{"id":"https://openalex.org/W2010429599","doi":"https://doi.org/10.1002/jat.2550090110","title":"Disposition of methacrylonitrile in rats and distribution in blood components","display_name":"Disposition of methacrylonitrile in rats and distribution in blood components","publication_year":1989,"publication_date":"1989-02-01","ids":{"openalex":"https://openalex.org/W2010429599","doi":"https://doi.org/10.1002/jat.2550090110","mag":"2010429599","pmid":"https://pubmed.ncbi.nlm.nih.gov/2926097"},"language":"en","primary_location":{"id":"doi:10.1002/jat.2550090110","doi":"https://doi.org/10.1002/jat.2550090110","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jat.2550090110","pdf_url":null,"source":{"id":"https://openalex.org/S81851855","display_name":"Journal of Applied Toxicology","issn_l":"0260-437X","issn":["0260-437X","1099-1263"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018101289","display_name":"Rogelio Cavazos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rogelio Cavazos","raw_affiliation_strings":["Department of Biological Sciences, Pan American University, Edinburg, TX 78539","Division of Environmental Toxicology, Department of Biological Sciences, Pan American University, 1201 West University Drive, Edinburg, TX 78539, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Pan American University, Edinburg, TX 78539","institution_ids":[]},{"raw_affiliation_string":"Division of Environmental Toxicology, Department of Biological Sciences, Pan American University, 1201 West University Drive, Edinburg, TX 78539, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007532089","display_name":"Mohammed Y. H. Farooqui","orcid":"https://orcid.org/0000-0002-1358-1751","observed_orcids":["https://orcid.org/0000-0002-1358-1751"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mohammed Y. H. Farooqui","raw_affiliation_strings":["Division of Environmental Toxicology, Department of Biological Sciences, Pan American University, 1201 West University Drive, Edinburg, TX 78539, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Environmental Toxicology, Department of Biological Sciences, Pan American University, 1201 West University Drive, Edinburg, TX 78539, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060265604","display_name":"Wesley W. Day","orcid":"https://orcid.org/0000-0002-6451-8752","observed_orcids":["https://orcid.org/0000-0002-6451-8752"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wesley W. Day","raw_affiliation_strings":["Division of Environmental Toxicology, Department of Biological Sciences, Pan American University, 1201 West University Drive, Edinburg, TX 78539, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Environmental Toxicology, Department of Biological Sciences, Pan American University, 1201 West University Drive, Edinburg, TX 78539, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113568327","display_name":"Maria I. Villarreal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria I. Villarreal","raw_affiliation_strings":["Division of Environmental Toxicology, Department of Biological Sciences, Pan American University, 1201 West University Drive, Edinburg, TX 78539, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Environmental Toxicology, Department of Biological Sciences, Pan American University, 1201 West University Drive, Edinburg, TX 78539, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089540289","display_name":"Enrique Massa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Enrique Massa","raw_affiliation_strings":["Division of Environmental Toxicology, Department of Biological Sciences, Pan American University, 1201 West University Drive, Edinburg, TX 78539, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Environmental Toxicology, Department of Biological Sciences, Pan American University, 1201 West University Drive, Edinburg, TX 78539, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5007532089"],"corresponding_institution_ids":[],"apc_list":{"value":3940,"currency":"USD","value_usd":3940},"apc_paid":null,"fwci":1.9246,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.85170326,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"1","first_page":"53","last_page":"57"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12305","display_name":"Cassava research and cyanide","score":0.5601000189781189,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12305","display_name":"Cassava research and cyanide","score":0.5601000189781189,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11635","display_name":"Poisoning and overdose treatments","score":0.14710000157356262,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.1062999963760376,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methacrylonitrile","display_name":"methacrylonitrile","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cyanide-poisoning","display_name":"cyanide poisoning","score":0.460999995470047},{"id":"https://openalex.org/keywords/blood-distribution","display_name":"blood distribution","score":0.3569999933242798},{"id":"https://openalex.org/keywords/erythrocytes","display_name":"erythrocytes","score":0.9210000038146973},{"id":"https://openalex.org/keywords/hemoglobin-binding","display_name":"hemoglobin binding","score":0.625},{"id":"https://openalex.org/keywords/covalent-protein-binding","display_name":"covalent protein binding","score":0.5860000252723694},{"id":"https://openalex.org/keywords/thiocyanate","display_name":"thiocyanate","score":0.7990000247955322},{"id":"https://openalex.org/keywords/urinary-excretion","display_name":"urinary excretion","score":0.8080000281333923},{"id":"https://openalex.org/keywords/expired-air","display_name":"expired air","score":0.3089999854564667},{"id":"https://openalex.org/keywords/hydrogen-cyanide","display_name":"hydrogen