{"id":"https://openalex.org/W2010564489","doi":"https://doi.org/10.1016/0147-6513(89)90005-5","title":"Hematotoxic effects in the rat of a toluene dinitro derivative after short-term exposure","display_name":"Hematotoxic effects in the rat of a toluene dinitro derivative after short-term exposure","publication_year":1989,"publication_date":"1989-02-01","ids":{"openalex":"https://openalex.org/W2010564489","doi":"https://doi.org/10.1016/0147-6513(89)90005-5","mag":"2010564489","pmid":"https://pubmed.ncbi.nlm.nih.gov/2714217"},"language":"en","primary_location":{"id":"doi:10.1016/0147-6513(89)90005-5","doi":"https://doi.org/10.1016/0147-6513(89)90005-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0147-6513(89)90005-5","pdf_url":null,"source":{"id":"https://openalex.org/S13733787","display_name":"Ecotoxicology and Environmental Safety","issn_l":"0147-6513","issn":["0147-6513","1090-2414"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ecotoxicology and Environmental Safety","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113480732","display_name":"C. Guastadisegni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27897274","display_name":"Istituto Superiore di Sanit\u00e0","ror":"https://ror.org/02hssy432","country_code":"IT","type":"government","lineage":["https://openalex.org/I27897274"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C. Guastadisegni","raw_affiliation_strings":["Laboratorio Tossicologia Comparata ed Ecotossicologia, Istituto Superiore di Sanit\u00e0, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio Tossicologia Comparata ed Ecotossicologia, Istituto Superiore di Sanit\u00e0, Rome, Italy","institution_ids":["https://openalex.org/I27897274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029248156","display_name":"Al. Mantovani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27897274","display_name":"Istituto Superiore di Sanit\u00e0","ror":"https://ror.org/02hssy432","country_code":"IT","type":"government","lineage":["https://openalex.org/I27897274"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Al. Mantovani","raw_affiliation_strings":["Laboratorio Tossicologia Comparata ed Ecotossicologia, e Istituto Superiore di Sanit\u00e0, 00161 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio Tossicologia Comparata ed Ecotossicologia, e Istituto Superiore di Sanit\u00e0, 00161 Rome, Italy","institution_ids":["https://openalex.org/I27897274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111645378","display_name":"Claudio Ricciardi","orcid":"https://orcid.org/0009-0001-7142-1166","observed_orcids":["https://orcid.org/0009-0001-7142-1166"]},"institutions":[{"id":"https://openalex.org/I27897274","display_name":"Istituto Superiore di Sanit\u00e0","ror":"https://ror.org/02hssy432","country_code":"IT","type":"government","lineage":["https://openalex.org/I27897274"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C. Ricciardi","raw_affiliation_strings":["Laboratorio Tossicologia Comparata ed Ecotossicologia, e Istituto Superiore di Sanit\u00e0, 00161 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio Tossicologia Comparata ed Ecotossicologia, e Istituto Superiore di Sanit\u00e0, 00161 Rome, Italy","institution_ids":["https://openalex.org/I27897274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015696518","display_name":"Anna Velia Stazi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27897274","display_name":"Istituto Superiore di Sanit\u00e0","ror":"https://ror.org/02hssy432","country_code":"IT","type":"government","lineage":["https://openalex.org/I27897274"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A.V. Stazi","raw_affiliation_strings":["Laboratorio Tossicologia Comparata ed Ecotossicologia, e Istituto Superiore di Sanit\u00e0, 00161 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio Tossicologia Comparata ed Ecotossicologia, e Istituto Superiore di Sanit\u00e0, 00161 Rome, Italy","institution_ids":["https://openalex.org/I27897274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061477456","display_name":"D. Maffi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27897274","display_name":"Istituto Superiore di Sanit\u00e0","ror":"https://ror.org/02hssy432","country_code":"IT","type":"government","lineage":["https://openalex.org/I27897274"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"D. Maffi","raw_affiliation_strings":["Laboratorio Biochimica Clinica, Istituto Superiore di Sanit\u00e0, 0016` Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio Biochimica Clinica, Istituto Superiore di Sanit\u00e0, 0016` Rome, Italy","institution_ids":["https://openalex.org/I27897274"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110003235","display_name":"Anna Maria Salvati","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27897274","display_name":"Istituto Superiore di Sanit\u00e0","ror":"https://ror.org/02hssy432","country_code":"IT","type":"government","lineage":["https://openalex.org/I27897274"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A.M. Salvati","raw_affiliation_strings":["Laboratorio Biochimica Clinica, Istituto Superiore di