{"id":"https://openalex.org/W2010589079","doi":"https://doi.org/10.1007/bf01656262","title":"Experimental results and future prospects for a nonpulsatile cardiac prosthesis","display_name":"Experimental results and future prospects for a nonpulsatile cardiac prosthesis","publication_year":1985,"publication_date":"1985-02-01","ids":{"openalex":"https://openalex.org/W2010589079","doi":"https://doi.org/10.1007/bf01656262","mag":"2010589079","pmid":"https://pubmed.ncbi.nlm.nih.gov/3984363"},"language":"en","primary_location":{"id":"doi:10.1007/bf01656262","doi":"https://doi.org/10.1007/bf01656262","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf01656262","pdf_url":null,"source":{"id":"https://openalex.org/S60318618","display_name":"World Journal of Surgery","issn_l":"0364-2313","issn":["0364-2313","1432-2323"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Surgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112142180","display_name":"Ryohei Yozu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryohei Yozu","raw_affiliation_strings":["Departments of Artificial Organs and Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Artificial Organs and Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio, USA","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108221552","display_name":"Leonard A.R. Golding","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leonard A. R. Golding","raw_affiliation_strings":["Departments of Artificial Organs and Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Artificial Organs and Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio, USA","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108240909","display_name":"Gordon B. Jacobs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gordon Jacobs","raw_affiliation_strings":["Departments of Artificial Organs and Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Artificial Organs and Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio, USA","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108411809","display_name":"Hiroaki Harasaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hiroaki Harasaki","raw_affiliation_strings":["Departments of Artificial Organs and Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Artificial Organs and Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio, USA","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102102002","display_name":"Yukihiko Nos\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yukihiko Nose","raw_affiliation_strings":["Departments of Artificial Organs and Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Artificial Organs and Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio, USA","institution_ids":["https://openalex.org/I1316902750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1316902750"],"apc_list":{"value":4000,"currency":"USD","value_usd":4000},"apc_paid":null,"fwci":1.6301,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.81299496,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"9","issue":"1","first_page":"116","last_page":"127"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10675","display_name":"Mechanical Circulatory Support Devices","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10675","display_name":"Mechanical Circulatory Support Devices","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiac-prosthesis","display_name":"cardiac prosthesis","score":0.8109999895095825},{"id":"https://openalex.org/keywords/total-artificial-heart","display_name":"total artificial heart","score":0.6919999718666077},{"id":"https://openalex.org/keywords/systemic-vascular-resistance","display_name":"systemic vascular resistance","score":0.8050000071525574},{"id":"https://openalex.org/keywords/catecholamines","display_name":"catecholamines","score":0.9850000143051147},{"id":"https://openalex.org/keywords/physiological-adaptation","display_name":"physiological adaptation","score":0.5559999942779541},{"id":"https://openalex.org/keywords/calf-model","display_name":"calf model","score":0.6660000085830688},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.7269999980926514},{"id":"https://openalex.org/keywords/endocrine-function","display_name":"endocrine function","score":0.8880000114440918}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6435152292251587},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.6401625871658325},{"id":"https://openalex.org/C79191276","wikidata":"https://www.wikidata.org/wiki/Q7259620","display_name":"Pulsatile flow","level":2,"score":0.5913686156272888},{"id":"https://openalex.org/C72859922","wikidata":"https://www.wikidata.org/wiki/Q11068","display_name":"Circulatory system","level":2,"score":0.5464920997619629},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.5318859219551086},{"id":"https://openalex.org/C58245268","wikidata":"https://www.wikidata.org/wiki/Q456026","display_name":"Vascular resistance","level":3,"score":0.5147290229797363},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.4782411456108093},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4654662609100342},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.45726853609085083},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.440862774848938},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.34559470415115356},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.12716761231422424},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001775","descriptor_name":"Blood Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001810","descriptor_name":"Blood Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004702","descriptor_name":"Endocrine