{"id":"https://openalex.org/W2010451444","doi":"https://doi.org/10.1074/jbc.m608800200","title":"A Putative Src Homology 3 Domain Binding Motif but Not the C-terminal Dystrophin WW Domain Binding Motif Is Required for Dystroglycan Function in Cellular Polarity in Drosophila","display_name":"A Putative Src Homology 3 Domain Binding Motif but Not the C-terminal Dystrophin WW Domain Binding Motif Is Required for Dystroglycan Function in Cellular Polarity in Drosophila","publication_year":2007,"publication_date":"2007-03-14","ids":{"openalex":"https://openalex.org/W2010451444","doi":"https://doi.org/10.1074/jbc.m608800200","mag":"2010451444","pmid":"https://pubmed.ncbi.nlm.nih.gov/17355978"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m608800200","doi":"https://doi.org/10.1074/jbc.m608800200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m608800200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m608800200","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028230129","display_name":"Andriy S. Yatsenko","orcid":"https://orcid.org/0000-0001-8730-5744","observed_orcids":["https://orcid.org/0000-0001-8730-5744"]},"institutions":[{"id":"https://openalex.org/I200280692","display_name":"Lviv University","ror":"https://ror.org/01s7y5e82","country_code":"UA","type":"education","lineage":["https://openalex.org/I200280692"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["UA","US"],"is_corresponding":false,"raw_author_name":"Andriy S. Yatsenko","raw_affiliation_strings":["Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA","Department of Biochemistry, University of Washington, Seattle, Washington 98195","Ivan Franko National University, Hrushevskogo Str. 4, Lviv 79005, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Biochemistry, University of Washington, Seattle, Washington 98195","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Ivan Franko National University, Hrushevskogo Str. 4, Lviv 79005, Ukraine","institution_ids":["https://openalex.org/I200280692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064276812","display_name":"Elizabeth E. Gray","orcid":"https://orcid.org/0000-0001-5257-7520","observed_orcids":["https://orcid.org/0000-0001-5257-7520"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth E. Gray","raw_affiliation_strings":["Department of Biochemistry, University of Washington, Seattle, Washington 98195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Washington, Seattle, Washington 98195","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066187407","display_name":"Halyna R. Shcherbata","orcid":"https://orcid.org/0000-0002-3855-0345","observed_orcids":["https://orcid.org/0000-0002-3855-0345"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210131661","display_name":"Max Planck Institute for Biophysical Chemistry","ror":"https://ror.org/03e76ya46","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210131661","https://openalex.org/I4387154714"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Halyna R. Shcherbata","raw_affiliation_strings":["Department of Biochemistry, University of Washington, Seattle, Washington 98195","Research Group of Gene Expression and Signaling, MPI for biophysical chemistry, Max Planck Society"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Washington, Seattle, Washington 98195","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Research Group of Gene Expression and Signaling, MPI for biophysical chemistry, Max Planck Society","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210131661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004829011","display_name":"Larissa B. Patterson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Larissa B. Patterson","raw_affiliation_strings":["Department of Biochemistry, University of Washington, Seattle, Washington 98195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Washington, Seattle, Washington 98195","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074926797","display_name":"Vanita D. Sood","orcid":"https://orcid.org/0000-0001-6714-3725","observed_orcids":["https://orcid.org/0000-0001-6714-3725"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vanita D. Sood","raw_affiliation_strings":["Department of Biochemistry, University of Washington, Seattle, Washington 98195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Washington, Seattle, Washington 98195","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047331188","display_name":"Mariya M. Kucherenko","orcid":"https://orcid.org/0000-0002-8637-2037","observed_orcids":["https://orcid.org/0000-0002-8637-2037"]},"institutions":[{"id":"https://openalex.org/I200280692","display_name":"Lviv University","ror":"https://ror.org/01s7y5e82","country_code":"UA","type":"education","lineage":["https://openalex.org/I200280692"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["UA","US"],"is_corresponding":false,"raw_author_name":"Mariya M. Kucherenko","raw_affiliation_strings":["Department of Biochemistry, University of Washington, Seattle, Washington 98195","Ivan Franko National University, Hrushevskogo Str. 4, Lviv 79005, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Washington, Seattle, Washington 98195","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Ivan Franko National University, Hrushevskogo Str. 