{"id":"https://openalex.org/W2010421788","doi":"https://doi.org/10.1007/s10549-011-1638-4","title":"Targeting low molecular weight cyclin E (LMW-E) in breast cancer","display_name":"Targeting low molecular weight cyclin E (LMW-E) in breast cancer","publication_year":2011,"publication_date":"2011-06-21","ids":{"openalex":"https://openalex.org/W2010421788","doi":"https://doi.org/10.1007/s10549-011-1638-4","mag":"2010421788","pmid":"https://pubmed.ncbi.nlm.nih.gov/21695458","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3855283"},"language":"en","primary_location":{"id":"doi:10.1007/s10549-011-1638-4","doi":"https://doi.org/10.1007/s10549-011-1638-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10549-011-1638-4","pdf_url":null,"source":{"id":"https://openalex.org/S142211178","display_name":"Breast Cancer Research and Treatment","issn_l":"0167-6806","issn":["0167-6806","1573-7217"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast Cancer Research and Treatment","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3855283","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063610899","display_name":"Angela Nanos-Webb","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela Nanos-Webb","raw_affiliation_strings":["Department of Experimental Radiation Oncology, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Radiation Oncology, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088339730","display_name":"Natalie A. Jabbour-Leung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalie A. Jabbour","raw_affiliation_strings":["Department of Experimental Radiation Oncology, M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA","M.D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Radiation Oncology, M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"M.D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037147613","display_name":"Asha S. Multani","orcid":"https://orcid.org/0000-0002-6989-8627","observed_orcids":["https://orcid.org/0000-0002-6989-8627"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Asha S. Multani","raw_affiliation_strings":["Department of Genetics, M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA","M.D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"M.D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052218127","display_name":"Hannah F. Wingate","orcid":"https://orcid.org/0000-0002-1055-8935","observed_orcids":["https://orcid.org/0000-0002-1055-8935"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hannah Wingate","raw_affiliation_strings":["Department of Surgical Oncology, M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA","M.D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Oncology, M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"M.D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061453004","display_name":"Nassima Oumata","orcid":"https://orcid.org/0000-0003-4074-7072","observed_orcids":["https://orcid.org/0000-0003-4074-7072"]},"institutions":[{"id":"https://openalex.org/I4210095983","display_name":"ManRos Therapeutics (France)","ror":"https://ror.org/00nkgjn49","country_code":"FR","type":"company","lineage":["https://openalex.org/I4210095983"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nassima Oumata","raw_affiliation_strings":["ManRos Therapeutics, Centre de Perharidy, 29680, Roscoff, France","Centre de Perharidy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ManRos Therapeutics, Centre de Perharidy, 29680, Roscoff, France","institution_ids":["https://openalex.org/I4210095983"]},{"raw_affiliation_string":"Centre de Perharidy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002218517","display_name":"Herv\u00e9 Galons","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210144972","display_name":"Laboratoire de Chimie Organique","ror":"https://ror.org/04db3be62","country_code":"FR","type":"facility","lineage":["https://openalex.org/I190752583","https://openalex.org/I2746051580","https://openalex.org/I4210144972","https://openalex.org/I98910050"]},{"id":"https://openalex.org/I4387156284","display_name":"Universit\u00e9 Paris Descartes","ror":"https://ror.org/0220k9r37","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387156284"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Herv\u00e9 Galons","raw_affiliation_strings":["Laboratoire de Chimie Organique 2, CNRS UMR8601, INSERM U 648, Universit\u00e9 Paris-Descartes, 4 avenue de l\u2019Observatoire, 75270, Paris cedex 06, France","Universit\u00e8 Paris Descartes#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Chimie Organique 2, CNRS UMR8601, INSERM U 648, Universit\u00e9 Paris-Descartes, 4 avenue de l\u2019Observatoire, 75270, Paris cedex 06, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210144972","https://openalex.org/I4387156284"]},{"raw_affiliation_string":"Universit\u00e8 Paris Descartes#TAB#","institution_ids":["https://openalex.org/I4387156284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089859546","display_name":"Beno\u0131\u0302t Joseph","orcid":"https://orcid.org/0000-0002-3932-8041","observed_orcids":["https://orcid.org/0000-0002-3932-8041"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I4210099454","display_name":"Institut de Chimie et Biochimie Mol\u00e9culaires et Supramol\u00e9culaires","ror":"https://ror.org/00gj33s30","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I203339264","https://openalex.org/I4210099454","https://openalex.org/I4210128300","https://openalex.org/I48430043","https://openalex.org/I59692284"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Beno\u00eet