{"id":"https://openalex.org/W2010524294","doi":"https://doi.org/10.1074/jbc.m501527200","title":"Interactions of Mitochondria-targeted and Untargeted Ubiquinones with the Mitochondrial Respiratory Chain and Reactive Oxygen Species","display_name":"Interactions of Mitochondria-targeted and Untargeted Ubiquinones with the Mitochondrial Respiratory Chain and Reactive Oxygen Species","publication_year":2005,"publication_date":"2005-03-23","ids":{"openalex":"https://openalex.org/W2010524294","doi":"https://doi.org/10.1074/jbc.m501527200","mag":"2010524294","pmid":"https://pubmed.ncbi.nlm.nih.gov/15788391"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m501527200","doi":"https://doi.org/10.1074/jbc.m501527200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m501527200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m501527200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021812477","display_name":"Andrew M. James","orcid":"https://orcid.org/0000-0002-0515-9649","observed_orcids":["https://orcid.org/0000-0002-0515-9649"]},"institutions":[{"id":"https://openalex.org/I79266365","display_name":"MRC Mitochondrial Biology Unit","ror":"https://ror.org/01vdt8f48","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I79266365","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew M. James","raw_affiliation_strings":["Medical Research Council Dunn Human Nutrition Unit, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 2XY, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Dunn Human Nutrition Unit, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 2XY, United Kingdom","institution_ids":["https://openalex.org/I79266365","https://openalex.org/I87048295","https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060532049","display_name":"Helena M. Cochem\u00e9","orcid":"https://orcid.org/0000-0001-8637-0042","observed_orcids":["https://orcid.org/0000-0001-8637-0042"]},"institutions":[{"id":"https://openalex.org/I79266365","display_name":"MRC Mitochondrial Biology Unit","ror":"https://ror.org/01vdt8f48","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I79266365","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Helena M. Cochem\u00e9","raw_affiliation_strings":["Medical Research Council Dunn Human Nutrition Unit, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 2XY, United Kingdom and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Dunn Human Nutrition Unit, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 2XY, United Kingdom and the","institution_ids":["https://openalex.org/I79266365","https://openalex.org/I87048295","https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042262530","display_name":"Robin A.J. Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80281795","display_name":"University of Otago","ror":"https://ror.org/01jmxt844","country_code":"NZ","type":"education","lineage":["https://openalex.org/I80281795"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Robin A.J. Smith","raw_affiliation_strings":["Department of Chemistry, University of Otago, P. O. Box 56, Dunedin, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Otago, P. O. Box 56, Dunedin, New Zealand","institution_ids":["https://openalex.org/I80281795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062511010","display_name":"Michael P. Murphy","orcid":"https://orcid.org/0000-0003-1115-9618","observed_orcids":["https://orcid.org/0000-0003-1115-9618"]},"institutions":[{"id":"https://openalex.org/I79266365","display_name":"MRC Mitochondrial Biology Unit","ror":"https://ror.org/01vdt8f48","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I79266365","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Michael P. Murphy","raw_affiliation_strings":["Medical Research Council Dunn Human Nutrition Unit, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 2XY, United Kingdom and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Dunn Human Nutrition Unit, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 2XY, United Kingdom and the","institution_ids":["https://openalex.org/I79266365","https://openalex.org/I87048295","https://openalex.org/I90344618"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5062511010"],"corresponding_institution_ids":["https://openalex.org/I79266365","https://openalex.org/I87048295","https://openalex.org/I90344618"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":6.2978,"has_fulltext":false,"cited_by_count":355,"citation_normalized_percentile":{"value":0.98027413,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"280","issue":"22","first_page":"21295","last_page":"21312"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13012","display_name":"Coenzyme Q10 studies and effects","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13012","display_name":"Coenzyme Q10 studies and effects","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.01720000058412552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-respiratory-chain","display_name":"mitochondrial respiratory chain","score":0.8560000061988831},{"id":"https://openalex.org/keywords/cytochrome-bc1-complex","display_name":"cytochrome bc1 complex","score":0.765999972820282},{"id":"https://openalex.org/keywords/superoxide-production","display_name":"superoxide