{"id":"https://openalex.org/W2010585094","doi":"https://doi.org/10.1164/rccm.200707-1022oc","title":"Poly(ester amine)-mediated, Aerosol-delivered Akt1 Small Interfering RNA Suppresses Lung Tumorigenesis","display_name":"Poly(ester amine)-mediated, Aerosol-delivered Akt1 Small Interfering RNA Suppresses Lung Tumorigenesis","publication_year":2008,"publication_date":"2008-06-18","ids":{"openalex":"https://openalex.org/W2010585094","doi":"https://doi.org/10.1164/rccm.200707-1022oc","mag":"2010585094","pmid":"https://pubmed.ncbi.nlm.nih.gov/18310482"},"language":"en","primary_location":{"id":"doi:10.1164/rccm.200707-1022oc","doi":"https://doi.org/10.1164/rccm.200707-1022oc","is_oa":false,"landing_page_url":"https://doi.org/10.1164/rccm.200707-1022oc","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory and Critical Care Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2441927","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009714134","display_name":"Cheng\u2010Xiong Xu","orcid":"https://orcid.org/0000-0001-5714-8207","observed_orcids":["https://orcid.org/0000-0001-5714-8207"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Cheng-Xiong Xu","raw_affiliation_strings":["Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University, Seoul, Korea","Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046269448","display_name":"Dhananjay Jere","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dhananjay Jere","raw_affiliation_strings":["Department of Agricultural Biotechnology, Seoul National University, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Agricultural Biotechnology, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101997994","display_name":"Hua Jin","orcid":"https://orcid.org/0000-0002-1988-8009","observed_orcids":["https://orcid.org/0000-0002-1988-8009"]},"institutions":[{"id":"https://openalex.org/I1295499534","display_name":"Seattle Children's Hospital","ror":"https://ror.org/01njes783","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534"]},{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hua Jin","raw_affiliation_strings":["Center for Developmental Pharmacology and Toxicology, Seattle Children\u2019s Hospital Research Institute, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Developmental Pharmacology and Toxicology, Seattle Children\u2019s Hospital Research Institute, Seattle, Washington","institution_ids":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112106987","display_name":"Seung-Hee Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seung-Hee Chang","raw_affiliation_strings":["Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University, Seoul, Korea","Nano Systems Institute\u2013National Core Research Center, Seoul National University, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Nano Systems Institute\u2013National Core Research Center, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110192557","display_name":"Youn-Sun Chung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Youn-Sun Chung","raw_affiliation_strings":["Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063588416","display_name":"Jiyoung Shin","orcid":"https://orcid.org/0000-0002-8099-2120","observed_orcids":["https://orcid.org/0000-0002-8099-2120","https://orcid.org/0009-0008-8106-5127"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ji-Young Shin","raw_affiliation_strings":["Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100412989","display_name":"Ji\u2010Eun Kim","orcid":"https://orcid.org/0000-0002-3643-2177","observed_orcids":["https://orcid.org/0000-0002-3643-2177"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ji-Eun Kim","raw_affiliation_strings":["Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University, Seoul, Korea","Nano Systems Institute\u2013National Core Research Center, Seoul National University, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Nano Systems Institute\u2013National Core Research Center, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100323608","display_name":"Sung Jin Park","orcid":"https://orcid.org/0000-0001-5801-5537","observed_orcids":["https://orcid.org/0000-0001-5801-5537","https://orcid.org/0000-0003-4754-5799"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sung-Jin Park","raw_affiliation_strings":["Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yong-Hoon Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yong-Hoon Lee","raw_affiliation_strings":["Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086969920","display_name":"Chanhee Chae","orcid":"https://orcid.org/0000-0002-0190-1957","observed_orcids":["https://orcid.org/0000-0002-0190-1957"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Chan-Hee Chae","raw_affiliation_strings":["Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110620382","display_name":"Kee Ho Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088603","display_name":"Korea Institute of Radiological and Medical Sciences","ror":"https://ror.org/00a8tg325","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210088603"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kee Ho Lee","raw_affiliation_strings":["Laboratory of Molecular Oncology, Korea Institute of Radiological and Medical Sciences, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Oncology, Korea Institute of Radiological and Medical Sciences, Seoul, Korea","institution_ids":["https://openalex.org/I4210088603"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056247686","display_name":"George R. Beck","orcid":"https://orcid.org/0000-0002-7623-4095","observed_orcids":["https://orcid.org/0000-0002-7623-4095"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George R. Beck","raw_affiliation_strings":["Division of Endocrinology, Metabolism, and Lipids, Emory University School of Medicine, Atlanta, Georgia; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Metabolism, and Lipids, Emory University School of Medicine, Atlanta, Georgia; and","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006720579","display_name":"Chong\u2010Su Cho","orcid":"https://orcid.org/0000-0003-4671-700X","observed_orcids":["https://orcid.org/0000-0003-4671-700X"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Chong-Su