{"id":"https://openalex.org/W201057788","doi":null,"title":"Evolutionary and Pharmacological Studies of NPY and QRFP Receptors","display_name":"Evolutionary and Pharmacological Studies of NPY and QRFP Receptors","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W201057788","mag":"201057788"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:uu-233461","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-233461","pdf_url":null,"source":{"id":"https://openalex.org/S4306402042","display_name":"Uppsala University Publications (Uppsala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123387679","host_organization_name":"Uppsala University","host_organization_lineage":["https://openalex.org/I123387679"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-233461","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101771544","display_name":"Bo Xu","orcid":"https://orcid.org/0000-0002-2913-514X","observed_orcids":["https://orcid.org/0000-0002-2913-514X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Bo Xu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5101771544"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuropeptide-y","display_name":"neuropeptide Y","score":0.9179999828338623},{"id":"https://openalex.org/keywords/y2-receptor","display_name":"Y2 receptor","score":0.847000002861023},{"id":"https://openalex.org/keywords/peptide-receptor-interaction","display_name":"peptide-receptor interaction","score":0.9380000233650208},{"id":"https://openalex.org/keywords/appetite-regulation","display_name":"appetite regulation","score":0.6959999799728394},{"id":"https://openalex.org/keywords/zebrafish","display_name":"zebrafish","score":0.796999990940094},{"id":"https://openalex.org/keywords/xenopus-tropicalis","display_name":"Xenopus tropicalis","score":0.9599999785423279},{"id":"https://openalex.org/keywords/sea-lamprey","display_name":"sea lamprey","score":0.9919999837875366},{"id":"https://openalex.org/keywords/amphioxus","display_name":"amphioxus","score":0.8410000205039978},{"id":"https://openalex.org/keywords/branchiostoma-floridae","display_name":"Branchiostoma floridae","score":0.8809999823570251},{"id":"https://openalex.org/keywords/receptor-structure","display_name":"receptor structure","score":0.4050000011920929},{"id":"https://openalex.org/keywords/receptor-pharmacology","display_name":"receptor pharmacology","score":0.5569999814033508},{"id":"https://openalex.org/keywords/drug-target-design","display_name":"drug target design","score":0.6169999837875366}],"concepts":[{"id":"https://openalex.org/C93984277","wikidata":"https://www.wikidata.org/wiki/Q24782073","display_name":"Neuropeptide Y receptor","level":4,"score":0.8296074271202087},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6503044366836548},{"id":"https://openalex.org/C75908981","wikidata":"https://www.wikidata.org/wiki/Q28578","display_name":"Appetite","level":2,"score":0.6176266074180603},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.5421186089515686},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49958109855651855},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.3964090347290039},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.39544877409935},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2993863821029663},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1260894238948822}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:uu-233461","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-233461","pdf_url":null,"source":{"id":"https://openalex.org/S4306402042","display_name":"Uppsala University Publications (Uppsala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123387679","host_organization_name":"Uppsala University","host_organization_lineage":["https://openalex.org/I123387679"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:201057788","doi":null,"is_oa":false,"landing_page_url":"http://uu.diva-portal.org/smash/record.jsf?pid=diva2%3A752819","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:uu-233461","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-233461","pdf_url":null,"source":{"id":"https://openalex.org/S4306402042","display_name":"Uppsala University Publications (Uppsala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123387679","host_organization_name":"Uppsala