{"id":"https://openalex.org/W2010544239","doi":"https://doi.org/10.1111/j.1600-0854.2010.01059.x","title":"Tec-Kinase-Mediated Phosphorylation of Fibroblast Growth Factor 2 is Essential for Unconventional Secretion","display_name":"Tec-Kinase-Mediated Phosphorylation of Fibroblast Growth Factor 2 is Essential for Unconventional Secretion","publication_year":2010,"publication_date":"2010-03-10","ids":{"openalex":"https://openalex.org/W2010544239","doi":"https://doi.org/10.1111/j.1600-0854.2010.01059.x","mag":"2010544239","pmid":"https://pubmed.ncbi.nlm.nih.gov/20230531"},"language":"en","primary_location":{"id":"doi:10.1111/j.1600-0854.2010.01059.x","doi":"https://doi.org/10.1111/j.1600-0854.2010.01059.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1600-0854.2010.01059.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1600-0854.2010.01059.x","source":{"id":"https://openalex.org/S174148068","display_name":"Traffic","issn_l":"1398-9219","issn":["1398-9219","1600-0854"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Traffic","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1600-0854.2010.01059.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046095673","display_name":"Antje Ebert","orcid":"https://orcid.org/0000-0002-3642-242X","observed_orcids":["https://orcid.org/0000-0002-3642-242X"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Antje D. Ebert","raw_affiliation_strings":["Heidelberg University Biochemistry Center; Im Neuenheimer Feld 328, 69120; Heidelberg; Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heidelberg University Biochemistry Center; Im Neuenheimer Feld 328, 69120; Heidelberg; Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045105637","display_name":"Mareike Lau\u00dfmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mareike Lau\u00dfmann","raw_affiliation_strings":["Heidelberg University Biochemistry Center; Im Neuenheimer Feld 328, 69120; Heidelberg; Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heidelberg University Biochemistry Center; Im Neuenheimer Feld 328, 69120; Heidelberg; Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065802674","display_name":"Sabine Wegehingel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sabine Wegehingel","raw_affiliation_strings":["Heidelberg University Biochemistry Center; Im Neuenheimer Feld 328, 69120; Heidelberg; Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heidelberg University Biochemistry Center; Im Neuenheimer Feld 328, 69120; Heidelberg; Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049849598","display_name":"Lars Kaderali","orcid":"https://orcid.org/0000-0002-2359-2294","observed_orcids":["https://orcid.org/0000-0002-2359-2294"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lars Kaderali","raw_affiliation_strings":["Bioquant-Zentrum, Heidelberg University, 69120 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioquant-Zentrum, Heidelberg University, 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026842723","display_name":"Holger Erfle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Holger Erfle","raw_affiliation_strings":["Bioquant-Zentrum, Heidelberg University, 69120 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioquant-Zentrum, Heidelberg University, 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010379694","display_name":"J\u00fcrgen Reichert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J\u00fcrgen Reichert","raw_affiliation_strings":["Heidelberg University Biochemistry Center; Im Neuenheimer Feld 328, 69120; Heidelberg; Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heidelberg University Biochemistry Center; Im Neuenheimer Feld 328, 69120; Heidelberg; Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110128896","display_name":"Johannes Lechner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Johannes Lechner","raw_affiliation_strings":["Heidelberg University Biochemistry Center; Im Neuenheimer Feld 328, 69120; Heidelberg; Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heidelberg University Biochemistry Center; Im Neuenheimer Feld 328, 69120; Heidelberg; Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017961900","display_name":"Hans\u2010Dietmar Beer","orcid":"https://orcid.org/0000-0002-8085-713X","observed_orcids":["https://orcid.org/0000-0002-8085-713X","https://orcid.org/0000-0001-9932-4045"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Hans-Dietmar Beer","raw_affiliation_strings":["Institute of Cell Biology, Department of Biology, ETH Zu\u0308rich, CH-8093 Zurich, Switzerland","Institute of Cell Biology, Department of Biology, ETH Z\u00fcrich CH-8093 Z\u00fcrich Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cell Biology, Department of Biology, ETH Zu\u0308rich, CH-8093 Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"Institute of Cell Biology, Department of Biology, ETH Z\u00fcrich CH-8093 Z\u00fcrich Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017298007","display_name":"Rainer Pepperkok","orcid":"https://orcid.org/0000-0002-9762-3583","observed_orcids":["https://orcid.org/0000-0002-9762-3583","https://orcid.org/0000-0001-9105-6381"]},"institutions":[{"id":"https://openalex.org/I4210138560","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/03mstc592","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rainer Pepperkok","raw_affiliation_strings":["European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany","institution_ids":["https://openalex.org/I4210138560"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019049417","display_name":"Walter