{"id":"https://openalex.org/W2010521682","doi":"https://doi.org/10.1038/modpathol.2008.10","title":"Thyroid carcinoma: molecular pathways and therapeutic targets","display_name":"Thyroid carcinoma: molecular pathways and therapeutic targets","publication_year":2008,"publication_date":"2008-04-25","ids":{"openalex":"https://openalex.org/W2010521682","doi":"https://doi.org/10.1038/modpathol.2008.10","mag":"2010521682","pmid":"https://pubmed.ncbi.nlm.nih.gov/18437172","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2673022"},"language":"en","primary_location":{"id":"doi:10.1038/modpathol.2008.10","doi":"https://doi.org/10.1038/modpathol.2008.10","is_oa":true,"landing_page_url":"https://doi.org/10.1038/modpathol.2008.10","pdf_url":"https://www.nature.com/articles/modpathol200810.pdf","source":{"id":"https://openalex.org/S33606366","display_name":"Modern Pathology","issn_l":"0893-3952","issn":["0893-3952","1530-0285"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern Pathology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2010521682"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.nature.com/articles/modpathol200810.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020353829","display_name":"Yuri E. Nikiforov","orcid":"https://orcid.org/0000-0002-2239-1095","observed_orcids":["https://orcid.org/0000-0002-2239-1095"]},"institutions":[{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yuri E Nikiforov","raw_affiliation_strings":["Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA. nikiforovye@upmc.edu","Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA. nikiforovye@upmc.edu","institution_ids":["https://openalex.org/I4210134769"]},{"raw_affiliation_string":"Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA","institution_ids":["https://openalex.org/I4210134769"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5020353829"],"corresponding_institution_ids":["https://openalex.org/I4210134769"],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":null,"fwci":3.9674,"has_fulltext":true,"cited_by_count":399,"citation_normalized_percentile":{"value":0.96428571,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"21","issue":null,"first_page":"S37","last_page":"S43"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyroid-cancer","display_name":"thyroid cancer","score":0.953000009059906},{"id":"https://openalex.org/keywords/papillary-thyroid-carcinoma","display_name":"papillary thyroid carcinoma","score":0.9950000047683716},{"id":"https://openalex.org/keywords/follicular-thyroid-carcinoma","display_name":"follicular thyroid carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/medullary-thyroid-carcinoma","display_name":"medullary thyroid carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.8709999918937683},{"id":"https://openalex.org/keywords/braf-mutation","display_name":"BRAF mutation","score":0.9039999842643738},{"id":"https://openalex.org/keywords/ras-mutations","display_name":"RAS mutations","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ret-ptc-rearrangement","display_name":"RET/PTC rearrangement","score":0.9549999833106995},{"id":"https://openalex.org/keywords/ret-mutations","display_name":"RET mutations","score":0.8339999914169312},{"id":"https://openalex.org/keywords/pax8-ppargamma-rearrangement","display_name":"PAX8/PPAR\u03b3 rearrangement","score":0.9629999995231628},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.8339999914169312},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.4830000102519989}],"concepts":[{"id":"https://openalex.org/C2993294228","wikidata":"https://www.wikidata.org/wiki/Q13632630","display_name":"Thyroid carcinoma","level":3,"score":0.685882031917572},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6759402751922607},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5883318781852722},{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.570972740650177},{"id":"https://openalex.org/C2776512331","wikidata":"https://www.wikidata.org/wiki/Q604075","display_name":"Multiple endocrine neoplasia type 2","level":5,"score":0.5434331297874451},{"id":"https://openalex.org/C1167327","wikidata":"https://www.wikidata.org/wiki/Q14884140","display_name":"HRAS","level":5,"score":0.5425640940666199},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.5084049105644226},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5003659725189209},{"id":"https://openalex.org/C124224327","wikidata":"https://www.wikidata.org/wiki/Q21120164","display_name":"PAX8","level":4,"score":0.48641085624694824},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.4833919107913971},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.4761669337749481},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44384124875068665},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.44295910000801086},{"id":"https://openalex.org/C2781461381","wikidata":"https://www.wikidata.org/wiki/Q2292945","display_name":"Papillary thyroid