Joseph","raw_affiliation_strings":["Institut de Chimie et Biochimie Mol\u00e9culaires et Supramol\u00e9culaires, Universit\u00e9 Claude Bernard-Lyon 1, B\u00e2timent Curien, 43 Boulevard du 11 Novembre 1918, 69622, Villeurbanne, France","Universit\u00e9 Claude Bernard. Lyon-1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Chimie et Biochimie Mol\u00e9culaires et Supramol\u00e9culaires, Universit\u00e9 Claude Bernard-Lyon 1, B\u00e2timent Curien, 43 Boulevard du 11 Novembre 1918, 69622, Villeurbanne, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I4210099454"]},{"raw_affiliation_string":"Universit\u00e9 Claude Bernard. Lyon-1","institution_ids":["https://openalex.org/I100532134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012532551","display_name":"Laurent Meijer","orcid":"https://orcid.org/0000-0003-3511-4916","observed_orcids":["https://orcid.org/0000-0003-3511-4916"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2802436875","display_name":"Station Biologique de Roscoff","ror":"https://ror.org/03s0pzj56","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2802436875","https://openalex.org/I39804081","https://openalex.org/I4210107625"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laurent Meijer","raw_affiliation_strings":["CNRS, \u2018Protein Phosphorylation & Human Disease\u2019 Group, Station Biologique, Bretagne, 29680, Roscoff, France","CNRS, \u2018Protein Phosphorylation & Human Disease\u2019 Group"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS, \u2018Protein Phosphorylation & Human Disease\u2019 Group, Station Biologique, Bretagne, 29680, Roscoff, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2802436875"]},{"raw_affiliation_string":"CNRS, \u2018Protein Phosphorylation & Human Disease\u2019 Group","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017411324","display_name":"Kelly K. Hunt","orcid":"https://orcid.org/0000-0001-9156-8723","observed_orcids":["https://orcid.org/0000-0001-9156-8723"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly K. Hunt","raw_affiliation_strings":["Department of Surgical Oncology, M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA","M.D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Oncology, M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"M.D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042960706","display_name":"Khandan Keyomarsi","orcid":"https://orcid.org/0000-0002-5440-0849","observed_orcids":["https://orcid.org/0000-0002-5440-0849"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Khandan Keyomarsi","raw_affiliation_strings":["Department of Experimental Radiation Oncology, M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA","M.D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Radiation Oncology, M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"M.D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5042960706"],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":null,"fwci":1.1878,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.78330129,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"132","issue":"2","first_page":"575","last_page":"588"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/low-molecular-weight-cyclin-e","display_name":"low molecular weight cyclin E","score":0.996999979019165},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9549999833106995},{"id":"https://openalex.org/keywords/cdk2","display_name":"CDK2","score":0.8230000138282776},{"id":"https://openalex.org/keywords/cyclin-dependent-kinase-inhibitors","display_name":"cyclin-dependent kinase inhibitors","score":0.8629999756813049},{"id":"https://openalex.org/keywords/roscovitine","display_name":"roscovitine","score":0.9900000095367432},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.9670000076293945},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7799999713897705},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.6639999747276306},{"id":"https://openalex.org/keywords/inducible-gene-expression","display_name":"inducible gene expression","score":0.6919999718666077},{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.8309999704360962},{"id":"https://openalex.org/keywords/polyploidy","display_name":"polyploidy","score":0.9779999852180481},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.9139999747276306},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.41600000858306885}],"concepts":[{"id":"https://openalex.org/C2778298596","wikidata":"https://www.wikidata.org/wiki/Q17143494","display_name":"CDK inhibitor","level":5,"score":0.7816418409347534},{"id":"https://openalex.org/C124320809","wikidata":"https://www.wikidata.org/wiki/Q46292","display_name":"Cyclin-dependent kinase","level":4,"score":0.7636168599128723},{"id":"https://openalex.org/C94561458","wikidata":"https://www.wikidata.org/wiki/Q24724860","display_name":"Cyclin E","level":5,"score":0.6230089068412781},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5988848209381104},{"id":"https://openalex.org/C82495950","wikidata":"https://www.wikidata.org/wiki/Q14911732","display_name":"Cyclin-dependent kinase 2","level":4,"score":0.5539851188659668},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.54133141040802},{"id":"https://openalex.org/C11882975","wikidata":"https://www.wikidata.org/wiki/Q24781041","display_name":"Cyclin