{"id":"https://openalex.org/W2010448608","doi":"https://doi.org/10.1046/j.1432-1327.1999.00552.x","title":"Plasminogen activator inhibitor type\u20102 (PAI\u20102) gene transcription requires a novel NF\u2010\u03baB\u2010like transcriptional regulatory motif","display_name":"Plasminogen activator inhibitor type\u20102 (PAI\u20102) gene transcription requires a novel NF\u2010\u03baB\u2010like transcriptional regulatory motif","publication_year":1999,"publication_date":"1999-08-01","ids":{"openalex":"https://openalex.org/W2010448608","doi":"https://doi.org/10.1046/j.1432-1327.1999.00552.x","mag":"2010448608","pmid":"https://pubmed.ncbi.nlm.nih.gov/10469140"},"language":"en","primary_location":{"id":"doi:10.1046/j.1432-1327.1999.00552.x","doi":"https://doi.org/10.1046/j.1432-1327.1999.00552.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1432-1327.1999.00552.x","pdf_url":null,"source":{"id":"https://openalex.org/S4210214924","display_name":"European Journal of Biochemistry","issn_l":"0014-2956","issn":["0014-2956","0945-5795","1432-1033"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111410260","display_name":"Donna Mahony","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I217937681","display_name":"QIMR Berghofer Medical Research Institute","ror":"https://ror.org/004y8wk30","country_code":"AU","type":"facility","lineage":["https://openalex.org/I217937681"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Donna Mahony","raw_affiliation_strings":["Cellular Oncology Laboratory, Queensland Institute of Medical Research,University of Queensland, Brisbane, Australia","Cellular Oncology Laboratory, Queensland Institute of Medical Research and University of Queensland, Brisbane, Australia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Oncology Laboratory, Queensland Institute of Medical Research,University of Queensland, Brisbane, Australia","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I217937681"]},{"raw_affiliation_string":"Cellular Oncology Laboratory, Queensland Institute of Medical Research and University of Queensland, Brisbane, Australia;","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I217937681"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048448147","display_name":"Bill Kalionis","orcid":"https://orcid.org/0000-0002-0132-9858","observed_orcids":["https://orcid.org/0000-0002-0132-9858"]},"institutions":[{"id":"https://openalex.org/I169541294","display_name":"Flinders University","ror":"https://ror.org/01kpzv902","country_code":"AU","type":"education","lineage":["https://openalex.org/I169541294"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Bill Kalionis","raw_affiliation_strings":["School of Medicine, Department of Obstetrics and Gynaecology, The Flinders University of South Australia, Bedford Park, Adelaide, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Department of Obstetrics and Gynaecology, The Flinders University of South Australia, Bedford Park, Adelaide, Australia","institution_ids":["https://openalex.org/I169541294"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027779533","display_name":"Toni Antalis","orcid":"https://orcid.org/0000-0002-0132-6171","observed_orcids":["https://orcid.org/0000-0002-0132-6171"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I217937681","display_name":"QIMR Berghofer Medical Research Institute","ror":"https://ror.org/004y8wk30","country_code":"AU","type":"facility","lineage":["https://openalex.org/I217937681"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Toni M. Antalis","raw_affiliation_strings":["Cellular Oncology Laboratory, Queensland Institute of Medical Research and University of Queensland, Brisbane, Australia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Oncology Laboratory, Queensland Institute of Medical Research and University of Queensland, Brisbane, Australia;","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I217937681"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2507,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.49526684,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"263","issue":"3","first_page":"765","last_page":"772"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9214000105857849,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9214000105857849,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0471000000834465,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasminogen-activator-inhibitor-2","display_name":"plasminogen activator inhibitor-2","score":0.9850000143051147},{"id":"https://openalex.org/keywords/transcriptional-regulatory-motifs","display_name":"transcriptional regulatory motifs","score":0.8889999985694885},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8679999709129333},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.6740000247955322},{"id":"https://openalex.org/keywords/constitutive-transcription","display_name":"constitutive transcription","score":0.5879999995231628},{"id":"https://openalex.org/keywords/promoter-regulation","display_name":"promoter regulation","score":0.628000020980835},{"id":"https://openalex.org/keywords/dna-binding-proteins","display_name":"DNA-binding proteins","score":0.8289999961853027}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7023725509643555},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6144297122955322},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.5214823484420776},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5155791640281677},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.4984149932861328},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4849741458892822},{"id":"https://openalex.org/C183978625","wikidata":"https://www.wikidata.org/wiki/Q903596","display_name":"Electrophoretic mobility shift assay","level":4,"score":0.46444064378738403},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.4462929666042328},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.4419211447238922},{"id":"https://openalex.org/C144825837","wikidata":"https://www.wikidata.org/wiki/Q2316030","display_name":"General transcription