{"id":"https://openalex.org/W2010535718","doi":"https://doi.org/10.3892/ijo.2.6.1063","title":"COMBINED POSTOPERATIVE RADIOTHERAPY AND PCV-CHEMOTHERAPY (CCNU, PROCARBAZINE AND VINCRISTINE) IN MANAGING ANAPLASTIC ASTROCYTOMA - A REPORT OF A LONG-TERM FOLLOW-UP","display_name":"COMBINED POSTOPERATIVE RADIOTHERAPY AND PCV-CHEMOTHERAPY (CCNU, PROCARBAZINE AND VINCRISTINE) IN MANAGING ANAPLASTIC ASTROCYTOMA - A REPORT OF A LONG-TERM FOLLOW-UP","publication_year":1993,"publication_date":"1993-06-01","ids":{"openalex":"https://openalex.org/W2010535718","doi":"https://doi.org/10.3892/ijo.2.6.1063","mag":"2010535718","pmid":"https://pubmed.ncbi.nlm.nih.gov/21573672"},"language":"en","primary_location":{"id":"doi:10.3892/ijo.2.6.1063","doi":"https://doi.org/10.3892/ijo.2.6.1063","is_oa":false,"landing_page_url":"https://doi.org/10.3892/ijo.2.6.1063","pdf_url":null,"source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111645287","display_name":"IG Ron","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2799807261","display_name":"Tel Aviv Sourasky Medical Center","ror":"https://ror.org/04nd58p63","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799807261"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"IG RON","raw_affiliation_strings":["TEL AVIV UNIV,TEL AVIV SOURASKY MED CTR,DEPT ONCOL,IL-69978 TEL AVIV,ISRAEL. TEL AVIV UNIV,SACKLER FAC MED,IL-69978 TEL AVIV,ISRAEL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TEL AVIV UNIV,TEL AVIV SOURASKY MED CTR,DEPT ONCOL,IL-69978 TEL AVIV,ISRAEL. TEL AVIV UNIV,SACKLER FAC MED,IL-69978 TEL AVIV,ISRAEL","institution_ids":["https://openalex.org/I16391192","https://openalex.org/I2799807261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042722799","display_name":"Neli Wigler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2799807261","display_name":"Tel Aviv Sourasky Medical Center","ror":"https://ror.org/04nd58p63","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799807261"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"N WIGLER","raw_affiliation_strings":["TEL AVIV UNIV,TEL AVIV SOURASKY MED CTR,DEPT ONCOL,IL-69978 TEL AVIV,ISRAEL. TEL AVIV UNIV,SACKLER FAC MED,IL-69978 TEL AVIV,ISRAEL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TEL AVIV UNIV,TEL AVIV SOURASKY MED CTR,DEPT ONCOL,IL-69978 TEL AVIV,ISRAEL. TEL AVIV UNIV,SACKLER FAC MED,IL-69978 TEL AVIV,ISRAEL","institution_ids":["https://openalex.org/I16391192","https://openalex.org/I2799807261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042644689","display_name":"Felix Kovner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2799807261","display_name":"Tel Aviv Sourasky Medical Center","ror":"https://ror.org/04nd58p63","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799807261"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"F KOVNER","raw_affiliation_strings":["TEL AVIV UNIV,TEL AVIV SOURASKY MED CTR,DEPT ONCOL,IL-69978 TEL AVIV,ISRAEL. TEL AVIV UNIV,SACKLER FAC MED,IL-69978 TEL AVIV,ISRAEL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TEL AVIV UNIV,TEL AVIV SOURASKY MED CTR,DEPT ONCOL,IL-69978 TEL AVIV,ISRAEL. TEL AVIV UNIV,SACKLER FAC MED,IL-69978 TEL AVIV,ISRAEL","institution_ids":["https://openalex.org/I16391192","https://openalex.org/I2799807261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041214836","display_name":"Moshe Inbar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2799807261","display_name":"Tel Aviv Sourasky Medical Center","ror":"https://ror.org/04nd58p63","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799807261"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"M INBAR","raw_affiliation_strings":["TEL AVIV UNIV,TEL AVIV SOURASKY MED CTR,DEPT ONCOL,IL-69978 TEL AVIV,ISRAEL. TEL AVIV UNIV,SACKLER FAC MED,IL-69978 TEL AVIV,ISRAEL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TEL AVIV UNIV,TEL AVIV SOURASKY MED CTR,DEPT ONCOL,IL-69978 TEL AVIV,ISRAEL. TEL AVIV UNIV,SACKLER FAC MED,IL-69978 TEL AVIV,ISRAEL","institution_ids":["https://openalex.org/I16391192","https://openalex.org/I2799807261"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081964253","display_name":"Samario Chaitchik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2799807261","display_name":"Tel Aviv Sourasky Medical Center","ror":"https://ror.org/04nd58p63","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799807261"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"S CHAITCHIK","raw_affiliation_strings":["TEL AVIV UNIV,TEL AVIV SOURASKY MED CTR,DEPT ONCOL,IL-69978 TEL AVIV,ISRAEL. TEL AVIV UNIV,SACKLER FAC MED,IL-69978 TEL AVIV,ISRAEL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TEL AVIV UNIV,TEL AVIV SOURASKY MED CTR,DEPT ONCOL,IL-69978 TEL AVIV,ISRAEL. TEL AVIV UNIV,SACKLER FAC MED,IL-69978 TEL