{"id":"https://openalex.org/W2010404558","doi":"https://doi.org/10.1016/0021-9150(76)90136-2","title":"Ischaemic disease in men and women with familial hypercholesterolaemia and xanthomatosis A comparative study of genetic and environmental factors in 274 heterozygous cases","display_name":"Ischaemic disease in men and women with familial hypercholesterolaemia and xanthomatosis A comparative study of genetic and environmental factors in 274 heterozygous cases","publication_year":1976,"publication_date":"1976-09-01","ids":{"openalex":"https://openalex.org/W2010404558","doi":"https://doi.org/10.1016/0021-9150(76)90136-2","mag":"2010404558","pmid":"https://pubmed.ncbi.nlm.nih.gov/971346"},"language":"en","primary_location":{"id":"doi:10.1016/0021-9150(76)90136-2","doi":"https://doi.org/10.1016/0021-9150(76)90136-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0021-9150(76)90136-2","pdf_url":null,"source":{"id":"https://openalex.org/S206830620","display_name":"Atherosclerosis","issn_l":"0021-9150","issn":["0021-9150","1879-1484"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Atherosclerosis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017606045","display_name":"V. Beaumont","orcid":"https://orcid.org/0000-0001-9626-0111","observed_orcids":["https://orcid.org/0000-0001-9626-0111"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I3019246885","display_name":"Centre Hospitalier Universitaire Henri-Mondor","ror":"https://ror.org/04m61mj84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019246885"]},{"id":"https://openalex.org/I4210130325","display_name":"H\u00f4pitaux Universitaires Henri-Mondor","ror":"https://ror.org/033yb0967","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210130325"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"V. Beaumont","raw_affiliation_strings":["Institut de Recherches sur les Maladies Vasculaires de l'Universit\u00e9 Paris, Val-de-Marne, and Unit\u00e9 de Recherches sur l'Ath\u00e9roscl\u00e9rose de l'I.N.S.E.R.M., H\u00f4pital Henri-Mondor, 94010 Cr\u00e9teil, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherches sur les Maladies Vasculaires de l'Universit\u00e9 Paris, Val-de-Marne, and Unit\u00e9 de Recherches sur l'Ath\u00e9roscl\u00e9rose de l'I.N.S.E.R.M., H\u00f4pital Henri-Mondor, 94010 Cr\u00e9teil, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I3019246885","https://openalex.org/I4210130325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081471809","display_name":"Bernard JACOTOT","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I3019246885","display_name":"Centre Hospitalier Universitaire Henri-Mondor","ror":"https://ror.org/04m61mj84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019246885"]},{"id":"https://openalex.org/I4210130325","display_name":"H\u00f4pitaux Universitaires Henri-Mondor","ror":"https://ror.org/033yb0967","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210130325"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"B. Jacotot","raw_affiliation_strings":["Institut de Recherches sur les Maladies Vasculaires de l'Universit\u00e9 Paris, Val-de-Marne, and Unit\u00e9 de Recherches sur l'Ath\u00e9roscl\u00e9rose de l'I.N.S.E.R.M., H\u00f4pital Henri-Mondor, 94010 Cr\u00e9teil, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherches sur les Maladies Vasculaires de l'Universit\u00e9 Paris, Val-de-Marne, and Unit\u00e9 de Recherches sur l'Ath\u00e9roscl\u00e9rose de l'I.N.S.E.R.M., H\u00f4pital Henri-Mondor, 94010 Cr\u00e9teil, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I3019246885","https://openalex.org/I4210130325"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103501001","display_name":"J. L. Beaumont","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I3019246885","display_name":"Centre Hospitalier Universitaire Henri-Mondor","ror":"https://ror.org/04m61mj84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019246885"]},{"id":"https://openalex.org/I4210130325","display_name":"H\u00f4pitaux Universitaires Henri-Mondor","ror":"https://ror.org/033yb0967","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210130325"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J.