{"id":"https://openalex.org/W2010524872","doi":"https://doi.org/10.1213/01.ane.0000223684.76783.bf","title":"Tolerance to Propofol\u2019s Sedative Effect in Mechanically Ventilated Rabbits","display_name":"Tolerance to Propofol\u2019s Sedative Effect in Mechanically Ventilated Rabbits","publication_year":2006,"publication_date":"2006-07-13","ids":{"openalex":"https://openalex.org/W2010524872","doi":"https://doi.org/10.1213/01.ane.0000223684.76783.bf","mag":"2010524872","pmid":"https://pubmed.ncbi.nlm.nih.gov/16861417"},"language":"en","primary_location":{"id":"doi:10.1213/01.ane.0000223684.76783.bf","doi":"https://doi.org/10.1213/01.ane.0000223684.76783.bf","is_oa":false,"landing_page_url":"https://doi.org/10.1213/01.ane.0000223684.76783.bf","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia &amp; Analgesia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072522523","display_name":"Petros Ypsilantis","orcid":"https://orcid.org/0000-0002-7744-3809","observed_orcids":["https://orcid.org/0000-0002-7744-3809"]},"institutions":[{"id":"https://openalex.org/I147962203","display_name":"Democritus University of Thrace","ror":"https://ror.org/03bfqnx40","country_code":"GR","type":"education","lineage":["https://openalex.org/I147962203"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Petros Ypsilantis","raw_affiliation_strings":["Laboratory of Experimental Surgery and Surgical Research, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece. pipsil@med.duth.gr","Laboratory of Experimental Surgery and Surgical Research and \u2020Thoracic and Cardiac Surgery Clinic, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Surgery and Surgical Research, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece. pipsil@med.duth.gr","institution_ids":["https://openalex.org/I147962203"]},{"raw_affiliation_string":"Laboratory of Experimental Surgery and Surgical Research and \u2020Thoracic and Cardiac Surgery Clinic, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece","institution_ids":["https://openalex.org/I147962203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048486748","display_name":"Dimitrios A. Mikroulis","orcid":"https://orcid.org/0000-0002-3585-0166","observed_orcids":["https://orcid.org/0000-0002-3585-0166"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dimitrios Mikroulis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021804658","display_name":"\u039c\u03b1\u03c1\u03af\u03b1 \u03a0\u03bf\u03bb\u03af\u03c4\u03bf\u03c5","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I147962203","display_name":"Democritus University of Thrace","ror":"https://ror.org/03bfqnx40","country_code":"GR","type":"education","lineage":["https://openalex.org/I147962203"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Maria Politou","raw_affiliation_strings":["Laboratory of Experimental Surgery and Surgical Research and \u2020Thoracic and Cardiac Surgery Clinic, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Surgery and Surgical Research and \u2020Thoracic and Cardiac Surgery Clinic, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece","institution_ids":["https://openalex.org/I147962203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111517418","display_name":"Heleni Tsoukali","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Heleni Tsoukali","raw_affiliation_strings":["Laboratory of Forensic Medicine and Toxicology, Medical School, and \u00a7Laboratory of Analytical Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Forensic Medicine and Toxicology, Medical School, and \u00a7Laboratory of Analytical Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111768826","display_name":"Michail S. Pitiakoudis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I147962203","display_name":"Democritus University of Thrace","ror":"https://ror.org/03bfqnx40","country_code":"GR","type":"education","lineage":["https://openalex.org/I147962203"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Michail Pitiakoudis","raw_affiliation_strings":["Laboratory of Experimental Surgery and Surgical Research and \u2020Thoracic and Cardiac Surgery Clinic, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Surgery and Surgical Research and \u2020Thoracic and Cardiac Surgery Clinic, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece","institution_ids":["https://openalex.org/I147962203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111548632","display_name":"Vasilios Didilis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vasilios Didilis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006492102","display_name":"Georgios