{"id":"https://openalex.org/W2010594700","doi":"https://doi.org/10.1159/000163931","title":"Progression of HIV Infection Is Associated with HLA-DQ Antigens in Caucasians and African Americans","display_name":"Progression of HIV Infection Is Associated with HLA-DQ Antigens in Caucasians and African Americans","publication_year":2008,"publication_date":"2008-10-08","ids":{"openalex":"https://openalex.org/W2010594700","doi":"https://doi.org/10.1159/000163931","mag":"2010594700","pmid":"https://pubmed.ncbi.nlm.nih.gov/7546273"},"language":"en","primary_location":{"id":"doi:10.1159/000163931","doi":"https://doi.org/10.1159/000163931","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000163931","pdf_url":null,"source":{"id":"https://openalex.org/S18964055","display_name":"Pathobiology","issn_l":"1015-2008","issn":["1015-2008","1423-0291"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathobiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066390352","display_name":"M.N. Brackin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.N. Brackin","raw_affiliation_strings":["Department of Pathology, University of Mississippi Medical Center, Jackson 39216, USA","Department of Pathology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Mississippi Medical Center, Jackson 39216, USA","institution_ids":["https://openalex.org/I29606459"]},{"raw_affiliation_string":"Department of Pathology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072416990","display_name":"Robert E. Lewis","orcid":"https://orcid.org/0000-0002-3616-2971","observed_orcids":["https://orcid.org/0000-0002-3616-2971","https://orcid.org/0009-0005-0177-220X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R.E. Lewis","raw_affiliation_strings":["Department of Pathology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033409251","display_name":"Bruce T. Brackin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103499","display_name":"Mississippi State Department of Health","ror":"https://ror.org/019c4md20","country_code":"US","type":"government","lineage":["https://openalex.org/I4210103499"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B.T. Brackin","raw_affiliation_strings":["Department of Preventive Medicine, and","Mississippi State Department of Health, Jackson, Miss., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine, and","institution_ids":[]},{"raw_affiliation_string":"Mississippi State Department of Health, Jackson, Miss., USA","institution_ids":["https://openalex.org/I4210103499"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076015726","display_name":"A.P. Achord","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Achord","raw_affiliation_strings":["Department of Pathology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084338844","display_name":"Heather Henderson","orcid":"https://orcid.org/0000-0002-2197-3149","observed_orcids":["https://orcid.org/0000-0002-2197-3149"]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Henderson","raw_affiliation_strings":["Department of Medicine, University of Mississippi Medical Center and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Mississippi Medical Center and","institution_ids":["https://openalex.org/I29606459"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Crawford","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Crawford","raw_affiliation_strings":["Department of Pathology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108591334","display_name":"Julius M. Cruse","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J.M. Cruse","raw_affiliation_strings":["Department of Pathology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1044,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.41874048,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"63","issue":"1","first_page":"22","last_page":"41"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-infection","display_name":"HIV infection","score":0.7820000052452087},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.6209999918937683},{"id":"https://openalex.org/keywords/aids","display_name":"AIDS","score":0.7879999876022339},{"id":"https://openalex.org/keywords/hla-dq","display_name":"HLA-DQ","score":0.9229999780654907},{"id":"https://openalex.org/keywords/hla-dq1","display_name":"HLA-DQ1","score":0.8029999732971191},{"id":"https://openalex.org/keywords/hla-dq2","display_name":"HLA-DQ2","score":0.9729999899864197},{"id":"https://openalex.org/keywords/hla-dq3","display_name":"HLA-DQ3","score":0.996999979019165},{"id":"https://openalex.org/keywords/hla-haplotypes","display_name":"HLA haplotypes","score":0.8529999852180481},{"id":"https://openalex.org/keywords/racial-differences","display_name":"racial differences","score":0.6259999871253967},{"id":"https://openalex.org/keywords/african-americans","display_name":"African Americans","score":0.9739999771118164},{"id":"https://openalex.org/keywords/caucasians","display_name":"Caucasians","score":0.9940000176429749},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6800000071525574},{"id":"https://openalex.org/keywords/immune-response-genes","display_name":"immune response