{"id":"https://openalex.org/W2010487672","doi":"https://doi.org/10.3727/000000003783992289","title":"Body Weight and Abdominal Fat Gene Expression Profile in Response to a Novel Hydroxycitric Acid-Based Dietary Supplement","display_name":"Body Weight and Abdominal Fat Gene Expression Profile in Response to a Novel Hydroxycitric Acid-Based Dietary Supplement","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2010487672","doi":"https://doi.org/10.3727/000000003783992289","mag":"2010487672","pmid":"https://pubmed.ncbi.nlm.nih.gov/15200237","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5991152"},"language":"en","primary_location":{"id":"doi:10.3727/000000003783992289","doi":"https://doi.org/10.3727/000000003783992289","is_oa":true,"landing_page_url":"https://doi.org/10.3727/000000003783992289","pdf_url":null,"source":{"id":"https://openalex.org/S134577766","display_name":"Gene Expression","issn_l":"1052-2166","issn":["1052-2166","1555-3884"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-70","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene Expression","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.3727/000000003783992289","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020018621","display_name":"Sashwati Roy","orcid":"https://orcid.org/0000-0002-9995-4917","observed_orcids":["https://orcid.org/0000-0002-9995-4917"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SASHWATI ROY","raw_affiliation_strings":["*Laboratory of Molecular Medicine, Department of Surgery, The Ohio State University Medical Center, Columbus, OH 43210","Laboratory of Molecular Medicine, Department of Surgery, The Ohio State University Medical Center, Columbus, OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Laboratory of Molecular Medicine, Department of Surgery, The Ohio State University Medical Center, Columbus, OH 43210","institution_ids":["https://openalex.org/I2802841970"]},{"raw_affiliation_string":"Laboratory of Molecular Medicine, Department of Surgery, The Ohio State University Medical Center, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041966279","display_name":"Cameron L. Rink","orcid":"https://orcid.org/0000-0002-3149-3624","observed_orcids":["https://orcid.org/0000-0002-3149-3624"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"CAMERON RINK","raw_affiliation_strings":["*Laboratory of Molecular Medicine, Department of Surgery, The Ohio State University Medical Center, Columbus, OH 43210"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Laboratory of Molecular Medicine, Department of Surgery, The Ohio State University Medical Center, Columbus, OH 43210","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029107258","display_name":"Savita Khanna","orcid":"https://orcid.org/0000-0001-6661-9293","observed_orcids":["https://orcid.org/0000-0001-6661-9293"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SAVITA KHANNA","raw_affiliation_strings":["*Laboratory of Molecular Medicine, Department of Surgery, The Ohio State University Medical Center, Columbus, OH 43210"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Laboratory of Molecular Medicine, Department of Surgery, The Ohio State University Medical Center, Columbus, OH 43210","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011007665","display_name":"Christina Phillips","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"CHRISTINA PHILLIPS","raw_affiliation_strings":["*Laboratory of Molecular Medicine, Department of Surgery, The Ohio State University Medical Center, Columbus, OH 43210"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Laboratory of Molecular Medicine, Department of Surgery, The Ohio State University Medical Center, Columbus, OH 43210","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019498762","display_name":"Debasis Bagchi","orcid":"https://orcid.org/0000-0001-9478-6427","observed_orcids":["https://orcid.org/0000-0001-9478-6427"]},"institutions":[{"id":"https://openalex.org/I114493937","display_name":"Creighton University","ror":"https://ror.org/05wf30g94","country_code":"US","type":"education","lineage":["https://openalex.org/I114493937"]},{"id":"https://openalex.org/I2800482329","display_name":"CHI Health Creighton University Medical Center - Bergan Mercy","ror":"https://ror.org/03z1w3b90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800482329","https://openalex.org/I2802665030","https://openalex.org/I2802797007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DEBASIS BAGCHI","raw_affiliation_strings":["\u2020School of Pharmacy and Health Professions, Creighton University Medical Center, Omaha, NE 68178"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020School of Pharmacy and Health Professions, Creighton University Medical Center, Omaha, NE 68178","institution_ids":["https://openalex.org/I114493937","https://openalex.org/I2800482329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025047849","display_name":"Manashi Bagchi","orcid":"https://orcid.org/0000-0002-1527-6419","observed_orcids":["https://orcid.org/0000-0002-1527-6419"]},"institutions":[{"id":"https://openalex.org/I114493937","display_name":"Creighton University","ror":"https://ror.org/05wf30g94","country_code":"US","type":"education","lineage":["https://openalex.org/I114493937"]},{"id":"https://openalex.org/I2800482329","display_name":"CHI Health Creighton University Medical Center - Bergan Mercy","ror":"https://ror.org/03z1w3b90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800482329","https://openalex.org/I2802665030","https://openalex.org/I2802797007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MANASHI BAGCHI","raw_affiliation_strings":["\u2020School of Pharmacy and Health Professions, Creighton University Medical Center, Omaha, NE 68178"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020School of Pharmacy and Health Professions, Creighton University Medical