{"id":"https://openalex.org/W2010519905","doi":"https://doi.org/10.1016/j.expneurol.2005.10.013","title":"Manipulating REM sleep in older adults by selective REM sleep deprivation and physiological as well as pharmacological REM sleep augmentation methods","display_name":"Manipulating REM sleep in older adults by selective REM sleep deprivation and physiological as well as pharmacological REM sleep augmentation methods","publication_year":2005,"publication_date":"2005-11-12","ids":{"openalex":"https://openalex.org/W2010519905","doi":"https://doi.org/10.1016/j.expneurol.2005.10.013","mag":"2010519905","pmid":"https://pubmed.ncbi.nlm.nih.gov/16289171"},"language":"en","primary_location":{"id":"doi:10.1016/j.expneurol.2005.10.013","doi":"https://doi.org/10.1016/j.expneurol.2005.10.013","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.expneurol.2005.10.013","pdf_url":null,"source":{"id":"https://openalex.org/S165592611","display_name":"Experimental Neurology","issn_l":"0014-4886","issn":["0014-4886","1090-2430"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113662232","display_name":"Orla Patricia Hornung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4392738228","display_name":"Stiftung Charit\u00e9","ror":"https://ror.org/016rf0n60","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4392738228","https://openalex.org/I7877124"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Orla P. Hornung","raw_affiliation_strings":["Department of Psychiatry and Psychotherapy, Charit\u00e9-University Medicine Berlin, Campus Benjamin Franklin, Eschenallee 3, 14050 Berlin, Germany. orla.hornung@charite.de","Department of Psychiatry and Psychotherapy, Charit\u00e9-University Medicine Berlin, Campus Benjamin Franklin, Eschenallee 3, 14050 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Psychotherapy, Charit\u00e9-University Medicine Berlin, Campus Benjamin Franklin, Eschenallee 3, 14050 Berlin, Germany. orla.hornung@charite.de","institution_ids":["https://openalex.org/I4392738228","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Department of Psychiatry and Psychotherapy, Charit\u00e9-University Medicine Berlin, Campus Benjamin Franklin, Eschenallee 3, 14050 Berlin, Germany","institution_ids":["https://openalex.org/I4392738228","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110453990","display_name":"Francesca Regen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4392738228","display_name":"Stiftung Charit\u00e9","ror":"https://ror.org/016rf0n60","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4392738228","https://openalex.org/I7877124"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Francesca Regen","raw_affiliation_strings":["Department of Psychiatry and Psychotherapy, Charit\u00e9-University Medicine Berlin, Campus Benjamin Franklin, Eschenallee 3, 14050 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Psychotherapy, Charit\u00e9-University Medicine Berlin, Campus Benjamin Franklin, Eschenallee 3, 14050 Berlin, Germany","institution_ids":["https://openalex.org/I4392738228","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078609491","display_name":"Michael Schredl","orcid":"https://orcid.org/0000-0002-8031-6608","observed_orcids":["https://orcid.org/0000-0002-8031-6608"]},"institutions":[{"id":"https://openalex.org/I4210105615","display_name":"Central Institute of Mental Health","ror":"https://ror.org/01hynnt93","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210105615"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Schredl","raw_affiliation_strings":["Central Institute of Mental Health, Mannheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Institute of Mental Health, Mannheim, Germany","institution_ids":["https://openalex.org/I4210105615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043504486","display_name":"Isabella Heuser","orcid":"https://orcid.org/0000-0001-7075-1158","observed_orcids":["https://orcid.org/0000-0001-7075-1158"]},"institutions":[{"id":"https://openalex.org/I4392738228","display_name":"Stiftung Charit\u00e9","ror":"https://ror.org/016rf0n60","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4392738228","https://openalex.org/I7877124"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Isabella Heuser","raw_affiliation_strings":["Department of Psychiatry and