{"id":"https://openalex.org/W2010428513","doi":"https://doi.org/10.1016/j.addr.2014.10.027","title":"Therapeutic strategies to combat antibiotic resistance","display_name":"Therapeutic strategies to combat antibiotic resistance","publication_year":2014,"publication_date":"2014-10-28","ids":{"openalex":"https://openalex.org/W2010428513","doi":"https://doi.org/10.1016/j.addr.2014.10.027","mag":"2010428513","pmid":"https://pubmed.ncbi.nlm.nih.gov/25450262"},"language":"en","primary_location":{"id":"doi:10.1016/j.addr.2014.10.027","doi":"https://doi.org/10.1016/j.addr.2014.10.027","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.addr.2014.10.027","pdf_url":null,"source":{"id":"https://openalex.org/S114437232","display_name":"Advanced Drug Delivery Reviews","issn_l":"0169-409X","issn":["0169-409X","1872-8294"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Drug Delivery Reviews","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001393643","display_name":"Benjamin D. Brooks","orcid":"https://orcid.org/0000-0001-7456-3074","observed_orcids":["https://orcid.org/0000-0001-7456-3074"]},"institutions":[{"id":"https://openalex.org/I4210092497","display_name":"Carterra (United States)","ror":"https://ror.org/002cajb45","country_code":"US","type":"company","lineage":["https://openalex.org/I4210092497"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin D. Brooks","raw_affiliation_strings":["Wasatch Microfluidics, Salt Lake City, UT 84112, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wasatch Microfluidics, Salt Lake City, UT 84112, USA","institution_ids":["https://openalex.org/I4210092497"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085575818","display_name":"Amanda E. Brooks","orcid":"https://orcid.org/0000-0001-9785-5969","observed_orcids":["https://orcid.org/0000-0001-9785-5969"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I57328836","display_name":"North Dakota State University","ror":"https://ror.org/05h1bnb22","country_code":"US","type":"education","lineage":["https://openalex.org/I57328836"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Amanda E. Brooks","raw_affiliation_strings":["Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT 84112, USA; Department of Pharmaceutical Sciences, North Dakota State University, Fargo, ND58108, USA. Electronic address: Amanda.e.brooks@ndsu.edu","Department of Pharmaceutical Sciences, North Dakota State University, Fargo, ND58108, USA","Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT 84112, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT 84112, USA; Department of Pharmaceutical Sciences, North Dakota State University, Fargo, ND58108, USA. Electronic address: Amanda.e.brooks@ndsu.edu","institution_ids":["https://openalex.org/I223532165","https://openalex.org/I57328836"]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences, North Dakota State University, Fargo, ND58108, USA","institution_ids":["https://openalex.org/I57328836"]},{"raw_affiliation_string":"Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT 84112, USA","institution_ids":["https://openalex.org/I223532165"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5085575818"],"corresponding_institution_ids":["https://openalex.org/I223532165","https://openalex.org/I57328836"],"apc_list":{"value":5550,"currency":"USD","value_usd":5550},"apc_paid":null,"fwci":1.6099,"has_fulltext":false,"cited_by_count":368,"citation_normalized_percentile":{"value":0.83760684,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"78","issue":null,"first_page":"14","last_page":"27"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.7710000276565552,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.7710000276565552,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":0.10000000149011612,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.03720000013709068,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.9929999709129333},{"id":"https://openalex.org/keywords/multidrug-resistant-bacteria","display_name":"multidrug-resistant bacteria","score":0.8389999866485596},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7099999785423279},{"id":"https://openalex.org/keywords/antimicrobial-stewardship","display_name":"antimicrobial stewardship","score":0.7390000224113464},{"id":"https://openalex.org/keywords/biologics","display_name":"biologics","score":0.8220000267028809},{"id":"https://openalex.org/keywords/controlled-drug-delivery","display_name":"controlled drug delivery","score":0.949999988079071},{"id":"https://openalex.org/keywords/infection-control","display_name":"infection control","score":0.7139999866485596},{"id":"https://openalex.org/keywords/novel-antibiotic-discovery","display_name":"new antibiotic