{"id":"https://openalex.org/W2010594349","doi":"https://doi.org/10.1111/j.1365-2125.1980.tb01065.x","title":"Pharmacokinetics of atenolol in patients with terminal renal failure and influence of haemodialysis.","display_name":"Pharmacokinetics of atenolol in patients with terminal renal failure and influence of haemodialysis.","publication_year":1980,"publication_date":"1980-04-01","ids":{"openalex":"https://openalex.org/W2010594349","doi":"https://doi.org/10.1111/j.1365-2125.1980.tb01065.x","mag":"2010594349","pmid":"https://pubmed.ncbi.nlm.nih.gov/7378254","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1429992"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2125.1980.tb01065.x","doi":"https://doi.org/10.1111/j.1365-2125.1980.tb01065.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2125.1980.tb01065.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.1980.tb01065.x","source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.1980.tb01065.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000041326","display_name":"B Flouvat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133069","display_name":"H\u00f4pital Ambroise-Par\u00e9","ror":"https://ror.org/03j6rvb05","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210133069"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"B Flouvat","raw_affiliation_strings":["Departement de Pharmacologie Clinique, Laboratoire de Toxicologie, H6pital Ambroise Pare, 9 avenue Charles de Gaulle, 92100 Boulogne, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departement de Pharmacologie Clinique, Laboratoire de Toxicologie, H6pital Ambroise Pare, 9 avenue Charles de Gaulle, 92100 Boulogne, France","institution_ids":["https://openalex.org/I4210133069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006374403","display_name":"S Decourt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133069","display_name":"H\u00f4pital Ambroise-Par\u00e9","ror":"https://ror.org/03j6rvb05","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210133069"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"S Decourt","raw_affiliation_strings":["Departement de Pharmacologie Clinique, Laboratoire de Toxicologie, H6pital Ambroise Pare, 9 avenue Charles de Gaulle, 92100 Boulogne, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departement de Pharmacologie Clinique, Laboratoire de Toxicologie, H6pital Ambroise Pare, 9 avenue Charles de Gaulle, 92100 Boulogne, France","institution_ids":["https://openalex.org/I4210133069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110034893","display_name":"Ph. Aubert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156825","display_name":"H\u00f4pital Foch","ror":"https://ror.org/058td2q88","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210156825"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"P Aubert","raw_affiliation_strings":["Departement de MWdecine et Nephrologie Hopital Foch, Suresnes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departement de MWdecine et Nephrologie Hopital Foch, Suresnes, France","institution_ids":["https://openalex.org/I4210156825"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004312082","display_name":"Luc Potaux","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112727","display_name":"H\u00f4pital Pellegrin","ror":"https://ror.org/02x581406","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443","https://openalex.org/I4210112727"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"L Potaux","raw_affiliation_strings":["Clinique Nephrologique Hopital Pellegrin, Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinique Nephrologique Hopital Pellegrin, Bordeaux, France","institution_ids":["https://openalex.org/I4210112727"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M Domart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133069","display_name":"H\u00f4pital Ambroise-Par\u00e9","ror":"https://ror.org/03j6rvb05","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210133069"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M Domart","raw_affiliation_strings":["Departement de Medecine et Nephrologie H6pital Ambroise Pare, Boulogne, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departement de Medecine et Nephrologie H6pital Ambroise Pare, Boulogne, France","institution_ids":["https://openalex.org/I4210133069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111787169","display_name":"A Goupil","orcid":"https://orcid.org/0009-0006-0180-3624","observed_orcids":["https://orcid.org/0009-0006-0180-3624"]},"institutions":[{"id":"https://openalex.org/I4210133069","display_name":"H\u00f4pital Ambroise-Par\u00e9","ror":"https://ror.org/03j6rvb05","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210133069"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"A Goupil","raw_affiliation_strings":["Departement de Medecine et Nephrologie H6pital Ambroise Pare, Boulogne, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departement de Medecine et Nephrologie H6pital Ambroise Pare, Boulogne, France","institution_ids":["https://openalex.org/I4210133069"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019384307","display_name":"Alain Baglin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133069","display_name":"H\u00f4pital Ambroise-Par\u00e9","ror":"https://ror.org/03j6rvb05","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210133069"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"A Baglin","raw_affiliation_strings":["Departement de Medecine et Nephrologie H6pital Ambroise Pare, Boulogne, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departement de Medecine et Nephrologie H6pital Ambroise Pare, Boulogne, France","institution_ids":["https://openalex.org/I4210133069"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":3.1877,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.9055381,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"9","issue":"4","first_page":"379","last_page":"385"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.8485999703407288,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.8485999703407288,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.04800000041723251,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.019600000232458115,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atenolol","display_name":"atenolol","score":1.0},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9700000286102295},{"id":"https://openalex.org/keywords/terminal-renal-failure","display_name":"terminal