{"id":"https://openalex.org/W2010525620","doi":"https://doi.org/10.1007/s004240000497","title":"Functional integrity of the vesicle transporting machinery is required for complete activation of CFTR expressed in Xenopus laevis oocytes","display_name":"Functional integrity of the vesicle transporting machinery is required for complete activation of CFTR expressed in Xenopus laevis oocytes","publication_year":2001,"publication_date":"2001-03-05","ids":{"openalex":"https://openalex.org/W2010525620","doi":"https://doi.org/10.1007/s004240000497","mag":"2010525620","pmid":"https://pubmed.ncbi.nlm.nih.gov/11316271"},"language":"en","primary_location":{"id":"doi:10.1007/s004240000497","doi":"https://doi.org/10.1007/s004240000497","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s004240000497","pdf_url":null,"source":{"id":"https://openalex.org/S203465302","display_name":"Pfl\u00fcgers Archiv - European Journal of Physiology","issn_l":"0031-6768","issn":["0031-6768","0365-267X","1432-2013"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pfl\ufffdgers Archiv European Journal of Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111627649","display_name":"Wolf-Michael Weber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Wolf-Michael Weber","raw_affiliation_strings":["Laboratory of Physiology, KU Leugen, Belgium. Michael.Weber@med.kuleuven.ac.be","Laboratory of Physiology, KU Leugen, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Physiology, KU Leugen, Belgium. Michael.Weber@med.kuleuven.ac.be","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Laboratory of Physiology, KU Leugen, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090614480","display_name":"Andrei Segal","orcid":"https://orcid.org/0000-0002-0981-9587","observed_orcids":["https://orcid.org/0000-0002-0981-9587"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Andrei Segal","raw_affiliation_strings":["Laboratory of Physiology, K. U. Leuven, Campus Gasthuisberg, 3000 Leuven, Belgium,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Physiology, K. U. Leuven, Campus Gasthuisberg, 3000 Leuven, Belgium,","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108469144","display_name":"Jeannine Simaels","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jeaninne Simaels","raw_affiliation_strings":["Laboratory of Physiology, K. U. Leuven, Campus Gasthuisberg, 3000 Leuven, Belgium,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Physiology, K. U. Leuven, Campus Gasthuisberg, 3000 Leuven, Belgium,","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058777914","display_name":"Anne Vankeerberghen","orcid":"https://orcid.org/0000-0002-8672-6974","observed_orcids":["https://orcid.org/0000-0002-8672-6974"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Anne Vankeerberghen","raw_affiliation_strings":["Center for Human Genetics, K. U. Leuven, Campus Gasthuisberg, 3000 Leuven, Belgium,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Genetics, K. U. Leuven, Campus Gasthuisberg, 3000 Leuven, Belgium,","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108425214","display_name":"Jean\u2010Jacques Cassiman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jean-Jacques Cassiman","raw_affiliation_strings":["Center for Human Genetics, K. U. Leuven, Campus Gasthuisberg, 3000 Leuven, Belgium,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Genetics, K. U. Leuven, Campus Gasthuisberg, 3000 Leuven, Belgium,","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104475109","display_name":"Willy Van Driessche","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Willy Van Driessche","raw_affiliation_strings":["Laboratory of Physiology, K. U. Leuven, Campus Gasthuisberg, 3000 Leuven, Belgium,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Physiology, K. U. Leuven, Campus Gasthuisberg, 3000 Leuven, Belgium,","institution_ids":["https://openalex.org/I99464096"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111627649"],"corresponding_institution_ids":["https://openalex.org/I99464096"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":1.7554,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.83886786,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"441","issue":"6","first_page":"850","last_page":"859"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.6875,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.6875,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.1914999932050705,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.07349999994039536,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cftr","display_name":"CFTR","score":0.953000009059906},{"id":"https://openalex.org/keywords/cystic-fibrosis-transmembrane-conductance-regulator","display_name":"cystic fibrosis transmembrane conductance regulator","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cftr-activation","display_name":"CFTR activation","score":0.7670000195503235},{"id":"https://openalex.org/keywords/protein-trafficking","display_name":"protein trafficking","score":0.6320000290870667},{"id":"https://openalex.org/keywords/vesicular-trafficking","display_name":"vesicle trafficking","score":0.7390000224113464},{"id":"https://openalex.org/keywords/exocytosis","display_name":"exocytosis","score":0.925000011920929},{"id":"https://openalex.org/keywords/membrane-capacitance","display_name":"membrane capacitance","score":0.7089999914169312},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.6620000004768372},{"id":"https://openalex.org/keywords/3-isobutyl-1-methylxanthine","display_name":"3-isobutyl-1-methylxanthine","score":0.9769999980926514},{"id":"https://openalex.org/keywords/brefeldin-a","display_name":"brefeldin