{"id":"https://openalex.org/W2010436799","doi":"https://doi.org/10.1126/science.7535476","title":"Antigen-Specific Development of Primary and Memory T Cells in Vivo","display_name":"Antigen-Specific Development of Primary and Memory T Cells in Vivo","publication_year":1995,"publication_date":"1995-04-07","ids":{"openalex":"https://openalex.org/W2010436799","doi":"https://doi.org/10.1126/science.7535476","mag":"2010436799","pmid":"https://pubmed.ncbi.nlm.nih.gov/7535476"},"language":"en","primary_location":{"id":"doi:10.1126/science.7535476","doi":"https://doi.org/10.1126/science.7535476","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.7535476","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2010436799"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075864327","display_name":"Michael G. McHeyzer\u2010Williams","orcid":"https://orcid.org/0000-0003-0459-569X","observed_orcids":["https://orcid.org/0000-0003-0459-569X"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael G. McHeyzer-Williams","raw_affiliation_strings":["Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025539602","display_name":"Mark M. Davis","orcid":"https://orcid.org/0000-0001-6868-657X","observed_orcids":["https://orcid.org/0000-0001-6868-657X"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark M. Davis","raw_affiliation_strings":["Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA","Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":14.7005,"has_fulltext":false,"cited_by_count":434,"citation_normalized_percentile":{"value":0.99363825,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"268","issue":"5207","first_page":"106","last_page":"111"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antigen-driven-selection","display_name":"antigen-driven selection","score":0.5230000019073486},{"id":"https://openalex.org/keywords/primary-t-cells","display_name":"primary T cells","score":0.5730000138282776},{"id":"https://openalex.org/keywords/memory-t-cells","display_name":"memory T cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cdr3-length","display_name":"CDR3 length","score":0.6700000166893005},{"id":"https://openalex.org/keywords/t-cell-receptor-diversity","display_name":"T cell receptor diversity","score":0.5659999847412109},{"id":"https://openalex.org/keywords/t-cell-clonal-expansion","display_name":"T cell clonal expansion","score":0.671999990940094},{"id":"https://openalex.org/keywords/secondary-immune-response","display_name":"secondary immune response","score":0.7929999828338623},{"id":"https://openalex.org/keywords/draining-lymph-nodes","display_name":"draining lymph nodes","score":0.8080000281333923},{"id":"https://openalex.org/keywords/t-cell-receptor-recognition","display_name":"T cell receptor recognition","score":0.5440000295639038}],"concepts":[{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6318048238754272},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.6258430480957031},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5867903828620911},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5531168580055237},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5019099712371826},{"id":"https://openalex.org/C7386963","wikidata":"https://www.wikidata.org/wiki/Q3954859","display_name":"Negative selection","level":4,"score":0.49935269355773926},{"id":"https://openalex.org/C85630698","wikidata":"https://www.wikidata.org/wiki/Q3826179","display_name":"Complementarity determining region","level":4,"score":0.48966720700263977},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.44687914848327637},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.44282472133636475},{"id":"https://openalex.org/C2779720271","wikidata":"https://www.wikidata.org/wiki/Q179422","display_name":"Lymph","level":2,"score":0.4363994598388672},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.41714581847190857},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.41007599234580994},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3600608706474304},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2795228064060211},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18790170550346375},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.18293529748916626},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14537003636360168},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.09805905818939209},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0957040786743164},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08929967880249023},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006377","descriptor_name":"T-Lymphocytes, Helper-Inducer","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007156","descriptor_name":"Immunologic