D","level":5,"score":0.5247951745986938},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5223382711410522},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5134652256965637},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.44824346899986267},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4213876724243164},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3915395140647888},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.38376671075820923},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.3316611349582672},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.31261301040649414},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13270750641822815}],"mesh":[{"descriptor_ui":"D000077546","descriptor_name":"Roscovitine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004790","descriptor_name":"Enzyme Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011123","descriptor_name":"Polyploidy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011687","descriptor_name":"Purines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019927","descriptor_name":"Cyclin E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019927","descriptor_name":"Cyclin E","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042822","descriptor_name":"Genomic Instability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051357","descriptor_name":"Cyclin-Dependent Kinase 2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051357","descriptor_name":"Cyclin-Dependent Kinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1007/s10549-011-1638-4","doi":"https://doi.org/10.1007/s10549-011-1638-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10549-011-1638-4","pdf_url":null,"source":{"id":"https://openalex.org/S142211178","display_name":"Breast Cancer Research and Treatment","issn_l":"0167-6806","issn":["0167-6806","1573-7217"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast Cancer Research and Treatment","raw_type":"journal-article"},{"id":"pmid:21695458","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21695458","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast cancer research and treatment","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2840415","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3855283","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3855283","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3855283","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Breast Cancer Res Treat","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-00691433v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-00691433","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Breast Cancer Research and Treatment, 2012, 132 (2), pp.575-88. ⟨10.1007/s10549-011-1638-4⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2840415","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3855283","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1170996406","display_name":"Proeolytic Processing of Cyclin E in Breast Cancer","funder_award_id":"5r01ca087548-14","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1345614600","display_name":null,"funder_award_id":"R01-CA087548","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1585007957","display_name":"UTMDACC SPORE in Breast Cancer","funder_award_id":"P50CA116199","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1619438925","display_name":null,"funder_award_id":"CA-16672","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3626265467","display_name":null,"funder_award_id":"CA87458","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7011247166","display_name":"Targeting the cell cycle in triple negative breast cancer","funder_award_id":"R01CA152228","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7382043797","display_name":"Center for Clinical and Translational Sciences","funder_award_id":"TL1RR024147","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G9000878657","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016672","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W30931427","https://openalex.org/W177595770","https://openalex.org/W1895365641","https://openalex.org/W1910656974","https://openalex.org/W1966797025","https://openalex.org/W1978507959","https://openalex.org/W1978984338","https://openalex.org/W1991054314","https://openalex.org/W1995038735","https://openalex.org/W1995788690","https://openalex.org/W2003570263","https://openalex.org/W2005353346","https://openalex.org/W2005766257","https://openalex.org/W2020118142","https://openalex.org/W2025618547","https://openalex.org/W2065442447","https://openalex.org/W2066469256","https://openalex.org/W2070147996","https://openalex.org/W2083433702","https://openalex.org/W2084147994","https://openalex.org/W2090303261","https://openalex.org/W2105934245","https://openalex.org/W2113662093","https://openalex.org/W2129072472","https://openalex.org/W2134590240","https://openalex.org/W2137487731","https://openalex.org/W2141884409","https://openalex.org/W2145717550","https://openalex.org/W2147460690","https://openalex.org/W2152028923","https://openalex.org/W2156157871","https://openalex.org/W2158728799","https://openalex.org/W2166615734","https://openalex.org/W2417090228","https://openalex.org/W2498069630"],"related_works":["https://openalex.org/W4282932032","https://openalex.org/W2081106130","https://openalex.org/W2158728799","https://openalex.org/W2322999506","https://openalex.org/W9262904","https://openalex.org/W2163129204","https://openalex.org/W1978507959","https://openalex.org/W4220806161","https://openalex.org/W2567342176","https://openalex.org/W4250669578"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}