Nickel","orcid":"https://orcid.org/0000-0002-6496-8286","observed_orcids":["https://orcid.org/0000-0002-6496-8286"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Walter Nickel","raw_affiliation_strings":["Heidelberg University Biochemistry Center; Im Neuenheimer Feld 328, 69120; Heidelberg; Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heidelberg University Biochemistry Center; Im Neuenheimer Feld 328, 69120; Heidelberg; Germany","institution_ids":["https://openalex.org/I223822909"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5019049417"],"corresponding_institution_ids":["https://openalex.org/I223822909"],"apc_list":{"value":4650,"currency":"USD","value_usd":4650},"apc_paid":null,"fwci":1.4867,"has_fulltext":true,"cited_by_count":88,"citation_normalized_percentile":{"value":0.8021307,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"11","issue":"6","first_page":"813","last_page":"826"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.016599999740719795,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tec-kinase","display_name":"Tec kinase","score":0.8209999799728394},{"id":"https://openalex.org/keywords/fibroblast-growth-factor-2","display_name":"fibroblast growth factor 2","score":0.9829999804496765},{"id":"https://openalex.org/keywords/unconventional-protein-secretion","display_name":"unconventional secretion","score":0.9580000042915344},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.8830000162124634},{"id":"https://openalex.org/keywords/membrane-translocation","display_name":"membrane translocation","score":0.8610000014305115},{"id":"https://openalex.org/keywords/phosphatidylinositol-4-5-bisphosphate","display_name":"phosphatidylinositol 4,5-bisphosphate","score":0.9210000038146973},{"id":"https://openalex.org/keywords/heparan-sulfate-proteoglycans","display_name":"heparan sulfate proteoglycans","score":0.9919999837875366},{"id":"https://openalex.org/keywords/rnai-screening","display_name":"RNAi screening","score":0.6510000228881836},{"id":"https://openalex.org/keywords/antiangiogenic-drugs","display_name":"antiangiogenic drugs","score":0.8510000109672546},{"id":"https://openalex.org/keywords/tyrosine-kinase-signaling","display_name":"tyrosine kinase signaling","score":0.5329999923706055}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7897487878799438},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6743471026420593},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.6376882791519165},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.5956896543502808},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.5795440077781677},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5258501172065735},{"id":"https://openalex.org/C119062480","wikidata":"https://www.wikidata.org/wiki/Q83181","display_name":"Golgi apparatus","level":3,"score":0.5122219920158386},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.4590434432029724},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.44516393542289734},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3848559260368347},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2813416123390198},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016475","descriptor_name":"3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019269","descriptor_name":"Phosphatidylinositol 4,5-Diphosphate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1111/j.1600-0854.2010.01059.x","doi":"https://doi.org/10.1111/j.1600-0854.2010.01059.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1600-0854.2010.01059.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1600-0854.2010.01059.x","source":{"id":"https://openalex.org/S174148068","display_name":"Traffic","issn_l":"1398-9219","issn":["1398-9219","1600-0854"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Traffic","raw_type":"journal-article"},{"id":"pmid:20230531","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20230531","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Traffic (Copenhagen, Denmark)","raw_type":"Journal Article"},{"id":"pmh:oai:www.zora.uzh.ch:41840","doi":null,"is_oa":false,"landing_page_url":"https://www.zora.uzh.ch/id/eprint/41840/1/Ebert_AD_et_al._-_Traffic_2010.pdf","pdf_url":"https://www.zora.uzh.ch/id/eprint/41840/1/Ebert_AD_et_al._-_Traffic_2010.pdf","source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Ebert, A D; Laussmann, M; Wegehingel, S; Kaderali, L; Erfle, H; Reichert, J; Lechner, J; Beer, H D; Pepperkok, R; Nickel, W (2010). Tec-kinase-mediated phosphorylation of fibroblast growth factor 2 is essential for unconventional secretion. Traffic, 11(6):813-86.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:www.zora.uzh.ch:20.500.14742/56785","doi":null,"is_oa":false,"landing_page_url":"https://www.zora.uzh.ch/handle/20.500.14742/56785","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Ebert, A. D., Laussmann, M., Wegehingel, S., Kaderali, L., Erfle, H., Reichert, J., Lechner, J., Beer, H. D., Pepperkok, R., & Nickel, W. (2010). Tec-kinase-mediated phosphorylation of fibroblast growth factor 2 is essential for unconventional secretion. Traffic, 11, 813\u2013886. https://doi.org/10.1111/j.1600-0854.2010.01059.x","raw_type":"Journal Article"},{"id":"doi:10.5167/uzh-41840","doi":"https://doi.org/10.5167/uzh-41840","is_oa":true,"landing_page_url":"https://doi.org/10.5167/uzh-41840","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1111/j.1600-0854.2010.01059.x","doi":"https://doi.org/10.1111/j.1600-0854.2010.01059.