Memory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016201","descriptor_name":"Receptors, Lymphocyte Homing","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016693","descriptor_name":"Receptors, Antigen, T-Cell, alpha-beta","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016693","descriptor_name":"Receptors, Antigen, T-Cell, alpha-beta","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018960","descriptor_name":"Hyaluronan Receptors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019041","descriptor_name":"L-Selectin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.7535476","doi":"https://doi.org/10.1126/science.7535476","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.7535476","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:7535476","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7535476","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W29164706","https://openalex.org/W70341877","https://openalex.org/W139308946","https://openalex.org/W1506066152","https://openalex.org/W1564746733","https://openalex.org/W1578793633","https://openalex.org/W1582432207","https://openalex.org/W1597898543","https://openalex.org/W1773751527","https://openalex.org/W1776883786","https://openalex.org/W1816934672","https://openalex.org/W1970579419","https://openalex.org/W1972354503","https://openalex.org/W1974906492","https://openalex.org/W1977641706","https://openalex.org/W1978408586","https://openalex.org/W1983302719","https://openalex.org/W1986945726","https://openalex.org/W1988146625","https://openalex.org/W1988374284","https://openalex.org/W1997203031","https://openalex.org/W1998065531","https://openalex.org/W2002724687","https://openalex.org/W2006981670","https://openalex.org/W2011352102","https://openalex.org/W2018416540","https://openalex.org/W2025036070","https://openalex.org/W2026729878","https://openalex.org/W2027981004","https://openalex.org/W2033365298","https://openalex.org/W2035339960","https://openalex.org/W2036368914","https://openalex.org/W2036419686","https://openalex.org/W2041278917","https://openalex.org/W2043850455","https://openalex.org/W2044009370","https://openalex.org/W2044163622","https://openalex.org/W2047269867","https://openalex.org/W2049596623","https://openalex.org/W2049924051","https://openalex.org/W2056236326","https://openalex.org/W2059927748","https://openalex.org/W2061140050","https://openalex.org/W2064072571","https://openalex.org/W2064888792","https://openalex.org/W2065889873","https://openalex.org/W2066347271","https://openalex.org/W2074534136","https://openalex.org/W2079946290","https://openalex.org/W2081915916","https://openalex.org/W2083331853","https://openalex.org/W2095903025","https://openalex.org/W2096018584","https://openalex.org/W2107455919","https://openalex.org/W2117582185","https://openalex.org/W2125518194","https://openalex.org/W2153683760","https://openalex.org/W2160985360","https://openalex.org/W2176716563","https://openalex.org/W2176905394","https://openalex.org/W2202483530","https://openalex.org/W2410709630","https://openalex.org/W4211183850","https://openalex.org/W4252737640"],"related_works":["https://openalex.org/W2068245597","https://openalex.org/W2030494254","https://openalex.org/W4313342490","https://openalex.org/W2916193724","https://openalex.org/W2256148956","https://openalex.org/W2168645803","https://openalex.org/W2120052711","https://openalex.org/W1964082268"],"abstract_inverted_index":{"The":[0],"expansion":[1,95],"and":[2,29,87],"contraction":[3],"of":[4,14,47,58,66,96],"specific":[5,97],"helper":[6],"T":[7,23,70,76,98],"cells":[8,32],"in":[9,44,69,83],"the":[10,45,48,59,64,84,91],"draining":[11],"lymph":[12],"nodes":[13],"normal":[15],"mice":[16],"after":[17],"injection":[18],"with":[19],"antigen":[20],"was":[21],"followed.":[22],"cell":[24,71,77,99],"receptors":[25],"from":[26],"purified":[27],"primary":[28],"memory":[30],"responder":[31],"had":[33],"highly":[34],"restricted":[35],"junctional":[36],"regions,":[37],"indicating":[38,63],"antigen-driven":[39],"selection.":[40],"Selection":[41],"for":[42,56],"homogeneity":[43],"length":[46],"third":[49],"complementarity-determining":[50],"region":[51],"(CDR3)":[52],"occurs":[53],"before":[54],"selection":[55],"some":[57],"characteristic":[60],"amino":[61],"acids,":[62],"importance":[65],"this":[67],"parameter":[68],"receptor":[72,78],"recognition.":[73],"Ultimately,":[74],"particular":[75],"sequences":[79],"come":[80],"to":[81],"predominate":[82],"secondary":[85],"response":[86],"others":[88],"disappear,":[89],"showing":[90],"selective":[92],"preservation":[93],"or":[94],"clones.":[100]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}