renal failure","score":0.8550000190734863},{"id":"https://openalex.org/keywords/hemodialysis","display_name":"hemodialysis","score":0.9309999942779541},{"id":"https://openalex.org/keywords/plasma-half-life","display_name":"plasma half-life","score":0.8370000123977661},{"id":"https://openalex.org/keywords/renal-clearance","display_name":"renal clearance","score":0.9539999961853027},{"id":"https://openalex.org/keywords/beta-blockers","display_name":"beta-blockers","score":0.6299999952316284},{"id":"https://openalex.org/keywords/dose-adjustment","display_name":"dose adjustment","score":0.6340000033378601},{"id":"https://openalex.org/keywords/creatinine-clearance","display_name":"creatinine clearance","score":0.777999997138977}],"concepts":[{"id":"https://openalex.org/C2776525901","wikidata":"https://www.wikidata.org/wiki/Q411325","display_name":"Atenolol","level":3,"score":0.9478282928466797},{"id":"https://openalex.org/C2779978075","wikidata":"https://www.wikidata.org/wiki/Q202301","display_name":"Dialysis","level":2,"score":0.7994184494018555},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7151623964309692},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6455854773521423},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.6131654977798462},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.563467800617218},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.4860261082649231},{"id":"https://openalex.org/C2778063415","wikidata":"https://www.wikidata.org/wiki/Q391744","display_name":"Hemodialysis","level":2,"score":0.4171947240829468},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3134019374847412},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.09940436482429504}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001262","descriptor_name":"Atenolol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001262","descriptor_name":"Atenolol","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006435","descriptor_name":"Renal Dialysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011412","descriptor_name":"Propanolamines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1365-2125.1980.tb01065.x","doi":"https://doi.org/10.1111/j.1365-2125.1980.tb01065.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2125.1980.tb01065.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.1980.tb01065.x","source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1429992","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1429992","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Clin Pharmacol","raw_type":"Text"},{"id":"pmid:7378254","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7378254","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of clinical pharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1365-2125.1980.tb01065.x","doi":"https://doi.org/10.1111/j.1365-2125.1980.tb01065.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2125.1980.tb01065.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.1980.tb01065.x","source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2010594349.pdf","grobid_xml":"https://content.openalex.org/works/W2010594349.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W80340148","https://openalex.org/W913829766","https://openalex.org/W1971760127","https://openalex.org/W1986211909","https://openalex.org/W1996218048","https://openalex.org/W2002274389","https://openalex.org/W2049110939","https://openalex.org/W2050944793","https://openalex.org/W2053312766","https://openalex.org/W2061296115","https://openalex.org/W2064148898","https://openalex.org/W2072315345","https://openalex.org/W2076085396","https://openalex.org/W2144818437","https://openalex.org/W2163564233","https://openalex.org/W2309241413","https://openalex.org/W2345446471","https://openalex.org/W2412232524","https://openalex.org/W2418113431","https://openalex.org/W2421304734","https://openalex.org/W4300062113"],"related_works":["https://openalex.org/W2086821723","https://openalex.org/W2055816301","https://openalex.org/W2398502684","https://openalex.org/W2035863117","https://openalex.org/W1985259840","https://openalex.org/W2061296115","https://openalex.org/W2053055431","https://openalex.org/W2412137408","https://openalex.org/W2031232550","https://openalex.org/W2160296964"],"abstract_inverted_index":{"1":[0],"The":[1,34,84],"pharmacokinetics":[2],"of":[3,24,57,99,104,128],"atenolol,":[4],"after":[5,82,96],"200":[6],"mg":[7],"orally,":[8],"were":[9,27],"studied":[10],"in":[11,44],"18":[12],"patients":[13],"with":[14],"terminal":[15],"renal":[16],"insufficiency":[17],"(creatinine":[18],"clearance":[19,103,115],"less":[20],"than":[21],"5":[22,113],"ml/min),":[23],"whom":[25],"twelve":[26],"being":[28],"treated":[29],"by":[30],"chronic":[31],"dialysis.":[32,83,100],"2":[33],"peak":[35],"plasma":[36,55,85],"level,":[37],"1.59":[38],"+/-":[39,46,63,72,79,110,120,130],"0.43":[40],"mg/l,":[41],"was":[42,59,88,106,118],"reached":[43],"4.7":[45],"2.1":[47],"h.":[48],"3":[49],"Without":[50],"dialysis":[51,117],"treatment,":[52],"the":[53,97],"apparent":[54],"half-life":[56],"atenolol":[58,86,105],"greatly":[60],"increased":[61],"(73.4":[62],"28.8":[64],"/).":[65],"During":[66],"dialysis,":[67],"it":[68],"dropped":[69],"to":[70,77],"7.5":[71],"3.7":[73],"h":[74,81],"but":[75],"returned":[76],"51.2":[78],"17.3":[80],"plot":[87],"a":[89,93,124,134],"rising":[90],"slope":[91],"for":[92,123,147],"few":[94],"hours":[95],"end":[98],"4":[101],"Renal":[102],"very":[107],"low":[108],"(4.6":[109],"1.5":[111],"ml/min).":[112],"Plasma":[114],"during":[116],"42.6":[119],"21.3":[121],"ml/min":[122,132],"mean":[125],"blood":[126],"flow-rate":[127],"236":[129],"25":[131],"through":[133],"cuprophane":[135],"membrane":[136],"dialyser.":[137],"6":[138],"These":[139],"results":[140],"suggest":[141],"that":[142],"dosage":[143],"should":[144],"be":[145],"modified":[146],"these":[148],"patients.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