production","score":0.5979999899864197},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9100000262260437},{"id":"https://openalex.org/keywords/peroxynitrite","display_name":"peroxynitrite","score":0.9599999785423279},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.8109999895095825},{"id":"https://openalex.org/keywords/nitric-oxide-consumption","display_name":"nitric oxide consumption","score":0.8190000057220459},{"id":"https://openalex.org/keywords/aconitase","display_name":"aconitase","score":0.8730000257492065},{"id":"https://openalex.org/keywords/glycerol-3-phosphate-dehydrogenase","display_name":"glycerol-3-phosphate dehydrogenase","score":0.8899999856948853},{"id":"https://openalex.org/keywords/alkyl-chain-length","display_name":"alkyl chain length","score":0.8410000205039978},{"id":"https://openalex.org/keywords/mitochondrial-antioxidants","display_name":"mitochondrial antioxidants","score":0.4950000047683716},{"id":"https://openalex.org/keywords/mitochondrial-oxidative-damage","display_name":"mitochondrial oxidative damage","score":0.3970000147819519}],"concepts":[{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.7561843395233154},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.715064287185669},{"id":"https://openalex.org/C3020761558","wikidata":"https://www.wikidata.org/wiki/Q211016","display_name":"Mitochondrial respiratory chain","level":3,"score":0.6330255270004272},{"id":"https://openalex.org/C3020377403","wikidata":"https://www.wikidata.org/wiki/Q211016","display_name":"Respiratory chain","level":3,"score":0.6093021631240845},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.5011515617370605},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44239628314971924},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.4199032485485077},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35776472091674805},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3572368025779724},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33926624059677124},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.05774250626564026},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000154","descriptor_name":"Aconitate Hydratase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004579","descriptor_name":"Electron Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005993","descriptor_name":"Glycerolphosphate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008930","descriptor_name":"Mitochondria, Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013438","descriptor_name":"Sulfhydryl Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013481","descriptor_name":"Superoxides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014451","descriptor_name":"Ubiquinone","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1074/jbc.m501527200","doi":"https://doi.org/10.1074/jbc.m501527200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m501527200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:15788391","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15788391","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:69221","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/69221/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Biol Chem , 280 (22) pp. 21295-21312. (2005)","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m501527200","doi":"https://doi.org/10.1074/jbc.m501527200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m501527200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.428600013256073}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":98,"referenced_works":["https://openalex.org/W57094281","https://openalex.org/W937204623","https://openalex.org/W1438668346","https://openalex.org/W1505439087","https://openalex.org/W1506043065","https://openalex.org/W1507385544","https://openalex.org/W1528809082","https://openalex.org/W1556017032","https://openalex.org/W1566232888","https://openalex.org/W1577403013","https://openalex.org/W1595136082","https://openalex.org/W1596431542","https://openalex.org/W1856874919","https://openalex.org/W1894069867","https://openalex.org/W1900912241","https://openalex.org/W1927592403","https://openalex.org/W1968089096","https://openalex.org/W1968112618","https://openalex.org/W1969102494","https://openalex.org/W1969628253","https://openalex.org/W1971714188","https://openalex.org/W1973494071","https://openalex.org/W1975924701","https://openalex.org/W1976719889","https://openalex.org/W1976995270","https://openalex.org/W1979438859","https://openalex.org/W1982764052","https://openalex.org/W1985889236","https://openalex.org/W1989479158","https://openalex.org/W1991728780","https://openalex.org/W1993062133","https://openalex.org/W1998998975","https://openalex.org/W2001565942","https://openalex.org/W2002625920","https://openalex.org/W2002764575","https://openalex.org/W2007238572","https://openalex.org/W2007737411","https://openalex.org/W2012634726","https://openalex.org/W2013903677","https://openalex.org/W2017005590","https://openalex.org/W2017478373","https://openalex.org/W2017692041","https://openalex.org/W2019881589","https://openalex.org/W2020214814","https://openalex.org/W2025338400","https://openalex.org/W2033510997","https://openalex.org/W2034290530","https://openalex.org/W2035127779","https://openalex.org/W2036193242","https://openalex.org/W2037465679","https://openalex.org/W2039254203","https://openalex.org/W2042779198","https://openalex.org/W