A","score":0.9010000228881836},{"id":"https://openalex.org/keywords/nocodazole","display_name":"nocodazole","score":0.9890000224113464},{"id":"https://openalex.org/keywords/primaquine","display_name":"primaquine","score":0.9520000219345093},{"id":"https://openalex.org/keywords/xenopus-oocytes","display_name":"Xenopus oocytes","score":0.7860000133514404},{"id":"https://openalex.org/keywords/membrane-conductance","display_name":"membrane conductance","score":0.4359999895095825}],"concepts":[{"id":"https://openalex.org/C2779535977","wikidata":"https://www.wikidata.org/wiki/Q1342298","display_name":"Xenopus","level":3,"score":0.9797263145446777},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6708599328994751},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4507855176925659},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37764623761177063},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1730717420578003},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09913298487663269}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002614","descriptor_name":"Chelating Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003550","descriptor_name":"Cystic Fibrosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004533","descriptor_name":"Egtazic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D004533","descriptor_name":"Egtazic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004553","descriptor_name":"Electric Conductivity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005089","descriptor_name":"Exocytosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005089","descriptor_name":"Exocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010726","descriptor_name":"Phosphodiesterase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011319","descriptor_name":"Primaquine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011500","descriptor_name":"Protein Synthesis Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013873","descriptor_name":"Thionucleotides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015056","descriptor_name":"1-Methyl-3-isobutylxanthine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015739","descriptor_name":"Nocodazole","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019005","descriptor_name":"Cystic Fibrosis Transmembrane Conductance Regulator","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019005","descriptor_name":"Cystic Fibrosis Transmembrane Conductance Regulator","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020126","descriptor_name":"Brefeldin A","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D022161","descriptor_name":"Transport Vesicles","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D022161","descriptor_name":"Transport Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s004240000497","doi":"https://doi.org/10.1007/s004240000497","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s004240000497","pdf_url":null,"source":{"id":"https://openalex.org/S203465302","display_name":"Pfl\u00fcgers Archiv - European Journal of Physiology","issn_l":"0031-6768","issn":["0031-6768","0365-267X","1432-2013"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pfl\ufffdgers Archiv European Journal of Physiology","raw_type":"journal-article"},{"id":"pmid:11316271","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11316271","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pflugers Archiv : European journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W140615384","https://openalex.org/W306207415","https://openalex.org/W1502387939","https://openalex.org/W1514789115","https://openalex.org/W1523858318","https://openalex.org/W1570003744","https://openalex.org/W1866995360","https://openalex.org/W1956777900","https://openalex.org/W1967595710","https://openalex.org/W1975553136","https://openalex.org/W1977946638","https://openalex.org/W1996462589","https://openalex.org/W2006115332","https://openalex.org/W2012857882","https://openalex.org/W2014771883","https://openalex.org/W2019099644","https://openalex.org/W2027625146","https://openalex.org/W2028628898","https://openalex.org/W2032710773","https://openalex.org/W2040483955","https://openalex.org/W2040665665","https://openalex.org/W2043324809","https://openalex.org/W2047233384","https://openalex.org/W2051446765","https://openalex.org/W2052347357","https://openalex.org/W2057683577","https://openalex.org/W2060281923","https://openalex.org/W2061160877","https://openalex.org/W2063785722","https://openalex.org/W2066278737","https://openalex.org/W2073654276","https://openalex.org/W2076605049","https://openalex.org/W2081365515","https://openalex.org/W2084747605","https://openalex.org/W2095544165","https://openalex.org/W2095852063","https://openalex.org/W2098498572","https://openalex.org/W2117819061","https://openalex.org/W2131375257","https://openalex.org/W2131933690","https://openalex.org/W2135418118","https://openalex.org/W2136681370","https://openalex.org/W2205864322","https://openalex.org/W2278577252","https://openalex.org/W2282852907","https://openalex.org/W2412883910","https://openalex.org/W2425480690","https://openalex.org/W2437831636","https://openalex.org/W4238242064"],"related_works":["https://openalex.org/W1986411276","https://openalex.org/W2043324809","https://openalex.org/W2425480690","https://openalex.org/W2204403774","https://openalex.org/W2014494673","https://openalex.org/W2044605061","https://openalex.org/W1526431922","https://openalex.org/W1965602860","https://openalex.org/W1992247157","https://openalex.org/W2422235131"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}