{"id":"https://openalex.org/W2010546805","doi":"https://doi.org/10.1158/1538-7445.am2011-1790","title":"Abstract 1790: Functional importance of EpCAM for the activity of tumor-initiating cancer cells and their eradication by EpCAM/CD3-bispecific antibody MT110","display_name":"Abstract 1790: Functional importance of EpCAM for the activity of tumor-initiating cancer cells and their eradication by EpCAM/CD3-bispecific antibody MT110","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W2010546805","doi":"https://doi.org/10.1158/1538-7445.am2011-1790","mag":"2010546805"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2011-1790","doi":"https://doi.org/10.1158/1538-7445.am2011-1790","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-1790","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048879987","display_name":"Markus M\u00fcnz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Markus Mu\u0308nz","raw_affiliation_strings":["1Micromet Inc., Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Micromet Inc., Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039256069","display_name":"Ines Herrmann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ines Herrmann","raw_affiliation_strings":["1Micromet Inc., Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Micromet Inc., Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034794115","display_name":"Matthias Friedrich","orcid":"https://orcid.org/0000-0002-7551-4853","observed_orcids":["https://orcid.org/0000-0002-7551-4853"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthias Friedrich","raw_affiliation_strings":["1Micromet Inc., Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Micromet Inc., Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061086393","display_name":"Alexander Murr","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander Murr","raw_affiliation_strings":["1Micromet Inc., Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Micromet Inc., Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008627097","display_name":"Peter Kufer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Kufer","raw_affiliation_strings":["1Micromet Inc., Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Micromet Inc., Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058901224","display_name":"Patrick A. Baeuerle","orcid":"https://orcid.org/0009-0006-7117-2784","observed_orcids":["https://orcid.org/0009-0006-7117-2784"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patrick A. Baeuerle","raw_affiliation_strings":["1Micromet Inc., Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Micromet Inc., Munich, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066304227","display_name":"Tobias Raum","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tobias Raum","raw_affiliation_strings":["1Micromet Inc., Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Micromet Inc., Munich, Germany","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"71","issue":"8_Supplement","first_page":"1790","last_page":"1790"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epcam","display_name":"EpCAM","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.9490000009536743},{"id":"https://openalex.org/keywords/bispecific-t-cell-engagers","display_name":"bispecific T-cell engagers","score":0.7310000061988831},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9470000267028809},{"id":"https://openalex.org/keywords/liver-cancer","display_name":"liver cancer","score":0.7179999947547913},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":1.0},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9440000057220459},{"id":"https://openalex.org/keywords/shrna","display_name":"shRNA","score":0.7599999904632568},{"id":"https://openalex.org/keywords/soft-agar-assay","display_name":"soft agar colony formation","score":0.8040000200271606},{"id":"https://openalex.org/keywords/xenograft-tumor-growth","display_name":"xenograft tumor growth","score":0.6589999794960022},{"id":"https://openalex.org/keywords/stem-like-phenotype","display_name":"stem cell-like phenotype","score":0.7009999752044678},{"id":"https://openalex.org/keywords/tumor-eradication","display_name":"tumor eradication","score":0.4129999876022339}],"concepts":[{"id":"https://openalex.org/C2776677690","wikidata":"https://www.wikidata.org/wiki/Q5383694","display_name":"Epithelial cell adhesion