{"id":"https://openalex.org/W2010451278","doi":"https://doi.org/10.1002/1097-0142(19870201)59:3+<668::aid-cncr2820591317>3.0.co;2-j","title":"Incidence and clinical significance of neutralizing antibodies in patients receiving recombinant interferon alfa-2a by intramuscular injection","display_name":"Incidence and clinical significance of neutralizing antibodies in patients receiving recombinant interferon alfa-2a by intramuscular injection","publication_year":1987,"publication_date":"1987-02-01","ids":{"openalex":"https://openalex.org/W2010451278","doi":"https://doi.org/10.1002/1097-0142(19870201)59:3+<668::aid-cncr2820591317>3.0.co;2-j","mag":"2010451278","pmid":"https://pubmed.ncbi.nlm.nih.gov/10822468"},"language":"en","primary_location":{"id":"doi:10.1002/1097-0142(19870201)59:3+<668::aid-cncr2820591317>3.0.co;2-j","doi":"https://doi.org/10.1002/1097-0142(19870201)59:3+<668::aid-cncr2820591317>3.0.co;2-j","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(19870201)59:3+<668::aid-cncr2820591317>3.0.co;2-j","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819870201%2959%3A3%20%3C668%3A%3AAID-CNCR2820591317%3E3.0.CO%3B2-J","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819870201%2959%3A3%20%3C668%3A%3AAID-CNCR2820591317%3E3.0.CO%3B2-J","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061549536","display_name":"Loretta Marie Itri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Loretta M. Itri","raw_affiliation_strings":["Hoffmann-La Roche Inc., Nutley, New Jersey 07110, USA","Hoffmann-La Roche Inc., Nutley, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hoffmann-La Roche Inc., Nutley, New Jersey 07110, USA","institution_ids":[]},{"raw_affiliation_string":"Hoffmann-La Roche Inc., Nutley, New Jersey","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110208176","display_name":"Marilyn Campion","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marilyn Campion","raw_affiliation_strings":["Hoffmann-La Roche Inc., Nutley, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hoffmann-La Roche Inc., Nutley, New Jersey","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108391012","display_name":"R Dennin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert A. Dennin","raw_affiliation_strings":["Hoffmann-La Roche Inc., Nutley, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hoffmann-La Roche Inc., Nutley, New Jersey","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109043546","display_name":"Alicia V. Palleroni","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alicia V. Palleroni","raw_affiliation_strings":["Hoffmann-La Roche Inc., Nutley, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hoffmann-La Roche Inc., Nutley, New Jersey","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111569636","display_name":"Jordan U. Gutterman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jordan U. Gutterman","raw_affiliation_strings":["M.D. Anderson Hospital and Tumor Institute, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M.D. Anderson Hospital and Tumor Institute, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073353369","display_name":"Jerome E. Groopman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerome E. Groopman","raw_affiliation_strings":["New England Deaconess Hospital, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New England Deaconess Hospital, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110332044","display_name":"Patrick W. Trown","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patrick W. Trown","raw_affiliation_strings":["Hoffmann-La Roche Inc., Nutley, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hoffmann-La Roche Inc., Nutley, New Jersey","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5061549536"],"corresponding_institution_ids":[],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":5.8701,"has_fulltext":true,"cited_by_count":117,"citation_normalized_percentile":{"value":0.96754379,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"59","issue":"S3","first_page":"668","last_page":"674"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.5375999808311462,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.5375999808311462,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.3086000084877014,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.06319999694824219,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neutralizing-antibodies","display_name":"neutralizing antibodies","score":0.7409999966621399},{"id":"https://openalex.org/keywords/interferon-alpha-2b","display_name":"interferon alfa-2b","score":0.7929999828338623},{"id":"https://openalex.org/keywords/antibody-incidence","display_name":"antibody incidence","score":0.5339999794960022},{"id":"https://openalex.org/keywords/intramuscular-injection","display_name":"intramuscular injection","score":0.6489999890327454},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.5630000233650208},{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"renal cell carcinoma","score":0.8569999933242798},{"id":"https://openalex.org/keywords/aids-associated-kaposi-s-sarcoma","display_name":"AIDS-related Kaposi's sarcoma","score":0.9559999704360962},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.6019999980926514},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.628000020980835}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8554760217666626},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.7445995807647705},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5272623300552368},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.5223537683486938},{"id":"https://openalex.org/C2781228144","wikidata":"https://www.wikidata.org/wiki/Q6046441","display_name":"Interferon alfa","level":4,"score":0.4947966933250427},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.4685180187225342},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4631708264350891},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4604727625846863},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.4267844259738922},{"id":"https://openalex.org/C2778758028","wikidata":"https://www.wikidata.org/wiki/Q19597582","display_name":"Immunoradiometric