4, Lviv 79005, Ukraine","institution_ids":["https://openalex.org/I200280692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053192926","display_name":"David A. Baker","orcid":"https://orcid.org/0000-0001-7896-6217","observed_orcids":["https://orcid.org/0000-0001-7896-6217"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Baker","raw_affiliation_strings":["Department of Biochemistry, University of Washington, Seattle, Washington 98195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Washington, Seattle, Washington 98195","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021999547","display_name":"Hannele Ruohola\u2010Baker","orcid":"https://orcid.org/0000-0002-5588-4531","observed_orcids":["https://orcid.org/0000-0002-5588-4531"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hannele Ruohola-Baker","raw_affiliation_strings":["Department of Biochemistry, University of Washington, Seattle, Washington 98195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Washington, Seattle, Washington 98195","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5021999547"],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.1913,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.75735992,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"282","issue":"20","first_page":"15159","last_page":"15169"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9429000020027161,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9429000020027161,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.013399999588727951,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dystroglycan","display_name":"dystroglycan","score":0.9919999837875366},{"id":"https://openalex.org/keywords/dystrophin","display_name":"dystrophin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/src-homology-3-domain","display_name":"Src homology 3 domain","score":0.8629999756813049},{"id":"https://openalex.org/keywords/cell-polarity","display_name":"cell polarity","score":0.828000009059906},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila","score":0.8009999990463257},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.6779999732971191},{"id":"https://openalex.org/keywords/muscular-dystrophy","display_name":"muscular dystrophy","score":0.6650000214576721},{"id":"https://openalex.org/keywords/brain-malformations","display_name":"brain malformations","score":0.8119999766349792}],"concepts":[{"id":"https://openalex.org/C2778384963","wikidata":"https://www.wikidata.org/wiki/Q5319588","display_name":"Dystroglycan","level":4,"score":0.8813521862030029},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6193143129348755},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.59804767370224},{"id":"https://openalex.org/C49353375","wikidata":"https://www.wikidata.org/wiki/Q189100","display_name":"Cell polarity","level":3,"score":0.5190056562423706},{"id":"https://openalex.org/C199216141","wikidata":"https://www.wikidata.org/wiki/Q4995178","display_name":"Conserved sequence","level":4,"score":0.4608146548271179},{"id":"https://openalex.org/C204491159","wikidata":"https://www.wikidata.org/wiki/Q24726881","display_name":"WW domain","level":3,"score":0.4350410997867584},{"id":"https://openalex.org/C2780394045","wikidata":"https://www.wikidata.org/wiki/Q412285","display_name":"Dystrophin","level":3,"score":0.4297834038734436},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.41739600896835327},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.32524675130844116},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3219948410987854},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.3094910681247711},{"id":"https://openalex.org/C2779814568","wikidata":"https://www.wikidata.org/wiki/Q58345","display_name":"Laminin","level":3,"score":0.25454679131507874},{"id":"https://openalex.org/C2778943923","wikidata":"https://www.wikidata.org/wiki/Q1648484","display_name":"Duchenne muscular dystrophy","level":2,"score":0.2043640911579132},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.14626863598823547},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.132034033536911}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016189","descriptor_name":"Dystrophin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016189","descriptor_name":"Dystrophin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017384","descriptor_name":"Sequence Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018909","descriptor_name":"src Homology Domains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049030","descriptor_name":"Dystroglycans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049030","descriptor_name":"Dystroglycans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m608800200","doi":"https://doi.org/10.1074/jbc.m608800200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m608800200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:17355978","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17355978","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pure.mpg.de:item_2426223","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11858/00-001M-0000-002D-1BA0-6","pdf_url":"https://hdl.handle.net/11858/00-001M-0000-002D-1BA2-2","source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Journal of Biological