{"id":"https://openalex.org/W2010456791","doi":"https://doi.org/10.1289/ehp.97105s2509","title":"Human Drug Discrimination and Multiple Chemical Sensitivity: Caffeine Exposure as an Experimental Model","display_name":"Human Drug Discrimination and Multiple Chemical Sensitivity: Caffeine Exposure as an Experimental Model","publication_year":1997,"publication_date":"1997-03-01","ids":{"openalex":"https://openalex.org/W2010456791","doi":"https://doi.org/10.1289/ehp.97105s2509","mag":"2010456791","pmid":"https://pubmed.ncbi.nlm.nih.gov/9167988","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1469818"},"language":"en","primary_location":{"id":"doi:10.1289/ehp.97105s2509","doi":"https://doi.org/10.1289/ehp.97105s2509","is_oa":true,"landing_page_url":"https://doi.org/10.1289/ehp.97105s2509","pdf_url":"https://ehp.niehs.nih.gov/doi/epdf/10.1289/ehp.97105s2509","source":{"id":"https://openalex.org/S10446503","display_name":"Environmental Health Perspectives","issn_l":"0091-6765","issn":["0091-6765","1552-9924"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Health Perspectives","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ehp.niehs.nih.gov/doi/epdf/10.1289/ehp.97105s2509","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064551545","display_name":"Thomas Eissenberg","orcid":"https://orcid.org/0000-0002-8277-5437","observed_orcids":["https://orcid.org/0000-0002-8277-5437"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T Eissenberg","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224-6823, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224-6823, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111503254","display_name":"Roland R. Griffiths","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R R Griffiths","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224-6823, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224-6823, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":0.6712,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.64861129,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"105","issue":"suppl 2","first_page":"509","last_page":"509"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11002","display_name":"Indoor Air Quality and Microbial Exposure","score":0.3449999988079071,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11002","display_name":"Indoor Air Quality and Microbial Exposure","score":0.3449999988079071,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11334","display_name":"Psychosomatic Disorders and Their Treatments","score":0.1923000067472458,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11282","display_name":"Fibromyalgia and Chronic Fatigue Syndrome Research","score":0.13500000536441803,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-chemical-sensitivity","display_name":"multiple chemical sensitivity","score":1.0},{"id":"https://openalex.org/keywords/drug-discrimination","display_name":"drug discrimination","score":0.7099999785423279},{"id":"https://openalex.org/keywords/caffeine","display_name":"caffeine","score":0.3149999976158142},{"id":"https://openalex.org/keywords/placebo","display_name":"placebo","score":0.3190000057220459},{"id":"https://openalex.org/keywords/double-blind-testing","display_name":"double-blind testing","score":0.7039999961853027},{"id":"https://openalex.org/keywords/training-dose","display_name":"training dose","score":0.6159999966621399},{"id":"https://openalex.org/keywords/discrimination-training","display_name":"discrimination training","score":0.621999979019165},{"id":"https://openalex.org/keywords/study-design","display_name":"research design","score":0.7440000176429749},{"id":"https://openalex.org/keywords/diagnostic-testing","display_name":"diagnostic testing","score":0.3540000021457672}],"concepts":[{"id":"https://openalex.org/C2778500429","wikidata":"https://www.wikidata.org/wiki/Q60235","display_name":"Caffeine","level":2,"score":0.7873919010162354},{"id":"https://openalex.org/C2779013996","wikidata":"https://www.wikidata.org/wiki/Q674461","display_name":"Multiple chemical sensitivity","level":2,"score":0.694229006767273},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5238897204399109},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48308423161506653},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4765232801437378},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.44110703468322754},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34208714962005615},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18045535683631897},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.16991236805915833},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.13102763891220093},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.11254435777664185},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002110","descriptor_name":"Caffeine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002110","descriptor_name":"Caffeine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004192","descriptor_name":"Discrimination, Psychological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004782","descriptor_name":"Environmental Health","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018777","descriptor_name":"Multiple