AVIV,ISRAEL","institution_ids":["https://openalex.org/I16391192","https://openalex.org/I2799807261"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.08591304,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2","issue":"6","first_page":"1063","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11251","display_name":"Meningioma and schwannoma management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anaplastic-astrocytoma","display_name":"anaplastic astrocytoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/postoperative-radiotherapy","display_name":"postoperative radiotherapy","score":0.9860000014305115},{"id":"https://openalex.org/keywords/pcv-chemotherapy","display_name":"PCV chemotherapy","score":0.9629999995231628},{"id":"https://openalex.org/keywords/lomustine","display_name":"lomustine","score":0.7710000276565552},{"id":"https://openalex.org/keywords/procarbazine","display_name":"procarbazine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/vincristine","display_name":"vincristine","score":0.9900000095367432},{"id":"https://openalex.org/keywords/long-term-survival","display_name":"long-term survival","score":0.8849999904632568},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9990000128746033},{"id":"https://openalex.org/keywords/age","display_name":"age","score":0.6230000257492065},{"id":"https://openalex.org/keywords/performance-status","display_name":"performance status","score":0.9100000262260437},{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.5139999985694885}],"concepts":[{"id":"https://openalex.org/C2779112685","wikidata":"https://www.wikidata.org/wiki/Q418656","display_name":"Procarbazine","level":5,"score":0.9722882509231567},{"id":"https://openalex.org/C2779434656","wikidata":"https://www.wikidata.org/wiki/Q415378","display_name":"Lomustine","level":5,"score":0.8857986927032471},{"id":"https://openalex.org/C2779429289","wikidata":"https://www.wikidata.org/wiki/Q408977","display_name":"Vincristine","level":4,"score":0.7965540885925293},{"id":"https://openalex.org/C2779083369","wikidata":"https://www.wikidata.org/wiki/Q486092","display_name":"Anaplastic astrocytoma","level":4,"score":0.692071795463562},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6710624694824219},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6233887076377869},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.620943546295166},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5489642024040222},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5206812620162964},{"id":"https://openalex.org/C2778880634","wikidata":"https://www.wikidata.org/wiki/Q177755","display_name":"Astrocytoma","level":3,"score":0.496907502412796},{"id":"https://openalex.org/C67082663","wikidata":"https://www.wikidata.org/wiki/Q3523816","display_name":"Molecular medicine","level":4,"score":0.4646420478820801},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.4569542407989502},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.37890541553497314},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.20084238052368164},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.17574280500411987},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.16425785422325134},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.09001848101615906}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3892/ijo.2.6.1063","doi":"https://doi.org/10.3892/ijo.2.6.1063","is_oa":false,"landing_page_url":"https://doi.org/10.3892/ijo.2.6.1063","pdf_url":null,"source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},{"id":"pmid:21573672","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21573672","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2125753345","https://openalex.org/W2327393891","https://openalex.org/W2074800003","https://openalex.org/W2163342290","https://openalex.org/W2421870731","https://openalex.org/W7097152814","https://openalex.org/W2029606592","https://openalex.org/W2161906126","https://openalex.org/W2127609491","https://openalex.org/W57774435"],"abstract_inverted_index":{"Postoperative":[0],"radiotherapy":[1],"together":[2],"with":[3,14,26],"CCNU,":[4],"procarbazine":[5],"and":[6,46],"vincristine":[7],"(PCV-chemotherapy":[8],"regimen)":[9],"were":[10],"analysed":[11],"in":[12,54,59],"patients":[13],"histologically":[15],"confirmed":[16,58],"anaplastic":[17],"astrocytoma.":[18],"This":[19],"report":[20],"evaluates":[21],"the":[22,38],"long-term":[23],"survival":[24,43],"correlated":[25],"important":[27,51],"prognostic":[28,52],"variables.":[29],"Patients":[30],"who":[31],"received":[32],"more":[33],"than":[34],"6":[35],"courses":[36],"of":[37],"PCV-chemotherapy":[39],"had":[40],"significantly":[41],"longer":[42],"(P=0.03).":[44],"Age":[45],"performance":[47],"status,":[48],"identified":[49],"as":[50],"factors":[53],"previous":[55],"studies,":[56],"are":[57],"this":[60],"analysis.":[61]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}