{"id":"https://openalex.org/W2010580958","doi":"https://doi.org/10.1023/a:1006250213357","title":"Meta\u2010analysis of trials comparing toremifene with tamoxifen and factors predicting outcome of antiestrogen therapy in postmenopausal women with breast cancer","display_name":"Meta\u2010analysis of trials comparing toremifene with tamoxifen and factors predicting outcome of antiestrogen therapy in postmenopausal women with breast cancer","publication_year":1999,"publication_date":"1999-07-01","ids":{"openalex":"https://openalex.org/W2010580958","doi":"https://doi.org/10.1023/a:1006250213357","mag":"2010580958","pmid":"https://pubmed.ncbi.nlm.nih.gov/10573106"},"language":"en","primary_location":{"id":"doi:10.1023/a:1006250213357","doi":"https://doi.org/10.1023/a:1006250213357","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1006250213357","pdf_url":null,"source":{"id":"https://openalex.org/S142211178","display_name":"Breast Cancer Research and Treatment","issn_l":"0167-6806","issn":["0167-6806","1573-7217"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast Cancer Research and Treatment","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089173478","display_name":"Seppo O Pyrh\u00f6nen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801970007","display_name":"Turku University Hospital","ror":"https://ror.org/05dbzj528","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2801970007","https://openalex.org/I4210127022"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"S. Pyrh\u00f6nen","raw_affiliation_strings":["Department of Oncology and Radiotherapy, Turku University Central Hospital, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology and Radiotherapy, Turku University Central Hospital, Finland","institution_ids":["https://openalex.org/I2801970007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064992854","display_name":"Juha Ellm\u00e9n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210118237","display_name":"Orion Corporation (Finland)","ror":"https://ror.org/0296s4x19","country_code":"FI","type":"company","lineage":["https://openalex.org/I4210118237"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"J. Ellm\u00e9n","raw_affiliation_strings":["Oncology, Orion Corporation, Orion Pharma, Clinical R & D, Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology, Orion Corporation, Orion Pharma, Clinical R & D, Turku, Finland","institution_ids":["https://openalex.org/I4210118237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110121410","display_name":"Jouni A. Vuorinen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210118237","display_name":"Orion Corporation (Finland)","ror":"https://ror.org/0296s4x19","country_code":"FI","type":"company","lineage":["https://openalex.org/I4210118237"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"J. Vuorinen","raw_affiliation_strings":["Biostatistics, Orion Corporation, Orion Pharma, Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics, Orion Corporation, Orion Pharma, Turku, Finland","institution_ids":["https://openalex.org/I4210118237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110317164","display_name":"M. Gershanovich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116304","display_name":"Institute of Oncology NN Petrov","ror":"https://ror.org/01mfpjp46","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210116304","https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"M. Gershanovich","raw_affiliation_strings":["N.N. Petrov Research Institute of Oncology, St. Petersburg, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N.N. Petrov Research Institute of Oncology, St. Petersburg, Russia","institution_ids":["https://openalex.org/I4210116304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110197498","display_name":"T. Tominaga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3020605285","display_name":"Tokyo Metropolitan Komagome Hospital","ror":"https://ror.org/04eqd2f30","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I3020605285"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. Tominaga","raw_affiliation_strings":["Tokyo Metropolitan Komagome Hospital, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokyo Metropolitan Komagome Hospital, Tokyo, Japan","institution_ids":["https://openalex.org/I3020605285"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102928611","display_name":"M. Kaufmann","orcid":"https://orcid.org/0009-0000-6818-3761","observed_orcids":["https://orcid.org/0009-0000-6818-3761"]},"institutions":[{"id":"https://openalex.org/I4210132578","display_name":"University Hospital Frankfurt","ror":"https://ror.org/03f6n9m15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210132578"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Kaufmann","raw_affiliation_strings":["Universit\u00e4ts\u2010Frauenklinik, Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4ts\u2010Frauenklinik, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I4210132578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069748055","display_name":"Daniel F. Hayes","orcid":"https://orcid.org/0000-0003-3620-7575","observed_orcids":["https://orcid.org/0000-0003-3620-7575"]},"institutions":[{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D.F. Hayes","raw_affiliation_strings":["Lombardi Cancer Center, Room E504, Research Building, NW, Washington, DC, USA","Lombardi Cancer Center, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lombardi Cancer Center, Room E504, Research Building, NW, Washington, DC, USA","institution_ids":["https://openalex.org/I4390039356"]},{"raw_affiliation_string":"Lombardi Cancer