{"id":"https://openalex.org/W2010480243","doi":"https://doi.org/10.1186/s12885-015-1220-2","title":"Homozygous deletions of UGT2B17 modifies effects of smoking on TP53-mutations and relapse of head and neck carcinoma","display_name":"Homozygous deletions of UGT2B17 modifies effects of smoking on TP53-mutations and relapse of head and neck carcinoma","publication_year":2015,"publication_date":"2015-03-30","ids":{"openalex":"https://openalex.org/W2010480243","doi":"https://doi.org/10.1186/s12885-015-1220-2","mag":"2010480243","pmid":"https://pubmed.ncbi.nlm.nih.gov/25886176","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4389803"},"language":"en","primary_location":{"id":"doi:10.1186/s12885-015-1220-2","doi":"https://doi.org/10.1186/s12885-015-1220-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-015-1220-2","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12885-015-1220-2.pdf","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s12885-015-1220-2.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015637136","display_name":"Aki Mafune","orcid":"https://orcid.org/0000-0002-6160-2879","observed_orcids":["https://orcid.org/0000-0002-6160-2879"]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Aki Mafune","raw_affiliation_strings":["Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan. mafu0218@yahoo.co.jp","Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan. mafu0218@yahoo.co.jp","Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan. mafu0218@yahoo.co.jp","institution_ids":["https://openalex.org/I115498069"]},{"raw_affiliation_string":"Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan. mafu0218@yahoo.co.jp","institution_ids":["https://openalex.org/I115498069"]},{"raw_affiliation_string":"Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024944463","display_name":"Takanori Hama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Takanori Hama","raw_affiliation_strings":["Department of Oto-Rhino-laryngology, Jikei University School of Medicine, 3 - 25 - 8 Nishi-shimbashi, Minato-ku, Tokyo, 105-8461, Japan. takanori@jikei.ac.jp","Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan. takanori@jikei.ac.jp","Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oto-Rhino-laryngology, Jikei University School of Medicine, 3 - 25 - 8 Nishi-shimbashi, Minato-ku, Tokyo, 105-8461, Japan. takanori@jikei.ac.jp","institution_ids":["https://openalex.org/I115498069"]},{"raw_affiliation_string":"Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan. takanori@jikei.ac.jp","institution_ids":["https://openalex.org/I115498069"]},{"raw_affiliation_string":"Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112130147","display_name":"Toshihito Suda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshihito Suda","raw_affiliation_strings":["Department of Oto-Rhino-laryngology, Jikei University School of Medicine, 3 - 25 - 8 Nishi-shimbashi, Minato-ku, Tokyo, 105-8461, Japan. tssuda@jikei.ac.jp","Department of Oto-Rhino-laryngology, Jikei University School of Medicine, 3 \u2013 25 - 8 Nishi-shimbashi, Minato-ku, Tokyo, 105-8461, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oto-Rhino-laryngology, Jikei University School of Medicine, 3 - 25 - 8 Nishi-shimbashi, Minato-ku, Tokyo, 105-8461, Japan. tssuda@jikei.ac.jp","institution_ids":["https://openalex.org/I115498069"]},{"raw_affiliation_string":"Department of Oto-Rhino-laryngology, Jikei University School of Medicine, 3 \u2013 25 - 8 Nishi-shimbashi, Minato-ku, Tokyo, 105-8461, Japan","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037621988","display_name":"Yutaka Suzuki","orcid":"https://orcid.org/0000-0002-2603-5688","observed_orcids":["https://orcid.org/0000-0002-2603-5688"]},"institutions":[{"id":"https://openalex.org/I79072001","display_name":"International University of Health and Welfare","ror":"https://ror.org/053d3tv41","country_code":"JP","type":"education","lineage":["https://openalex.org/I79072001"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yutaka Suzuki","raw_affiliation_strings":["Department of Surgery, International University of Health and welfare, Tochigi, Japan. yutaka@iuhw.ac.jp","Department of Surgery, International University of Health and welfare, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, International University of Health and welfare, Tochigi, Japan. yutaka@iuhw.ac.jp","institution_ids":["https://openalex.org/I79072001"]},{"raw_affiliation_string":"Department of Surgery, International University of Health and welfare, Tochigi, Japan","institution_ids":["https://openalex.org/I79072001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112818416","display_name":"Masahiro