-L. Beaumont","raw_affiliation_strings":["Institut de Recherches sur les Maladies Vasculaires de l'Universit\u00e9 Paris, Val-de-Marne, and Unit\u00e9 de Recherches sur l'Ath\u00e9roscl\u00e9rose de l'I.N.S.E.R.M., H\u00f4pital Henri-Mondor, 94010 Cr\u00e9teil, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherches sur les Maladies Vasculaires de l'Universit\u00e9 Paris, Val-de-Marne, and Unit\u00e9 de Recherches sur l'Ath\u00e9roscl\u00e9rose de l'I.N.S.E.R.M., H\u00f4pital Henri-Mondor, 94010 Cr\u00e9teil, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I3019246885","https://openalex.org/I4210130325"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4020,"currency":"USD","value_usd":4020},"apc_paid":null,"fwci":3.6512,"has_fulltext":false,"cited_by_count":85,"citation_normalized_percentile":{"value":0.91596639,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"24","issue":"3","first_page":"441","last_page":"450"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/familial-hypercholesterolemia","display_name":"familial hypercholesterolemia","score":0.9860000014305115},{"id":"https://openalex.org/keywords/xanthomatosis","display_name":"xanthomatosis","score":0.9660000205039978},{"id":"https://openalex.org/keywords/ischemic-heart-disease","display_name":"ischemic heart disease","score":0.847000002861023},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9430000185966492},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.9509999752044678},{"id":"https://openalex.org/keywords/cigarette-smoking","display_name":"cigarette smoking","score":0.6819999814033508},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.8069999814033508},{"id":"https://openalex.org/keywords/age-of-onset","display_name":"age of onset","score":0.734000027179718},{"id":"https://openalex.org/keywords/genetic-and-environmental-risk-factors","display_name":"genetic and environmental risk factors","score":0.5799999833106995}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7920708656311035},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.6755156517028809},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.6256023049354553},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6193046569824219},{"id":"https://openalex.org/C2779120738","wikidata":"https://www.wikidata.org/wiki/Q2711291","display_name":"Familial hypercholesterolemia","level":3,"score":0.5844782590866089},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5454561710357666},{"id":"https://openalex.org/C3018759053","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Ischaemic heart disease","level":2,"score":0.4904620349407196},{"id":"https://openalex.org/C3019085024","wikidata":"https://www.wikidata.org/wiki/Q7212330","display_name":"Cigarette smoking","level":2,"score":0.44289979338645935},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.43071362376213074},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.324160635471344},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3229672908782959},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006937","descriptor_name":"Hypercholesterolemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006937","descriptor_name":"Hypercholesterolemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009135","descriptor_name":"Muscular Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013710","descriptor_name":"Tendons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014527","descriptor_name":"Uric Acid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014973","descriptor_name":"Xanthomatosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D014973","descriptor_name":"Xanthomatosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0021-9150(76)90136-2","doi":"https://doi.org/10.1016/0021-9150(76)90136-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0021-9150(76)90136-2","pdf_url":null,"source":{"id":"https://openalex.org/S206830620","display_name":"Atherosclerosis","issn_l":"0021-9150","issn":["0021-9150","1879-1484"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Atherosclerosis","raw_type":"journal-article"},{"id":"pmid:971346","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/971346","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Atherosclerosis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1562430392","https://openalex.org/W1893943578","https://openalex.org/W1965649591","https://openalex.org/W1968398092","https://openalex.org/W1975036384","https://openalex.org/W1990835137","https://openalex.org/W1993589783","https://openalex.org/W1998208967","https://openalex.org/W2034260978","https://openalex.org/W2047406962","https://openalex.org/W2061883889","https://openalex.org/W2090883245","https://openalex.org/W2112698709","https://openalex.org/W2408811950","https://openalex.org/W2433312964","https://openalex.org/W2465434047","https://openalex.org/W3022521753","https://openalex.org/W4301248400"],"related_works":["https://openalex.org/W1510032227","https://openalex.org/W1994259508","https://openalex.org/W3148125018","https://openalex.org/W2606515602","https://openalex.org/W3098751029","https://openalex.org/W4360612516","https://openalex.org/W4410431083","https://openalex.org/W4386247602","https://openalex.org/W4391823438","https://openalex.org/W3216108238"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}