A. Theodoridis","orcid":"https://orcid.org/0000-0002-2015-108X","observed_orcids":["https://orcid.org/0000-0002-2015-108X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Georgios Theodoridis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108415149","display_name":"Georgios Bougioukas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Georgios Bougioukas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109114573","display_name":"Constantinos E. Simopoulos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I147962203","display_name":"Democritus University of Thrace","ror":"https://ror.org/03bfqnx40","country_code":"GR","type":"education","lineage":["https://openalex.org/I147962203"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Constantinos Simopoulos","raw_affiliation_strings":["Laboratory of Experimental Surgery and Surgical Research and \u2020Thoracic and Cardiac Surgery Clinic, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Surgery and Surgical Research and \u2020Thoracic and Cardiac Surgery Clinic, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece","institution_ids":["https://openalex.org/I147962203"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5021804658","https://openalex.org/A5072522523","https://openalex.org/A5109114573","https://openalex.org/A5111768826"],"corresponding_institution_ids":["https://openalex.org/I147962203"],"apc_list":null,"apc_paid":null,"fwci":1.2065,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.78871215,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"103","issue":"2","first_page":"359","last_page":"365"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11905","display_name":"Veterinary Pharmacology and Anesthesia","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10867","display_name":"Intensive Care Unit Cognitive Disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/propofol","display_name":"propofol","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mechanical-ventilation","display_name":"mechanical ventilation","score":0.9150000214576721},{"id":"https://openalex.org/keywords/critically-ill-patients","display_name":"critically ill patients","score":0.6129999756813049},{"id":"https://openalex.org/keywords/systemic-clearance","display_name":"systemic clearance","score":0.6850000023841858},{"id":"https://openalex.org/keywords/plasma-drug-concentration","display_name":"plasma drug concentration","score":0.5789999961853027},{"id":"https://openalex.org/keywords/continuous-intravenous-infusion","display_name":"continuous intravenous infusion","score":0.6539999842643738},{"id":"https://openalex.org/keywords/depth-of-sedation","display_name":"sedation depth","score":0.6079999804496765},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C2776277131","wikidata":"https://www.wikidata.org/wiki/Q422740","display_name":"Propofol","level":2,"score":0.9610360860824585},{"id":"https://openalex.org/C2776814716","wikidata":"https://www.wikidata.org/wiki/Q574801","display_name":"Sedation","level":2,"score":0.9120821952819824},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8310641050338745},{"id":"https://openalex.org/C2777602617","wikidata":"https://www.wikidata.org/wiki/Q847705","display_name":"Sedative","level":2,"score":0.786095380783081},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.7344326972961426},{"id":"https://openalex.org/C2777080012","wikidata":"https://www.wikidata.org/wiki/Q3766250","display_name":"Mechanical ventilation","level":2,"score":0.6712073087692261},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.4513857960700989},{"id":"https://openalex.org/C200457457","wikidata":"https://www.wikidata.org/wiki/Q584049","display_name":"Ventilation (architecture)","level":2,"score":0.4205549657344818},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13726741075515747},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004361","descriptor_name":"Drug Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006993","descriptor_name":"Hypnotics and Sedatives","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012121","descriptor_name":"Respiration, Artificial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015742","descriptor_name":"Propofol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015742","descriptor_name":"Propofol","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D015742","descriptor_name":"Propofol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1213/01.ane.0000223684.76783.bf","doi":"https://doi.org/10.1213/01.ane.0000223684.76783.bf","is_oa":false,"landing_page_url":"https://doi.org/10.1213/01.ane.0000223684.76783.bf","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia &amp; Analgesia","raw_type":"journal-article"},{"id":"pmid:16861417","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16861417","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia and analgesia","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.317.9758","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.317.9758","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.anesthesia-analgesia.org/content/103/2/359.