{"id":"https://openalex.org/W2010543192","doi":"https://doi.org/10.3402/fnr.v59.25866","title":"Arachidonic acid has a dominant effect to regulate lipogenic genes in 3T3-L1 adipocytes compared to omega-3 fatty acids","display_name":"Arachidonic acid has a dominant effect to regulate lipogenic genes in 3T3-L1 adipocytes compared to omega-3 fatty acids","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2010543192","doi":"https://doi.org/10.3402/fnr.v59.25866","mag":"2010543192","pmid":"https://pubmed.ncbi.nlm.nih.gov/25797050","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4369559"},"language":"en","primary_location":{"id":"doi:10.3402/fnr.v59.25866","doi":"https://doi.org/10.3402/fnr.v59.25866","is_oa":true,"landing_page_url":"https://doi.org/10.3402/fnr.v59.25866","pdf_url":"https://foodandnutritionresearch.net/index.php/fnr/article/download/827/2634","source":{"id":"https://openalex.org/S199424200","display_name":"Food & Nutrition Research","issn_l":"1654-661X","issn":["1654-661X","1654-6628"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317151","host_organization_name":"Swedish Nutrition Foundation","host_organization_lineage":["https://openalex.org/P4310317151"],"host_organization_lineage_names":["Swedish Nutrition Foundation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food &amp; Nutrition Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://foodandnutritionresearch.net/index.php/fnr/article/download/827/2634","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036655502","display_name":"Hitesh B. Vaidya","orcid":"https://orcid.org/0000-0002-2346-8023","observed_orcids":["https://orcid.org/0000-0002-2346-8023"]},"institutions":[{"id":"https://openalex.org/I130438778","display_name":"Memorial University of Newfoundland","ror":"https://ror.org/04haebc03","country_code":"CA","type":"education","lineage":["https://openalex.org/I130438778"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Hitesh Vaidya","raw_affiliation_strings":["Department of Biochemistry, Memorial University, St. John's, NL, Canada","Department of Biochemistry, Memorial University, St. John's, NL A1B3X9, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Memorial University, St. John's, NL, Canada","institution_ids":["https://openalex.org/I130438778"]},{"raw_affiliation_string":"Department of Biochemistry, Memorial University, St. John's, NL A1B3X9, Canada","institution_ids":["https://openalex.org/I130438778"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025216670","display_name":"Sukhinder Kaur Cheema","orcid":"https://orcid.org/0000-0002-4806-7648","observed_orcids":["https://orcid.org/0000-0002-4806-7648"]},"institutions":[{"id":"https://openalex.org/I130438778","display_name":"Memorial University of Newfoundland","ror":"https://ror.org/04haebc03","country_code":"CA","type":"education","lineage":["https://openalex.org/I130438778"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Sukhinder Kaur Cheema","raw_affiliation_strings":["Department of Biochemistry, Memorial University, St. John's, NL, Canada; skaur@mun.ca","#N#Memorial University#N#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Memorial University, St. John's, NL, Canada; skaur@mun.ca","institution_ids":["https://openalex.org/I130438778"]},{"raw_affiliation_string":"#N#Memorial University#N#","institution_ids":["https://openalex.org/I130438778"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5025216670"],"corresponding_institution_ids":["https://openalex.org/I130438778"],"apc_list":{"value":1950,"currency":"EUR","value_usd":2103},"apc_paid":{"value":1950,"currency":"EUR","value_usd":2103},"fwci":2.602,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.87465452,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"59","issue":"1","first_page":"25866","last_page":"25866"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arachidonic-acid","display_name":"arachidonic acid","score":1.0},{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":0.9700000286102295},{"id":"https://openalex.org/keywords/eicosapentaenoic-acid","display_name":"eicosapentaenoic acid","score":0.8700000047683716},{"id":"https://openalex.org/keywords/docosahexaenoic-acid","display_name":"docosahexaenoic acid","score":1.0},{"id":"https://openalex.org/keywords/docosapentaenoic-acid","display_name":"docosapentaenoic acid","score":0.996999979019165},{"id":"https://openalex.org/keywords/3t3-l1-adipocytes","display_name":"3T3-L1 adipocytes","score":0.9440000057220459},{"id":"https://openalex.org/keywords/lipogenic-gene-expression","display_name":"lipogenic