{"id":"https://openalex.org/W2010444300","doi":"https://doi.org/10.1016/s1357-4310(99)01558-0","title":"Gene therapy for HIV infection: safe if not efficacious","display_name":"Gene therapy for HIV infection: safe if not efficacious","publication_year":1999,"publication_date":"1999-09-01","ids":{"openalex":"https://openalex.org/W2010444300","doi":"https://doi.org/10.1016/s1357-4310(99)01558-0","mag":"2010444300"},"language":"en","primary_location":{"id":"doi:10.1016/s1357-4310(99)01558-0","doi":"https://doi.org/10.1016/s1357-4310(99)01558-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1357-4310(99)01558-0","pdf_url":null,"source":{"id":"https://openalex.org/S202950613","display_name":"Molecular Medicine Today","issn_l":"1357-4310","issn":["1357-4310","1878-4178"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine Today","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052362487","display_name":"Natasha J. Caplen","orcid":"https://orcid.org/0000-0002-0001-9460","observed_orcids":["https://orcid.org/0000-0002-0001-9460"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Natasha J. Caplen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5052362487"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.12724819,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"9","first_page":"375","last_page":"375"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9496999979019165,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9496999979019165,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.048700001090765,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-infection","display_name":"HIV-1 infection","score":0.7950000166893005},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.8140000104904175},{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.9750000238418579},{"id":"https://openalex.org/keywords/retroviral-vectors","display_name":"retroviral vectors","score":0.8709999918937683},{"id":"https://openalex.org/keywords/cd34-cells","display_name":"CD34+ cells","score":0.8199999928474426},{"id":"https://openalex.org/keywords/vector-persistence","display_name":"vector persistence","score":0.45399999618530273},{"id":"https://openalex.org/keywords/hiv-drug-resistance","display_name":"HIV drug resistance","score":0.44600000977516174},{"id":"https://openalex.org/keywords/ex-vivo-gene-transfer","display_name":"ex vivo gene transfer","score":0.5889999866485596},{"id":"https://openalex.org/keywords/clinical-trial-safety","display_name":"clinical trial safety","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.7382388114929199},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.6505071520805359},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.6402763724327087},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.6336985230445862},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5413884520530701},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.5404456853866577},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5366235971450806},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5112903118133545},{"id":"https://openalex.org/C130403756","wikidata":"https://www.wikidata.org/wiki/Q2776413","display_name":"Marker gene","level":3,"score":0.48167240619659424},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.45407190918922424},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.4459538757801056},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3374292850494385},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.14167851209640503},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09645253419876099},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.052921950817108154}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s1357-4310(99)01558-0","doi":"https://doi.org/10.1016/s1357-4310(99)01558-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1357-4310(99)01558-0","pdf_url":null,"source":{"id":"https://openalex.org/S202950613","display_name":"Molecular Medicine Today","issn_l":"1357-4310","issn":["1357-4310","1878-4178"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine Today","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W79630512"],"related_works":["https://openalex.org/W79630512","https://openalex.org/W139225458","https://openalex.org/W2151475547","https://openalex.org/W1482247814","https://openalex.org/W2415850224","https://openalex.org/W2035732512","https://openalex.org/W7100432520","https://openalex.org/W2170771513","https://openalex.org/W4319766290","https://openalex.org/W2367561894"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-07-28T07:46:37.118299","created_date":"2016-06-24T00:00:00"}