{"id":"https://openalex.org/W2010582345","doi":"https://doi.org/10.1158/1538-7445.am2012-1692","title":"Abstract 1692: Expression of argininosuccinate synthetase protein and correlation with response to the novel therapeutic pegylated arginine deiminase (ADI-PEG20) in osteosarcoma","display_name":"Abstract 1692: Expression of argininosuccinate synthetase protein and correlation with response to the novel therapeutic pegylated arginine deiminase (ADI-PEG20) in osteosarcoma","publication_year":2012,"publication_date":"2012-04-01","ids":{"openalex":"https://openalex.org/W2010582345","doi":"https://doi.org/10.1158/1538-7445.am2012-1692","mag":"2010582345"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2012-1692","doi":"https://doi.org/10.1158/1538-7445.am2012-1692","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2012-1692","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064538521","display_name":"Rebecca S. Sowers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135976","display_name":"Children's Hospital at Montefiore","ror":"https://ror.org/03n0fp725","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210135976"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca Sowers","raw_affiliation_strings":["1The Children's Hospital at Montefiore, Bronx, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Children's Hospital at Montefiore, Bronx, NY","institution_ids":["https://openalex.org/I4210135976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007808102","display_name":"John S. Bomalaski","orcid":"https://orcid.org/0000-0002-9454-7271","observed_orcids":["https://orcid.org/0000-0002-9454-7271"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Bomalaski","raw_affiliation_strings":["2Polaris Group, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Polaris Group, San Diego, CA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032743242","display_name":"Richard Greg Gorlick","orcid":"https://orcid.org/0000-0001-8995-2929","observed_orcids":["https://orcid.org/0000-0001-8995-2929"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I4210135976","display_name":"Children's Hospital at Montefiore","ror":"https://ror.org/03n0fp725","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210135976"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Gorlick","raw_affiliation_strings":["3The Children's Hospital at Montefiore, Albert Einstein College of Medicine, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3The Children's Hospital at Montefiore, Albert Einstein College of Medicine, NY","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I4210135976"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"72","issue":"8_Supplement","first_page":"1692","last_page":"1692"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12996","display_name":"Cancer Research and Treatments","score":0.7554000020027161,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12996","display_name":"Cancer Research and Treatments","score":0.7554000020027161,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.11420000344514847,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.09989999979734421,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.8370000123977661},{"id":"https://openalex.org/keywords/argininosuccinate-synthetase","display_name":"argininosuccinate synthetase","score":0.9629999995231628},{"id":"https://openalex.org/keywords/pegylated-arginine-deiminase","display_name":"pegylated arginine deiminase","score":0.9549999833106995},{"id":"https://openalex.org/keywords/adi-peg20","display_name":"ADI-PEG20","score":0.9990000128746033},{"id":"https://openalex.org/keywords/arginine-deprivation","display_name":"arginine deprivation","score":0.8379999995231628},{"id":"https://openalex.org/keywords/arginine-metabolism","display_name":"arginine metabolism","score":0.7799999713897705},{"id":"https://openalex.org/keywords/targeted-cancer-therapy","display_name":"targeted cancer therapy","score":0.6880000233650208},{"id":"https://openalex.org/keywords/tumor-response-biomarkers","display_name":"tumor response biomarkers","score":0.4860000014305115},{"id":"https://openalex.org/keywords/osteosarcoma-cell-lines","display_name":"osteosarcoma cell lines","score":0.8199999928474426},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.675000011920929},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.6890000104904175},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.746999979019165}],"concepts":[{"id":"https://openalex.org/C2777186326","wikidata":"https://www.wikidata.org/wiki/Q24722788","display_name":"Arginine deiminase","level":4,"score":0.9328356981277466},{"id":"https://openalex.org/C188610204","wikidata":"https://www.wikidata.org/wiki/Q24741403","display_name":"Argininosuccinate