Chemistry","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:edoc.mpg.de:372071","doi":null,"is_oa":false,"landing_page_url":"http://edoc.mpg.de/372071","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Journal of Biological Chemistry, v.282, 15159-15169 (2007)","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m608800200","doi":"https://doi.org/10.1074/jbc.m608800200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m608800200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306101","display_name":"National Aeronautics and Space Administration","ror":"https://ror.org/027ka1x80"},{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320307853","display_name":"CRDF Global","ror":"https://ror.org/01zpbb709"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1517693690","https://openalex.org/W1748445510","https://openalex.org/W1913862483","https://openalex.org/W1939431494","https://openalex.org/W1963495112","https://openalex.org/W1963949441","https://openalex.org/W1967387547","https://openalex.org/W1973836212","https://openalex.org/W1974416367","https://openalex.org/W1975070570","https://openalex.org/W1993579677","https://openalex.org/W1995635449","https://openalex.org/W1996880045","https://openalex.org/W2001236385","https://openalex.org/W2008980136","https://openalex.org/W2009721369","https://openalex.org/W2012569825","https://openalex.org/W2013325082","https://openalex.org/W2015107839","https://openalex.org/W2019065906","https://openalex.org/W2035424802","https://openalex.org/W2035913349","https://openalex.org/W2035975703","https://openalex.org/W2036328490","https://openalex.org/W2040379229","https://openalex.org/W2046484505","https://openalex.org/W2058382939","https://openalex.org/W2059827743","https://openalex.org/W2059843465","https://openalex.org/W2062628051","https://openalex.org/W2062885257","https://openalex.org/W2065609600","https://openalex.org/W2066089411","https://openalex.org/W2097028894","https://openalex.org/W2101347416","https://openalex.org/W2101533505","https://openalex.org/W2108357309","https://openalex.org/W2116306687","https://openalex.org/W2124439071","https://openalex.org/W2125519183","https://openalex.org/W2126068134","https://openalex.org/W2128561011","https://openalex.org/W2138530343","https://openalex.org/W2138827544","https://openalex.org/W2144195038","https://openalex.org/W2148258346","https://openalex.org/W2160658743","https://openalex.org/W2164330595","https://openalex.org/W2399838398"],"related_works":["https://openalex.org/W7098721228","https://openalex.org/W2118137506","https://openalex.org/W7162222009","https://openalex.org/W7098399035","https://openalex.org/W1748445510","https://openalex.org/W2001236385","https://openalex.org/W2013325082","https://openalex.org/W2145502582","https://openalex.org/W2933871760","https://openalex.org/W1991111395"],"abstract_inverted_index":{"The":[0],"conserved":[1,68],"dystroglycan-dystrophin":[2],"(Dg.Dys)":[3],"complex":[4,21,42],"connects":[5],"the":[6,10,37,40,65,86,89,95,100,166],"extracellular":[7],"matrix":[8],"to":[9,103,132,143,165,174,204],"cytoskeleton.":[11],"In":[12,163],"humans":[13,146],"as":[14,16],"well":[15],"Drosophila,":[17],"perturbation":[18],"of":[19,39,64,99,140],"this":[20,119,123],"results":[22],"in":[23,30,46,54,79,83,145,192],"muscular":[24],"dystrophies":[25],"and":[26,29,56,150,154,159],"brain":[27],"malformations":[28],"some":[31],"cases":[32],"cellular":[33,81,193],"polarity":[34,82],"defects.":[35],"However,":[36],"regulation":[38],"Dg.Dys":[41],"is":[43],"poorly":[44],"understood":[45],"any":[47],"cell":[48],"type.":[49],"We":[50,121],"now":[51],"find":[52],"that":[53,109,134,197],"loss-of-function":[55],"overexpression":[57],"studies":[58],"more":[59],"than":[60],"half":[61],"(34":[62],"residues)":[63],"Dg":[66,141,190],"proline-rich":[67],"C-terminal":[69],"regions":[70],"can":[71,116],"be":[72,205],"truncated":[73],"without":[74],"significantly":[75],"compromising":[76],"its":[77],"function":[78,191],"regulating":[80],"Drosophila.":[84],"Notably,":[85],"truncation":[87],"eliminates":[88],"WW":[90,113,136],"domain":[91,137,185],"binding":[92,114,138,187],"motif":[93,115],"at":[94],"very":[96],"C":[97],"terminus":[98],"protein":[101],"thought":[102],"mediate":[104,118],"interactions":[105],"with":[106,209],"dystrophin,":[107],"suggesting":[108],"a":[110,127,171,180],"second,":[111],"internal":[112],"also":[117],"interaction.":[120],"confirm":[122],"hypothesis":[124],"by":[125],"using":[126],"sensitive":[128],"fluorescence":[129],"polarization":[130],"assay":[131],"show":[133],"both":[135],"sites":[139],"bind":[142],"Dys":[144],"(K(d)":[147,156],"=":[148,157],"7.6":[149],"81":[151],"microM,":[152,161],"respectively)":[153],"Drosophila":[155],"16":[158],"46":[160],"respectively).":[162],"contrast":[164],"large":[167],"deletion":[168],"mentioned":[169],"above,":[170],"single":[172],"proline":[173],"an":[175,198],"alanine":[176],"point":[177],"mutation":[178],"within":[179],"predicted":[181],"Src":[182],"homology":[183],"3":[184],"(SH3)":[186],"site":[188],"abolishes":[189],"polarity.":[194],"This":[195],"suggests":[196],"SH3-containing":[199],"protein,":[200],"which":[201],"has":[202],"yet":[203],"identified,":[206],"functionally":[207],"interacts":[208],"Dg.":[210]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}