University","host_organization_lineage":["https://openalex.org/I123387679"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":164,"referenced_works":["https://openalex.org/W51161921","https://openalex.org/W72465559","https://openalex.org/W72689258","https://openalex.org/W221200352","https://openalex.org/W1487776394","https://openalex.org/W1508673826","https://openalex.org/W1518307932","https://openalex.org/W1520089666","https://openalex.org/W1571861757","https://openalex.org/W1601226179","https://openalex.org/W1774444115","https://openalex.org/W1833104430","https://openalex.org/W1909149883","https://openalex.org/W1937309249","https://openalex.org/W1967901105","https://openalex.org/W1968582019","https://openalex.org/W1969441974","https://openalex.org/W1970314616","https://openalex.org/W1970613671","https://openalex.org/W1971155338","https://openalex.org/W1971545492","https://openalex.org/W1975691556","https://openalex.org/W1977784637","https://openalex.org/W1978022170","https://openalex.org/W1979728801","https://openalex.org/W1982339839","https://openalex.org/W1984134771","https://openalex.org/W1986366392","https://openalex.org/W1987306390","https://openalex.org/W1988087189","https://openalex.org/W1989374301","https://openalex.org/W1994655412","https://openalex.org/W1997060814","https://openalex.org/W1997753143","https://openalex.org/W1998392177","https://openalex.org/W1998493877","https://openalex.org/W1998670296","https://openalex.org/W2000959507","https://openalex.org/W2001362474","https://openalex.org/W2001936817","https://openalex.org/W2003070021","https://openalex.org/W2003769230","https://openalex.org/W2008727508","https://openalex.org/W2008728387","https://openalex.org/W2010426451","https://openalex.org/W2011035069","https://openalex.org/W2013058701","https://openalex.org/W2013184139","https://openalex.org/W2014611661","https://openalex.org/W2015301110","https://openalex.org/W2015529507","https://openalex.org/W2015865718","https://openalex.org/W2016408686","https://openalex.org/W2017789562","https://openalex.org/W2018229634","https://openalex.org/W2018263864","https://openalex.org/W2019591778","https://openalex.org/W2019650000","https://openalex.org/W2019933465","https://openalex.org/W2025292322","https://openalex.org/W2025547640","https://openalex.org/W2026322268","https://openalex.org/W2026333686","https://openalex.org/W2027145859","https://openalex.org/W2027919177","https://openalex.org/W2028623046","https://openalex.org/W2029240910","https://openalex.org/W2029335938","https://openalex.org/W2031380339","https://openalex.org/W2034848801","https://openalex.org/W2034856292","https://openalex.org/W2035011520","https://openalex.org/W2036833206","https://openalex.org/W2037667470","https://openalex.org/W2039243127","https://openalex.org/W2039789253","https://openalex.org/W2040626092","https://openalex.org/W2040756789","https://openalex.org/W2041449466","https://openalex.org/W2044536055","https://openalex.org/W2045078990","https://openalex.org/W2045947576","https://openalex.org/W2046271526","https://openalex.org/W2047405437","https://openalex.org/W2047409372","https://openalex.org/W2047567287","https://openalex.org/W2048025753","https://openalex.org/W2051106500","https://openalex.org/W2052073016","https://openalex.org/W2052972724","https://openalex.org/W2053726057","https://openalex.org/W2054945416","https://openalex.org/W2056572830","https://openalex.org/W2056964956","https://openalex.org/W2058024745","https://openalex.org/W2059082491","https://openalex.org/W2059805279","https://openalex.org/W2061248972","https://openalex.org/W2064348625","https://openalex.org/W2064912476","https://openalex.org/W2066522056","https://openalex.org/W2070128052","https://openalex.org/W2070686601","https://openalex.org/W2071178772","https://openalex.org/W2073455525","https://openalex.org/W2075164158","https://openalex.org/W2075968822","https://openalex.org/W2077598676","https://openalex.org/W2078437840","https://openalex.org/W2078948823","https://openalex.org/W2079523532","https://openalex.org/W2079585758","https://openalex.org/W2079681415","https://openalex.org/W2082086395","https://openalex.org/W2083728294","https://openalex.org/W2084486673","https://openalex.org/W2085919691","https://openalex.org/W2086169523","https://openalex.org/W2086745052","https://openalex.org/W2087605279","https://openalex.org/W2088362332","https://openalex.org/W2089658653","https://openalex.org/W2090643737","https://openalex.org/W2091685843","https://openalex.org/W2093755515","https://openalex.org/W2094885706","https://openalex.org/W2097955657","https://openalex.org/W2097961893","https://openalex.org/W2098092258","https://openalex.org/W2100112706","https://openalex.org/W2103087497","https://openalex.org/W2103732388","https://openalex.org/W2107277218","https://openalex.org/W2107904278","https://openalex.org/W2109014958","https://openalex.org/W2111211467","https://openalex.org/W2112282765","https://openalex.org/W2113916199","https://openalex.org/W2116578933","https://openalex.org/W2118839461","https://openalex.org/W2119392173","https://openalex.org/W2122315165","https://openalex.org/W2122469035","https://openalex.org/W2123318089","https://openalex.org/W2127640271","https://openalex.org/W2127990392","https://openalex.org/W2129474