cancer","level":4,"score":0.4407125413417816},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.32684528827667236},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30153796076774597},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29307934641838074},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.27623310685157776},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16897934675216675},{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.14675867557525635},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.0835021436214447},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0678444504737854},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.05714315176010132},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1038/modpathol.2008.10","doi":"https://doi.org/10.1038/modpathol.2008.10","is_oa":true,"landing_page_url":"https://doi.org/10.1038/modpathol.2008.10","pdf_url":"https://www.nature.com/articles/modpathol200810.pdf","source":{"id":"https://openalex.org/S33606366","display_name":"Modern Pathology","issn_l":"0893-3952","issn":["0893-3952","1530-0285"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern Pathology","raw_type":"journal-article"},{"id":"pmid:18437172","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18437172","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2673022","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2673022/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Mod Pathol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/modpathol.2008.10","doi":"https://doi.org/10.1038/modpathol.2008.10","is_oa":true,"landing_page_url":"https://doi.org/10.1038/modpathol.2008.10","pdf_url":"https://www.nature.com/articles/modpathol200810.pdf","source":{"id":"https://openalex.org/S33606366","display_name":"Modern Pathology","issn_l":"0893-3952","issn":["0893-3952","1530-0285"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern Pathology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3398179215","display_name":"Mechanisms of RET/PTC Rearrangement in Thyroid Cancer","funder_award_id":"R01CA088041","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2010521682.pdf","grobid_xml":"https://content.openalex.org/works/W2010521682.grobid-xml"},"referenced_works_count":80,"referenced_works":["https://openalex.org/W976714","https://openalex.org/W17178929","https://openalex.org/W76234450","https://openalex.org/W1506952471","https://openalex.org/W1523746131","https://openalex.org/W1534448933","https://openalex.org/W1670226482","https://openalex.org/W1933537883","https://openalex.org/W1963972106","https://openalex.org/W1969482148","https://openalex.org/W1970582967","https://openalex.org/W1972166687","https://openalex.org/W1974407322","https://openalex.org/W1974513412","https://openalex.org/W1977332018","https://openalex.org/W1978189407","https://openalex.org/W1978546090","https://openalex.org/W1980342487","https://openalex.org/W1980761308","https://openalex.org/W1982745900","https://openalex.org/W1990196512","https://openalex.org/W2006938406","https://openalex.org/W2012617002","https://openalex.org/W2019869717","https://openalex.org/W2020240767","https://openalex.org/W2022394260","https://openalex.org/W2026390338","https://openalex.org/W2029819995","https://openalex.org/W2031614751","https://openalex.org/W2045020328","https://openalex.org/W2046468922","https://openalex.org/W2052179498","https://openalex.org/W2056671717","https://openalex.org/W2061903640","https://openalex.org/W2062491181","https://openalex.org/W2069347512","https://openalex.org/W2069398477","https://openalex.org/W2076981991","https://openalex.org/W2080686146","https://openalex.org/W2087916660","https://openalex.org/W2098999691","https://openalex.org/W2102021118","https://openalex.org/W2104875539","https://openalex.org/W2106625264","https://openalex.org/W2107712702","https://openalex.org/W2113242315","https://openalex.org/W2113912069","https://openalex.org/W2115548657","https://openalex.org/W2118986295","https://openalex.org/W2122339876","https://openalex.org/W2123360704","https://openalex.org/W2124662474","https://openalex.org/W2125916043","https://openalex.org/W2132185197","https://openalex.org/W2136656327","https://openalex.org/W2137867595","https://openalex.org/W2139273584","https://openalex.org/W2140765540","https://openalex.org/W2143933280","https://openalex.org/W2145455579","https://openalex.org/W2147289344","https://openalex.org/W2154493372","https://openalex.org/W2157108601","https://openalex.org/W2157532190","https://openalex.org/W2159650626","https://openalex.org/W2161756157","https://openalex.org/W2166026513","https://openalex.org/W2166195139","https://openalex.org/W2171003891","https://openalex.org/W2171126418","https://openalex.org/W2171379946","https://openalex.org/W2173284474","https://openalex.org/W2259987557","https://openalex.org/W2417219239","https://openalex.org/W4232928267","https://openalex.org/W6603109565","https://openalex.org/W6678685281","https://openalex.org/W6680712565","https://openalex.org/W6684263564","https://openalex.org/W6692707412"],"related_works":["https://openalex.org/W2109544257","https://openalex.org/W2023325202","https://openalex.org/W2556160241","https://openalex.org/W1508880004","https://openalex.org/W4311256435","https://openalex.org/W2112179305","https://openalex.org/W4211118813","https://openalex.org/W2976715974"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":15},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":18},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":22},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":29},{"year":2017,"cited_by_count":22},{"year":2016,"cited_by_count":17},{"year":2015,"cited_by_count":28},{"year":2014,"cited_by_count":26},{"year":2013,"cited_by_count":22},{"year":2012,"cited_by_count":20}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}