{"id":"https://openalex.org/W2010452085","doi":"https://doi.org/10.1034/j.1600-079x.2002.02935.x","title":"Regulation of gene expression by melatonin: a microarray survey of the rat retina","display_name":"Regulation of gene expression by melatonin: a microarray survey of the rat retina","publication_year":2002,"publication_date":"2002-09-06","ids":{"openalex":"https://openalex.org/W2010452085","doi":"https://doi.org/10.1034/j.1600-079x.2002.02935.x","mag":"2010452085","pmid":"https://pubmed.ncbi.nlm.nih.gov/12220334"},"language":"en","primary_location":{"id":"doi:10.1034/j.1600-079x.2002.02935.x","doi":"https://doi.org/10.1034/j.1600-079x.2002.02935.x","is_oa":false,"landing_page_url":"https://doi.org/10.1034/j.1600-079x.2002.02935.x","pdf_url":null,"source":{"id":"https://openalex.org/S114728194","display_name":"Journal of Pineal Research","issn_l":"0742-3098","issn":["0742-3098","1600-079X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pineal Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061151961","display_name":"Allan F. Wiechmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Allan F. Wiechmann","raw_affiliation_strings":["Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA. allan-wiechmann@ouhsc.edu","Departments of Cell Biology and Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma, OK, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA. allan-wiechmann@ouhsc.edu","institution_ids":["https://openalex.org/I49332381"]},{"raw_affiliation_string":"Departments of Cell Biology and Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma, OK, USA","institution_ids":["https://openalex.org/I49332381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5061151961"],"corresponding_institution_ids":["https://openalex.org/I49332381"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":1.1569,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.76125073,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"33","issue":"3","first_page":"178","last_page":"185"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9160000085830688,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9160000085830688,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.08370000123977661,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melatonin","display_name":"melatonin","score":1.0},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.8769999742507935},{"id":"https://openalex.org/keywords/retina","display_name":"retina","score":0.796999990940094},{"id":"https://openalex.org/keywords/retinal-pigment-epithelium","display_name":"retinal pigment epithelium","score":0.890999972820282},{"id":"https://openalex.org/keywords/photoreceptor-cell-death","display_name":"photoreceptor cell death","score":0.8629999756813049},{"id":"https://openalex.org/keywords/melatonin-receptors","display_name":"melatonin receptors","score":0.8830000162124634},{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"circadian rhythm","score":0.7710000276565552},{"id":"https://openalex.org/keywords/differential-gene-expression","display_name":"differential gene expression","score":0.7620000243186951},{"id":"https://openalex.org/keywords/retinal-degeneration","display_name":"retinal degeneration","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.9496222734451294},{"id":"https://openalex.org/C202023056","wikidata":"https://www.wikidata.org/wiki/Q3241787","display_name":"Pinealocyte","level":4,"score":0.8205599784851074},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.7803469896316528},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7678207755088806},{"id":"https://openalex.org/C2781269140","wikidata":"https://www.wikidata.org/wiki/Q24784310","display_name":"Melatonin receptor","level":3,"score":0.7039302587509155},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.560589075088501},{"id":"https://openalex.org/C2780059843","wikidata":"https://www.wikidata.org/wiki/Q198654","display_name":"Pineal gland","level":3,"score":0.5490784645080566},{"id":"https://openalex.org/C2778024200","wikidata":"https://www.wikidata.org/wiki/Q2346242","display_name":"Retinal pigment epithelium","level":3,"score":0.5463441610336304},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.5028076171875},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4929475784301758},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.47123846411705017},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4490726888179779},{"id":"https://openalex.org/C2780916184","wikidata":"https://www.wikidata.org/wiki/Q748049","display_name":"Photoreceptor cell","level":3,"score":0.4349468946456909},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.41172653436660767},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3768150210380554},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35488075017929077},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3287510275840759},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.32115867733955383},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.1788991391658783},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08974045515060425},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07690957188606262}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008550","descriptor_name":"Melatonin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008550","descriptor_name":"Melatonin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010857","descriptor_name":"Pigment Epithelium of Eye","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010857","descriptor_name":"Pigment Epithelium of Eye","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020419","descriptor_name":"Photoreceptor Cells, Vertebrate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020419","descriptor_name":"Photoreceptor Cells, Vertebrate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1034/j.1600-079x.2002.02935.x","doi":"https://doi.org/10.1034/j.1600-079x.2002.02935.x","is_oa":false,"landing_page_url":"https://doi.org/10.1034/j.1600-079x.2002.02935.x","pdf_url":null,"source":{"id":"https://openalex.org/S114728194","display_name":"Journal of Pineal Research","issn_l":"0742-3098","issn":["0742-3098","1600-079X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pineal Research","raw_type":"journal-article"},{"id":"pmid:12220334","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12220334","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pineal