2043832602","https://openalex.org/W2045698434","https://openalex.org/W2046601184","https://openalex.org/W2050863429","https://openalex.org/W2055829143","https://openalex.org/W2056119306","https://openalex.org/W2058137293","https://openalex.org/W2061144992","https://openalex.org/W2063968553","https://openalex.org/W2077120170","https://openalex.org/W2077722456","https://openalex.org/W2078265076","https://openalex.org/W2081193771","https://openalex.org/W2084723599","https://openalex.org/W2087561593","https://openalex.org/W2090602593","https://openalex.org/W2099354599","https://openalex.org/W2100151397","https://openalex.org/W2100454943","https://openalex.org/W2102778596","https://openalex.org/W2105178675","https://openalex.org/W2111501638","https://openalex.org/W2114244415","https://openalex.org/W2116642215","https://openalex.org/W2123550664","https://openalex.org/W2128569391","https://openalex.org/W2134855793","https://openalex.org/W2135414906","https://openalex.org/W2142734267","https://openalex.org/W2146481406","https://openalex.org/W2147993424","https://openalex.org/W2151376247","https://openalex.org/W2154919554","https://openalex.org/W2155167730","https://openalex.org/W2156698929","https://openalex.org/W2160750657","https://openalex.org/W2163187840","https://openalex.org/W2168816567","https://openalex.org/W2169706900","https://openalex.org/W2171088963","https://openalex.org/W2171471740","https://openalex.org/W2171552928","https://openalex.org/W2190135669","https://openalex.org/W4232534952","https://openalex.org/W4244473822","https://openalex.org/W4247088117"],"related_works":["https://openalex.org/W7073657090","https://openalex.org/W4245013971","https://openalex.org/W1964964493","https://openalex.org/W2036936467","https://openalex.org/W2164298973","https://openalex.org/W2089669276","https://openalex.org/W2017692041","https://openalex.org/W2062415168","https://openalex.org/W4300560659","https://openalex.org/W1996885665"],"abstract_inverted_index":{"Antioxidants,":[0],"such":[1],"as":[2,10,249,252],"ubiquinones,":[3],"are":[4],"widely":[5],"used":[6,55],"in":[7,71,119,181,186],"mitochondrial":[8,58,67,79,257],"studies":[9],"both":[11,221],"potential":[12],"therapies":[13,250],"and":[14,61,89,134,141,153,166,217,240,247,251],"useful":[15],"research":[16,253],"tools.":[17],"However,":[18,74],"the":[19,64,78,86,142,182,187,192,233],"effects":[20],"of":[21,66,81,98,124,149,189,194,222,235],"exogenous":[22,109,169,236],"ubiquinones":[23,237],"can":[24,31],"be":[25,33],"difficult":[26],"to":[27,56,62,173,198,207,213,255],"interpret":[28],"because":[29,122],"they":[30],"also":[32,171],"pro-oxidants":[34],"or":[35],"electron":[36],"carriers":[37],"that":[38,48,113],"facilitate":[39],"respiration.":[40],"Recently":[41],"we":[42,94],"developed":[43],"a":[44,158],"mitochondria-targeted":[45],"ubiquinone":[46],"(MitoQ10)":[47],"accumulates":[49],"within":[50],"mitochondria.":[51],"MitoQ10":[52,114,156,204],"has":[53],"been":[54],"prevent":[57],"oxidative":[59],"damage":[60,208],"infer":[63],"involvement":[65],"reactive":[68],"oxygen":[69],"species":[70],"signaling":[72,227],"pathways.":[73,228],"uncertainties":[75],"remain":[76],"about":[77],"reduction":[80,152],"MitoQ10,":[82],"its":[83,90,150],"oxidation":[84,123],"by":[85,127,203],"respiratory":[87],"chain,":[88],"pro-oxidant":[91],"potential.":[92],"Therefore,":[93],"compared":[95],"MitoQ":[96,125,139],"analogs":[97,126],"varying":[99],"alkyl":[100],"chain":[101,146],"lengths":[102],"(MitoQn,":[103],"n":[104],"=":[105],"3-15)":[106],"with":[107,238],"untargeted":[108],"ubiquinones.":[110],"We":[111],"found":[112],"could":[115],"not":[116],"restore":[117],"respiration":[118],"ubiquinone-deficient":[120],"mitochondria":[121,239],"complex":[128],"III":[129],"was":[130,205],"minimal.":[131],"Complex":[132],"II":[133],"glycerol":[135],"3-phosphate":[136],"dehydrogenase":[137],"reduced":[138],"analogs,":[140],"rate":[143,193],"depended":[144],"on":[145],"length.":[147],"Because":[148],"rapid":[151],"negligible":[154],"oxidation,":[155],"is":[157,196],"more":[159],"effective":[160],"antioxidant":[161],"against":[162],"lipid":[163],"peroxidation,":[164],"peroxynitrite":[165],"superoxide.":[167],"Paradoxically,":[168],"ubiquinols":[170],"autoxidize":[172],"generate":[174],"superoxide,":[175],"but":[176,210],"this":[177],"requires":[178],"their":[179,244],"deprotonation":[180],"aqueous":[183],"phase.":[184],"Consequently,":[185],"presence":[188],"phospholipid":[190],"bilayers,":[191],"autoxidation":[195],"proportional":[197],"ubiquinol":[199],"hydrophilicity.":[200],"Superoxide":[201],"production":[202,216],"insufficient":[206],"aconitase":[209],"did":[211],"lead":[212],"hydrogen":[214],"peroxide":[215],"nitric":[218],"oxide":[219],"consumption,":[220],"which":[223],"may":[224],"affect":[225],"cell":[226],"Our":[229],"results":[230],"comprehensively":[231],"describe":[232],"interaction":[234],"have":[241],"implications":[242],"for":[243],"rational":[245],"design":[246],"use":[248],"tools":[254],"probe":[256],"function.":[258]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":21},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":20},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":20},{"year":2013,"cited_by_count":19},{"year":2012,"cited_by_count":25}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