Ikegami","orcid":"https://orcid.org/0000-0002-0036-4109","observed_orcids":["https://orcid.org/0000-0002-0036-4109"]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Ikegami","raw_affiliation_strings":["Department of Pathology, Jikei University School of Medicine, Tokyo, Japan. ikegami@jikei.ac.jp","Department of Pathology, Jikei University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Jikei University School of Medicine, Tokyo, Japan. ikegami@jikei.ac.jp","institution_ids":["https://openalex.org/I115498069"]},{"raw_affiliation_string":"Department of Pathology, Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000321288","display_name":"Chikako Sakanashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chikako Sakanashi","raw_affiliation_strings":["Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan. c.sakanashi@gmail.com","Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan. c.sakanashi@gmail.com","institution_ids":["https://openalex.org/I115498069"]},{"raw_affiliation_string":"Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059054844","display_name":"Satoko Imai","orcid":"https://orcid.org/0000-0001-7223-5579","observed_orcids":["https://orcid.org/0000-0001-7223-5579"]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoko Imai","raw_affiliation_strings":["Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan. h22ms-imai@jikei.ac.jp","Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan. h22ms-imai@jikei.ac.jp","institution_ids":["https://openalex.org/I115498069"]},{"raw_affiliation_string":"Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058924139","display_name":"Akio Nakashima","orcid":"https://orcid.org/0000-0002-3730-0301","observed_orcids":["https://orcid.org/0000-0002-3730-0301"]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akio Nakashima","raw_affiliation_strings":["Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan. a-nakashima@jikei.ac.jp","Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan. a-nakashima@jikei.ac.jp","Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan. a-nakashima@jikei.ac.jp","institution_ids":["https://openalex.org/I115498069"]},{"raw_affiliation_string":"Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan. a-nakashima@jikei.ac.jp","institution_ids":["https://openalex.org/I115498069"]},{"raw_affiliation_string":"Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Takashi Yokoo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Yokoo","raw_affiliation_strings":["Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan. tyokoo@jikei.ac.jp","Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan. tyokoo@jikei.ac.jp","institution_ids":["https://openalex.org/I115498069"]},{"raw_affiliation_string":"Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102373215","display_name":"Kota Wada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]},{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kota Wada","raw_affiliation_strings":["Department of Oto-Rhino-laryngology, Jikei University School of Medicine, 3 - 25 - 8 Nishi-shimbashi, Minato-ku, Tokyo, 105-8461, Japan. k.wada@mbd.ocn.ne.jp","Department of Otorhinolaryngology, Toho University, Tokyo, Japan. k.wada@mbd.ocn.ne.jp","Department of Oto-Rhino-laryngology, Jikei University School of Medicine, 3 \u2013 25 - 8 Nishi-shimbashi, Minato-ku, Tokyo, 105-8461, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oto-Rhino-laryngology, Jikei University School of Medicine, 3 - 25 - 8 Nishi-shimbashi, Minato-ku, Tokyo, 105-8461, Japan. k.wada@mbd.ocn.ne.jp","institution_ids":["https://openalex.org/I115498069"]},{"raw_affiliation_string":"Department of Otorhinolaryngology, Toho University, Tokyo, Japan. k.wada@mbd.ocn.ne.jp","institution_ids":["https://openalex.org/I129634264"]},{"raw_affiliation_string":"Department of Oto-Rhino-laryngology, Jikei University School of Medicine, 3 \u2013 25 - 8 Nishi-shimbashi, Minato-ku, Tokyo, 105-8461, Japan","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020649395","display_name":"Hiromi Kojima","orcid":"https://orcid.org/0000-0003-2967-2110","observed_orcids":["https://orcid.org/0000-0003-2967-2110"]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromi Kojima","raw_affiliation_strings":["Department of Oto-Rhino-laryngology, Jikei University School of Medicine, 3 - 25 - 8 Nishi-shimbashi, Minato-ku, Tokyo, 105-8461, Japan. kojimah@jikei.ac.jp","Department of Oto-Rhino-laryngology, Jikei University School of Medicine, 3 \u2013 25 - 8 Nishi-shimbashi, Minato-ku, Tokyo, 105-8461, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oto-Rhino-laryngology, Jikei University School of Medicine, 3 - 25 - 8 Nishi-shimbashi, Minato-ku, Tokyo, 