genes","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.7734013795852661},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7154272794723511},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6039915680885315},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.5789036750793457},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5214428305625916},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.42783671617507935},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.4268578886985779},{"id":"https://openalex.org/C2780648854","wikidata":"https://www.wikidata.org/wiki/Q2745824","display_name":"Immunopathology","level":2,"score":0.41406819224357605},{"id":"https://openalex.org/C2779910283","wikidata":"https://www.wikidata.org/wiki/Q5630144","display_name":"HLA-DQ","level":5,"score":0.4139532148838043},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.4122195839881897},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.3739285469055176},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34491974115371704},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23616251349449158},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0949019193649292},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001741","descriptor_name":"Black or African American","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006683","descriptor_name":"HLA-DQ Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006683","descriptor_name":"HLA-DQ Antigens","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044383","descriptor_name":"Black People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D044465","descriptor_name":"White People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1159/000163931","doi":"https://doi.org/10.1159/000163931","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000163931","pdf_url":null,"source":{"id":"https://openalex.org/S18964055","display_name":"Pathobiology","issn_l":"1015-2008","issn":["1015-2008","1423-0291"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathobiology","raw_type":"journal-article"},{"id":"pmid:7546273","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7546273","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathobiology : journal of immunopathology, molecular and cellular biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G3800089373","display_name":"BIOMEDICAL RESEARCH SUPPORT","funder_award_id":"S07RR005386","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1974205580","https://openalex.org/W1988924276","https://openalex.org/W1987345677","https://openalex.org/W2093003590","https://openalex.org/W2087374643","https://openalex.org/W2021087921","https://openalex.org/W2171789044","https://openalex.org/W74141650","https://openalex.org/W1969047821","https://openalex.org/W2037865470"],"abstract_inverted_index":{"In":[0,162],"our":[1],"previous":[2],"work":[3],"with":[4,29,44,93,154,156,171,173,185,187,203,220,224,255],"human":[5,11],"leukocyte":[6],"antigen":[7],"(HLA)":[8],"association":[9,202,223],"in":[10,54,67,147,250,270],"immunodeficiency":[12],"virus":[13],"(HIV)":[14],"infection,":[15],"African":[16],"Americans":[17],"(Afr":[18],"Ams)":[19],"and":[20,50,57,78,107,134,179,211,226,234],"Caucasians":[21],"(Caucs)":[22],"exhibited":[23],"HLA":[24],"markers":[25],"that":[26,196,245],"were":[27,42,83,110,116,209,232,253],"associated":[28,43,153,170,184,254],"protection":[30],"or":[31],"disease.":[32],"The":[33,60,237,272],"present":[34],"study":[35],"was":[36,72,152,169,183],"designed":[37],"to":[38,52,74,85,198,247],"establish":[39],"if":[40,283],"HLAs":[41],"the":[45,68,75,79,148,163,200,221,265,279],"severity":[46],"of":[47,62,104,123,160,177,191,206,229,240,267,281],"HIV":[48,207,230,268,282],"infection":[49,208,231,269],"progression":[51,205,228,249,266,280],"AIDS":[53],"Afr":[55,129,193],"Am":[56,150,194],"Cauc":[58,218],"adults.":[59,271],"frequency":[61],"serologically":[63],"determined":[64],"antigens":[65],"(Ags)":[66],"regional":[69],"control":[70,264],"population":[71,77],"compared":[73,84],"HIV-infected":[76,80],"slow":[81,227],"progressors":[82,87],"rapid":[86,204,225,248],"by":[88],"race.":[89],"chi":[90],"2":[91,126],"analysis":[92],"Bonferroni":[94],"adjustment,":[95],"Kaplan-Meier":[96],"survival":[97],"analysis,":[98],"linear":[99],"logistic":[100],"regression,":[101],"Cox":[102],"model":[103],"proportional":[105],"hazards":[106],"standardized":[108],"deltas":[109],"applied":[111],"as":[112,214,216,285],"applicable.":[113],"Immune":[114],"parameters":[115],"monitored":[117],"over":[118],"a":[119,157,166,174,180,188,286],"mean":[120],"follow-up":[121],"period":[122],"23":[124],"+/-":[125,136],"months":[127,138],"for":[128,139],"Ams":[130],"(n":[131,141],"=":[132,142],"35)":[133],"25":[135],"5":[137],"Caucs":[140],"24).":[143],"A":[144],"better":[145],"prognosis":[146,168,182],"HIV+Afr":[149],"group":[151],"HLA-DQ1":[155],"risk":[158,175,189],"ratio":[159,176,190],"0.295.":[161],"HIV+Cauc":[164],"group,":[165],"preferable":[167],"HLA-DQ3":[172],"0.11,":[178],"poor":[181],"HLA-DQ2":[186],"7.":[192],"haplotypes":[195,213,219],"appeared":[197],"have":[199],"greatest":[201],"A69(28)-B40":[210],"related":[212],"well":[215],"B12-DR14(6).":[217],"strongest":[222],"A28-B17-DR9":[233],"A30(19)-B67,":[235],"respectively.":[236],"DR":[238],"Ags":[239],"at":[241],"least":[242],"one":[243],"haplotype":[244],"led":[246],"both":[251],"races":[252],"DQ9(3).":[256],"An":[257],"'immune":[258],"response'":[259],"gene":[260],"(DQ":[261],"region)":[262],"may":[263],"rapidly":[273],"progressive":[274],"DQ-associated":[275],"peptide":[276],"might":[277],"block":[278],"given":[284],"novel":[287],"vaccine.":[288]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