Cho","raw_affiliation_strings":["Department of Agricultural Biotechnology, Seoul National University, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Agricultural Biotechnology, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075453290","display_name":"Myung\u2010Haing Cho","orcid":"https://orcid.org/0000-0002-3993-2011","observed_orcids":["https://orcid.org/0000-0002-3993-2011"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Myung-Haing Cho","raw_affiliation_strings":["Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University, Seoul, Korea","Nano Systems Institute\u2013National Core Research Center, Seoul National University, Seoul, Korea","National Institute of Toxicological Research, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Nano Systems Institute\u2013National Core Research Center, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"National Institute of Toxicological Research, Seoul, Korea","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5006720579","https://openalex.org/A5075453290"],"corresponding_institution_ids":["https://openalex.org/I139264467"],"apc_list":null,"apc_paid":null,"fwci":2.3574,"has_fulltext":false,"cited_by_count":102,"citation_normalized_percentile":{"value":0.88318508,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"178","issue":"1","first_page":"60","last_page":"73"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/akt1","display_name":"AKT1","score":0.8019999861717224},{"id":"https://openalex.org/keywords/sirna","display_name":"siRNA","score":0.9789999723434448},{"id":"https://openalex.org/keywords/aerosol-gene-delivery","display_name":"aerosol gene delivery","score":0.9520000219345093},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.875},{"id":"https://openalex.org/keywords/lung-carcinogenesis","display_name":"lung carcinogenesis","score":0.8190000057220459},{"id":"https://openalex.org/keywords/urethane-induced-lung-cancer","display_name":"urethane-induced lung cancer","score":0.9470000267028809},{"id":"https://openalex.org/keywords/nose-only-inhalation","display_name":"nose-only inhalation","score":0.890999972820282},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.6700000166893005},{"id":"https://openalex.org/keywords/cell-cycle-inhibition","display_name":"cell cycle inhibition","score":0.7009999752044678},{"id":"https://openalex.org/keywords/noninvasive-cancer-therapy","display_name":"noninvasive cancer therapy","score":0.6359999775886536}],"concepts":[{"id":"https://openalex.org/C154137905","wikidata":"https://www.wikidata.org/wiki/Q17816452","display_name":"AKT1","level":4,"score":0.7484172582626343},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.708261251449585},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.687605619430542},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6236647367477417},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5460588335990906},{"id":"https://openalex.org/C131779359","wikidata":"https://www.wikidata.org/wiki/Q471875","display_name":"Amine gas treating","level":2,"score":0.5441440939903259},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5148707628250122},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48687687516212463},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.43008002638816833},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.41561949253082275},{"id":"https://openalex.org/C2778807442","wikidata":"https://www.wikidata.org/wiki/Q6152005","display_name":"Treatment of lung cancer","level":3,"score":0.41371309757232666},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.39513325691223145},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.3116034269332886},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2563459277153015},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23876091837882996},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.190190851688385},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1684325635433197},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.13178172707557678},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13058015704154968},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.091570645570755}],"mesh":[{"descriptor_ui":"D000280","descriptor_name":"Administration, Inhalation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000280","descriptor_name":"Administration, Inhalation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000280","descriptor_name":"Administration, Inhalation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000336","descriptor_name":"Aerosols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000336","descriptor_name":"Aerosols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000336","descriptor_name":"Aerosols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011073","descriptor_name":"Polyamines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011073","descriptor_name":"Polyamines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011073","descriptor_name":"Polyamines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011091","descriptor_name":"Polyesters","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011091","descriptor_name":"Polyesters","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011091","descriptor_name":"Polyesters","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011905","descriptor_name":"Genes, ras","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011905","descriptor_name":"Genes, ras","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011905","descriptor_name":"Genes, ras","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014520","descriptor_name":"Urethane","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014520","descriptor_name":"Urethane","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014520","descriptor_name":"Urethane","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053761","descriptor_name":"Nanocomposites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053761","descriptor_name":"Nanocomposites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053761","descriptor_name":"Nanocomposites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1164/rccm.200707-1022oc","doi":"https://doi.org/10.1164/rccm.200707-1022oc","is_oa":false,"landing_page_url":"https://doi.org/10.1164/rccm.200707-1022oc","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory and Critical Care Medicine","raw_type":"journal-article"},{"id":"pmid:18310482","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18310482","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of respiratory and critical care medicine","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:1478972","doi":null,"is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2441927","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2441927","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2441927","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Am J Respir Crit Care Med","raw_type":"Text"},{"id":"pmh:oai:s-space.snu.ac.kr:10371/8283","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10371/8283","pdf_url":null,"source":{"id":"https://openalex.org/S4306401345","display_name":"Seoul National University Open Repository (Seoul National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139264467","host_organization_name":"Seoul National University","host_organization_lineage":["https://openalex.org/I139264467"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2441927","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2441927","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Am J Respir Crit Care Med","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8399999737739563}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W101590649","https://openalex.org/W1487052925","https://openalex.org/W1492868262","https://openalex.org/W1509610657","https://openalex.org/W1611210979","https://openalex.org/W1611419331","https://openalex.org/W1637251086","https://openalex.org/W1908445283","https://openalex.org/W1967358886","https://openalex.org/W1968220328","https://openalex.org/W1970115847","https://openalex.org/W1970753299","https://openalex.org/W1973458116","https://openalex.org/W1990369593","https://openalex.org/W1991394829","https://openalex.org/W1992897439","https://openalex.org/W2002744434","https://openalex.org/W2006999981","https://openalex.org/W2009508594","https://openalex.org/W2010655741","https://openalex.org/W2016742083","https://openalex.org/W2018729653","https://openalex.org/W2020850118","https://openalex.org/W2020869337","https://openalex.org/W2021887610","https://openalex.org/W2023898364","https://openalex.org/W2024719999","https://openalex.org/W2025391287","https://openalex.org/W2029370718","https://openalex.org/W2032830735","https://openalex.org/W2035490871","https://openalex.org/W2036864710","https://openalex.org/W2041874034","https://openalex.org/W2044112473","https://openalex.org/W2048572493","https://openalex.org/W2048649566","https://openalex.org/W2054918406","https://openalex.org/W2056079856","https://openalex.org/W2076635847","https://openalex.org/W2079537922","https://openalex.org/W2080204564","https://openalex.org/W2081905503","https://openalex.org/W2088532124","https://openalex.org/W2088650511","https://openalex.org/W2088849426","https://openalex.org/W2090834124","https://openalex.org/W2097702370","https://openalex.org/W2099717039","https://openalex.org/W2100470338","https://openalex.org/W2107376648","https://openalex.org/W2112911113","https://openalex.org/W2125649123","https://openalex.org/W2126022920","https://openalex.org/W2134679799","https://openalex.org/W2141729181","https://openalex.org/W2142007209","https://openalex.org/W2142325703","https://openalex.org/W2147648567","https://openalex.org/W2151053438","https://openalex.org/W2153074282","https://openalex.org/W2157497892","https://openalex.org/W2158753973","https://openalex.org/W2166915947","https://openalex.org/W2169927110","https://openalex.org/W2388163742","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2502977070","https://openalex.org/W2417129447","https://openalex.org/W2392872728","https://openalex.org/W2559572678","https://openalex.org/W2153033713","https://openalex.org/W2376497504","https://openalex.org/W2046048266","https://openalex.org/W2056207151","https://openalex.org/W4387711705","https://openalex.org/W2947598636"],"abstract_inverted_index":{"RATIONALE:":[0],"The":[1,109,127,144],"low":[2],"efficiency":[3],"of":[4,11,20,34,43,55,59,90,111,146,157],"conventional":[5],"therapies":[6],"in":[7,26],"achieving":[8],"long-term":[9],"survival":[10],"patients":[12],"with":[13],"lung":[14,44,72,101,115,132,166],"cancer":[15,73,102,116,167],"calls":[16],"for":[17,37,71,165],"the":[18,32,38,49,53],"development":[19],"novel":[21],"therapeutic":[22],"options.":[23],"Recent":[24],"advances":[25],"aerosol-mediated":[27],"gene":[28,86],"delivery":[29,58,156],"have":[30],"provided":[31],"possibility":[33],"an":[35,66,151],"alternative":[36],"safe":[39],"and":[40,51,68,82,99,118,140,154,169],"effective":[41,67,152],"treatment":[42,168],"cancer.":[45],"OBJECTIVES:":[46],"To":[47],"demonstrate":[48],"feasibility":[50],"emphasize":[52],"importance":[54],"noninvasive":[56],"aerosol":[57,89,155],"Akt1":[60,112,129,158],"small":[61],"interfering":[62],"RNA":[63],"(siRNA)":[64],"as":[65,84,150],"selective":[69],"option":[70],"treatment.":[74],"METHODS:":[75],"Nanosized":[76],"poly(ester":[77,91,147],"amine)":[78,148],"polymer":[79],"was":[80,95],"synthesized":[81],"used":[83],"a":[85,105,162],"carrier.":[87],"An":[88],"amine)/Akt1":[92],"siRNA":[93,113,130,159],"complex":[94],"delivered":[96],"into":[97],"K-ras(LA1)":[98],"urethane-induced":[100],"models":[103],"through":[104,136],"nose-only":[106],"inhalation":[107],"system.":[108],"effects":[110],"on":[114],"progression":[117,134],"Akt-related":[119,138],"signals":[120,139],"were":[121],"evaluated.":[122],"MEASUREMENTS":[123],"AND":[124],"MAIN":[125],"RESULTS:":[126],"aerosol-delivered":[128],"suppressed":[131],"tumor":[133],"significantly":[135],"inhibiting":[137],"cell":[141],"cycle.":[142],"CONCLUSIONS:":[143],"use":[145],"serves":[149],"carrier,":[153],"may":[160],"be":[161],"promising":[163],"approach":[164],"prevention.":[170]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":11}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}