synthase","level":5,"score":0.8055940866470337},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.6457517147064209},{"id":"https://openalex.org/C2777760704","wikidata":"https://www.wikidata.org/wiki/Q549534","display_name":"Osteosarcoma","level":2,"score":0.6066234111785889},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5897865295410156},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5504669547080994},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.47578179836273193},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3955744206905365},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3707036077976227},{"id":"https://openalex.org/C2779129087","wikidata":"https://www.wikidata.org/wiki/Q408641","display_name":"Citrulline","level":4,"score":0.3381834030151367},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16512873768806458},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.13319465517997742},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2012-1692","doi":"https://doi.org/10.1158/1538-7445.am2012-1692","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2012-1692","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.800000011920929,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2965171919","https://openalex.org/W2051510657","https://openalex.org/W2033556277","https://openalex.org/W2075447230","https://openalex.org/W2322921414","https://openalex.org/W2080915191","https://openalex.org/W2036988793","https://openalex.org/W2248402548","https://openalex.org/W2270095792","https://openalex.org/W2315074929"],"abstract_inverted_index":{"Abstract":[0],"The":[1,205],"amino":[2],"acid":[3],"arginine":[4,24,34,111,284,293],"is":[5,14,27],"involved":[6],"in":[7,46,71,104,115,253,258,281,308,329],"protein":[8,54,125,156,183,203,215,248,268],"synthesis":[9],"and":[10,13,36,43,58,79,107,245,263],"tumor":[11],"metabolism":[12],"essential":[15],"for":[16,154,165,304,348],"the":[17,139,191,252,272,324,340,345],"growth":[18],"of":[19,40,74,110,129,143,181,213,219,229,239,256,271,326,339,344],"human":[20],"cancer":[21],"cells.":[22],"Pegylated":[23],"deiminase":[25],"(ADI-PEG20)":[26],"a":[28,127,163,237,300],"novel":[29],"therapy":[30],"that":[31,66,91,159,292],"lowers":[32],"extracellular":[33],"levels":[35,180],"has":[37,63],"shown":[38,65],"evidence":[39],"clinical":[41],"response":[42,282],"low":[44],"toxicity":[45],"patients":[47,306],"with":[48,84,113,123,188,217,266,286,295],"tumors":[49],"lacking":[50],"argininosuccinate":[51],"synthetase":[52],"(ASS1)":[53],"expression,":[55,126],"including":[56,318],"melanoma":[57],"hepatocellular":[59],"carcinoma.":[60],"Recently":[61],"it":[62],"been":[64],"ASS1":[67,81,92,96,124,144,155,182,202,214,230,247,267,273,309],"expression":[68,184,216,249],"was":[69,82,134],"deficient":[70,274,307],"63%":[72],"(39/62)":[73],"Japanese":[75],"osteosarcoma":[76,98,130,160,174,260,305],"patient":[77],"samples,":[78],"reduced":[80],"associated":[83],"pulmonary":[85],"metastases.":[86],"In":[87,311],"addition,":[88,312],"they":[89],"showed":[90,277],"deficient,":[93],"but":[94],"not":[95,102],"expressing,":[97],"cells":[99],"lines":[100,176,194,198,209,222,241,262,276],"did":[101],"grow":[103],"arginine-deficient":[105],"media,":[106],"recommended":[108],"evaluation":[109],"depletion":[112,285,294],"ADI-PEG20":[114,118,166,257],"osteosarcoma.":[116,330],"Because":[117],"efficacy":[119],"appears":[120],"to":[121,137,178,186,250,283,321],"correlate":[122],"cohort":[128],"tissue":[131],"sections":[132],"(n=171)":[133],"stained":[135],"immunohistochemically":[136],"determine":[138,179,251],"presence":[140],"or":[141,151],"absence":[142],"protein.":[145,231],"Sixty-four":[146],"percent":[147],"(n=109)":[148],"indicated":[149],"negligible":[150],"no":[152],"staining":[153],"suggesting":[157],"further":[158,313],"might":[161],"be":[162,299],"candidate":[164],"sensitivity.":[167],"Western":[168],"blots":[169],"were":[170,234],"performed":[171,235],"on":[172,236],"patient-derived":[173,259],"cell":[175,193,197,208,221,240,261,275,279],"(n=18)":[177],"prior":[185],"treatment":[187,303],"ADI-PEG20.":[189],"Of":[190],"18":[192],"studied,":[195],"four":[196],"had":[199],"noticeably":[200],"diminished":[201],"expression.":[204,269,310],"remaining":[206],"13":[207],"exhibited":[210],"varying":[211],"amounts":[212],"five":[218],"these":[220],"appearing":[223],"strongly":[224],"positive":[225],"indicating":[226],"possible":[227],"overexpression":[228],"Cytotoxicity":[232],"assays":[233],"subset":[238],"representing":[242],"both":[243],"elevated":[244],"decreased":[246,278],"vitro":[254],"effectiveness":[255],"its":[264],"correlation":[265],"Some":[270],"viability":[280],"ADI-PEG":[287,296],"20.":[288],"These":[289],"findings":[290],"suggest":[291],"20":[297],"may":[298],"potential":[301],"targeted":[302],"preclinical":[314],"studies":[315],"are":[316],"ongoing,":[317],"xenograft":[319],"models,":[320],"understand":[322],"better":[323],"mechanism":[325],"this":[327],"agent":[328],"Citation":[331],"Format:":[332],"{Authors}.":[333],"{Abstract":[334],"title}":[335],"[abstract].":[336],"In:":[337],"Proceedings":[338],"103rd":[341],"Annual":[342],"Meeting":[343],"American":[346],"Association":[347],"Cancer":[349,360],"Research;":[350],"2012":[351],"Mar":[352],"31-Apr":[353],"4;":[354],"Chicago,":[355],"IL.":[356],"Philadelphia":[357],"(PA):":[358],"AACR;":[359],"Res":[361],"2012;72(8":[362],"Suppl):Abstract":[363],"nr":[364],"1692.":[365],"doi:1538-7445.AM2012-1692":[366]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}