/archophthalmol.2012.393","doi":"https://doi.org/10.1001/archophthalmol.2012.393","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archophthalmol.2012.393","pdf_url":null,"source":{"id":"https://openalex.org/S80523760","display_name":"Archives of Ophthalmology","issn_l":"0003-9950","issn":["0003-9950","1538-3601"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Ophthalmology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107226388","display_name":"Ranjan Rajendram","orcid":"https://orcid.org/0000-0003-3926-8824","observed_orcids":["https://orcid.org/0000-0003-3926-8824"]},"institutions":[{"id":"https://openalex.org/I1325675289","display_name":"Moorfields Eye Hospital NHS Foundation Trust","ror":"https://ror.org/03zaddr67","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325675289"]},{"id":"https://openalex.org/I4210150574","display_name":"Moorfields Eye Hospital","ror":"https://ror.org/03tb37539","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325675289","https://openalex.org/I4210150574"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ranjan Rajendram","raw_affiliation_strings":["Department of Medical Retina, Moorfields Eye Hospital, 162 City Rd, London EC1V 2PD, England, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Retina, Moorfields Eye Hospital, 162 City Rd, London EC1V 2PD, England, UK","institution_ids":["https://openalex.org/I1325675289","https://openalex.org/I4210150574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075865583","display_name":"Samantha Fraser\u2010Bell","orcid":"https://orcid.org/0000-0001-5646-9359","observed_orcids":["https://orcid.org/0000-0001-5646-9359"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Samantha Fraser-Bell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059542576","display_name":"Andrew Kaines","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew Kaines","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077508604","display_name":"Michel Michaelides","orcid":"https://orcid.org/0000-0002-1552-7046","observed_orcids":["https://orcid.org/0000-0002-1552-7046","https://orcid.org/0000-0003-0398-4917"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michel Michaelides","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042624834","display_name":"ROBIN D. HAMILTON","orcid":"https://orcid.org/0000-0003-2861-8761","observed_orcids":["https://orcid.org/0000-0003-2861-8761"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robin D. Hamilton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108620139","display_name":"Simona Degli Esposti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simona Degli Esposti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018227698","display_name":"T\u00fcnde Pet\u0151","orcid":"https://orcid.org/0000-0001-6265-0381","observed_orcids":["https://orcid.org/0000-0001-6265-0381"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tunde Peto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036890769","display_name":"Catherine A. Egan","orcid":"https://orcid.org/0000-0001-5593-1169","observed_orcids":["https://orcid.org/0000-0001-5593-1169","https://orcid.org/0000-0002-4439-3489"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Catherine Egan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069032977","display_name":"Catey Bunce","orcid":"https://orcid.org/0000-0002-0935-3713","observed_orcids":["https://orcid.org/0000-0002-0935-3713"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Catey Bunce","raw_affiliation_strings":["Primary Care & Public Health Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Primary Care & Public Health Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039395009","display_name":"Richard David Leslie","orcid":"https://orcid.org/0000-0002-1786-1531","observed_orcids":["https://orcid.org/0000-0002-1786-1531"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard David Leslie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5055076524","display_name":"Philip G. Hykin","orcid":"https://orcid.org/0000-0003-0459-0055","observed_orcids":["https://orcid.org/0000-0003-0459-0055"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philip G. Hykin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":34.9109,"has_fulltext":false,"cited_by_count":389,"citation_normalized_percentile":{"value":0.99904655,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"130","issue":"8","first_page":"972","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-macular-edema","display_name":"diabetic macular edema","score":0.9929999709129333},{"id":"https://openalex.org/keywords/intravitreal-bevacizumab","display_name":"intravitreal bevacizumab","score":0.9589999914169312},{"id":"https://openalex.org/keywords/best-corrected-visual-acuity","display_name":"best-corrected visual acuity","score":0.8320000171661377},{"id":"https://openalex.org/keywords/central-macular-thickness","display_name":"central macular thickness","score":0.9539999961853027},{"id":"https://openalex.org/keywords/anti-vegf-therapy","display_name":"anti-VEGF therapy","score":0.8270000219345093},{"id":"https://openalex.org/keywords/long-term-visual-outcomes","display_name":"long-term visual outcomes","score":0.5839999914169312},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.5180000066757202},{"id":"https://openalex.org/keywords/diabetic-retinopathy","display_name":"diabetic retinopathy","score":0.6119999885559082},{"id":"https://openalex.org/keywords/retinopathy-severity","display_name":"retinopathy severity","score":0.5400000214576721},{"id":"https://openalex.org/keywords/treatment-burden","display_name":"treatment