{"id":"https://openalex.org/W2010559886","doi":"https://doi.org/10.1095/biolreprod55.2.427","title":"Oxytocin-Stimulated Responses in a Pregnant Human Immortalized Myometrial Cell Line1","display_name":"Oxytocin-Stimulated Responses in a Pregnant Human Immortalized Myometrial Cell Line1","publication_year":1996,"publication_date":"1996-08-01","ids":{"openalex":"https://openalex.org/W2010559886","doi":"https://doi.org/10.1095/biolreprod55.2.427","mag":"2010559886","pmid":"https://pubmed.ncbi.nlm.nih.gov/8828850"},"language":"en","primary_location":{"id":"doi:10.1095/biolreprod55.2.427","doi":"https://doi.org/10.1095/biolreprod55.2.427","is_oa":false,"landing_page_url":"https://doi.org/10.1095/biolreprod55.2.427","pdf_url":null,"source":{"id":"https://openalex.org/S130598054","display_name":"Biology of Reproduction","issn_l":"0006-3363","issn":["0006-3363","1529-7268"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of Reproduction","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061102414","display_name":"Manju Monga","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manju Monga","raw_affiliation_strings":["Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Texas Houston Medical School 77225, USA","Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Texas Houston Medical School, Houston, Texas 77225"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Texas Houston Medical School 77225, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Texas Houston Medical School, Houston, Texas 77225","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068738605","display_name":"Chun-Ying Ku","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chun-Ying Ku","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, Houston, Texas 77225"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, Houston, Texas 77225","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029738376","display_name":"Kimberly L. Dodge\u2010Kafka","orcid":"https://orcid.org/0000-0003-0500-5698","observed_orcids":["https://orcid.org/0000-0003-0500-5698"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kimberly Dodge","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, Houston, Texas 77225"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, Houston, Texas 77225","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071126400","display_name":"Barbara M. Sanborn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Barbara M. Sanborn","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, Houston, Texas 77225","Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Texas Houston Medical School, Houston, Texas 77225"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, Houston, Texas 77225","institution_ids":[]},{"raw_affiliation_string":"Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Texas Houston Medical School, Houston, Texas 77225","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5071126400"],"corresponding_institution_ids":[],"apc_list":{"value":4605,"currency":"USD","value_usd":4605},"apc_paid":null,"fwci":8.0102,"has_fulltext":true,"cited_by_count":67,"citation_normalized_percentile":{"value":0.97023538,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"55","issue":"2","first_page":"427","last_page":"432"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.45339998602867126,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.45339998602867126,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.1891999989748001,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10453","display_name":"Maternal and Perinatal Health Interventions","score":0.057999998331069946,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxytocin","display_name":"oxytocin","score":0.8980000019073486},{"id":"https://openalex.org/keywords/myometrium","display_name":"myometrium","score":0.9070000052452087},{"id":"https://openalex.org/keywords/smooth-muscle-cells","display_name":"smooth muscle cells","score":0.703000009059906},{"id":"https://openalex.org/keywords/oxytocin-receptor","display_name":"oxytocin receptor","score":0.7239999771118164},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.621999979019165},{"id":"https://openalex.org/keywords/phosphatidylinositol-turnover","display_name":"phosphatidylinositol turnover","score":0.9990000128746033},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.7570000290870667},{"id":"https://openalex.org/keywords/hpv-16","display_name":"HPV16","score":0.8309999704360962},{"id":"https://openalex.org/keywords/alpha-actin","display_name":"alpha-actin","score":0.8209999799728394},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.800000011920929},{"id":"https://openalex.org/keywords/cell-immortalization","display_name":"cell immortalization","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8358027935028076},{"id":"https://openalex.org/C2776176026","wikidata":"https://www.wikidata.org/wiki/Q169960","display_name":"Oxytocin","level":2,"score":0.7448365092277527},{"id":"https://openalex.org/C181612422","wikidata":"https://www.wikidata.org/wiki/Q14908140","display_name":"Oxytocin receptor","level":3,"score":0.7409248948097229},{"id":"https://openalex.org/C2778164554","wikidata":"https://www.wikidata.org/wiki/Q2562472","display_name":"Myometrium","level":3,"score":0.6394333243370056},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.6316251158714294},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6024236679077148},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5727059841156006},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5606814026832581},{"id":"https://openalex.org/C6045943","wikidata":"https://www.wikidata.org/wiki/Q21014462","display_name":"Immortalised cell