gene expression","score":0.8299999833106995},{"id":"https://openalex.org/keywords/adipogenic-gene-expression","display_name":"adipogenic gene expression","score":0.9620000123977661},{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":0.8920000195503235},{"id":"https://openalex.org/keywords/acetyl-coa-carboxylase-1","display_name":"acetyl-CoA carboxylase 1","score":0.9940000176429749},{"id":"https://openalex.org/keywords/stearoyl-coa-desaturase-1","display_name":"stearoyl-CoA desaturase 1","score":0.996999979019165},{"id":"https://openalex.org/keywords/fatty-acid-composition","display_name":"fatty acid composition","score":0.7149999737739563},{"id":"https://openalex.org/keywords/omega-6-fatty-acids","display_name":"omega-6 fatty acids","score":0.847000002861023}],"concepts":[{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.7102745771408081},{"id":"https://openalex.org/C2779557605","wikidata":"https://www.wikidata.org/wiki/Q9890","display_name":"Omega","level":2,"score":0.6014554500579834},{"id":"https://openalex.org/C141359234","wikidata":"https://www.wikidata.org/wiki/Q2734301","display_name":"Lipogenesis","level":3,"score":0.5721714496612549},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5235728621482849},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5019021034240723},{"id":"https://openalex.org/C3017514745","wikidata":"https://www.wikidata.org/wiki/Q191756","display_name":"Omega 3 fatty acid","level":5,"score":0.48124027252197266},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4248884916305542},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.4155643582344055},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4146914482116699},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34608665108680725},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3351946473121643},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2825372815132141},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.22777295112609863},{"id":"https://openalex.org/C2777171753","wikidata":"https://www.wikidata.org/wiki/Q423345","display_name":"Docosahexaenoic acid","level":4,"score":0.19198766350746155},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.05830767750740051},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3402/fnr.v59.25866","doi":"https://doi.org/10.3402/fnr.v59.25866","is_oa":true,"landing_page_url":"https://doi.org/10.3402/fnr.v59.25866","pdf_url":"https://foodandnutritionresearch.net/index.php/fnr/article/download/827/2634","source":{"id":"https://openalex.org/S199424200","display_name":"Food & Nutrition Research","issn_l":"1654-661X","issn":["1654-661X","1654-6628"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317151","host_organization_name":"Swedish Nutrition Foundation","host_organization_lineage":["https://openalex.org/P4310317151"],"host_organization_lineage_names":["Swedish Nutrition Foundation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food &amp; Nutrition Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3348117","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4369559","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:25797050","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25797050","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food & nutrition research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4369559","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4369559/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food Nutr Res","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.788.386","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.788.386","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/09/b9/FNR-59-25866.PMC4369559.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:1d83fd00e8964f9984fb7adb5f89a0fb","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/1d83fd00e8964f9984fb7adb5f89a0fb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Food & Nutrition Research, Vol 59, Iss 0, Pp 1-6 (2015)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3402/fnr.v59.25866","doi":"https://doi.org/10.3402/fnr.v59.25866","is_oa":true,"landing_page_url":"https://doi.org/10.3402/fnr.v59.25866","pdf_url":"https://foodandnutritionresearch.net/index.php/fnr/article/download/827/2634","source":{"id":"https://openalex.org/S199424200","display_name":"Food & Nutrition Research","issn_l":"1654-661X","issn":["1654-661X","1654-6628"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317151","host_organization_name":"Swedish Nutrition Foundation","host_organization_lineage":["https://openalex.org/P4310317151"],"host_organization_lineage_names":["Swedish Nutrition Foundation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food &amp; Nutrition Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2010543192.pdf","grobid_xml":"https://content.openalex.org/works/W2010543192.