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W36702807","https://openalex.org/W184383788","https://openalex.org/W321467173","https://openalex.org/W1522538277","https://openalex.org/W1566608500","https://openalex.org/W1599827419","https://openalex.org/W2025035050","https://openalex.org/W2026028435","https://openalex.org/W2031003242","https://openalex.org/W2056642582","https://openalex.org/W2071243102","https://openalex.org/W2072870313","https://openalex.org/W2078343103","https://openalex.org/W2154727969","https://openalex.org/W2158870731","https://openalex.org/W2399045151","https://openalex.org/W2470800533","https://openalex.org/W2543455960","https://openalex.org/W2791114118","https://openalex.org/W3198199546"],"related_works":["https://openalex.org/W2153028967","https://openalex.org/W1996133370","https://openalex.org/W36702807","https://openalex.org/W7211996681","https://openalex.org/W2356737917","https://openalex.org/W2122480302","https://openalex.org/W2389146758","https://openalex.org/W2057977282","https://openalex.org/W2367058878","https://openalex.org/W2373281146"],"abstract_inverted_index":{"Propofol":[0,94,241],"is":[1],"commonly":[2],"used":[3],"for":[4,59,248,257],"the":[5,25,71,78,199,273,282],"sedation":[6,58,79],"of":[7,27,74,77,92,112,121,136,146,195,276],"critically":[8],"ill":[9],"patients":[10,15],"undergoing":[11],"mechanical":[12,37],"ventilation.":[13,38],"These":[14],"may":[16],"develop":[17],"tolerance":[18,28,267],"during":[19,35,198],"long-term":[20],"administration.":[21],"Here,":[22],"we":[23],"describe":[24],"development":[26],"to":[29,56,69,203,268,279,281],"propofol's":[30,269],"sedative":[31,270],"effect":[32,271],"in":[33,98,201],"rabbits":[34,45,265],"prolonged":[36],"Six":[39],"healthy":[40],"male":[41],"New":[42],"Zealand":[43],"White":[44],"were":[46,81,90,96,125,245],"endotracheally":[47],"intubated":[48],"and":[49,119,185,230,253],"received":[50],"propofol":[51,63,196,204],"by":[52],"continuous":[53],"IV":[54],"infusion":[55,64],"maintain":[57,70],"48":[60],"h.":[61,261],"The":[62,127,144,193],"rate":[65,129],"(IR)":[66],"was":[67,108,130],"adjusted":[68],"desired":[72],"level":[73,80,111],"sedation.":[75],"Assessments":[76],"made":[82],"every":[83,102],"30":[84],"min":[85],"or":[86],"earlier":[87],"if":[88],"there":[89,107],"signs":[91],"awakening.":[93],"concentrations":[95,197,222,233],"measured":[97],"arterial":[99],"plasma":[100],"after":[101],"other":[103],"IR":[104,147,155,166,180,205,225,236],"adjustment,":[105],"provided":[106],"an":[109],"adequate":[110],"sedation,":[113],"using":[114],"high":[115],"performance":[116],"liquid":[117],"chromatography,":[118],"calculations":[120],"systemic":[122,242],"clearance":[123,243],"rates":[124,244],"made.":[126],"mortality":[128],"100%":[131],"with":[132,213,223,234],"a":[133,150,207],"survival":[134],"period":[135],"30.8":[137],"+/-":[138,142,157,161,168,175,182,190,217,227,238,250,259],"6.0":[139,249],"h":[140,252],"(mean":[141,156],"sd).":[143],"course":[145,194],"adjustments":[148],"followed":[149,206],"5-phase":[151],"pattern:":[152,209],"1)":[153,210],"steady":[154,172,187,211],"sd":[158],"duration;":[159],"1.2":[160,176],"0.6":[162],"h),":[163,170,177,184,219,229],"2)":[164,220],"increasing":[165,214,221,224,232],"(9.4":[167],"5.5":[169],"3)":[171,231],"high-IR":[173],"(2.3":[174],"4)":[178],"decreasing":[179,235],"(13.7":[181],"1.9":[183],"5)":[186],"low-IR":[188],"(5.0":[189],"2.7":[191,218,251],"h).":[192,240],"experiment":[200],"relation":[202],"3-phase":[208],"concentration":[212],"IRs":[215],"(6.0":[216],"(5.8":[226],"2.5":[228],"(18.8":[237],"3.3":[239],"progressively":[246],"increased":[247],"then":[254],"gradually":[255],"decreased":[256],"24.6":[258],"4.7":[260],"In":[262],"conclusion,":[263],"all":[264],"developed":[266],"within":[272],"first":[274],"hours":[275],"administration":[277],"related":[278],"changes":[280],"drug's":[283],"metabolic":[284],"clearance.":[285]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