burden","score":0.5440000295639038}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9182759523391724},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.9033649563789368},{"id":"https://openalex.org/C2779829184","wikidata":"https://www.wikidata.org/wiki/Q631361","display_name":"Diabetic retinopathy","level":3,"score":0.812516450881958},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.6397740840911865},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.6248751282691956},{"id":"https://openalex.org/C2778257484","wikidata":"https://www.wikidata.org/wiki/Q555066","display_name":"Visual acuity","level":2,"score":0.6158098578453064},{"id":"https://openalex.org/C2780347916","wikidata":"https://www.wikidata.org/wiki/Q1813737","display_name":"Macular edema","level":3,"score":0.548371434211731},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.46885761618614197},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.39106547832489014},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3079599142074585},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.06268438696861267},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068258","descriptor_name":"Bevacizumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000068258","descriptor_name":"Bevacizumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000068258","descriptor_name":"Bevacizumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005451","descriptor_name":"Fluorescein Angiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005451","descriptor_name":"Fluorescein Angiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005451","descriptor_name":"Fluorescein Angiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008269","descriptor_name":"Macular Edema","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008269","descriptor_name":"Macular Edema","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008269","descriptor_name":"Macular Edema","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008269","descriptor_name":"Macular Edema","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008269","descriptor_name":"Macular Edema","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008269","descriptor_name":"Macular Edema","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008269","descriptor_name":"Macular Edema","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D008269","descriptor_name":"Macular Edema","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D008269","descriptor_name":"Macular Edema","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D008269","descriptor_name":"Macular Edema","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008269","descriptor_name":"Macular Edema","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008269","descriptor_name":"Macular Edema","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014792","descriptor_name":"Visual Acuity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014792","descriptor_name":"Visual Acuity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014792","descriptor_name":"Visual Acuity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017075","descriptor_name":"Laser Coagulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017075","descriptor_name":"Laser Coagulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017075","descriptor_name":"Laser Coagulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019233","descriptor_name":"Retreatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019233","descriptor_name":"Retreatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019233","descriptor_name":"Retreatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D041623","descriptor_name":"Tomography, Optical Coherence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041623","descriptor_name":"Tomography, Optical Coherence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041623","descriptor_name":"Tomography, Optical Coherence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D058449","descriptor_name":"Intravitreal Injections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058449","descriptor_name":"Intravitreal Injections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058449","descriptor_name":"Intravitreal Injections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1001/archophthalmol.2012.393","doi":"https://doi.org/10.1001/archophthalmol.2012.393","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archophthalmol.2012.393","pdf_url":null,"source":{"id":"https://openalex.org/S80523760","display_name":"Archives of Ophthalmology","issn_l":"0003-9950","issn":["0003-9950","1538-3601"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Ophthalmology","raw_type":"journal-article"},{"id":"pmid:22491395","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22491395","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of ophthalmology (Chicago, Ill. : 1960)","raw_type":"Comparative Study"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/94fa44cf-02d6-47a3-9604-5f90fb711e85","doi":null,"is_oa":false,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/94fa44cf-02d6-47a3-9604-5f90fb711e85","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Rajendram, R, Fraser-Bell, S, Kaines, A, Michaelides, M, Hamilton, R D, Esposti, S D, Peto, T, Egan, C, Bunce, C, Leslie, R D & Hykin, P G 2012, 'A 2-year prospective randomized controlled trial of intravitreal bevacizumab or laser therapy (BOLT) in the management of diabetic macular edema : 24-month data: report 3', Archives of Ophthalmology, vol. 130, no. 8, pp. 972-9. https://doi.org/10.1001/archophthalmol.2012.393","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.qub.ac.uk/portal:publications/148806a1-f1d7-448e-be31-8c2f580df5c0","doi":null,"is_oa":false,"landing_page_url":"https://pure.qub.ac.uk/en/publications/148806a1-f1d7-448e-be31-8c2f580df5c0","pdf_url":null,"source":{"id":"https://openalex.org/S4306402319","display_name":"Research