Sanit\u00e0, 0016` Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio Biochimica Clinica, Istituto Superiore di Sanit\u00e0, 0016` Rome, Italy","institution_ids":["https://openalex.org/I27897274"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I27897274"],"apc_list":{"value":3650,"currency":"USD","value_usd":3650},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.08616717,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"17","issue":"1","first_page":"21","last_page":"29"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.6991999745368958,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.6991999745368958,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.16110000014305115,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.11710000038146973,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hematological-toxicity","display_name":"hematologic toxicity","score":0.8130000233650208},{"id":"https://openalex.org/keywords/methemoglobinemia","display_name":"methemoglobinemia","score":0.8619999885559082},{"id":"https://openalex.org/keywords/leukocytosis","display_name":"leukocytosis","score":0.8339999914169312},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"bone marrow","score":0.7649999856948853},{"id":"https://openalex.org/keywords/spleen","display_name":"spleen","score":0.7739999890327454},{"id":"https://openalex.org/keywords/groundwater-contamination","display_name":"groundwater contamination","score":0.7269999980926514},{"id":"https://openalex.org/keywords/dinitroaniline-herbicides","display_name":"dinitroaniline herbicides","score":0.9190000295639038},{"id":"https://openalex.org/keywords/environmental-persistence","display_name":"environmental persistence","score":0.47699999809265137},{"id":"https://openalex.org/keywords/public-health-risk","display_name":"public health risk","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.7100878953933716},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.6555554866790771},{"id":"https://openalex.org/C2778488018","wikidata":"https://www.wikidata.org/wiki/Q42395","display_name":"White blood cell","level":2,"score":0.6415410041809082},{"id":"https://openalex.org/C26865036","wikidata":"https://www.wikidata.org/wiki/Q416833","display_name":"Methemoglobin","level":3,"score":0.6259511709213257},{"id":"https://openalex.org/C2778232189","wikidata":"https://www.wikidata.org/wiki/Q626936","display_name":"White pulp","level":3,"score":0.6212294697761536},{"id":"https://openalex.org/C2777092883","wikidata":"https://www.wikidata.org/wiki/Q1093858","display_name":"Red pulp","level":3,"score":0.5082578063011169},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.492525190114975},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4717075526714325},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4481743574142456},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41567695140838623},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3789684772491455},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.28329434990882874}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002263","descriptor_name":"Carboxyhemoglobin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004137","descriptor_name":"Dinitrochlorobenzene","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D004137","descriptor_name":"Dinitrochlorobenzene","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D006402","descriptor_name":"Hematologic Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008706","descriptor_name":"Methemoglobin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010108","descriptor_name":"Oxyhemoglobins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014873","descriptor_name":"Water Pollutants","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D014874","descriptor_name":"Water Pollutants, Chemical","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0147-6513(89)90005-5","doi":"https://doi.org/10.1016/0147-6513(89)90005-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0147-6513(89)90005-5","pdf_url":null,"source":{"id":"https://openalex.org/S13733787","display_name":"Ecotoxicology and Environmental Safety","issn_l":"0147-6513","issn":["0147-6513","1090-2414"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ecotoxicology and Environmental Safety","raw_type":"journal-article"},{"id":"pmid:2714217","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2714217","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ecotoxicology and environmental safety","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W13185235","https://openalex.org/W1508358616","https://openalex.org/W1966372587","https://openalex.org/W1979355851","https://openalex.org/W2207219909"],"related_works":["https://openalex.org/W13185235","https://openalex.org/W2415229464","https://openalex.org/W2417836279","https://openalex.org/W4249406218","https://openalex.org/W2406369251","https://openalex.org/W2002379730","https://openalex.org/W2023455927","https://openalex.org/W4297576829","https://openalex.org/W2014684059","https://openalex.org/W2143719508"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}