Chemical Sensitivity","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D018777","descriptor_name":"Multiple Chemical Sensitivity","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D018777","descriptor_name":"Multiple Chemical Sensitivity","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D018849","descriptor_name":"Controlled Clinical Trials as Topic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1289/ehp.97105s2509","doi":"https://doi.org/10.1289/ehp.97105s2509","is_oa":true,"landing_page_url":"https://doi.org/10.1289/ehp.97105s2509","pdf_url":"https://ehp.niehs.nih.gov/doi/epdf/10.1289/ehp.97105s2509","source":{"id":"https://openalex.org/S10446503","display_name":"Environmental Health Perspectives","issn_l":"0091-6765","issn":["0091-6765","1552-9924"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Health Perspectives","raw_type":"journal-article"},{"id":"doi:10.2307/3433361","doi":"https://doi.org/10.2307/3433361","is_oa":true,"landing_page_url":"https://doi.org/10.2307/3433361","pdf_url":null,"source":{"id":"https://openalex.org/S10446503","display_name":"Environmental Health Perspectives","issn_l":"0091-6765","issn":["0091-6765","1552-9924"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Health Perspectives","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1469818","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1469818","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environ Health Perspect","raw_type":"Text"},{"id":"pmid:9167988","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9167988","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental health perspectives","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.276.7841","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.276.7841","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/05/cf/Environ_Health_Perspect_1997_Mar_105(Suppl_2)_509-513.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1289/ehp.97105s2509","doi":"https://doi.org/10.1289/ehp.97105s2509","is_oa":true,"landing_page_url":"https://doi.org/10.1289/ehp.97105s2509","pdf_url":"https://ehp.niehs.nih.gov/doi/epdf/10.1289/ehp.97105s2509","source":{"id":"https://openalex.org/S10446503","display_name":"Environmental Health Perspectives","issn_l":"0091-6765","issn":["0091-6765","1552-9924"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Health Perspectives","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8013372746","display_name":"Licit Abused Drugs","funder_award_id":"R01DA003890","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G9000894987","display_name":"Human Behavioral Pharmacology of Substance Abuse","funder_award_id":"T32DA007209","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2010456791.pdf","grobid_xml":"https://content.openalex.org/works/W2010456791.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W10382812","https://openalex.org/W199192075","https://openalex.org/W1506020877","https://openalex.org/W1987135612","https://openalex.org/W1987361707","https://openalex.org/W1993178061","https://openalex.org/W2009772095","https://openalex.org/W2017634465","https://openalex.org/W2033223573","https://openalex.org/W2036721504","https://openalex.org/W2052330120","https://openalex.org/W2054868037","https://openalex.org/W2057942301","https://openalex.org/W2068609979","https://openalex.org/W2069200516","https://openalex.org/W2097340910","https://openalex.org/W2149312487","https://openalex.org/W2179792476","https://openalex.org/W4230563404"],"related_works":["https://openalex.org/W2114403267","https://openalex.org/W2802810515","https://openalex.org/W4250045696","https://openalex.org/W1967490977","https://openalex.org/W2170817435","https://openalex.org/W2322130441","https://openalex.org/W7019078544","https://openalex.org/W2152854820","https://openalex.org/W1980827563","https://openalex.org/W1974888909"],"abstract_inverted_index":{"Multiple":[0],"chemical":[1,41,49],"sensitivity":[2,42],"is":[3],"a":[4,29,104],"controversial":[5],"diagnosis.":[6],"Rigorous,":[7],"controlled,":[8],"laboratory-based":[9],"research":[10,96],"can":[11,33],"reduce":[12],"this":[13],"controversy":[14],"and":[15,88,92,100],"lead":[16],"to":[17,46,55,66],"potential":[18],"clinical":[19],"confirmatory":[20],"tests.":[21],"The":[22],"literature":[23],"on":[24],"human":[25],"caffeine":[26,57,70],"discrimination":[27,71,93],"provides":[28],"rigorous":[30],"methodology":[31],"that":[32,36],"address":[34],"reports":[35],"patients":[37,54,75,99],"who":[38],"suffer":[39],"multiple":[40],"(MCS)":[43],"are":[44,78],"sensitive":[45],"usually":[47],"well-tolerated":[48],"doses;":[50],"the":[51,67],"studies":[52,72],"require":[53],"discriminate":[56],"from":[58],"placebo":[59],"under":[60],"double-blind":[61],"conditions.":[62],"Several":[63],"issues":[64,81],"relevant":[65],"conduct":[68],"of":[69,86,106],"using":[73],"MCS":[74],"as":[76],"subjects":[77],"addressed;":[79],"these":[80],"include":[82],"study":[83],"design,":[84],"determination":[85],"safe":[87],"tolerable":[89],"training":[90],"doses,":[91],"training.":[94],"Such":[95],"will":[97],"benefit":[98],"clinicians":[101],"dealing":[102],"with":[103],"diagnosis":[105],"MCS.":[107]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}