development","score":0.6320000290870667},{"id":"https://openalex.org/keywords/resistance-mechanisms","display_name":"resistance mechanisms","score":0.7770000100135803}],"concepts":[{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.6993553042411804},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6599181294441223},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.6533591151237488},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.477723091840744},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4624616801738739},{"id":"https://openalex.org/C2777950569","wikidata":"https://www.wikidata.org/wiki/Q17021836","display_name":"Stewardship (theology)","level":3,"score":0.4385475516319275},{"id":"https://openalex.org/C166888038","wikidata":"https://www.wikidata.org/wiki/Q4118322","display_name":"Infection control","level":2,"score":0.41757622361183167},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.35926973819732666},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26520752906799316},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.16651436686515808},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.07365071773529053},{"id":"https://openalex.org/C94625758","wikidata":"https://www.wikidata.org/wiki/Q7163","display_name":"Politics","level":2,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024901","descriptor_name":"Drug Resistance, Multiple, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.addr.2014.10.027","doi":"https://doi.org/10.1016/j.addr.2014.10.027","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.addr.2014.10.027","pdf_url":null,"source":{"id":"https://openalex.org/S114437232","display_name":"Advanced Drug Delivery Reviews","issn_l":"0169-409X","issn":["0169-409X","1872-8294"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Drug Delivery Reviews","raw_type":"journal-article"},{"id":"pmid:25450262","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25450262","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced drug delivery reviews","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":193,"referenced_works":["https://openalex.org/W119802090","https://openalex.org/W192243001","https://openalex.org/W846546774","https://openalex.org/W999738804","https://openalex.org/W1570416034","https://openalex.org/W1598136901","https://openalex.org/W1875906722","https://openalex.org/W1911234722","https://openalex.org/W1963973481","https://openalex.org/W1964141703","https://openalex.org/W1964463137","https://openalex.org/W1965063429","https://openalex.org/W1965399445","https://openalex.org/W1965991261","https://openalex.org/W1968701956","https://openalex.org/W1971560969","https://openalex.org/W1971668211","https://openalex.org/W1972775656","https://openalex.org/W1977814929","https://openalex.org/W1980357487","https://openalex.org/W1981842620","https://openalex.org/W1981936083","https://openalex.org/W1982027539","https://openalex.org/W1982488247","https://openalex.org/W1982551127","https://openalex.org/W1984044241","https://openalex.org/W1988045696","https://openalex.org/W1989734247","https://openalex.org/W1990053723","https://openalex.org/W1990407294","https://openalex.org/W1990593974","https://openalex.org/W1991333977","https://openalex.org/W1991924027","https://openalex.org/W1992098811","https://openalex.org/W1993521270","https://openalex.org/W1996507856","https://openalex.org/W1997152791","https://openalex.org/W1999936841","https://openalex.org/W2000598102","https://openalex.org/W2000606891","https://openalex.org/W2002138727","https://openalex.org/W2003885943","https://openalex.org/W2004075221","https://openalex.org/W2005327412","https://openalex.org/W2006002537","https://openalex.org/W2006596001","https://openalex.org/W2010011305","https://openalex.org/W2010047058","https://openalex.org/W2010792073","https://openalex.org/W2012977051","https://openalex.org/W2014069105","https://openalex.org/W2014242358","https://openalex.org/W2015178572","https://openalex.org/W2015721897","https://openalex.org/W2015944885","https://openalex.org/W2016579435","https://openalex.org/W2017268899","https://openalex.org/W2017616352","https://openalex.org/W2017652889","https://openalex.org/W2018517592","https://openalex.org/W2018613885","https://openalex.org/W2020045592","https://openalex.org/W2021135382","https://openalex.org/W2023893212","https://openalex.org/W2024228476","https://openalex.org/W2024334224","https://openalex.org/W2024759473","https://openalex.org/W2024933647","https://openalex.org/W2026482455","https://openalex.org/W2029080394","https://openalex.org/W2031423988","https://openalex.org/W2034094342","https://openalex.org/W2040570580","https://openalex.org/W2041777288","https://openalex.org/W2042049226","https://openalex.org/W2042684813","https://openalex.org/W2045618634","https://openalex.org/W2050492994","https://openalex.