{"id":"https://openalex.org/W2010528412","doi":"https://doi.org/10.1093/carcin/5.6.735","title":"Interaction of epidermal growth factor with basal and differentiating epidermal cells of mice resistant and sensitive to carcinogenesis","display_name":"Interaction of epidermal growth factor with basal and differentiating epidermal cells of mice resistant and sensitive to carcinogenesis","publication_year":1984,"publication_date":"1984-01-01","ids":{"openalex":"https://openalex.org/W2010528412","doi":"https://doi.org/10.1093/carcin/5.6.735","mag":"2010528412","pmid":"https://pubmed.ncbi.nlm.nih.gov/6327111"},"language":"en","primary_location":{"id":"doi:10.1093/carcin/5.6.735","doi":"https://doi.org/10.1093/carcin/5.6.735","is_oa":false,"landing_page_url":"https://doi.org/10.1093/carcin/5.6.735","pdf_url":null,"source":{"id":"https://openalex.org/S184620562","display_name":"Carcinogenesis","issn_l":"0143-3334","issn":["0143-3334","1460-2180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027569768","display_name":"James E. Strickland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James E. Strickland","raw_affiliation_strings":["Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer InstituteBethesda, MD 20205, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer InstituteBethesda, MD 20205, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007501845","display_name":"Anton M. Jetten","orcid":"https://orcid.org/0000-0003-0954-4445","observed_orcids":["https://orcid.org/0000-0003-0954-4445"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anton M. Jetten","raw_affiliation_strings":["Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute Bethesda, MD 20205, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute Bethesda, MD 20205, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008059577","display_name":"Hideki Kawamura","orcid":"https://orcid.org/0000-0001-9073-972X","observed_orcids":["https://orcid.org/0000-0001-9073-972X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hideki Kawamura","raw_affiliation_strings":["Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute Bethesda, MD 20205, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute Bethesda, MD 20205, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045531616","display_name":"Stuart H. Yuspa","orcid":"https://orcid.org/0000-0003-4785-337X","observed_orcids":["https://orcid.org/0000-0003-4785-337X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stuart H. Yuspa","raw_affiliation_strings":["Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute Bethesda, MD 20205, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute Bethesda, MD 20205, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4835,"currency":"USD","value_usd":4835},"apc_paid":null,"fwci":1.5988,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.85589651,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"5","issue":"6","first_page":"735","last_page":"740"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epidermal-growth-factor","display_name":"epidermal growth factor","score":0.996999979019165},{"id":"https://openalex.org/keywords/egf-binding","display_name":"EGF binding","score":0.8379999995231628},{"id":"https://openalex.org/keywords/epidermal-cells","display_name":"epidermal cells","score":0.7300000190734863},{"id":"https://openalex.org/keywords/basal-cells","display_name":"basal cells","score":0.7590000033378601},{"id":"https://openalex.org/keywords/keratinocyte-differentiation","display_name":"keratinocyte differentiation","score":0.8259999752044678},{"id":"https://openalex.org/keywords/cancer-susceptibility","display_name":"cancer susceptibility","score":0.5270000100135803},{"id":"https://openalex.org/keywords/sencar-mice","display_name":"SENCAR mice","score":0.7599999904632568},{"id":"https://openalex.org/keywords/balb-c-mice","display_name":"BALB/c mice","score":0.9959999918937683},{"id":"https://openalex.org/keywords/retinoic-acid","display_name":"retinoic acid","score":0.8220000267028809},{"id":"https://openalex.org/keywords/phorbol-myristate-acetate","display_name":"phorbol myristate acetate","score":0.9639999866485596},{"id":"https://openalex.org/keywords/cell-density","display_name":"cell density","score":0.5830000042915344},{"id":"https://openalex.org/keywords/calcium-induced-differentiation","display_name":"calcium-induced differentiation","score":0.6899999976158142},{"id":"https://openalex.org/keywords/initiation-and-promotion","display_name":"initiation-promotion","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.7713335752487183},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.4945933520793915},{"id":"https://openalex.org/C98147612","wikidata":"https://www.wikidata.org/wiki/Q215599","display_name":"Promotion (chess)","level":3,"score":0.4859398603439331},{"id":"https://openalex.org/C2780122803","wikidata":"https://www.wikidata.org/wiki/Q7852681","display_name":"Tumor promotion","level":4,"score":0.46601489186286926},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4424108862876892},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3874119222164154},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.38730669021606445},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3675083518028259},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3432157635688782},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25739359855651855},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.17369723320007324},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.09784805774688721},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C94625758","wikidata":"https://www.wikidata.org/wiki/Q7163","display_name":"Politics","level":2,"score":0.0},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010704","descriptor_name":"Phorbols","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012879","descriptor_name":"Skin Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013755","descriptor_name":"Tetradecanoylphorbol Acetate","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/carcin/5.6.735","doi":"https://doi.org/10.1093/carcin/5.6.735","is_oa":false,"landing_page_url":"https://doi.org/10.1093/carcin/5.6.735","pdf_url":null,"source":{"id":"https://openalex.org/S184620562","display_name":"Carcinogenesis","issn_l":"0143-3334","issn":["0143-3334","1460-2180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"journal-article"},{"id":"pmid:6327111","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6327111","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1993801915","https://openalex.org/W2167651310","https://openalex.org/W1982615118","https://openalex.org/W2068867045","https://openalex.org/W1979143009","https://openalex.org/W2092812856","https://openalex.org/W855756485","https://openalex.org/W2292480305","https://openalex.org/W2008909453","https://openalex.org/W2024393772"],"abstract_inverted_index":{"Epidermal":[0],"growth":[1,34,199],"factor":[2],"(EGF)":[3],"interactions":[4],"with":[5,71,141],"primary":[6],"epidermal":[7,93,224],"cells":[8,78,94,106,115,126,156,225],"in":[9,13,76,109,136,146,207,236,239],"culture":[10],"were":[11,107],"examined":[12],"BALB/c":[14,221],"and":[15,20,41,56,104,164,222,228],"SENCAR":[16,223],"mice,":[17],"strains":[18,97,243],"resistant":[19],"sensitive,":[21],"respectively,":[22],"to":[23,119,131,226,229,244],"carcinogenesis":[24],"by":[25,154,161],"initiation-promotion.":[26],"Using":[27],"low":[28],"(less":[29],"than":[30,180],"0.1":[31],"mM)":[32],"calcium":[33],"conditions,":[35],"which":[36,82],"select":[37],"for":[38],"basal":[39,77,103,125,201],"cells,":[40],"calcium-induced":[42],"terminal":[43],"differentiation,":[44],"we":[45],"determined":[46],"the":[47,51,65,205,211,237],"effects":[48],"of":[49,61,79,89,95,102,124,189,195,200,204,220,231,241],"retinoids,":[50],"tumor":[52],"promoter":[53],"12-O-tetradecanoylphorbol-13-acetate":[54],"(TPA),":[55],"cell":[57,73],"density":[58,74],"on":[59],"binding":[60,69,153,208,233],"125I-labeled":[62],"EGF.":[63,90,100,121],"Over":[64],"range":[66],"tested,":[67],"EGF":[68,137,152,192,227,232],"increased":[70,148],"increasing":[72],"similarly":[75],"both":[80,96],"strains,":[81,213],"at":[83],"similar":[84,87],"densities":[85],"bound":[86,98,116],"amounts":[88],"Increasingly":[91],"differentiated":[92],"less":[99,159],"Responses":[101],"differentiating":[105,114,155],"dissimilar":[108],"several":[110],"respects.":[111],"Most":[112],"notably,":[113],"but":[117],"failed":[118],"metabolize":[120],"TPA":[122,162],"treatment":[123,140,176],"from":[127],"either":[128,181],"strain":[129],"led":[130],"a":[132],"rapid,":[133],"pronounced":[134],"reduction":[135],"binding,":[138],"while":[139,174],"retinoic":[142,165],"acid,":[143],"an":[144,184],"antipromoter":[145],"vivo,":[147],"binding.":[149],"In":[150],"contrast,":[151],"was":[157,171,177],"much":[158],"affected":[160],"treatment,":[163],"acid":[166],"had":[167],"no":[168],"effect":[169],"or":[170],"slightly":[172],"inhibitory,":[173],"combined":[175],"more":[178],"inhibitory":[179],"alone.":[182],"Given":[183],"adequate":[185],"plating":[186],"density,":[187],"inclusion":[188],"1":[190],"ng":[191],"per":[193],"ml":[194],"media":[196],"significantly":[197],"enhanced":[198],"cells.":[202],"Because":[203],"similarities":[206],"patterns":[209],"between":[210],"two":[212],"it":[214],"seems":[215],"unlikely":[216],"that":[217],"differential":[218],"responses":[219],"modulators":[230],"are":[234],"involved":[235],"differences":[238],"susceptibility":[240],"these":[242],"carcinogenesis.":[245]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}