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1600-0854.2010.01059.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1600-0854.2010.01059.x","source":{"id":"https://openalex.org/S174148068","display_name":"Traffic","issn_l":"1398-9219","issn":["1398-9219","1600-0854"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Traffic","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.46810001134872437,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1844135813","display_name":null,"funder_award_id":"GRK 1188","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G3314513464","display_name":null,"funder_award_id":"SFB 638","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320301","display_name":"European Science Foundation","ror":"https://ror.org/04esata81"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2010544239.pdf","grobid_xml":"https://content.openalex.org/works/W2010544239.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W121387658","https://openalex.org/W155527741","https://openalex.org/W1507317291","https://openalex.org/W1576409357","https://openalex.org/W1607784912","https://openalex.org/W1624946627","https://openalex.org/W1836834096","https://openalex.org/W1875008703","https://openalex.org/W1920060813","https://openalex.org/W1968465516","https://openalex.org/W1987764545","https://openalex.org/W1994125744","https://openalex.org/W1995622771","https://openalex.org/W2003594531","https://openalex.org/W2004166313","https://openalex.org/W2015140940","https://openalex.org/W2024081693","https://openalex.org/W2025116006","https://openalex.org/W2028464006","https://openalex.org/W2036054611","https://openalex.org/W2036574499","https://openalex.org/W2043312574","https://openalex.org/W2044418937","https://openalex.org/W2044655036","https://openalex.org/W2049087515","https://openalex.org/W2055733223","https://openalex.org/W2058917763","https://openalex.org/W2060424984","https://openalex.org/W2065330071","https://openalex.org/W2065635384","https://openalex.org/W2075043312","https://openalex.org/W2085678099","https://openalex.org/W2090610760","https://openalex.org/W2091884933","https://openalex.org/W2092249847","https://openalex.org/W2100358971","https://openalex.org/W2103063095","https://openalex.org/W2103890955","https://openalex.org/W2107773259","https://openalex.org/W2117004224","https://openalex.org/W2119743134","https://openalex.org/W2128040025","https://openalex.org/W2130461300","https://openalex.org/W2134283668","https://openalex.org/W2135661313","https://openalex.org/W2136124244","https://openalex.org/W2143811153","https://openalex.org/W2150280909","https://openalex.org/W2150351373","https://openalex.org/W2152255514","https://openalex.org/W2161750451","https://openalex.org/W2162424885","https://openalex.org/W2165623503","https://openalex.org/W2167249865","https://openalex.org/W2167303139","https://openalex.org/W2168117857","https://openalex.org/W2171431333"],"related_works":["https://openalex.org/W2734959416","https://openalex.org/W2460557882","https://openalex.org/W2163952331","https://openalex.org/W6922081981","https://openalex.org/W4211000982","https://openalex.org/W2058917763","https://openalex.org/W2036054611","https://openalex.org/W2138757496","https://openalex.org/W2016618099","https://openalex.org/W2059307851"],"abstract_inverted_index":{"Fibroblast":[0],"growth":[1],"factor":[2,87],"2":[3],"(FGF2)":[4],"is":[5,10],"a":[6,31,74,85,108,121,138,155,162],"potent":[7],"mitogen":[8],"that":[9,33],"exported":[11],"from":[12],"cells":[13],"by":[14,25,101],"an":[15,102],"endoplasmic":[16],"reticulum":[17],"(ER)/Golgi-independent":[18],"mechanism.":[19],"Unconventional":[20],"secretion":[21,91,100,147],"of":[22,55,64,92,116,161,165,171],"FGF2":[23,66,99,112,117,129,146],"occurs":[24],"direct":[26],"translocation":[27,131],"across":[28],"plasma":[29,56],"membranes,":[30],"process":[32],"depends":[34],"on":[35],"the":[36,42,52,65,159,169,172],"phosphoinositide":[37],"phosphatidylinositol":[38],"4,5-biphosphate":[39],"(PI(4,5)P(2))":[40],"at":[41,51,118],"inner":[43],"leaflet":[44,54],"as":[45,47,84],"well":[46],"heparan":[48],"sulfate":[49],"proteoglycans":[50],"outer":[53],"membranes;":[57],"however,":[58],"additional":[59],"core":[60],"and":[61],"regulatory":[62],"components":[63],"export":[67],"machinery":[68],"have":[69],"remained":[70],"elusive.":[71],"Here,":[72],"using":[73],"highly":[75],"effective":[76],"RNAi":[77],"screening":[78],"approach,":[79],"we":[80],"discovered":[81],"Tec":[82,94,142],"kinase":[83,95,143],"novel":[86,163],"involved":[88],"in":[89,114,144],"unconventional":[90],"FGF2.":[93],"does":[96],"not":[97],"affect":[98],"indirect":[103],"mechanism,":[104],"but":[105],"rather":[106],"forms":[107],"heterodimeric":[109],"complex":[110],"with":[111],"resulting":[113],"phosphorylation":[115],"tyrosine":[119],"82,":[120],"post-translational":[122],"modification":[123],"shown":[124],"to":[125,132],"be":[126],"essential":[127],"for":[128,141,158],"membrane":[130],"cell":[133],"surfaces.":[134],"Our":[135],"findings":[136],"suggest":[137],"crucial":[139],"role":[140],"regulating":[145],"under":[148],"various":[149],"physiological":[150],"conditions":[151],"and,":[152],"therefore,":[153],"provide":[154],"new":[156],"perspective":[157],"development":[160],"class":[164],"antiangiogenic":[166],"drugs":[167],"targeting":[168],"formation":[170],"FGF2/Tec":[173],"complex.":[174]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