org/W2051695178","https://openalex.org/W2051940354","https://openalex.org/W2052300481","https://openalex.org/W2055287897","https://openalex.org/W2056589536","https://openalex.org/W2056917379","https://openalex.org/W2057401975","https://openalex.org/W2058169173","https://openalex.org/W2058952776","https://openalex.org/W2063790803","https://openalex.org/W2064683586","https://openalex.org/W2065855453","https://openalex.org/W2066399117","https://openalex.org/W2067595614","https://openalex.org/W2067835715","https://openalex.org/W2068581230","https://openalex.org/W2069969741","https://openalex.org/W2072084534","https://openalex.org/W2073097129","https://openalex.org/W2073556554","https://openalex.org/W2075023168","https://openalex.org/W2075854662","https://openalex.org/W2076233570","https://openalex.org/W2076260563","https://openalex.org/W2077143565","https://openalex.org/W2077754621","https://openalex.org/W2078722485","https://openalex.org/W2079035062","https://openalex.org/W2079194661","https://openalex.org/W2079752712","https://openalex.org/W2080777238","https://openalex.org/W2082190364","https://openalex.org/W2083849909","https://openalex.org/W2084146546","https://openalex.org/W2084299481","https://openalex.org/W2084387253","https://openalex.org/W2084817720","https://openalex.org/W2086223988","https://openalex.org/W2086801586","https://openalex.org/W2086919865","https://openalex.org/W2087703844","https://openalex.org/W2088786967","https://openalex.org/W2089511414","https://openalex.org/W2090651792","https://openalex.org/W2092605333","https://openalex.org/W2092799157","https://openalex.org/W2093700124","https://openalex.org/W2094565909","https://openalex.org/W2097780578","https://openalex.org/W2101362243","https://openalex.org/W2102439233","https://openalex.org/W2106223312","https://openalex.org/W2106360753","https://openalex.org/W2106536314","https://openalex.org/W2108058261","https://openalex.org/W2108306069","https://openalex.org/W2108638835","https://openalex.org/W2108808146","https://openalex.org/W2112088808","https://openalex.org/W2112487751","https://openalex.org/W2112833584","https://openalex.org/W2112903691","https://openalex.org/W2113574179","https://openalex.org/W2115076532","https://openalex.org/W2115486016","https://openalex.org/W2117681922","https://openalex.org/W2118471200","https://openalex.org/W2118801485","https://openalex.org/W2119784812","https://openalex.org/W2120016302","https://openalex.org/W2120603988","https://openalex.org/W2125603952","https://openalex.org/W2127535305","https://openalex.org/W2127609756","https://openalex.org/W2129819819","https://openalex.org/W2132911648","https://openalex.org/W2135465392","https://openalex.org/W2136746831","https://openalex.org/W2139365228","https://openalex.org/W2139806506","https://openalex.org/W2139911027","https://openalex.org/W2140353364","https://openalex.org/W2140735648","https://openalex.org/W2143544264","https://openalex.org/W2145744900","https://openalex.org/W2145952139","https://openalex.org/W2146639370","https://openalex.org/W2147115456","https://openalex.org/W2148488439","https://openalex.org/W2149377698","https://openalex.org/W2150422406","https://openalex.org/W2150905091","https://openalex.org/W2152618703","https://openalex.org/W2153290403","https://openalex.org/W2159445822","https://openalex.org/W2161583355","https://openalex.org/W2161956102","https://openalex.org/W2163817553","https://openalex.org/W2164075000","https://openalex.org/W2164620474","https://openalex.org/W2166740816","https://openalex.org/W2166890714","https://openalex.org/W2171282720","https://openalex.org/W2299636470","https://openalex.org/W2320749597","https://openalex.org/W2320971255","https://openalex.org/W2329188153","https://openalex.org/W2332598084","https://openalex.org/W2412315627","https://openalex.org/W2414118913","https://openalex.org/W2418132573","https://openalex.org/W2916084778","https://openalex.org/W3142106066","https://openalex.org/W4242318543","https://openalex.org/W6672611181"],"related_works":["https://openalex.org/W4408612867","https://openalex.org/W2988249661","https://openalex.org/W7221517252","https://openalex.org/W3167809977","https://openalex.org/W4403788382","https://openalex.org/W4315701808","https://openalex.org/W7221291094","https://openalex.org/W2013116382","https://openalex.org/W1982551127","https://openalex.org/W4387044477"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":29},{"year":2024,"cited_by_count":32},{"year":2023,"cited_by_count":36},{"year":2022,"cited_by_count":48},{"year":2021,"cited_by_count":39},{"year":2020,"cited_by_count":31},{"year":2019,"cited_by_count":43},{"year":2018,"cited_by_count":24},{"year":2017,"cited_by_count":39},{"year":2016,"cited_by_count":25},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