Center, Washington, DC, USA","institution_ids":["https://openalex.org/I4390039356"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":null,"fwci":2.8948,"has_fulltext":false,"cited_by_count":105,"citation_normalized_percentile":{"value":0.91271186,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"56","issue":"2","first_page":"131","last_page":"141"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.86080002784729,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.86080002784729,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.06669999659061432,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.05050000175833702,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/toremifene","display_name":"toremifene","score":0.996999979019165},{"id":"https://openalex.org/keywords/tamoxifen","display_name":"tamoxifen","score":1.0},{"id":"https://openalex.org/keywords/antiestrogen-therapy","display_name":"antiestrogen therapy","score":0.8420000076293945},{"id":"https://openalex.org/keywords/advanced-breast-cancer","display_name":"advanced breast cancer","score":0.8709999918937683},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":0.9779999852180481},{"id":"https://openalex.org/keywords/estrogen-receptor-positive-breast-cancer","display_name":"estrogen receptor-positive breast cancer","score":0.8989999890327454},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.753000020980835},{"id":"https://openalex.org/keywords/treatment-failure","display_name":"treatment failure","score":0.3019999861717224}],"concepts":[{"id":"https://openalex.org/C2777637070","wikidata":"https://www.wikidata.org/wiki/Q3993743","display_name":"Toremifene","level":5,"score":0.9490777254104614},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.856955885887146},{"id":"https://openalex.org/C2777176818","wikidata":"https://www.wikidata.org/wiki/Q412178","display_name":"Tamoxifen","level":4,"score":0.7779533863067627},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.7569209337234497},{"id":"https://openalex.org/C2776067312","wikidata":"https://www.wikidata.org/wiki/Q50429983","display_name":"Antiestrogen","level":5,"score":0.7408014535903931},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7151272296905518},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6243639588356018},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6154815554618835},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5004165172576904},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.4943654537200928},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.486129492521286},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.4702790081501007},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.37710151076316833}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017211","descriptor_name":"Treatment Failure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017312","descriptor_name":"Toremifene","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D017312","descriptor_name":"Toremifene","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D017698","descriptor_name":"Postmenopause","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018931","descriptor_name":"Antineoplastic Agents, Hormonal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D018931","descriptor_name":"Antineoplastic Agents, Hormonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D020845","descriptor_name":"Selective Estrogen Receptor Modulators","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D020845","descriptor_name":"Selective Estrogen Receptor Modulators","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D020847","descriptor_name":"Estrogen Receptor Modulators","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D020847","descriptor_name":"Estrogen Receptor Modulators","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1023/a:1006250213357","doi":"https://doi.org/10.1023/a:1006250213357","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1006250213357","pdf_url":null,"source":{"id":"https://openalex.org/S142211178","display_name":"Breast Cancer Research and Treatment","issn_l":"0167-6806","issn":["0167-6806","1573-7217"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast Cancer Research and Treatment","raw_type":"journal-article"},{"id":"pmid:10573106","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10573106","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast cancer research and treatment","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W206480088","https://openalex.org/W1810933484","https://openalex.org/W1821522531","https://openalex.org/W1933260678","https://openalex.org/W1963125733","https://openalex.org/W1967615118","https://openalex.org/W1970573301","https://openalex.org/W1974540993","https://openalex.org/W1975538443","https://openalex.org/W1979115901","https://openalex.org/W1982518867","https://openalex.org/W1983240067","https://openalex.org/W1985951975","https://openalex.org/W1993193232","https://openalex.org/W1993789828","https://openalex.org/W2002905683","https://openalex.org/W2014778298","https://openalex.org/W2020547886","https://openalex.org/W2030587002","https://openalex.org/W2032661530","https://openalex.org/W2035025788","https://openalex.org/W2052960284","https://openalex.org/W2056607956","https://openalex.org/W2057786970","https://openalex.org/W2062870076","https://openalex.org/W2069050763","https://openalex.org/W2076668534","https://openalex.org/W2082218494","https://openalex.org/W2082382339","https://openalex.org/W2087045037","https://openalex.org/W2089081822","https://openalex.org/W2093741445","https://openalex.org/W2099510505","https://openalex.org/W2100629056","https://openalex.org/W2105883471","https://openalex.org/W2137792512","https://openalex.org/W2161147823","https://openalex.org/W2164871552","https://openalex.org/W2167805334","https://openalex.org/W2401466257","https://openalex.org/W2411241963","https://openalex.org/W2412644323","https://openalex.org/W3198500581"],"related_works":["https://openalex.org/W2062870076","https://openalex.org/W2020547886","https://openalex.org/W1983801145","https://openalex.org/W1989757783","https://openalex.org/W2123006593","https://openalex.org/W2279386667","https://openalex.org/W2137792512","https://openalex.org/W2349334278","https://openalex.org/W2047698495","https://openalex.org/W2115949742"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}