Psychotherapy, Charit\u00e9-University Medicine Berlin, Campus Benjamin Franklin, Eschenallee 3, 14050 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Psychotherapy, Charit\u00e9-University Medicine Berlin, Campus Benjamin Franklin, Eschenallee 3, 14050 Berlin, Germany","institution_ids":["https://openalex.org/I4392738228","https://openalex.org/I7877124"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073883544","display_name":"Heidi Danker\u2010Hopfe","orcid":"https://orcid.org/0000-0001-7001-1715","observed_orcids":["https://orcid.org/0000-0001-7001-1715"]},"institutions":[{"id":"https://openalex.org/I4392738228","display_name":"Stiftung Charit\u00e9","ror":"https://ror.org/016rf0n60","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4392738228","https://openalex.org/I7877124"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Heidi Danker-Hopfe","raw_affiliation_strings":["Department of Psychiatry and Psychotherapy, Charit\u00e9-University Medicine Berlin, Campus Benjamin Franklin, Eschenallee 3, 14050 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Psychotherapy, Charit\u00e9-University Medicine Berlin, Campus Benjamin Franklin, Eschenallee 3, 14050 Berlin, Germany","institution_ids":["https://openalex.org/I4392738228","https://openalex.org/I7877124"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5113662232"],"corresponding_institution_ids":["https://openalex.org/I4392738228","https://openalex.org/I7877124"],"apc_list":{"value":4110,"currency":"USD","value_usd":4110},"apc_paid":null,"fwci":0.4942,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.63464642,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"197","issue":"2","first_page":"486","last_page":"494"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11373","display_name":"Sleep and Work-Related Fatigue","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rem-sleep","display_name":"REM sleep","score":0.9290000200271606},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.9169999957084656},{"id":"https://openalex.org/keywords/acetylcholinesterase-inhibitors","display_name":"acetylcholinesterase inhibitors","score":0.8759999871253967},{"id":"https://openalex.org/keywords/rem-sleep-rebound","display_name":"REM sleep rebound","score":0.8109999895095825},{"id":"https://openalex.org/keywords/rem-latency","display_name":"REM latency","score":0.7749999761581421},{"id":"https://openalex.org/keywords/rem-density","display_name":"REM density","score":0.9679999947547913}],"concepts":[{"id":"https://openalex.org/C20566671","wikidata":"https://www.wikidata.org/wiki/Q1752878","display_name":"Non-rapid eye movement sleep","level":3,"score":0.8796303272247314},{"id":"https://openalex.org/C2775841894","wikidata":"https://www.wikidata.org/wiki/Q4683692","display_name":"Sleep (system call)","level":2,"score":0.7305739521980286},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.6823391914367676},{"id":"https://openalex.org/C110539466","wikidata":"https://www.wikidata.org/wiki/Q3964845","display_name":"Slow-wave sleep","level":3,"score":0.5786832571029663},{"id":"https://openalex.org/C2779213384","wikidata":"https://www.wikidata.org/wiki/Q211402","display_name":"Rapid eye movement sleep","level":3,"score":0.5442188382148743},{"id":"https://openalex.org/C2778329153","wikidata":"https://www.wikidata.org/wiki/Q1364801","display_name":"Sleep deprivation","level":3,"score":0.5252827405929565},{"id":"https://openalex.org/C185711340","wikidata":"https://www.wikidata.org/wiki/Q5347381","display_name":"Effects of sleep deprivation on cognitive performance","level":3,"score":0.5159597992897034},{"id":"https://openalex.org/C112144039","wikidata":"https://www.wikidata.org/wiki/Q4994651","display_name":"K-complex","level":4,"score":0.5021114349365234},{"id":"https://openalex.org/C95423882","wikidata":"https://www.wikidata.org/wiki/Q1043667","display_name":"Sleep debt","level":4,"score":0.48458898067474365},{"id":"https://openalex.org/C153050134","wikidata":"https://www.wikidata.org/wiki/Q760256","display_name":"Eye movement","level":2,"score":0.4381730556488037},{"id":"https://openalex.org/C2781053850","wikidata":"https://www.wikidata.org/wiki/Q7539763","display_name":"Sleep onset latency","level":4,"score":0.43596696853637695},{"id":"https://openalex.org/C31094802","wikidata":"https://www.wikidata.org/wiki/Q7539756","display_name":"Sleep