105-8461, Japan. kojimah@jikei.ac.jp","institution_ids":["https://openalex.org/I115498069"]},{"raw_affiliation_string":"Department of Oto-Rhino-laryngology, Jikei University School of Medicine, 3 \u2013 25 - 8 Nishi-shimbashi, Minato-ku, Tokyo, 105-8461, Japan","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075947539","display_name":"Mitsuyoshi Urashima","orcid":"https://orcid.org/0000-0002-7395-5831","observed_orcids":["https://orcid.org/0000-0002-7395-5831"]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsuyoshi Urashima","raw_affiliation_strings":["Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan. urashima@jikei.ac.jp","Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan. urashima@jikei.ac.jp","institution_ids":["https://openalex.org/I115498069"]},{"raw_affiliation_string":"Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5024944463"],"corresponding_institution_ids":["https://openalex.org/I115498069"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":{"value":3390,"currency":"USD","value_usd":3390},"fwci":0.6338,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.68052812,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"15","issue":"1","first_page":"205","last_page":"205"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.7925000190734863,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.7925000190734863,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.18619999289512634,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/homozygous-deletion","display_name":"homozygous deletion","score":0.9440000057220459},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.8870000243186951},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.8809999823570251},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.8989999890327454},{"id":"https://openalex.org/keywords/p16-expression","display_name":"p16 expression","score":0.8109999895095825},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.8339999914169312},{"id":"https://openalex.org/keywords/copy-number-variation","display_name":"copy number variation","score":0.8360000252723694},{"id":"https://openalex.org/keywords/gene-environment-interaction","display_name":"gene-environment interaction","score":0.7609999775886536},{"id":"https://openalex.org/keywords/japanese-patients","display_name":"Japanese patients","score":0.6679999828338623}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.519351601600647},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4953542947769165},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.49174097180366516},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47245267033576965},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.43468135595321655},{"id":"https://openalex.org/C120821319","wikidata":"https://www.wikidata.org/wiki/Q1501491","display_name":"Copy-number variation","level":4,"score":0.42713695764541626},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.39155134558677673},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3895476758480072},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.38225629925727844},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35005244612693787},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.33194974064826965},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.32096219062805176},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006720","descriptor_name":"Homozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014453","descriptor_name":"Glucuronosyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015778","descriptor_name":"Minor Histocompatibility Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017384","descriptor_name":"Sequence Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019941","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p16","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019941","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p16","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12885-015-1220-2","doi":"https://doi.org/10.1186/s12885-015-1220-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-015-1220-2","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12885-015-1220-2.pdf","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3355449","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4389803","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:25886176","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25886176","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4389803","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4389803/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12885-015-1220-2","doi":"https://doi.org/10.1186/s12885-015-1220-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-015-1220-2","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12885-015-1220-2.pdf","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6437300650","display_name":"Antibody-dependent cytotoxic activity and cancer immune surveillance mechanism in head and neck cancer","funder_award_id":"26462624","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320324809","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2010480243.pdf","grobid_xml":"https://content.openalex.org/works/W2010480243.