234","https://openalex.org/W2131266487","https://openalex.org/W2131871062","https://openalex.org/W2137015675","https://openalex.org/W2139273810","https://openalex.org/W2139380021","https://openalex.org/W2139786901","https://openalex.org/W2149963584","https://openalex.org/W2150296056","https://openalex.org/W2151522819","https://openalex.org/W2154842844","https://openalex.org/W2156815152","https://openalex.org/W2158477075","https://openalex.org/W2170007502","https://openalex.org/W2225750755","https://openalex.org/W2335345703","https://openalex.org/W2341751247","https://openalex.org/W4255893942"],"related_works":["https://openalex.org/W2112282765","https://openalex.org/W2126077609","https://openalex.org/W56509896","https://openalex.org/W2155173698","https://openalex.org/W2056884201","https://openalex.org/W1981733510","https://openalex.org/W2039243127","https://openalex.org/W2082375870","https://openalex.org/W2033816024","https://openalex.org/W1508153732"],"abstract_inverted_index":{"The":[0,74,93,257],"neuropeptide":[1],"Y":[2],"(NPY)":[3],"system":[4,47,76],"consists":[5],"of":[6,41,44,50,57,159,178,231,283,297,306,331,347],"3-4":[7],"peptides":[8,109,233],"and":[9,21,35,54,88,97,100,218,224,246,265,270,322,326],"4-7":[10],"receptors":[11,94,259],"in":[12,24,71,79,110,181,192,201,208,262,287],"vertebrates.":[13,161],"It":[14],"has":[15],"powerful":[16],"effects":[17],"on":[18,243],"appetite":[19],"regulation":[20],"is":[22],"involved":[23,70,286],"many":[25,171],"other":[26,225],"biological":[27],"processes":[28],"including":[29],"blood":[30],"pressure":[31],"regulation,":[32],"bone":[33],"formation":[34],"anxiety.":[36],"This":[37,184],"thesis":[38,314],"describes":[39],"studies":[40,56,113,163,228],"the":[42,45,58,107,133,137,153,157,160,166,187,193,202,235,295,307,319,328,332],"evolution":[43],"NPY":[46,75,134,188,217,321],"by":[48,267],"comparison":[49],"several":[51,309],"vertebrate":[52,168,204],"species":[53],"structural":[55,244,329],"human":[59,236,333],"Y2":[60,237],"receptor,":[61],"which":[62,179,197,284],"reduces":[63],"appetite,":[64],"to":[65,132,250,278,302],"identify":[66],"amino":[67],"acid":[68],"residues":[69,275],"peptide-receptor":[72,120,280,298,324],"interactions.":[73],"was":[77,140,145],"studied":[78],"zebrafish":[80],"(Danio":[81],"rerio),":[82],"western":[83],"clawed":[84],"frog":[85],"(Xenopus":[86],"tropicalis),":[87],"sea":[89],"lamprey":[90],"(Petromyzon":[91],"marinus).":[92],"were":[95,104,122,248,260,276,300],"cloned":[96,146],"functionally":[98],"expressed":[99,261],"their":[101],"pharmacological":[102],"profiles":[103],"determined":[105],"using":[106],"native":[108],"either":[111],"binding":[112,269],"or":[114],"a":[115,292],"signal":[116],"transduction":[117],"assay.":[118],"Some":[119,211],"preferences":[121],"observed,":[123],"indicating":[124],"functional":[125,271],"specialization.":[126],"A":[127,142],"receptor":[128,144,154,189,220,274,289],"family":[129],"closely":[130],"related":[131],"receptors,":[135,139,175,335],"called":[136],"QRFP":[138,143,174,219,323],"investigated.":[141],"from":[147],"amphioxus,":[148],"Branchistoma":[149],"floridae,":[150],"showing":[151],"that":[152,165],"arose":[155],"before":[156],"origin":[158],"Evolutionary":[162],"demonstrated":[164],"ancestral":[167,203],"had":[169,198],"as":[170,172],"four":[173],"only":[176,206],"one":[177],"remains":[180],"mammals":[182],"today.":[183],"correlates":[185],"with":[186,234,254],"family,":[190],"located":[191],"same":[194],"chromosomal":[195],"regions,":[196],"seven":[199],"members":[200],"but":[205],"4-5":[207],"living":[209],"mammals.":[210,226],"vertebrates":[212],"have":[213],"considerably":[214],"more":[215],"complex":[216,320],"systems":[221,325],"than":[222],"humans":[223],"Two":[227],"investigated":[229,266],"interactions":[230,253],"NPY-family":[232,334,348],"receptor.":[238],"Candidate":[239],"residues,":[240],"selected":[241],"based":[242],"modeling":[245],"docking,":[247],"mutated":[249],"disrupt":[251],"possible":[252],"peptide":[255],"ligands.":[256],"modified":[258],"cultured":[263],"cells":[264],"measuring":[268],"responses.":[272],"Several":[273],"found":[277,301],"influence":[279],"interactions,":[281],"some":[282],"are":[285],"maintaining":[288],"structure.":[290],"In":[291,311],"pilot":[293],"study,":[294],"kinetics":[296],"interaction":[299],"be":[303],"very":[304],"slow,":[305],"order":[308],"hours.":[310],"conclusion,":[312],"this":[313],"clarifies":[315],"evolutionary":[316],"relationships":[317],"for":[318,345],"improves":[327],"models":[330],"especially":[336],"Y2.":[337],"These":[338],"results":[339],"will":[340],"hopefully":[341],"facilitate":[342],"drug":[343],"design":[344],"targeting":[346],"receptors.":[349]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}