induction","level":3,"score":0.434403657913208},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.35835108160972595},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.35694167017936707},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.30452078580856323},{"id":"https://openalex.org/C1513209611","wikidata":"https://www.wikidata.org/wiki/Q177190","display_name":"Sleep disorder","level":3,"score":0.26847708225250244},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2655808925628662},{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.1965629756450653},{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.08489990234375},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077265","descriptor_name":"Donepezil","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007189","descriptor_name":"Indans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012892","descriptor_name":"Sleep Deprivation","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012895","descriptor_name":"Sleep, REM","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012895","descriptor_name":"Sleep, REM","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017286","descriptor_name":"Polysomnography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.expneurol.2005.10.013","doi":"https://doi.org/10.1016/j.expneurol.2005.10.013","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.expneurol.2005.10.013","pdf_url":null,"source":{"id":"https://openalex.org/S165592611","display_name":"Experimental Neurology","issn_l":"0014-4886","issn":["0014-4886","1090-2430"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Neurology","raw_type":"journal-article"},{"id":"pmid:16289171","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16289171","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental neurology","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W640743221","https://openalex.org/W963102702","https://openalex.org/W1789636960","https://openalex.org/W1834725027","https://openalex.org/W1968521796","https://openalex.org/W1969259418","https://openalex.org/W1972426521","https://openalex.org/W1975476104","https://openalex.org/W1977634125","https://openalex.org/W1982401763","https://openalex.org/W1985471830","https://openalex.org/W1986893391","https://openalex.org/W1991636123","https://openalex.org/W1993840785","https://openalex.org/W1995816159","https://openalex.org/W1998695436","https://openalex.org/W2004530307","https://openalex.org/W2004608825","https://openalex.org/W2006598783","https://openalex.org/W2007735192","https://openalex.org/W2011894996","https://openalex.org/W2012748324","https://openalex.org/W2015017344","https://openalex.org/W2017389675","https://openalex.org/W2018986797","https://openalex.org/W2019815146","https://openalex.org/W2021872021","https://openalex.org/W2024346969","https://openalex.org/W2025536697","https://openalex.org/W2026677898","https://openalex.org/W2033414327","https://openalex.org/W2035092612","https://openalex.org/W2036437406","https://openalex.org/W2037560701","https://openalex.org/W2041380134","https://openalex.org/W2043826825","https://openalex.org/W2045249801","https://openalex.org/W2057914888","https://openalex.org/W2058755793","https://openalex.org/W2059341419","https://openalex.org/W2061914600","https://openalex.org/W2063159977","https://openalex.org/W2078995997","https://openalex.org/W2114571045","https://openalex.org/W2121562335","https://openalex.org/W2148919860","https://openalex.org/W2158120984","https://openalex.org/W2171360537","https://openalex.org/W2171697010","https://openalex.org/W2313372757","https://openalex.org/W2321234294","https://openalex.org/W2332996633","https://openalex.org/W2407794666","https://openalex.org/W2409285038","https://openalex.org/W3022302886","https://openalex.org/W4210389365","https://openalex.org/W6702305138"],"related_works":["https://openalex.org/W2313911456","https://openalex.org/W1982076847","https://openalex.org/W2031730715","https://openalex.org/W2024346969","https://openalex.org/W2148919860","https://openalex.org/W2066297786","https://openalex.org/W2767807023","https://openalex.org/W177118594","https://openalex.org/W2131935566","https://openalex.org/W7218194966"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}