{"id":"https://openalex.org/W2010449169","doi":"https://doi.org/10.1016/0306-4522(96)00174-1","title":"Excitotoxic lesion of rat brain with quinolinic acid induces expression of p53 messenger RNA and protein and p53-inducible genes Bax and Gadd-45 in brain areas showing DNA fragmentation","display_name":"Excitotoxic lesion of rat brain with quinolinic acid induces expression of p53 messenger RNA and protein and p53-inducible genes Bax and Gadd-45 in brain areas showing DNA fragmentation","publication_year":1996,"publication_date":"1996-09-24","ids":{"openalex":"https://openalex.org/W2010449169","doi":"https://doi.org/10.1016/0306-4522(96)00174-1","mag":"2010449169","pmid":"https://pubmed.ncbi.nlm.nih.gov/8895882"},"language":"en","primary_location":{"id":"doi:10.1016/0306-4522(96)00174-1","doi":"https://doi.org/10.1016/0306-4522(96)00174-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0306-4522(96)00174-1","pdf_url":null,"source":{"id":"https://openalex.org/S30122339","display_name":"Neuroscience","issn_l":"0306-4522","issn":["0306-4522","1873-7544"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102816712","display_name":"Paul E. Hughes","orcid":"https://orcid.org/0000-0003-1095-9883","observed_orcids":["https://orcid.org/0000-0003-1095-9883"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"P.E. Hughes","raw_affiliation_strings":["Department of Neurogerontology, Andrus Gerontology Centre, Los Angeles, CA 90089-0191, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurogerontology, Andrus Gerontology Centre, Los Angeles, CA 90089-0191, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022567561","display_name":"Tajrena Alexi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. Alexi","raw_affiliation_strings":["Department of Physiological Sciences, University of California at Los Angeles, Los Angeles, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Sciences, University of California at Los Angeles, Los Angeles, U.S.A","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026194201","display_name":"Toru Yoshida","orcid":"https://orcid.org/0000-0002-1384-2210","observed_orcids":["https://orcid.org/0000-0002-1384-2210"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Yoshida","raw_affiliation_strings":["Department of Neurogerontology, Andrus Gerontology Centre, 3715 McClintock Avenue, Los Angeles, CA 90089-0191, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurogerontology, Andrus Gerontology Centre, 3715 McClintock Avenue, Los Angeles, CA 90089-0191, U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"S.S. Schreiber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S.S. Schreiber","raw_affiliation_strings":["Departments of Neurology, Cell and Neurobiology, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089-0191, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurology, Cell and Neurobiology, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089-0191, U.S.A","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043191335","display_name":"Beat Kn\u00fcsel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. Knusel","raw_affiliation_strings":["Department of Neurogerontology, Andrus Gerontology Centre, 3715 McClintock Avenue, Los Angeles, CA 90089-0191, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurogerontology, Andrus Gerontology Centre, 3715 McClintock Avenue, Los Angeles, CA 90089-0191, U.S.A","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5102816712"],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":4.7854,"has_fulltext":false,"cited_by_count":112,"citation_normalized_percentile":{"value":0.95586161,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"74","issue":"4","first_page":"1143","last_page":"1160"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.7875999808311462,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.7875999808311462,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.1891999989748001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9190000295639038},{"id":"https://openalex.org/keywords/quinolinic-acid","display_name":"quinolinic acid","score":0.8880000114440918},{"id":"https://openalex.org/keywords/excitotoxic-brain-injury","display_name":"excitotoxic brain injury","score":0.9229999780654907},{"id":"https://openalex.org/keywords/nmda-receptor-agonist","display_name":"NMDA receptor agonist","score":0.8059999942779541},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.8960000276565552},{"id":"https://openalex.org/keywords/dna-fragmentation","display_name":"DNA fragmentation","score":0.8859999775886536},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6039999723434448},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6420000195503235},{"id":"https://openalex.org/keywords/neuronal-death","display_name":"neuronal cell death","score":0.6899999976158142},{"id":"https://openalex.org/keywords/brain-injury-response","display_name":"brain injury response","score":0.6769999861717224},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.375}],"concepts":[{"id":"https://openalex.org/C2777896816","wikidata":"https://www.wikidata.org/wiki/Q411945","display_name":"Quinolinic acid","level":4,"score":0.816112756729126},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.6205313205718994},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5921125411987305},{"id":"https://openalex.org/C43759708","wikidata":"https://www.wikidata.org/wiki/Q3749256","display_name":"DNA fragmentation","level":4,"score":0.5578441023826599},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.5071282386779785},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5007467269897461},{"id":"https://openalex.org/C3020813896","wikidata":"https://www.wikidata.org/wiki/Q283350","display_name":"P53 