factor","level":5,"score":0.4362666606903076},{"id":"https://openalex.org/C21592294","wikidata":"https://www.wikidata.org/wiki/Q3238407","display_name":"Regulatory sequence","level":4,"score":0.41899847984313965},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.38108620047569275},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19733884930610657}],"mesh":[{"descriptor_ui":"D000090063","descriptor_name":"Proto-Oncogene Mas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005354","descriptor_name":"Fibrosarcoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012045","descriptor_name":"Regulatory Sequences, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015500","descriptor_name":"Chloramphenicol O-Acetyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017384","descriptor_name":"Sequence Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017396","descriptor_name":"Plasminogen Activator Inhibitor 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020298","descriptor_name":"U937 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1432-1327.1999.00552.x","doi":"https://doi.org/10.1046/j.1432-1327.1999.00552.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1432-1327.1999.00552.x","pdf_url":null,"source":{"id":"https://openalex.org/S4210214924","display_name":"European Journal of Biochemistry","issn_l":"0014-2956","issn":["0014-2956","0945-5795","1432-1033"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Biochemistry","raw_type":"journal-article"},{"id":"pmid:10469140","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10469140","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W120387323","https://openalex.org/W207397168","https://openalex.org/W308156445","https://openalex.org/W1533816737","https://openalex.org/W1557407558","https://openalex.org/W1595199664","https://openalex.org/W1607686789","https://openalex.org/W1657916616","https://openalex.org/W1835352600","https://openalex.org/W1904705252","https://openalex.org/W1971972871","https://openalex.org/W1973527505","https://openalex.org/W1979808392","https://openalex.org/W1998591058","https://openalex.org/W1999512677","https://openalex.org/W2000554710","https://openalex.org/W2008209139","https://openalex.org/W2014726611","https://openalex.org/W2031089158","https://openalex.org/W2033741891","https://openalex.org/W2043882178","https://openalex.org/W2055043387","https://openalex.org/W2057093252","https://openalex.org/W2061903251","https://openalex.org/W2067091576","https://openalex.org/W2080420548","https://openalex.org/W2087082586","https://openalex.org/W2089368521","https://openalex.org/W2105415988","https://openalex.org/W2107908226","https://openalex.org/W2151892297","https://openalex.org/W2186224527","https://openalex.org/W2265807804","https://openalex.org/W2278969192","https://openalex.org/W2414120567","https://openalex.org/W2466253098"],"related_works":["https://openalex.org/W3209756213","https://openalex.org/W2014726611","https://openalex.org/W2054703612","https://openalex.org/W2035558413","https://openalex.org/W1689505982","https://openalex.org/W1503157719","https://openalex.org/W2000554710","https://openalex.org/W2265807804","https://openalex.org/W2979505371","https://openalex.org/W2220979377"],"abstract_inverted_index":{"Induction":[0],"of":[1,13,56,89,95,100,123,166,173,214],"human":[2],"plasminogen":[3],"activator":[4],"inhibitor":[5],"type-2":[6],"(PAI-2)":[7],"gene":[8,33,76,92,228,260],"transcription":[9,34,48],"is":[10],"the":[11,20,47,54,63,90,101,167,180,195,208,215],"response":[12,36],"macrophages":[14],"to":[15,37,69,114,159],"inflammatory":[16],"stimuli,":[17],"such":[18],"as":[19,121,183],"pleiotropic":[21],"cytokine,":[22],"tumour":[23],"necrosis":[24],"factor-alpha":[25],"(TNFalpha).":[26],"Here":[27],"we":[28],"have":[29,52],"examined":[30],"whether":[31],"PAI-2":[32,64,91,119,128,242,259],"in":[35,62,131,150,227,258],"TNFalpha":[38,70,87],"may":[39,254],"be":[40,115],"mediated":[41],"through":[42,93],"a":[43,174,184,221,235,256],"regulatory":[44,105,169,237],"pathway":[45],"involving":[46],"factor,":[49],"NF-kappaB.":[50],"We":[51],"tested":[53],"function":[55],"two":[57,97,187],"potential":[58,246],"NF-kappaB-like":[59,102],"sites":[60],"present":[61,108,149],"proximal":[65],"promoter":[66,129],"for":[67,86,117,224,240],"responsiveness":[68],"using":[71,179],"chloramphenicol":[72],"acetyl":[73],"transferase":[74],"reporter":[75],"deletion":[77],"and":[78,136,153,207,244],"mutation":[79,122],"analyses.":[80],"While":[81],"no":[82],"evidence":[83],"was":[84,112,205],"found":[85,113],"regulation":[88],"either":[94],"these":[96,232],"sites,":[98],"one":[99,203],"motifs,":[103],"transcriptional":[104],"motif":[106,125,161],"(TRM),":[107],"at":[109],"position":[110],"-400":[111,181],"essential":[116],"constitutive":[118,241],"transcription,":[120,243],"this":[124,160,225,251],"abolished":[126],"basal":[127],"activity":[130],"both":[132],"monocyte-like":[133],"U937":[134],"cells":[135],"HT1080":[137,152],"fibrosarcoma":[138],"cells.":[139],"Competition":[140],"electrophoretic":[141],"mobility":[142],"shift":[143],"assays":[144],"identified":[145,186],"four":[146],"TRM-binding":[147],"proteins":[148,248],"U937,":[151],"HeLa":[154,175],"cell":[155,176],"extracts,":[156],"which":[157,192],"bound":[158,194],"but":[162],"were":[163],"not":[164],"components":[165],"NF-kappaB":[168],"complex.":[170],"Expression":[171],"screening":[172],"cDNA":[177,204,210],"library":[178],"TRM":[182,196],"probe":[185],"cDNAs":[188],"encoding":[189],"partial":[190],"peptides":[191],"specifically":[193],"motif.":[197],"DNA":[198],"sequence":[199],"analysis":[200],"revealed":[201],"that":[202,253],"novel,":[206],"second":[209],"encoded":[211],"exon":[212],"5":[213],"nephroblastoma":[216],"overexpressed":[217],"(novH)":[218],"proto-oncogene,":[219],"suggesting":[220],"new":[222,236],"role":[223,257],"peptide":[226],"regulation.":[229,261],"Taken":[230],"together,":[231],"findings":[233],"identify":[234,245],"element":[238,252],"required":[239],"DNA-binding":[247],"associated":[249],"with":[250],"play":[255]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