molecule","level":3,"score":0.7479724287986755},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.6138970255851746},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6002318263053894},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5582315325737},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5543950796127319},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5251564383506775},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.45757269859313965},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4340297281742096},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3758991062641144},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3419332802295685},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06993737816810608}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2011-1790","doi":"https://doi.org/10.1158/1538-7445.am2011-1790","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-1790","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7096065368","https://openalex.org/W2024837280","https://openalex.org/W2083558581","https://openalex.org/W2110264417","https://openalex.org/W1531196062","https://openalex.org/W1540512738","https://openalex.org/W1817501103","https://openalex.org/W1912498439","https://openalex.org/W2475541375","https://openalex.org/W2742126632"],"abstract_inverted_index":{"Abstract":[0],"We":[1],"have":[2],"recently":[3],"shown":[4,164],"that":[5,47,317],"tumor-initiating":[6,266],"cells":[7,296],"(TICs)":[8],"derived":[9,49],"from":[10,50],"colorectal":[11,76,126,203,333,366],"cancer":[12,54,77,367],"tissue":[13,55],"express":[14],"EpCAM":[15,82,123,138,151,161,182,194,211,278,320,344],"and":[16,52,83,97,171,187,232,245,359],"can":[17],"be":[18,102],"eradicated":[19,103],"in":[20,58,86,110,125,159,214,227,256,360],"cell":[21,62,215,229],"culture":[22,216,230],"experiments":[23],"as":[24,26,64,66,108,163,242],"well":[25],"established":[27],"xenograft":[28],"mouse":[29],"models":[30],"by":[31,104,169,177,261],"EpCAM/CD3-bispecific":[32],"BiTE":[33,105],"antibody":[34,106],"MT110":[35,107],"(Hermann":[36],"et":[37,351],"al.,":[38],"2010;":[39],"PLoS":[40],"ONE,":[41],"5:":[42],"e13474).":[43],"Here":[44],"we":[45,128],"show":[46],"TICs":[48,100,204,208,255,269,280,304],"liver":[51,98],"breast":[53,96],"grow":[56],"tumors":[57],"SCID":[59],"mice":[60],"at":[61,165,172,291],"doses":[63],"low":[65],"100":[67],"after":[68,297],"a":[69,111,196,225,228,274,289,292,309,318,328,339,346],"latency":[70],"period":[71,308],"of":[72,92,122,149,191,202,236,254,268,277,294,311,327,332,343,363,365,377,382],"37-58":[73],"days.":[74],"Like":[75],"tissue-derived":[78],"TICs,":[79,127],"they":[80],"expressed":[81],"grew":[84],"colonies":[85],"soft":[87,113,257],"agar.":[88],"In":[89,116],"the":[90,120,145,150,154,166,173,181,192,200,234,265,282,301,361,378,383],"presence":[91],"human":[93],"T":[94],"cells,":[95],"cancer-derived":[99],"could":[101,220,285],"tested":[109],"sensitive":[112],"agar":[114,258],"assay.":[115],"order":[117],"to":[118,144,248,271],"assess":[119],"role":[121,342],"expression":[124,175,212,235,321],"used":[129],"short":[130],"hairpin":[131],"RNA":[132],"molecules":[133],"for":[134,325,386],"specifically":[135],"knocking":[136],"down":[137],"expression.":[139,279],"A":[140],"shRNA":[141,284],"molecule":[142],"binding":[143],"coding,":[146],"non-translated":[147],"3\u2019-UTR":[148],"mRNA":[152,167],"showed":[153],"highest":[155],"efficacy":[156],"(ca":[157],"10-fold)":[158],"suppressing":[160],"expression,":[162,195],"level":[168,176,276,322],"RT-PCR":[170],"surface":[174],"FACS":[178],"analysis.":[179],"Although":[180],"knockdown":[183],"was":[184,205,259],"not":[185],"complete":[186],"left":[188],"ca":[189],"10%":[190],"normal":[193],"strong":[197],"impact":[198],"on":[199,273],"phenotype":[201,331],"observed.":[206],"Morphologically,":[207],"with":[209,338],"reduced":[210,233,260],"adopted":[213],"an":[217],"epithelial-like":[218],"phenotype,":[219],"no":[221,286],"longer":[222,287],"efficiently":[223],"close":[224],"scratch":[226],"experiment,":[231],"epithelial-mesenchymal":[237],"transition":[238],"(EMT)-associated":[239],"proteins":[240],"such":[241],"fibronectin,":[243],"vimentin":[244],"slug.":[246],"Compared":[247],"non-sense":[249,302],"control":[250],"shRNA,":[251],"colony":[252],"formation":[253],">60%.":[262],"Most":[263],"importantly,":[264],"potential":[267],"appeared":[270],"depend":[272],"high":[275],"expressing":[281],"EpCAM-specific":[283],"form":[288],"tumor":[290,310],"dose":[293],"500":[295],"116":[298],"days,":[299],"whereas":[300],"shRNA-expressing":[303],"formed":[305],"during":[306],"this":[307],"0.5":[312],"cm3.":[313],"Our":[314],"data":[315],"suggest":[316],"certain":[319],"is":[323,336],"required":[324],"maintenance":[326],"stem":[329],"cell-like":[330],"TICs.":[334],"This":[335],"consistent":[337],"signal":[340],"transducing":[341],"within":[345],"non-canonical":[347],"wnt":[348],"pathway":[349],"(Maetzel":[350],"al.":[352],"2009;":[353],"Nature":[354],"Cell":[355],"Biol.":[356],"11:":[357],"162-171),":[358],"process":[362],"EMT":[364],"cells.":[368],"Citation":[369],"Format:":[370],"{Authors}.":[371],"{Abstract":[372],"title}":[373],"[abstract].":[374],"In:":[375],"Proceedings":[376],"102nd":[379],"Annual":[380],"Meeting":[381],"American":[384],"Association":[385],"Cancer":[387,397],"Research;":[388],"2011":[389],"Apr":[390],"2-6;":[391],"Orlando,":[392],"FL.":[393],"Philadelphia":[394],"(PA):":[395],"AACR;":[396],"Res":[398],"2011;71(8":[399],"Suppl):Abstract":[400],"nr":[401],"1790.":[402],"doi:10.1158/1538-7445.AM2011-1790":[403]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-09-23T05:00:35.095934","created_date":"2016-06-24T00:00:00"}