Portal (Queen's University Belfast)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126231945","host_organization_name":"Queen's University Belfast","host_organization_lineage":["https://openalex.org/I126231945"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Rajendram, R, Fraser-Bell, S, Kaines, A, Michaelides, M, Hamilton, R D, Esposti, S D, Peto, T, Egan, C, Bunce, C, Leslie, R D & Hykin, P G 2012, 'A 2-year prospective randomized controlled trial of intravitreal bevacizumab or laser therapy (BOLT) in the management of diabetic macular edema : 24-month data: report 3', Archives of Ophthalmology, vol. 130, no. 8, pp. 972-9. https://doi.org/10.1001/archophthalmol.2012.393","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.800000011920929,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W22189248","https://openalex.org/W1481978003","https://openalex.org/W1499617936","https://openalex.org/W1577751848","https://openalex.org/W1985695422","https://openalex.org/W1998866793","https://openalex.org/W2001175239","https://openalex.org/W2009425569","https://openalex.org/W2013157195","https://openalex.org/W2022886290","https://openalex.org/W2030103443","https://openalex.org/W2036712095","https://openalex.org/W2037978728","https://openalex.org/W2048664953","https://openalex.org/W2049036672","https://openalex.org/W2060308011","https://openalex.org/W2073888700","https://openalex.org/W2087224371","https://openalex.org/W2115274617","https://openalex.org/W2150713236","https://openalex.org/W2151241130","https://openalex.org/W2161279821","https://openalex.org/W2161588304","https://openalex.org/W2769264260"],"related_works":["https://openalex.org/W1977181510","https://openalex.org/W2348628890","https://openalex.org/W1668980245","https://openalex.org/W3011249866","https://openalex.org/W2754757901","https://openalex.org/W2023516579","https://openalex.org/W4225968295","https://openalex.org/W1988341374","https://openalex.org/W3063310417","https://openalex.org/W2562678857"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"report":[2],"the":[3,7,132,140,211,231,238,292],"2-year":[4],"outcomes":[5],"of":[6,55,150,164,172,179,244,265,298],"BOLT":[8],"study,":[9],"a":[10,41,148,161,296],"prospective":[11],"randomized":[12,44,60],"controlled":[13,45],"trial":[14],"evaluating":[15],"intravitreous":[16,266],"bevacizumab":[17,64,133,145,168,196,219,232,252,267,285],"and":[18,52,89,99,112,135,187,199,253,279],"modified":[19],"Early":[20],"Treatment":[21],"Diabetic":[22],"Retinopathy":[23],"Study":[24],"(ETDRS)":[25],"macular":[26,36,107,225,281],"laser":[27],"therapy":[28],"(MLT)":[29],"in":[30,70,82,105,131,139,210,223,230,237,277],"patients":[31,48,180],"with":[32,49,160,284,295],"persistent":[33,269],"clinically":[34],"significant":[35],"edema":[37],"(CSME).":[38],"METHODS:":[39],"In":[40],"2-year,":[42],"single-center,":[43],"trial,":[46],"80":[47],"center-involving":[50,270],"CSME":[51],"visual":[53,73],"acuity":[54,74],"20/40":[56],"to":[57,61],"20/320":[58],"were":[59,289],"receive":[62],"either":[63],"or":[65,183],"MLT.":[66,176,202,256],"PRIMARY":[67],"OUTCOME:":[68],"difference":[69],"ETDRS":[71,93,109,121,152],"best-corrected":[72],"(BCVA)":[75],"between":[76],"arms.":[77],"SECONDARY":[78],"OUTCOMES:":[79],"mean":[80,119,162,297],"change":[81,104],"BCVA,":[83],"proportion":[84],"gaining":[85],"at":[86,90,100,190,286],"least":[87,91,101,191],"15":[88,98,192,208],"10":[92,182],"letters,":[94,103],"losing":[95],"fewer":[96,206],"than":[97,207],"30":[102],"central":[106,224,280],"thickness,":[108],"retinopathy":[110],"severity,":[111],"safety":[113],"outcomes.":[114],"RESULTS:":[115],"At":[116],"2":[117],"years,":[118],"(SD)":[120],"BCVA":[122,278],"was":[123,214,227,249],"64.4":[124],"(13.3)":[125],"(ETDRS":[126],"equivalent":[127],"Snellen":[128],"fraction:":[129],"20/50)":[130],"arm":[134,142,146,213,233],"54.8":[136],"(12.6)":[137],"(20/80)":[138],"MLT":[141,158,212,239],"(P=.005).":[143],"The":[144,241],"gained":[147,181,189],"median":[149,242],"9":[151],"letters":[153,156,166,174,185,193,209],"vs":[154,169,197,216,234],"2.5":[155],"for":[157,167,175,195,201,218,251,255,268],"(P=.005),":[159],"gain":[163],"8.6":[165],"amean":[170],"loss":[171],"0.5":[173],"Forty-nine":[177],"percent":[178],"more":[184],"(P=.001)":[186],"32%":[188],"(P=.004)":[194],"7%":[198],"4%":[200],"Percentage":[203],"who":[204],"lost":[205],"86%":[215],"100%":[217],"(P=.03).":[220],"Mean":[221],"reduction":[222],"thickness":[226,282],"146":[228],"\u03bcm":[229,236],"118":[235],"arm.":[240],"number":[243],"treatments":[245],"over":[246,291],"24":[247],"months":[248],"13":[250],"4":[254,299],"CONCLUSIONS:":[257],"This":[258],"study":[259],"provides":[260],"evidence":[261],"supporting":[262],"longer-term":[263],"use":[264],"CSME.":[271],"APPLICATION":[272],"TO":[273],"CLINICAL":[274],"PRACTICE:":[275],"Improvements":[276],"seen":[283],"1":[287],"year":[288,294],"maintained":[290],"second":[293],"injections.":[300],"TRIAL":[301],"REGISTRATION:":[302],"eudract.ema.europa.eu":[303],"Identifier:":[304],"2007-000847-89":[305]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":20},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":21},{"year":2021,"cited_by_count":23},{"year":2020,"cited_by_count":25},{"year":2019,"cited_by_count":25},{"year":2018,"cited_by_count":29},{"year":2017,"cited_by_count":39},{"year":2016,"cited_by_count":49},{"year":2015,"cited_by_count":53},{"year":2014,"cited_by_count":31},{"year":2013,"cited_by_count":37},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}