{"id":"https://openalex.org/W201057040","doi":"https://doi.org/10.1096/fasebj.21.5.a412","title":"Norketamine in combination with morphine for inflammatory pain","display_name":"Norketamine in combination with morphine for inflammatory pain","publication_year":2007,"publication_date":"2007-04-01","ids":{"openalex":"https://openalex.org/W201057040","doi":"https://doi.org/10.1096/fasebj.21.5.a412","mag":"201057040"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.21.5.a412","doi":"https://doi.org/10.1096/fasebj.21.5.a412","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.5.a412","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054088112","display_name":"J JOHNSONHARDY","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaime K Johnson","raw_affiliation_strings":["Anesthesiology, University of Kentucky, 800 Rose St, N-202, Lexington, KY, 40536"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anesthesiology, University of Kentucky, 800 Rose St, N-202, Lexington, KY, 40536","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049488705","display_name":"Elzbieta P. Wala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elzbieta P Wala","raw_affiliation_strings":["Anesthesiology, University of Kentucky, 800 Rose St, N-202, Lexington, KY, 40536"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anesthesiology, University of Kentucky, 800 Rose St, N-202, Lexington, KY, 40536","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113522554","display_name":"Peter Anthony Crooks","orcid":"https://orcid.org/0000-0002-1312-6150","observed_orcids":["https://orcid.org/0000-0002-1312-6150"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter A Crooks","raw_affiliation_strings":["College of Pharmacy, University of Kentucky, 501B College of Pharmacy Building, Lexington, KY, 40536","Yaupon Therapeutics, Inc, 259 Radnor Chester Road, WAyne, PA, 19087"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, University of Kentucky, 501B College of Pharmacy Building, Lexington, KY, 40536","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Yaupon Therapeutics, Inc, 259 Radnor Chester Road, WAyne, PA, 19087","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025996458","display_name":"Lize\u2010mari Dorfling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lize\u2010mari Dorfling","raw_affiliation_strings":["Anesthesiology, University of Kentucky, 800 Rose St, N-202, Lexington, KY, 40536"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anesthesiology, University of Kentucky, 800 Rose St, N-202, Lexington, KY, 40536","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113996776","display_name":"Joseph R. Holtman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph R Holtman","raw_affiliation_strings":["Anesthesiology, University of Kentucky, 800 Rose St, N-202, Lexington, KY, 40536","College of Pharmacy, University of Kentucky, 501B College of Pharmacy Building, Lexington, KY, 40536"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anesthesiology, University of Kentucky, 800 Rose St, N-202, Lexington, KY, 40536","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"College of Pharmacy, University of Kentucky, 501B College of Pharmacy Building, Lexington, KY, 40536","institution_ids":["https://openalex.org/I143302722"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I143302722"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.03218771,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"21","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/norketamine","display_name":"norketamine","score":0.9869999885559082},{"id":"https://openalex.org/keywords/morphine","display_name":"morphine","score":0.9580000042915344},{"id":"https://openalex.org/keywords/inflammatory-pain","display_name":"inflammatory pain","score":0.5839999914169312},{"id":"https://openalex.org/keywords/formalin-test","display_name":"formalin test","score":0.7360000014305115},{"id":"https://openalex.org/keywords/central-sensitization","display_name":"central sensitization","score":0.8140000104904175},{"id":"https://openalex.org/keywords/opioid-tolerance","display_name":"opioid tolerance","score":0.796999990940094},{"id":"https://openalex.org/keywords/nmda-receptor-antagonist","display_name":"NMDA receptor antagonists","score":0.8349999785423279},{"id":"https://openalex.org/keywords/enantiomers","display_name":"enantiomers","score":0.7419999837875366},{"id":"https://openalex.org/keywords/analgesic-combination-therapy","display_name":"analgesic combination therapy","score":0.7110000252723694},{"id":"https://openalex.org/keywords/opioid-side-effects","display_name":"opioid side effects","score":0.5130000114440918},{"id":"https://openalex.org/keywords/neuropathic-pain","display_name":"neuropathic