Glands","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005080","descriptor_name":"Exercise Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006354","descriptor_name":"Heart, Artificial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011674","descriptor_name":"Pulse","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014655","descriptor_name":"Vascular Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf01656262","doi":"https://doi.org/10.1007/bf01656262","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf01656262","pdf_url":null,"source":{"id":"https://openalex.org/S60318618","display_name":"World Journal of Surgery","issn_l":"0364-2313","issn":["0364-2313","1432-2323"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Surgery","raw_type":"journal-article"},{"id":"pmid:3984363","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3984363","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World journal of surgery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1239831265","display_name":null,"funder_award_id":"HL 26267","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1591831722","display_name":null,"funder_award_id":"HL 26267","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2656578426","display_name":null,"funder_award_id":"HL 24286","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3681329923","display_name":null,"funder_award_id":"HL 24286","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1129970868","https://openalex.org/W1970437805","https://openalex.org/W1978283202","https://openalex.org/W1989355182","https://openalex.org/W1991326410","https://openalex.org/W2006125850","https://openalex.org/W2009342047","https://openalex.org/W2012544168","https://openalex.org/W2014234572","https://openalex.org/W2068734467","https://openalex.org/W2073191736","https://openalex.org/W2077714560","https://openalex.org/W2079600153","https://openalex.org/W2092712284","https://openalex.org/W2092945112","https://openalex.org/W2124904457","https://openalex.org/W2165543134","https://openalex.org/W2167137921","https://openalex.org/W2259070528","https://openalex.org/W2345616659","https://openalex.org/W2396749944","https://openalex.org/W2400313354","https://openalex.org/W2400328093","https://openalex.org/W2401466189","https://openalex.org/W2404556833","https://openalex.org/W2405790580","https://openalex.org/W2408295188","https://openalex.org/W2408600688","https://openalex.org/W2409037129","https://openalex.org/W2410305481","https://openalex.org/W2410780138","https://openalex.org/W2410825642","https://openalex.org/W2411313107","https://openalex.org/W2412202506","https://openalex.org/W2412389655","https://openalex.org/W2413057784","https://openalex.org/W2416337303","https://openalex.org/W2417450728","https://openalex.org/W2418141306","https://openalex.org/W2419278577","https://openalex.org/W2463873294","https://openalex.org/W2470354010","https://openalex.org/W2581605534","https://openalex.org/W3141828228"],"related_works":["https://openalex.org/W2408600688","https://openalex.org/W2076278384","https://openalex.org/W2009342047","https://openalex.org/W6940742367","https://openalex.org/W2473885810","https://openalex.org/W2036031051","https://openalex.org/W2060739365","https://openalex.org/W53821682","https://openalex.org/W2009151901","https://openalex.org/W2064172805"],"abstract_inverted_index":{"Abstract":[0],"Replacing":[1],"the":[2,126],"heart":[3],"function":[4],"by":[5,111],"means":[6],"of":[7,33,47,137],"a":[8,13,153],"nonpulsatile":[9,37,52,71,86,148],"blood":[10,21,38,72,149],"pump":[11],"is":[12,96,109,151],"great":[14],"challenge":[15],"to":[16,35,80,104,120,156],"nature,":[17],"which":[18,100,118],"evolved":[19],"pulsatile":[20],"circulation.":[22],"Some":[23],"years":[24],"ago,":[25],"we":[26],"hypothesized":[27],"that":[28,91,147],"mammalian":[29,158],"physiology":[30,77],"was":[31],"capable":[32],"adapting":[34],"chronic":[36],"flow":[39,53,150],"and":[40,141],"maintaining":[41],"normal":[42,76,135],"organ":[43],"function.":[44,143],"The":[45],"methodology":[46],"complete":[48],"circulatory":[49],"replacement":[50],"with":[51,70,74,122],"has":[54],"been":[55],"established":[56],"in":[57,61,125],"awake":[58],"calf":[59],"experiments":[60],"our":[62],"institution.":[63],"To":[64],"date,":[65],"5":[66],"animals":[67,88,133],"have":[68,89],"lived":[69],"perfusion":[73],"near":[75],"for":[78],"up":[79],"3":[81],"months.":[82],"Our":[83,144],"studies":[84],"on":[85],"biventricular":[87],"shown":[90],"immediately":[92],"following":[93],"surgery":[94],"there":[95],"an":[97,123],"adaptation":[98],"phase":[99,108],"lasts":[101],"approximately":[102],"7":[103],"10":[105],"days.":[106],"This":[107],"characterized":[110],"increased":[112],"total":[113],"systemic":[114],"vascular":[115],"resistance":[116],"(SVR),":[117],"appears":[119],"correlate":[121],"increase":[124],"circulating":[127],"catecholamines.":[128],"After":[129],"this":[130],"phase,":[131],"these":[132],"showed":[134],"values":[136],"SVR,":[138],"renal,":[139],"biochemical,":[140],"endocrine":[142],"data":[145],"show":[146],"not":[152],"limiting":[154],"factor":[155],"maintain":[157],"life.":[159]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