line","level":3,"score":0.5590991377830505},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5091347098350525},{"id":"https://openalex.org/C2780610907","wikidata":"https://www.wikidata.org/wiki/Q2273248","display_name":"Phosphatidylinositol","level":3,"score":0.4486373960971832},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.42424681782722473},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37393832206726074},{"id":"https://openalex.org/C2779066055","wikidata":"https://www.wikidata.org/wiki/Q9612","display_name":"Uterus","level":2,"score":0.2542344331741333},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.20696699619293213},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11705988645553589},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002461","descriptor_name":"Cell Line, Transformed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009215","descriptor_name":"Myometrium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009215","descriptor_name":"Myometrium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009215","descriptor_name":"Myometrium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010121","descriptor_name":"Oxytocin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010716","descriptor_name":"Phosphatidylinositols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014668","descriptor_name":"Vasotocin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D014668","descriptor_name":"Vasotocin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1095/biolreprod55.2.427","doi":"https://doi.org/10.1095/biolreprod55.2.427","is_oa":false,"landing_page_url":"https://doi.org/10.1095/biolreprod55.2.427","pdf_url":null,"source":{"id":"https://openalex.org/S130598054","display_name":"Biology of Reproduction","issn_l":"0006-3363","issn":["0006-3363","1529-7268"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of Reproduction","raw_type":"journal-article"},{"id":"pmid:8828850","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8828850","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of reproduction","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2817756941","display_name":null,"funder_award_id":"HD09618","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W190015672","https://openalex.org/W196263068","https://openalex.org/W1519557516","https://openalex.org/W1557764831","https://openalex.org/W1945199177","https://openalex.org/W1977779461","https://openalex.org/W1977839166","https://openalex.org/W1992040551","https://openalex.org/W2006050008","https://openalex.org/W2014108392","https://openalex.org/W2018563470","https://openalex.org/W2027987155","https://openalex.org/W2028185711","https://openalex.org/W2030653254","https://openalex.org/W2039382131","https://openalex.org/W2042709942","https://openalex.org/W2043951140","https://openalex.org/W2055967353","https://openalex.org/W2057328367","https://openalex.org/W2059841215","https://openalex.org/W2074751798","https://openalex.org/W2090511184","https://openalex.org/W2094620213","https://openalex.org/W2099562950","https://openalex.org/W2105264030","https://openalex.org/W2110566071","https://openalex.org/W2119558625","https://openalex.org/W2134372483","https://openalex.org/W2146743605","https://openalex.org/W2153491389","https://openalex.org/W2167717876","https://openalex.org/W2169830226","https://openalex.org/W2337171706","https://openalex.org/W2399242866","https://openalex.org/W4252973277"],"related_works":["https://openalex.org/W7095848554","https://openalex.org/W2100733494","https://openalex.org/W2006932173","https://openalex.org/W2057709380","https://openalex.org/W2109419790","https://openalex.org/W1964830725","https://openalex.org/W2379781372","https://openalex.org/W1977459532","https://openalex.org/W7098440087","https://openalex.org/W3090216414"],"abstract_inverted_index":{"Smooth":[0],"muscle":[1,45,61],"cells":[2,62,79,136],"isolated":[3],"from":[4],"the":[5,21,100,164],"myometrium":[6],"of":[7,24,43,58,123,131],"a":[8,16,116,121,127],"pregnant":[9],"woman":[10],"at":[11],"term":[12],"were":[13,90,112],"infected":[14],"with":[15,120,140,163],"replication-defective":[17],"adenovirus":[18],"vector":[19],"expressing":[20],"E6/E7":[22],"proteins":[23],"human":[25,180],"papilloma":[26],"virus":[27],"16.":[28],"A":[29],"clonal":[30],"line,":[31],"PHM1-41,":[32],"was":[33,159],"selected":[34],"by":[35,94,115,161],"resistance":[36],"to":[37,49,67,138,179],"Geneticin":[38],"and":[39,47,70,84,106,126,150],"examined":[40],"for":[41,65,74,176],"maintenance":[42],"smooth":[44,60,81],"phenotype":[46],"response":[48],"oxytocin.":[50],"The":[51,78,110],"immortalized":[52,169],"cell":[53,96,171],"line":[54,172],"retained":[55,85],"morphological":[56],"characteristics":[57],"proliferating":[59],"in":[63,143,153],"culture":[64],"up":[66],"22":[68],"passages":[69],"has":[71],"been":[72],"used":[73],"over":[75],"2":[76],"years.":[77],"expressed":[80],"muscle-specific":[82],"alpha-actin":[83],"estrogen":[86],"receptors.":[87],"Oxytocin":[88],"receptors":[89],"present,":[91],"as":[92,104,108],"measured":[93],"whole":[95],"binding":[97,118,128],"assay":[98],"using":[99],"oxytocin":[101,107,139],"antagonist":[102],"125I-d(CH2)5[Tyr-(Me)2,Thr4,-Orn8,Tyr9-NH2]":[103],"ligand":[105],"competitor.":[109],"data":[111],"best":[113],"described":[114],"one-site":[117],"model,":[119],"Kd":[122],"0.36":[124],"nM":[125],"site":[129],"concentration":[130],"37":[132],"fmol/microgram":[133],"DNA.":[134],"PHM1-41":[135],"responded":[137],"an":[141,151],"increase":[142,152],"intracellular":[144],"free":[145],"calcium":[146],"(EC50":[147],"15":[148],"nM)":[149],"phosphatidylinositol":[154,157],"turnover.":[155],"Oxytocin-stimulated":[156],"turnover":[158],"inhibited":[160],"preincubation":[162],"cAMP":[165],"analog":[166],"CPT-cAMP.":[167],"This":[168],"myometrial":[170,181],"should":[173],"prove":[174],"useful":[175],"studies":[177],"relating":[178],"function.":[182]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