Center, Omaha, NE 68178","institution_ids":["https://openalex.org/I114493937","https://openalex.org/I2800482329"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056267400","display_name":"Chandan K. Sen","orcid":"https://orcid.org/0000-0003-3151-5202","observed_orcids":["https://orcid.org/0000-0003-3151-5202","https://orcid.org/0000-0002-2936-417X"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"CHANDAN K. SEN","raw_affiliation_strings":["*Laboratory of Molecular Medicine, Department of Surgery, The Ohio State University Medical Center, Columbus, OH 43210"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Laboratory of Molecular Medicine, Department of Surgery, The Ohio State University Medical Center, Columbus, OH 43210","institution_ids":["https://openalex.org/I2802841970"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8242,"has_fulltext":false,"cited_by_count":82,"citation_normalized_percentile":{"value":0.82733389,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"11","issue":"5","first_page":"251","last_page":"262"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12087","display_name":"Natural Compound Pharmacology Studies","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydroxycitric-acid","display_name":"hydroxycitric acid","score":0.9929999709129333},{"id":"https://openalex.org/keywords/garcinia-cambogia","display_name":"Garcinia cambogia","score":0.9810000061988831},{"id":"https://openalex.org/keywords/dietary-supplements","display_name":"dietary supplements","score":0.6549999713897705},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9409999847412109},{"id":"https://openalex.org/keywords/weight-gain","display_name":"weight gain","score":0.8100000023841858},{"id":"https://openalex.org/keywords/abdominal-adiposity","display_name":"abdominal fat","score":0.9800000190734863},{"id":"https://openalex.org/keywords/gene-expression-profiles","display_name":"gene expression profiles","score":0.6830000281333923},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.9419999718666077},{"id":"https://openalex.org/keywords/serotonin-receptors","display_name":"serotonin receptors","score":0.9399999976158142},{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"adipose tissue","score":0.5799999833106995},{"id":"https://openalex.org/keywords/weight-management","display_name":"weight management","score":0.4749999940395355}],"concepts":[{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.6173256635665894},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.6132546663284302},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.5057611465454102},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.5044056177139282},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4851885437965393},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.4717693626880646},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.4714953303337097},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4486458897590637},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4116533398628235},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.4029160141944885},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39102891087532043},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3697839081287384},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3692016005516052},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34778928756713867},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.3319839835166931},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33168500661849976},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28484439849853516}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002951","descriptor_name":"Citrates","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002951","descriptor_name":"Citrates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002951","descriptor_name":"Citrates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009004","descriptor_name":"Monosaccharide Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009124","descriptor_name":"Muscle Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019440","descriptor_name":"Anti-Obesity Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D028321","descriptor_name":"Plant Preparations","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D028321","descriptor_name":"Plant Preparations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D029761","descriptor_name":"Garcinia cambogia","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051272","descriptor_name":"Glucose Transporter Type 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051275","descriptor_name":"Glucose Transporter Type 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3727/000000003783992289","doi":"https://doi.org/10.3727/000000003783992289","is_oa":true,"landing_page_url":"https://doi.org/10.3727/000000003783992289","pdf_url":null,"source":{"id":"https://openalex.org/S134577766","display_name":"Gene Expression","issn_l":"1052-2166","issn":["1052-2166","1555-3884"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-70","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene Expression","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4953408","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5991152","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5991152","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5991152","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene Expr","raw_type":"Text"},{"id":"pmid:15200237","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15200237","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene expression","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3727/000000003783992289","doi":"https://doi.org/10.3727/000000003783992289","is_oa":true,"landing_page_url":"https://doi.org/10.3727/000000003783992289","pdf_url":null,"source":{"id":"https://openalex.org/S134577766","display_name":"Gene