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1843799521","https://openalex.org/W1977052256","https://openalex.org/W1977475884","https://openalex.org/W1984522168","https://openalex.org/W1986076152","https://openalex.org/W2003657273","https://openalex.org/W2004637409","https://openalex.org/W2015561818","https://openalex.org/W2038500217","https://openalex.org/W2062312459","https://openalex.org/W2073166174","https://openalex.org/W2108244474","https://openalex.org/W2110664940","https://openalex.org/W2123526038","https://openalex.org/W2133476676","https://openalex.org/W2160491244","https://openalex.org/W2162504881","https://openalex.org/W2163186602","https://openalex.org/W2169463741","https://openalex.org/W2170225028","https://openalex.org/W2312732552","https://openalex.org/W2470020720"],"related_works":["https://openalex.org/W2131739492","https://openalex.org/W7095835908","https://openalex.org/W2327069967","https://openalex.org/W1977052256","https://openalex.org/W7100332233","https://openalex.org/W1577116496","https://openalex.org/W2160491244","https://openalex.org/W3019319665","https://openalex.org/W2142687560","https://openalex.org/W1917320814"],"abstract_inverted_index":{"BACKGROUND:":[0],"Smoking":[1],"induces":[2],"oncogenic":[3],"TP53-mutations":[4,95,140,175,197,237,245],"in":[5,24,47,131,217],"head":[6],"and":[7,17,30,74,96,113,123,157,171,195,238],"neck":[8],"squamous":[9],"cell":[10],"carcinomas":[11],"(HNSCCs).":[12],"Disruptive":[13],"mutations":[14],"of":[15,19,54,92,105,133,234],"TP53-gene":[16],"expression":[18],"p16":[20,88,121,172,229],"protein":[21],"[p16":[22],"(+)]":[23],"tumor":[25],"tissue":[26],"associate":[27],"with":[28,81,165,169,192,228,242,253],"worse":[29],"better":[31],"prognosis,":[32],"respectively.":[33,126],"UDP-glucuronosyltransferase":[34],"2":[35],"family,":[36],"polypeptide":[37],"B17":[38],"(UGT2B17)":[39],"detoxifies":[40],"smoking-related":[41],"metabolites.":[42],"Differences":[43],"among":[44,65,72,145,180,183,250],"ethnic":[45],"groups":[46],"UGT2B17":[48,55],"are":[49,58],"extremely":[50],"high.":[51],"Homozygous":[52],"deletions":[53],"gene":[56],"(UGT2B17-deletion)":[57],"a":[59,69,102,106,218],"common":[60,70,144,179],"copy":[61],"number":[62],"variant":[63],"(CNV)":[64],"Japanese,":[66],"but":[67,152],"not":[68,160],"CNV":[71],"Africans":[73],"Europeans.":[75],"Thus,":[76],"we":[77],"examined":[78],"Japanese":[79,251],"patients":[80,168,204,252],"HNSCC":[82],"to":[83,118,212,246],"explore":[84],"if":[85],"UGT2B17-deletion":[86,128,170,194,226],"and/or":[87],"(+)":[89,230],"modify":[90,232],"effects":[91,233],"smoking":[93,235],"on":[94,236],"affect":[97],"relapse.":[98],"METHODS:":[99],"We":[100],"conducted":[101],"posthoc":[103],"analysis":[104],"prospective":[107],"cohort.":[108],"Polymerase":[109],"chain":[110],"reaction,":[111],"immunohistochemistry,":[112],"direct":[114],"sequencing":[115],"were":[116,141,176],"used":[117],"determine":[119],"UGT2B17-deletion,":[120],"(+),":[122,173],"detailed":[124],"TP53-mutations,":[125],"RESULTS:":[127],"was":[129,159],"observed":[130],"80%":[132],"this":[134,138,153],"study":[135],"population.":[136],"For":[137],"80%,":[139],"significantly":[142],"more":[143,178],"smokers":[146,156,181],"than":[147,182,202],"non-smokers":[148,184],"(P":[149],"=":[150,189,215],"0.0016),":[151],"difference":[154],"between":[155],"nonsmokers":[158],"significant":[161],"for":[162],"the":[163,243],"20%":[164],"UGT2B17.":[166],"In":[167],"simultaneously,":[174],"much":[177],"(81%":[185],"versus":[186],"17%;":[187],"P":[188,214],"0.0050).":[190],"Patients":[191],"both":[193],"disruptive":[196,244],"had":[198],"higher":[199],"relapse":[200,248],"rates":[201,249],"other":[203],"(hazard":[205],"ratio,":[206],"2.22;":[207],"95%":[208],"confidence":[209],"interval,":[210],"1.30":[211],"3.80,":[213],"0.004)":[216],"stepwise":[219],"method.":[220],"CONCLUSIONS:":[221],"These":[222],"results":[223],"suggest":[224],"that":[225],"interacting":[227],"may":[231,239],"further":[240],"interact":[241],"raise":[247],"HNSCC.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