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W563893807","https://openalex.org/W1759653963","https://openalex.org/W1878535762","https://openalex.org/W1966509583","https://openalex.org/W1980383860","https://openalex.org/W1981091569","https://openalex.org/W2011044890","https://openalex.org/W2014253275","https://openalex.org/W2014259643","https://openalex.org/W2027442810","https://openalex.org/W2030207960","https://openalex.org/W2045159219","https://openalex.org/W2048047917","https://openalex.org/W2048952408","https://openalex.org/W2051648756","https://openalex.org/W2072462257","https://openalex.org/W2074978486","https://openalex.org/W2086518575","https://openalex.org/W2093139675","https://openalex.org/W2096926867","https://openalex.org/W2100331269","https://openalex.org/W2114874359","https://openalex.org/W2121574656","https://openalex.org/W2133537554","https://openalex.org/W2136075519","https://openalex.org/W2143789137","https://openalex.org/W2146433346","https://openalex.org/W2147332639","https://openalex.org/W2156190198","https://openalex.org/W2166487029","https://openalex.org/W2168526937","https://openalex.org/W2216457179","https://openalex.org/W2324387122","https://openalex.org/W4211260120"],"related_works":["https://openalex.org/W7098175674","https://openalex.org/W2161378092","https://openalex.org/W1952797651","https://openalex.org/W2011044890","https://openalex.org/W2339795481","https://openalex.org/W2359027752","https://openalex.org/W2586094565","https://openalex.org/W2051255852","https://openalex.org/W2090413485","https://openalex.org/W2349922588"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,114,124],"effects":[2,54],"of":[3,15,35,40,55,68,87,90,117,128,148,175,186,215,220,226,245],"long-chain":[4],"n-3":[5,56,137,192,230],"and":[6,58,70,100,119,153,165,169,204],"n-6":[7,63],"polyunsaturated":[8],"fatty":[9,22,42,125],"acids":[10,23,43,218],"(PUFA)":[11],"on":[12,65,144,242],"the":[13,32,38,53,66,83,145,158,172,183,243],"regulation":[14,34,67,244],"adipocytes":[16,36,79,129,221],"metabolism":[17],"are":[18,24],"well":[19],"known.":[20,49],"These":[21],"generally":[25],"consumed":[26],"together":[27,46],"in":[28,37,73,82,248],"our":[29],"diets;":[30],"however,":[31,151],"metabolic":[33],"presence":[39,84],"these":[41],"when":[44],"given":[45],"is":[47],"not":[48],"OBJECTIVE:":[50],"To":[51],"investigate":[52],"PUFA":[57,138],"arachidonic":[59],"acid":[60,126],"(AA),":[61],"an":[62],"PUFA,":[64,193],"adipogenic":[69,118],"lipogenic":[71,120,246],"genes":[72,121,247],"mature":[74],"3T3-L1":[75,78],"adipocytes.":[76,249],"METHODS:":[77],"were":[80],"incubated":[81],"or":[85,104,139],"absence":[86],"100":[88],"\u00b5M":[89],"eicosapentaenoic":[91],"acid,":[92,95,98],"EPA;":[93],"docosahexaenoic":[94],"DHA;":[96],"docosapentaenoic":[97],"DPA":[99],"AA,":[101],"either":[102],"alone":[103],"AA+n-3":[105],"PUFA;":[106],"control":[107,162,201],"cells":[108,163],"received":[109],"bovine":[110],"serum":[111],"albumin":[112],"alone.":[113],"mRNA":[115,146,173,184],"expression":[116,147,159,174,185,209],"was":[122,130],"measured.":[123],"composition":[127],"analyzed":[131],"using":[132],"gas":[133],"chromatography.":[134],"RESULTS:":[135],"Individual":[136],"AA":[140,168,180,227,237],"had":[141,196],"no":[142,197],"effect":[143,198,214,241],"peroxisome-proliferator-activated":[149],"receptor-\u03b3;":[150],"AA+EPA":[152,170],"AA+DPA":[154,205],"significantly":[155],"increased":[156,171],"(P<0.05)":[157,210],"compared":[160,199,228],"to":[161,200,229],"(38":[164],"42%,":[166],"respectively).":[167],"acetyl-CoA":[176],"carboxylase":[177],"1":[178],"(P<0.05).":[179],"treatment":[181],"decreased":[182],"stearoyl-CoA":[187],"desaturase":[188],"(SCD1)":[189],"(P<0.01),":[190],"while":[191],"except":[194],"EPA,":[195],"cells.":[202],"AA+DHA":[203],"inhibited":[206],"SCD1":[207],"gene":[208],"suggesting":[211],"a":[212,223,239],"dominant":[213,240],"AA.":[216],"Fatty":[217],"analysis":[219],"revealed":[222],"higher":[224],"accretion":[225],"PUFA.":[231],"CONCLUSIONS:":[232],"Our":[233],"findings":[234],"reveal":[235],"that":[236],"has":[238]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