Expression","issn_l":"1052-2166","issn":["1052-2166","1555-3884"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-70","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene Expression","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W88962908","https://openalex.org/W125104575","https://openalex.org/W1536956916","https://openalex.org/W1818198366","https://openalex.org/W1879746969","https://openalex.org/W1883680853","https://openalex.org/W1969591644","https://openalex.org/W1970588384","https://openalex.org/W1971753118","https://openalex.org/W1974655115","https://openalex.org/W1981038669","https://openalex.org/W1989796905","https://openalex.org/W1998520815","https://openalex.org/W1999289755","https://openalex.org/W2001312923","https://openalex.org/W2002714824","https://openalex.org/W2005166222","https://openalex.org/W2005441991","https://openalex.org/W2013859358","https://openalex.org/W2014014450","https://openalex.org/W2017669890","https://openalex.org/W2021239799","https://openalex.org/W2037316960","https://openalex.org/W2038437697","https://openalex.org/W2048662143","https://openalex.org/W2049447129","https://openalex.org/W2056759488","https://openalex.org/W2057461207","https://openalex.org/W2063161450","https://openalex.org/W2068407196","https://openalex.org/W2071013125","https://openalex.org/W2093482537","https://openalex.org/W2094280313","https://openalex.org/W2109421395","https://openalex.org/W2125510262","https://openalex.org/W2126957957","https://openalex.org/W2134285011","https://openalex.org/W2138349577","https://openalex.org/W2143716267","https://openalex.org/W2161089139","https://openalex.org/W2161853022","https://openalex.org/W2164519355","https://openalex.org/W2183613382","https://openalex.org/W2272993211","https://openalex.org/W2394792487","https://openalex.org/W2401209661","https://openalex.org/W2410917954","https://openalex.org/W2411839821","https://openalex.org/W2416975709","https://openalex.org/W4301155091"],"related_works":["https://openalex.org/W2041776243","https://openalex.org/W6091562","https://openalex.org/W2126957957","https://openalex.org/W2119628404","https://openalex.org/W1998520815","https://openalex.org/W2403581438","https://openalex.org/W2063843967","https://openalex.org/W1576910562","https://openalex.org/W2133613422","https://openalex.org/W2317364906"],"abstract_inverted_index":{"Obesity":[0],"is":[1,58,102,110],"a":[2,59,68,97,218,290],"global":[3],"public":[4],"health":[5],"problem,":[6],"with":[7,191],"about":[8],"315":[9],"million":[10],"people":[11],"worldwide":[12],"estimated":[13],"to":[14,82,125,145,150,231,265],"fall":[15],"into":[16],"the":[17,113,152,159,214,251,259],"WHO-defined":[18],"obesity":[19],"categories.":[20],"Traditional":[21],"herbal":[22],"medicines":[23],"may":[24],"have":[25,41],"some":[26],"potential":[27],"in":[28,79,112,129,132,138,213,268,273],"managing":[29],"obesity.":[30],"Botanical":[31],"dietary":[32,180,232,294],"supplements":[33],"often":[34],"contain":[35],"complex":[36],"mixtures":[37],"of":[38,50,62,100,142,154,168,207,223,227,250,278,284,293],"phytochemicals":[39],"that":[40,92,108,173,282],"additive":[42],"or":[43,94],"synergistic":[44],"interactions.":[45],"The":[46],"dried":[47],"fruit":[48],"rind":[49],"Garcinia":[51],"cambogia,":[52],"also":[53],"known":[54],"as":[55,116,135,137],"Malabar":[56],"tamarind,":[57],"unique":[60],"source":[61],"(-)-hydroxycitric":[63],"acid":[64],"(HCA),":[65],"which":[66,244],"exhibits":[67],"distinct":[69,291],"sour":[70],"taste":[71],"and":[72,107,162,210,243],"has":[73,89,122],"been":[74,90,123],"safely":[75],"used":[76],"for":[77,177,240,247],"centuries":[78],"Southeastern":[80],"Asia":[81],"make":[83],"meals":[84],"more":[85],"filling.":[86],"Recently":[87],"it":[88],"demonstrated":[91],"HCA-SX":[93,109,121,157,181,263,295],"Super":[95],"Citrimax,":[96],"novel":[98],"derivative":[99],"HCA,":[101],"safe":[103],"when":[104],"taken":[105],"orally":[106],"bioavailable":[111],"human":[114,178],"plasma":[115,198],"studied":[117],"by":[118,256],"GC-MS.":[119],"Although":[120],"observed":[124,172],"be":[126,146,266],"conditionally":[127],"effective":[128,267],"weight":[130,161,185,271],"management":[131],"experimental":[133,261],"animals":[134],"well":[136],"humans,":[139],"its":[140],"mechanism":[141],"action":[143],"remains":[144],"understood.":[147],"We":[148,171],"sought":[149],"determine":[151],"effects":[153],"low-dose":[155],"oral":[156],"on":[158],"body":[160,184,270],"abdominal":[163,193],"fat":[164,194,215],"gene":[165],"expression":[166,196],"profile":[167],"Sprague-Dawley":[169],"rats.":[170,275],"at":[174],"doses":[175],"relevant":[176],"consumption":[179],"significantly":[182],"contained":[183],"growth.":[186],"This":[187],"response":[188],"was":[189],"associated":[190],"lowered":[192],"leptin":[195,199],"while":[197],"levels":[200],"remained":[201],"unaffected.":[202],"Repeated":[203],"high-density":[204],"microarray":[205],"analysis":[206],"9960":[208],"genes":[209,225,229,238,280,285],"ESTs":[211],"present":[212],"tissue":[216],"identified":[217],"small":[219],"set":[220],"(approximately":[221],"1%":[222],"all":[224],"screened)":[226],"specific":[228],"sensitive":[230],"HCA-SX.":[233,257],"Other":[234],"genes,":[235],"including":[236],"vital":[237],"transcribing":[239],"mitochondrial/nuclear":[241],"proteins":[242],"are":[245],"necessary":[246],"fundamental":[248],"support":[249],"tissue,":[252],"were":[253],"not":[254],"affected":[255],"Under":[258],"current":[260],"conditions,":[262],"proved":[264],"restricting":[269],"gain":[272],"adult":[274],"Functional":[276],"characterization":[277],"HCA-SX-sensitive":[279],"revealed":[281],"upregulation":[283],"encoding":[286],"serotonin":[287],"receptors":[288],"represent":[289],"effect":[292],"supplementation.":[296]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}