protein","level":3,"score":0.45088469982147217},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.42942938208580017},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3946264684200287},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.38649702072143555},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.2598162889480591},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.22522801160812378},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2042756974697113},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15166056156158447},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12512412667274475},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.08180981874465942},{"id":"https://openalex.org/C2776706248","wikidata":"https://www.wikidata.org/wiki/Q181003","display_name":"Tryptophan","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000097642","descriptor_name":"GADD45 Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004253","descriptor_name":"DNA Nucleotidylexotransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007267","descriptor_name":"Injections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D016202","descriptor_name":"N-Methylaspartate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017072","descriptor_name":"Neostriatum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017072","descriptor_name":"Neostriatum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017072","descriptor_name":"Neostriatum","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017378","descriptor_name":"Quinolinic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017378","descriptor_name":"Quinolinic Acid","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051028","descriptor_name":"bcl-2-Associated X Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053938","descriptor_name":"DNA Fragmentation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053938","descriptor_name":"DNA Fragmentation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/0306-4522(96)00174-1","doi":"https://doi.org/10.1016/0306-4522(96)00174-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0306-4522(96)00174-1","pdf_url":null,"source":{"id":"https://openalex.org/S30122339","display_name":"Neuroscience","issn_l":"0306-4522","issn":["0306-4522","1873-7544"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience","raw_type":"journal-article"},{"id":"doi:10.1016/s0306-4522(96)00174-1","doi":"https://doi.org/10.1016/s0306-4522(96)00174-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0306-4522(96)00174-1","pdf_url":null,"source":{"id":"https://openalex.org/S30122339","display_name":"Neuroscience","issn_l":"0306-4522","issn":["0306-4522","1873-7544"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience","raw_type":"journal-article"},{"id":"pmid:8895882","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8895882","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334749","display_name":"Health Research Council of New Zealand","ror":"https://ror.org/00zbf3d93"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W97746810","https://openalex.org/W192455570","https://openalex.org/W249845531","https://openalex.org/W1512214997","https://openalex.org/W1613986623","https://openalex.org/W1672170632","https://openalex.org/W1965173366","https://openalex.org/W1971335269","https://openalex.org/W1971457128","https://openalex.org/W1973771128","https://openalex.org/W1975572257","https://openalex.org/W1979176029","https://openalex.org/W1983634837","https://openalex.org/W1984011022","https://openalex.org/W1986179131","https://openalex.org/W1986362325","https://openalex.org/W1987434382","https://openalex.org/W1989936068","https://openalex.org/W1995856480","https://openalex.org/W1998776093","https://openalex.org/W2002763309","https://openalex.org/W2003236156","https://openalex.org/W2012053348","https://openalex.org/W2012732349","https://openalex.org/W2015519364","https://openalex.org/W2019572526","https://openalex.org/W2023462313","https://openalex.org/W2028914787","https://openalex.org/W2029629215","https://openalex.org/W2029737040","https://openalex.org/W2031595027","https://openalex.org/W2036142609","https://openalex.org/W2039375468","https://openalex.org/W2041483782","https://openalex.org/W2042316019","https://openalex.org/W2044333041","https://openalex.org/W2045086385","https://openalex.org/W2047254990","https://openalex.org/W2048443442","https://openalex.org/W2049390904","https://openalex.org/W2055349083","https://openalex.org/W2066291825","https://openalex.org/W2072489106","https://openalex.org/W2074222004","https://openalex.org/W2076308773","https://openalex.org/W2078106239","https://openalex.org/W2078581194","https://openalex.org/W2083407432","https://openalex.org/W2094973947","https://openalex.org/W2117802418","https://openalex.org/W2126517273","https://openalex.org/W2134979684","https://openalex.org/W2137675878","https://openalex.org/W2138302361","https://openalex.org/W2141372702","https://openalex.org/W2148918821","https://openalex.org/W2150097377","https://openalex.org/W2157513585","https://openalex.org/W2163815564","https://openalex.org/W2169423285","https://openalex.org/W2295110019","https://openalex.org/W6604031468","https://openalex.org/W6655386242","https://openalex.org/W6659628447","https://openalex.org/W6682199445"],"related_works":["https://openalex.org/W2036142609","https://openalex.org/W2020834781","https://openalex.org/W1920883260","https://openalex.org/W1977632821","https://openalex.org/W1549338235","https://openalex.org/W1532440724","https://openalex.org/W1874032102","https://openalex.org/W2084959937","https://openalex.org/W2319650990","https://openalex.org/W2151982496"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}