assay","level":3,"score":0.41601935029029846},{"id":"https://openalex.org/C2909179924","wikidata":"https://www.wikidata.org/wiki/Q6046488","display_name":"Alpha interferon","level":3,"score":0.3859958052635193},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.36676734685897827},{"id":"https://openalex.org/C176685330","wikidata":"https://www.wikidata.org/wiki/Q857638","display_name":"Radioimmunoassay","level":2,"score":0.24565273523330688},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.093446284532547},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077190","descriptor_name":"Interferon alpha-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007273","descriptor_name":"Injections, Intramuscular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009500","descriptor_name":"Neutralization Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012514","descriptor_name":"Sarcoma, Kaposi","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012514","descriptor_name":"Sarcoma, Kaposi","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016719","descriptor_name":"Radioimmunodetection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017088","descriptor_name":"AIDS-Related Opportunistic Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D017088","descriptor_name":"AIDS-Related Opportunistic Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/1097-0142(19870201)59:3+<668::aid-cncr2820591317>3.0.co;2-j","doi":"https://doi.org/10.1002/1097-0142(19870201)59:3+<668::aid-cncr2820591317>3.0.co;2-j","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(19870201)59:3+<668::aid-cncr2820591317>3.0.co;2-j","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819870201%2959%3A3%20%3C668%3A%3AAID-CNCR2820591317%3E3.0.CO%3B2-J","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:10822468","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10822468","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1002/1097-0142(19870201)59:3+<668::aid-cncr2820591317>3.0.co;2-j","doi":"https://doi.org/10.1002/1097-0142(19870201)59:3+<668::aid-cncr2820591317>3.0.co;2-j","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(19870201)59:3+<668::aid-cncr2820591317>3.0.co;2-j","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819870201%2959%3A3%20%3C668%3A%3AAID-CNCR2820591317%3E3.0.CO%3B2-J","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2010451278.pdf","grobid_xml":"https://content.openalex.org/works/W2010451278.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W1606300676","https://openalex.org/W1875354643","https://openalex.org/W1970433135","https://openalex.org/W1973409404","https://openalex.org/W1975978239","https://openalex.org/W1980103613","https://openalex.org/W2034489572","https://openalex.org/W2037650318","https://openalex.org/W2052128395","https://openalex.org/W2052677652","https://openalex.org/W2066957976","https://openalex.org/W2128394628","https://openalex.org/W2201802658","https://openalex.org/W2307147645","https://openalex.org/W2339932366"],"related_works":["https://openalex.org/W2046130951","https://openalex.org/W1973385519","https://openalex.org/W1807393995","https://openalex.org/W2431442613","https://openalex.org/W1975978239","https://openalex.org/W2066569831","https://openalex.org/W2002871050","https://openalex.org/W2414855299","https://openalex.org/W2416088536","https://openalex.org/W2412948981"],"abstract_inverted_index":{"More":[0],"than":[1,137],"1600":[2],"patients":[3,47,94,106],"with":[4,37,107],"neoplastic":[5],"disorders":[6],"have":[7],"received":[8,49],"recombinant":[9,176,214],"human":[10],"interferon":[11,32,44,67,177],"alfa-2a":[12,33],"(Roferon-A,":[13],"Hoffmann-La":[14],"Roche,":[15],"Nutley,":[16],"NJ)":[17],"as":[18],"part":[19],"of":[20,31,40,79,81,89,91,101,126,130,156,173,197,211],"ongoing":[21],"or":[22,72,149,154],"completed":[23],"clinical":[24],"trials.":[25],"In":[26],"this":[27,43],"report,":[28],"the":[29,38,50,82,92,124,162,171,185,207],"efficacy":[30],"therapy":[34],"was":[35,189],"compared":[36,166],"incidence":[39,100,210],"antibodies":[41,174,212],"to":[42,152,167,175,191,213],"in":[45,76,86],"617":[46],"who":[48],"drug":[51],"by":[52],"intramuscular":[53],"administration.":[54],"Antibody":[55],"measurements":[56],"were":[57,132,165],"performed":[58],"using":[59],"a":[60],"highly":[61],"sensitive":[62],"enzyme":[63],"immunoassay,":[64],"and":[65,85,111,120,128],"an":[66],"antiviral":[68],"neutralization":[69],"bioassay.":[70],"Partial":[71],"complete":[73],"remission":[74],"occurred":[75,104],"28%":[77],"(43":[78],"152)":[80],"antibody-positive":[83,136],"patients,":[84],"24%":[87],"(112":[88],"465)":[90],"antibody-negative":[93,139],"(P":[95],"=":[96],"0.33).":[97],"The":[98],"highest":[99],"antibody":[102,198],"formation":[103],"among":[105],"renal":[108],"cell":[109],"carcinoma":[110],"acquired":[112],"immune":[113],"deficiency":[114],"syndrome":[115],"(AIDS)-related":[116],"Kaposi's":[117],"sarcoma":[118],"(44%":[119],"34%,":[121],"respectively).":[122],"Both":[123],"duration":[125,155],"treatment":[127],"length":[129],"survival":[131],"significantly":[133],"longer":[134],"for":[135,138,146,150,170,195,206],"patients.":[140],"No":[141],"significant":[142],"intergroup":[143],"differences":[144],"emerged":[145],"response":[147],"rates":[148],"time":[151],"onset":[153],"therapeutic":[157],"response.":[158],"When":[159],"results":[160],"from":[161],"above":[163],"assays":[164],"those":[168],"used":[169],"detection":[172],"alfa-2b":[178,215],"(Intron":[179],"A,":[180],"Schering-Plough":[181],"Inc.,":[182],"Kenilworth,":[183],"NJ),":[184],"immunoradiometric":[186],"assay":[187,202],"method":[188],"determined":[190],"be":[192],"seriously":[193],"deficient":[194],"determination":[196],"incidence.":[199],"This":[200],"decreased":[201],"sensitivity":[203],"may":[204],"account":[205],"reportedly":[208],"lower":[209],"interferon.":[216]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}