research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1854954188","display_name":"Core Grant for Vision Research","funder_award_id":"P30EY012190","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G424729679","display_name":null,"funder_award_id":"EY-12190","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320310627","display_name":"Oklahoma Center for the Advancement of Science and Technology","ror":"https://ror.org/02q578v20"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":79,"referenced_works":["https://openalex.org/W25555042","https://openalex.org/W66541472","https://openalex.org/W124501418","https://openalex.org/W128120275","https://openalex.org/W174014175","https://openalex.org/W194703774","https://openalex.org/W197021737","https://openalex.org/W239003693","https://openalex.org/W1490175621","https://openalex.org/W1493772670","https://openalex.org/W1574655661","https://openalex.org/W1590907104","https://openalex.org/W1592825584","https://openalex.org/W1689258335","https://openalex.org/W1712412471","https://openalex.org/W1963653572","https://openalex.org/W1971446783","https://openalex.org/W1972740519","https://openalex.org/W1972830950","https://openalex.org/W1976221126","https://openalex.org/W1978566768","https://openalex.org/W1984049236","https://openalex.org/W1984082716","https://openalex.org/W1987938124","https://openalex.org/W1991569123","https://openalex.org/W1992539816","https://openalex.org/W1995686520","https://openalex.org/W1996135882","https://openalex.org/W1997917957","https://openalex.org/W1998448534","https://openalex.org/W2013016555","https://openalex.org/W2014032935","https://openalex.org/W2015542694","https://openalex.org/W2016200686","https://openalex.org/W2016868037","https://openalex.org/W2026657731","https://openalex.org/W2028242823","https://openalex.org/W2029710860","https://openalex.org/W2032980634","https://openalex.org/W2036120795","https://openalex.org/W2036720565","https://openalex.org/W2038544609","https://openalex.org/W2041194848","https://openalex.org/W2044031095","https://openalex.org/W2045982402","https://openalex.org/W2048252930","https://openalex.org/W2048306894","https://openalex.org/W2050746954","https://openalex.org/W2053102875","https://openalex.org/W2054343892","https://openalex.org/W2054915106","https://openalex.org/W2055050880","https://openalex.org/W2060740560","https://openalex.org/W2065654021","https://openalex.org/W2065819455","https://openalex.org/W2070887858","https://openalex.org/W2072445299","https://openalex.org/W2075007959","https://openalex.org/W2080546332","https://openalex.org/W2083354813","https://openalex.org/W2087927964","https://openalex.org/W2091385411","https://openalex.org/W2092673550","https://openalex.org/W2095432971","https://openalex.org/W2102695020","https://openalex.org/W2103495778","https://openalex.org/W2103696198","https://openalex.org/W2127569347","https://openalex.org/W2136829487","https://openalex.org/W2141859501","https://openalex.org/W2145747172","https://openalex.org/W2147440920","https://openalex.org/W2153312133","https://openalex.org/W2153600623","https://openalex.org/W2154888109","https://openalex.org/W2164737063","https://openalex.org/W2466698282","https://openalex.org/W2485778398","https://openalex.org/W4403984577"],"related_works":["https://openalex.org/W2076521862","https://openalex.org/W1977953139","https://openalex.org/W1990297793","https://openalex.org/W7164939017","https://openalex.org/W2135810930","https://openalex.org/W2048306894","https://openalex.org/W7030082866","https://openalex.org/W2058154605","https://openalex.org/W2003576389","https://openalex.org/W2666558979"],"abstract_inverted_index":{"The":[0,182],"pineal":[1],"secretory":[2],"product":[3],"melatonin":[4,28,52,78,103,197,211,226,243],"is":[5],"synthesized":[6],"by":[7,59,131,238],"pinealocytes":[8],"and":[9,113,120,155,166,177,202,222,247,255],"retinal":[10,63,68,93,121],"photoreceptors":[11,50],"on":[12,212,235],"a":[13,60,205,230],"cyclic":[14],"rhythm,":[15],"with":[16,109],"highest":[17],"levels":[18,72],"occurring":[19],"at":[20],"night.":[21],"Our":[22],"previous":[23],"work":[24],"has":[25],"demonstrated":[26],"that":[27,46,67,84,95,157],"treatment":[29],"increases":[30],"the":[31,34,44,114,117,159,171,193,200,208,240,245,248],"sensitivity":[32],"of":[33,49,62,133,152,185,196,210,218,242,250],"rat":[35,140],"retina":[36],"to":[37,51,77,86,102,137,148,225],"light-induced":[38,87,213],"photoreceptor":[39,88,214,258],"cell":[40,89,215],"death.":[41,90,216],"This":[42],"raises":[43],"possibility":[45],"inappropriate":[47],"exposure":[48],"may":[53,79,203,228],"result":[54],"in":[55,75,82,100,158,192,199,207,244,253],"visual":[56],"impairment,":[57],"caused":[58],"loss":[61],"photoreceptors.":[64],"We":[65],"hypothesize":[66],"genes":[69,94,163,174,179,188,221],"whose":[70],"expression":[71,130],"are":[73,96,189],"altered":[74],"response":[76,101,224],"be":[80],"involved":[81,191],"processes":[83],"contribute":[85],"To":[91],"identify":[92],"up-":[97],"or":[98,110],"down-regulated":[99],"receptor":[104],"binding,":[105],"rats":[106],"were":[107,125,146,164,168,175,180],"treated":[108],"without":[111],"melatonin,":[112,239],"RNA":[115],"from":[116],"neural":[118,160],"retinas":[119],"pigment":[122],"epithelium":[123],"(RPE)":[124],"analyzed":[126],"for":[127,232],"differential":[128],"gene":[129,236],"hybridization":[132,150],"labeled":[134],"cRNA":[135],"probes":[136],"an":[138],"Affymetrix":[139],"genome":[141],"microarray":[142],"set.":[143],"GeneChip":[144],"algorithms":[145],"applied":[147],"measured":[149],"intensities":[151],"compared":[153],"samples":[154],"showed":[156],"retina,":[161,201,246],"six":[162],"up-regulated,":[165,176],"eight":[167],"down-regulated.":[169,181],"In":[170],"RPE,":[172],"15":[173],"two":[178],"protein":[183],"products":[184],"these":[186,219],"specific":[187],"potentially":[190],"molecular":[194],"mechanism":[195],"action":[198],"play":[204],"role":[206,249],"effect":[209],"Identification":[217],"candidate":[220],"their":[223],"administration":[227],"provide":[229],"foundation":[231],"further":[233],"studies":[234],"regulation":[237],"function":[241],"circadian":[251],"signaling":[252],"inherited":[254],"environmentally":[256],"induced":[257],"degenerations.":[259]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}