cyanide","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C2780282147","wikidata":"https://www.wikidata.org/wiki/Q2088171","display_name":"Methacrylonitrile","level":5,"score":0.8171249628067017},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7145910859107971},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.6949374675750732},{"id":"https://openalex.org/C2781046861","wikidata":"https://www.wikidata.org/wiki/Q26075","display_name":"Hydrogen cyanide","level":2,"score":0.5839178562164307},{"id":"https://openalex.org/C2778455166","wikidata":"https://www.wikidata.org/wiki/Q55076544","display_name":"Cyanide","level":2,"score":0.571973443031311},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.5432459115982056},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5337793231010437},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5291224718093872},{"id":"https://openalex.org/C61716771","wikidata":"https://www.wikidata.org/wiki/Q496","display_name":"Feces","level":2,"score":0.5111926198005676},{"id":"https://openalex.org/C2778372188","wikidata":"https://www.wikidata.org/wiki/Q342968","display_name":"Acrylonitrile","level":4,"score":0.4995758533477783},{"id":"https://openalex.org/C2776294642","wikidata":"https://www.wikidata.org/wiki/Q77747995","display_name":"Thiocyanate","level":2,"score":0.47087419033050537},{"id":"https://openalex.org/C195289149","wikidata":"https://www.wikidata.org/wiki/Q2256694","display_name":"Toxicokinetics","level":3,"score":0.45175448060035706},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4218495190143585},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4152088761329651},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.36092472076416016},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3607769012451172},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3152593970298767},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17568689584732056},{"id":"https://openalex.org/C15920480","wikidata":"https://www.wikidata.org/wiki/Q421281","display_name":"Copolymer","level":3,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000179","descriptor_name":"Acrylates","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008689","descriptor_name":"Methacrylates","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008689","descriptor_name":"Methacrylates","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D008689","descriptor_name":"Methacrylates","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jat.2550090110","doi":"https://doi.org/10.1002/jat.2550090110","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jat.2550090110","pdf_url":null,"source":{"id":"https://openalex.org/S81851855","display_name":"Journal of Applied Toxicology","issn_l":"0260-437X","issn":["0260-437X","1099-1263"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Toxicology","raw_type":"journal-article"},{"id":"pmid:2926097","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2926097","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied toxicology : JAT","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3567808094","display_name":"MBRS PROGRAM AT PAN AMERICAN UNIVERSITY","funder_award_id":"S06RR008038","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1750042459","https://openalex.org/W1966496220","https://openalex.org/W1975573241","https://openalex.org/W1990514914","https://openalex.org/W1997801490","https://openalex.org/W1998729742","https://openalex.org/W2010875494","https://openalex.org/W2012243722","https://openalex.org/W2032112344","https://openalex.org/W2045843861","https://openalex.org/W2369753003","https://openalex.org/W2410340511","https://openalex.org/W4250450857","https://openalex.org/W4297756632"],"related_works":["https://openalex.org/W1998450236","https://openalex.org/W1975573241","https://openalex.org/W4251296713","https://openalex.org/W2330972578","https://openalex.org/W2022695642","https://openalex.org/W2032112344","https://openalex.org/W1815112380","https://openalex.org/W2082798740","https://openalex.org/W2463020895","https://openalex.org/W2063292074"],"abstract_inverted_index":{"The":[0,62],"interaction":[1],"of":[2,8,24,35,69,88,107,118,139,156],"2[14C]methyl-2,3[14C]acrylonitrile":[3],"(MeAN)":[4],"with":[5],"the":[6,31,36,39,43,48,79,89,113,119,128,131,137,145,152],"components":[7],"blood":[9,64],"and":[10,45,101,130,148],"its":[11],"disposition":[12],"in":[13,38,42,47,53,81,91,112,127,153],"male":[14],"Sprague-Dawley":[15],"rats":[16,32],"has":[17],"been":[18],"investigated.":[19],"Following":[20],"an":[21],"oral":[22],"administration":[23],"100":[25],"mg/kg":[26],"(0.5":[27],"LD50,":[28],"8":[29],"microCi/kg),":[30],"excreted":[33],"43%":[34],"[14C]":[37],"urine,":[40],"15%":[41],"feces":[44],"2.5%":[46],"expired":[49],"air":[50],"as":[51,95,125],"14CO2":[52],"5":[54],"days.":[55],"Hydrogen":[56],"cyanide":[57],"(H14CN)":[58],"was":[59,93,109,123],"not":[60,149],"detectable.":[61],"red":[63],"cells":[65],"retained":[66],"significant":[67],"amounts":[68],"radioactivity":[70,90,108],"for":[71],"more":[72],"than":[73,86],"five":[74],"days":[75],"after":[76],"administration,":[77],"whereas":[78],"[14C]-activity":[80],"plasma":[82,129],"declined":[83],"sharply.":[84],"More":[85],"50%":[87],"erythrocytes":[92],"detected":[94],"covalently":[96],"bound":[97],"to":[98,144,151],"cytoplasmic":[99],"(hemoglobin)":[100],"membrane":[102],"proteins.":[103],"A":[104],"small":[105],"amount":[106],"also":[110],"found":[111],"heme":[114],"fraction.":[115],"About":[116],"13%":[117],"total":[120],"dose":[121],"administered":[122],"recovered":[124],"thiocyanate":[126],"urine.":[132],"These":[133],"results":[134],"suggest":[135],"that":[136],"toxicity":[138],"MeAN":[140],"may":[141],"be":[142],"attributable":[143],"whole":[146],"molecule":[147],"entirely":[150],"vivo":[154],"liberation":[155],"cyanide.":[157]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}