pain","score":0.7960000038146973}],"concepts":[{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.7711635828018188},{"id":"https://openalex.org/C2777389121","wikidata":"https://www.wikidata.org/wiki/Q81225","display_name":"Morphine","level":2,"score":0.7695008516311646},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6489303112030029},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.6453990936279297},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.6212133169174194},{"id":"https://openalex.org/C2780795376","wikidata":"https://www.wikidata.org/wiki/Q243547","display_name":"Ketamine","level":2,"score":0.6142116189002991},{"id":"https://openalex.org/C2776217527","wikidata":"https://www.wikidata.org/wiki/Q944828","display_name":"Sensitization","level":2,"score":0.5848251581192017},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5522972941398621},{"id":"https://openalex.org/C2778750930","wikidata":"https://www.wikidata.org/wiki/Q4540629","display_name":"(+)-Naloxone","level":4,"score":0.5107800960540771},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.48338404297828674},{"id":"https://openalex.org/C2777107010","wikidata":"https://www.wikidata.org/wiki/Q2798704","display_name":"Neuropathic pain","level":2,"score":0.46449923515319824},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4304124712944031},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2199995517730713},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2100202739238739},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.05146929621696472}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.21.5.a412","doi":"https://doi.org/10.1096/fasebj.21.5.a412","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.5.a412","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8100000023841858,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2082839418","https://openalex.org/W42133223","https://openalex.org/W3174795123","https://openalex.org/W2154651017","https://openalex.org/W80356008","https://openalex.org/W2049046179","https://openalex.org/W2091751728","https://openalex.org/W1989188733","https://openalex.org/W4225408465","https://openalex.org/W2092931379"],"abstract_inverted_index":{"Both":[0,134],"opioids":[1],"(i.e.":[2,9],"morphine,":[3],"MOR)":[4],"and":[5,31,64,77,126,137,196,204],"NMDA":[6,79],"receptor":[7],"antagonists":[8],"ketamine,":[10],"KET)":[11],"have":[12,181],"activity":[13],"in":[14,84,132,144,165,174],"the":[15,47,85,93,98,149,155,161,166],"rat":[16],"formalin":[17],"nociceptive":[18,115,195],"test.":[19],"This":[20,81],"model":[21],"has":[22,68,108],"two":[23],"phases":[24,131],"representing":[25],"inflammatory":[26],"nocicepive":[27],"pain":[28,32,191],"(phase":[29,37],"1)":[30],"involving":[33],"central":[34],"sensitization":[35],"mechanism":[36],"2).":[38],"There":[39],"are":[40],"significant":[41],"side":[42,66,110],"effects":[43,67,111],"issues":[44],"related":[45],"to":[46,57,70,120,193],"use":[48],"of":[49,74,95,101,122,163,190],"these":[50],"drugs":[51],"chronically":[52],"for":[53,188],"pain.":[54],"One":[55],"approach":[56],"increase":[58],"efficacy,":[59],"block":[60],"opioid":[61,76],"tolerance":[62],"development":[63],"limit":[65],"been":[69],"combine":[71],"low":[72],"doses":[73],"an":[75,78,123],"antagonist.":[80],"was":[82,90,118],"done":[83],"present":[86],"study":[87],"were":[88],"MOR":[89,141,164,173],"co\u2010administered":[91],"with":[92,176],"enantiomers":[94],"norketamine\u2010HCL":[96],"(NKET),":[97],"major":[99],"metabolite":[100],"KET.":[102,113],"We":[103],"previously":[104],"found":[105,119],"that":[106,172],"NKET":[107],"fever":[109],"than":[112],"Formalin\u2010induced":[114],"behavior":[116],"(flinches)":[117],"consist":[121],"early":[124,167],"(nociceptive)":[125],"a":[127,145,184],"late":[128,150],"(central":[129],"sensitization)":[130],"rats.":[133],"S(+)\u2010NKET":[135,159,177],"(0.01\u20131mg/kg)":[136],"R(\u2212)\u2010NKET":[138],"(0.5\u20131.5mg/kg)":[139],"enhanced":[140],"(0.5mg/kg)":[142],"analgesia,":[143],"dose\u2010related":[146],"manner,":[147],"during":[148],"phase":[151],"[the":[152],"S(+)":[153],">":[154],"R(\u2212)].":[156],"In":[157],"addition,":[158],"potentiated":[160],"effect":[162],"phase.":[168],"These":[169],"data":[170],"suggest":[171],"combination":[175,186],"(low":[178],"doses)":[179],"may":[180],"potential":[182],"as":[183],"novel":[185],"therapy":[187],"treatment":[189],"due":[192],"both":[194],"neuropathic":[197],"etiologies.":[198],"Support:":[199],"NIDA":[200],"R\u201042":[201],"DA017529":[202],"\u201002A1":[203],"KSEF\u2010949\u2010RDE\u2010008":[205],"(JRH)":[206]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
